{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:36:59Z","timestamp":1789663019542,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"Public Health Service, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI067888"],"award-info":[{"award-number":["AI067888"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"Public Health Service, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI092129"],"award-info":[{"award-number":["AI092129"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Studies in humans indicate that certain Chlamydia trachomatis serovars are more pathogenic than others. Specifically, several studies concluded that serovars from the C-complex are more pathogenic than those from the B-complex, although there are reports that do not support this finding. To investigate these results in an animal model, the eight genitourinary C. trachomatis serovars were tested in two strains of mice: C3H\/HeN and BALB\/c. These two strains of mice were investigated because C3H\/HeN is more susceptible to Chlamydia muridarum infections than BALB\/c, indicative of differences in their immunogenetic background. Mice were infected transcervically with 105 inclusion forming units of each of the C. trachomatis serovars, and vaginal cultures were collected. To determine the pathogenicity and its impact on fertility, at week seven post-infection, female mice were caged with male mice. In the C3H\/HeN mice, significant differences in vaginal shedding and fertility were observed between serovars from the B-complex (D and E) and those from the C-complex (H, I, J) and B- and C-related complexes (G, F, and K). The animals infected with serovars F, G, H, I, J, and K shed less but had significantly more infertility than the mice infected with serovars D or E. The experiments in the BALB\/c mice, however, did not show major differences in pathogenicity between the eight C. trachomatis serovars. These results support the findings in humans and emphasize the critical importance of the immunogenetic background of the host on the outcome of C. trachomatis infections. The data imply that management of C. trachomatis-infected patients may require a more personalized approach.<\/jats:p>","DOI":"10.3390\/pathogens14010097","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:47:32Z","timestamp":1737460052000},"page":"97","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chlamydia trachomatis Serovars from the C-Complex and the B- and C-Related Complexes Are Significantly More Pathogenic than Those from the B-Complex in C3H\/HeN but Not in BALB\/c Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Sukumar","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia F.","family":"Tifrea","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Tatarenkova","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"de la Maza","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697-4800, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"ref_1","unstructured":"CDC (2024, October 22). Division of STI Prevention, Available online: https:\/\/www.cdc.gov\/std\/statistics\/2024\/overview.htm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.vaccine.2016.03.111","article-title":"The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps","volume":"34","author":"Gottlieb","year":"2016","journal-title":"Vaccine"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Schachter, J., and Dawson, C.R. (1978). Human Chlamydial Infections, PSG Pub. Co.","DOI":"10.1056\/NEJM197803092981005"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00007435-199207000-00001","article-title":"Pelvic inflammatory disease and fertility. A cohort study of 1844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results","volume":"19","author":"Westrom","year":"1992","journal-title":"Sex. Transm. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta20220","article-title":"The natural history of Chlamydia trachomatis infection in women: A multi-parameter evidence synthesis","volume":"20","author":"Price","year":"2016","journal-title":"Health Technol. Assess."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4049\/jimmunol.90.6.849","article-title":"Classification of Trachoma Virus Strains by Protection of Mice from Toxic Death","volume":"90","author":"Wang","year":"1963","journal-title":"J. Immunol."},{"key":"ref_7","unstructured":"de la Maza, L.M., and Peterson, E.M. (1984). Medical Virology III, Elsevier Science Publishing Co., Inc."},{"key":"ref_8","first-page":"892","article-title":"Phylogenetic analysis of the outer-membrane-protein genes of Chlamydiae, and its implication for vaccine development","volume":"10","author":"Fitch","year":"1993","journal-title":"Mol. Biol. Evol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1128\/jcm.29.7.1333-1338.1991","article-title":"Simplified microtiter cell culture method for rapid immunotyping of Chlamydia trachomatis","volume":"29","author":"Suchland","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"ref_10","first-page":"E128","article-title":"Molecular epidemiology and genotyping of Chlamydia trachomatis infection in a cohort of young asymptomatic sexually active women (18\u201325 years) in Milan, Italy","volume":"57","author":"Bianchi","year":"2016","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4103\/ijmr.IJMR_1171_17","article-title":"Distribution of Chlamydia trachomatis omp A genotypes in patients attending a sexually transmitted disease outpatient clinic in New Delhi, India","volume":"149","author":"Rawre","year":"2019","journal-title":"Indian J. Med. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/infdis\/160.2.332","article-title":"Correlation of infecting serovar and local inflammation in genital chlamydial infections","volume":"160","author":"Batteiger","year":"1989","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/clinids\/19.4.756","article-title":"Clinical manifestations of genital infection due to Chlamydia trachomatis in women: Differences related to serovar","volume":"19","author":"Workowski","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"ref_14","first-page":"107","article-title":"Chlamydia trachomatis C-complex serovars are a risk factor for preterm birth","volume":"21","author":"Hollegaard","year":"2007","journal-title":"In Vivo"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/humrep\/13.11.3121","article-title":"Characterization of ciliary activity in distal Fallopian tube biopsies of women with obstructive tubal infertility","volume":"13","author":"Leng","year":"1998","journal-title":"Hum. Reprod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1086\/516291","article-title":"Chlamydia trachomatis genotypes: Correlation with clinical manifestations of infection and patients\u2019 characteristics","volume":"26","author":"Ossewaarde","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1128\/JCM.02076-06","article-title":"Distribution study of Chlamydia trachomatis serovars among high-risk women in China performed using PCR-restriction fragment length polymorphism genotyping","volume":"45","author":"Gao","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1128\/jcm.33.12.3194-3197.1995","article-title":"Prevalence and serovar distribution of asymptomatic cervical Chlamydia trachomatis infections as determined by highly sensitive PCR","volume":"33","author":"Lan","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007435-200302000-00013","article-title":"The relationship of serovar to clinical manifestations of urogenital Chlamydia trachomatis infection","volume":"30","author":"Geisler","year":"2003","journal-title":"Sex. Transm. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/infdis\/172.4.1013","article-title":"Major outer membrane protein variants of Chlamydia trachomatis are associated with severe upper genital tract infections and histopathology in San Francisco","volume":"172","author":"Dean","year":"1995","journal-title":"J. Infect. Dis."},{"key":"ref_21","first-page":"261","article-title":"Differences in clinical manifestations of genital chlamydial infections related to serovars","volume":"72","author":"Fennema","year":"1996","journal-title":"Genitourin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1128\/JCM.38.6.2292-2296.2000","article-title":"Urogenital Chlamydia trachomatis serovars in men and women with a symptomatic or asymptomatic infection: An association with clinical manifestations?","volume":"38","author":"Morre","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1128\/JB.186.8.2457-2465.2004","article-title":"Population-based genetic and evolutionary analysis of Chlamydia trachomatis urogenital strain variation in the United States","volume":"186","author":"Millman","year":"2004","journal-title":"J. Bacteriol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1086\/428287","article-title":"The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: A 5-year follow-up study","volume":"191","author":"Molano","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1086\/315778","article-title":"Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping","volume":"182","author":"Dean","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.285.1.47","article-title":"Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma","volume":"285","author":"Anttila","year":"2001","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1128\/iai.62.8.3354-3362.1994","article-title":"Intravaginal inoculation of mice with the Chlamydia trachomatis mouse pneumonitis biovar results in infertility","volume":"62","author":"Pal","year":"1994","journal-title":"Infect. Immun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1128\/IAI.69.8.5203-5206.2001","article-title":"Susceptibility of mice to vaginal infection with Chlamydia trachomatis mouse pneumonitis is dependent on the age of the animal","volume":"69","author":"Pal","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/iai.31.3.1161-1176.1981","article-title":"Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis","volume":"31","author":"Caldwell","year":"1981","journal-title":"Infect. Immun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.micinf.2012.12.001","article-title":"Differences in infectivity and induction of infertility: A comparative study of Chlamydia trachomatis strains in the murine model","volume":"15","author":"Carmichael","year":"2013","journal-title":"Microbes Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.4049\/jimmunol.1103032","article-title":"CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract","volume":"189","author":"Gondek","year":"2012","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1128\/iai.62.8.3354-3362.1994","article-title":"Protection against infertility in a BALB\/c mouse salpingitis model by intranasal immunization with the mouse pneumonitis biovar of Chlamydia trachomatis","volume":"62","author":"Pal","year":"1994","journal-title":"Infect. Immun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/iai.56.4.885-891.1988","article-title":"Protective role of magnesium in the neutralization by antibodies of Chlamydia trachomatis infectivity","volume":"56","author":"Peterson","year":"1988","journal-title":"Infect. Immun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"10969","DOI":"10.1007\/s11229-021-03276-4","article-title":"When to adjust alpha during multiple testing: A consideration of disjunction, conjunction, and individual testing","volume":"199","author":"Rubin","year":"2021","journal-title":"Synthese"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1574-6968.1981.tb07622.x","article-title":"Progesterone as a key factor in the development of a mouse model for genital-tract infection with Chlamydia trachomatis","volume":"12","author":"Tuffrey","year":"1981","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_36","first-page":"605","article-title":"Salpingitis in mice induced by human strains of Chlamydia trachomatis","volume":"67","author":"Tuffrey","year":"1986","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/jrf.0.0780251","article-title":"Infertility in mice infected genitally with a human strain of Chlamydia trachomatis","volume":"78","author":"Tuffrey","year":"1986","journal-title":"J. Reprod. Fertil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1472-9792(03)00017-9","article-title":"Susceptibility to Mycobacterium tuberculosis: Lessons from inbred strains of mice","volume":"83","author":"Chackerian","year":"2003","journal-title":"Tuberculosis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1128\/iai.58.6.2021-2023.1990","article-title":"Variation in virulence among oculogenital serovars of Chlamydia trachomatis in experimental genital tract infection","volume":"58","author":"Ito","year":"1990","journal-title":"Infect. Immun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jcp.2003.013086","article-title":"Chlamydia trachomatis serovar E isolates from patients with different clinical manifestations have similar courses of infection in a murine model: Host factors as major determinants of C trachomatis mediated pathogenesis","volume":"57","author":"Lyons","year":"2004","journal-title":"J. Clin. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1128\/IAI.70.3.1538-1546.2002","article-title":"Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection","volume":"70","author":"Maxion","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dockterman, J., Reitano, J.R., Everitt, J.I., Wallace, G.D., Hendrix, M., Taylor, G.A., and Coers, J. (2024). Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection. mBio, 15.","DOI":"10.1128\/mbio.00303-24"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1128\/JB.183.20.5997-6008.2001","article-title":"Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism","volume":"183","author":"Millman","year":"2001","journal-title":"J. Bacteriol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2217\/fmb.13.80","article-title":"Genetic variation in Chlamydia trachomatis and their hosts: Impact on disease severity and tissue tropism","volume":"8","author":"Abdelsamed","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/CMR.00035-15","article-title":"Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women","volume":"28","author":"Menon","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000346207","article-title":"Chlamydia trachomatis infections and subfertility: Opportunities to translate host pathogen genomic data into public health","volume":"16","author":"Lal","year":"2013","journal-title":"Public Health Genom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1093\/humrep\/17.8.2073","article-title":"HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: A case-control study","volume":"17","author":"Kinnunen","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.humimm.2010.12.012","article-title":"Cytokine gene polymorphism and Chlamydia trachomatis-specific immune responses","volume":"72","author":"Ohman","year":"2011","journal-title":"Hum. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/infdis\/jiz087","article-title":"Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection","volume":"220","author":"Poston","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1128\/IAI.00711-09","article-title":"Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses","volume":"78","author":"Packiam","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/expr.1999.4426","article-title":"Ixodes scapularis: Effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB\/c and C3H\/HeN mice","volume":"92","author":"Schoeler","year":"1999","journal-title":"Exp. Parasitol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wells, C.A., Ravasi, T., Faulkner, G.J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M., Wainwright, B.J., and Hume, D.A. (2003). Genetic control of the innate immune response. BMC Immunol., 4.","DOI":"10.1186\/1471-2172-4-5"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00436-006-0419-1","article-title":"Differential immune profiles following experimental Echinostoma hortense infection in BALB\/c and C3H\/HeN mice","volume":"100","author":"Cho","year":"2007","journal-title":"Parasitol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1530\/jrf.0.1010287","article-title":"Induction of infertility by the Chlamydia trachomatis mouse pneumonitis biovar in strains of mice that differ in their response to the 60 kDa heat shock protein","volume":"101","author":"Khamesipour","year":"1994","journal-title":"J. Reprod. Fertil."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Vicetti Miguel, R.D., Quispe Calla, N.E., Pavelko, S.D., and Cherpes, T.L. (2016). Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162445"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1530\/jrf.0.0880295","article-title":"Correlation of infertility with altered tubal morphology and function in mice with salpingitis induced by a human genital-tract isolate of Chlamydia trachomatis","volume":"88","author":"Tuffrey","year":"1990","journal-title":"J. Reprod. Fertil."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.fertnstert.2012.07.1113","article-title":"From mice to women and back again: Causalities and clues for Chlamydia-induced tubal ectopic pregnancy","volume":"98","author":"Shao","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1099\/00221287-136-6-1109","article-title":"Chlamydia trachomatis infection of human fallopian tube organ cultures","volume":"136","author":"Cooper","year":"1990","journal-title":"J. Gen. Microbiol."},{"key":"ref_59","first-page":"422","article-title":"Chlamydia trachomatis infection of the Fallopian tubes. Histological findings in two patients","volume":"55","author":"Moller","year":"1979","journal-title":"Br. J. Vener. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1473-3099(19)30279-8","article-title":"Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: A first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial","volume":"19","author":"Abraham","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1086\/315738","article-title":"Quantitative Chlamydia trachomatis cultures: Correlation of chlamydial inclusion-forming units with serovar, age, sex, and race","volume":"182","author":"Eckert","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Malogajski, J., Brankovic, I., Land, J.A., Thomas, P.P.M., Morre, S.A., and Ambrosino, E. (2019). The Potential role for host genetic profiling in screening for Chlamydia-associated tubal factor infertility (TFI)-New perspectives. Genes, 10.","DOI":"10.3390\/genes10060410"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/1\/97\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:31:51Z","timestamp":1759919511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/1\/97"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,19]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["pathogens14010097"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14010097","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,19]]}}}