{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:46:18Z","timestamp":1759970778027,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direcci\u00f3n General de Investigaciones de la Universidad Santiago de Cali","award":["01-2024"],"award-info":[{"award-number":["01-2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background\/Objectives: Leclercia adecarboxylata (L. adecarboxylata) is a rare opportunistic pathogen that can cause severe infections like empyema, particularly in immunocompromised individuals. We aim to highlight the importance of the early detection and personalized treatment of L. adecarboxylata infections in patients with comorbidities such as malignant mesothelioma. Methods: We present the case of a 57-year-old man with type 2 diabetes mellitus, hypertension, and malignant mesothelioma who developed a parapneumonic effusion that progressed to empyema. After undergoing pleurectomy and pleurodesis, intraoperative cultures identified L. adecarboxylata. Targeted antibiotic therapy was initiated based on the culture results, and the patient\u2019s response was closely monitored. Results: The patient responded well to targeted antibiotic therapy with ampicillin\/sulbactam following the initial empirical treatment with piperacillin\/tazobactam. The identification of L. adecarboxylata\u2014a rare finding in empyema cases\u2014was crucial for effective management. The patient recovered fully without complications, highlighting the importance of the early identification and individualized treatment of infections caused by rare pathogens. Conclusions: This case underscores the need to consider L. adecarboxylata in immunocompromised patients presenting with unusual infections. Early detection through advanced diagnostic techniques and personalized antibiotic therapy can improve clinical outcomes and help prevent antimicrobial resistance. Increased clinical awareness and further research into the resistance patterns and treatment approaches for L. adecarboxylata are essential to enhance patient care.<\/jats:p>","DOI":"10.3390\/pathogens14020125","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:08:23Z","timestamp":1738235303000},"page":"125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Postoperative Empyema Due to Leclercia adecarboxylata Following Mesothelioma Surgery: A Case Report"],"prefix":"10.3390","volume":"14","author":[{"given":"John Fernando","family":"Montenegro","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"},{"name":"Programa de Especializaci\u00f3n en Medicina Interna, Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Diaz-Diaz","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Medicina Interna, Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinthia","family":"Vidal-Ca\u00f1as","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-7908","authenticated-orcid":false,"given":"Gustavo","family":"Urriago","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Medicina Interna, Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Correa","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Medicina Interna, Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"},{"name":"Departamento de Investigaci\u00f3n y Educaci\u00f3n, Cl\u00ednica de Occidente S.A., Cali 760046, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis \u00c1lvaro","family":"Melo-Burbano","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Medicina Interna, Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-8725","authenticated-orcid":false,"given":"Yamil","family":"Liscano","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 5183000, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.47102\/annals-acadmedsg.202195","article-title":"Leclercia adecarboxylata Bacteraemia: Clinical Features and Antibiotic Susceptibilities in 2 Hospitals in Singapore","volume":"50","author":"Sng","year":"2021","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.22354\/in.v22i4.741","article-title":"Leclercia adecarboxylata, a Rare Cause of Soft Tissue Infections in Immunocompromised Patients, Case Report and Review of the Literature","volume":"22","author":"Bravo","year":"2018","journal-title":"Infectio"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/23744235.2018.1536830","article-title":"Leclercia adecarboxylata: A Case Report and Literature Review of 74 Cases Demonstrating Its Pathogenicity in Immunocompromised Patients","volume":"51","author":"Spiegelhauer","year":"2018","journal-title":"Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100075","DOI":"10.1016\/j.medmic.2022.100075","article-title":"First Clinical Case of VIM-1-Producing Leclercia adecarboxylata: A Case Report and Literature Review","volume":"15","author":"Kumar","year":"2023","journal-title":"Med. Microecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MRM.0000000000000142","article-title":"Carbapenem and Colistin Resistance in Enterobacteriaceae: Worldwide Spread and Future Perspectives","volume":"29","author":"Ghasemian","year":"2018","journal-title":"Rev. Med. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Garza-Gonz\u00e1lez, E., Bocanegra-Ibarias, P., Rodr\u00edguez-Noriega, E., Gonz\u00e1lez-D\u00edaz, E., Silva-Sanchez, J., Garza-Ramos, U., Contreras-Coronado-Tovar, I.F., Santos-Hern\u00e1ndez, J.E., Guti\u00e9rrez-Ba\u00f1uelos, D., and Mena-Ramirez, J.P. (2021). Molecular Investigation of an Outbreak Associated with Total Parenteral Nutrition Contaminated with NDM-Producing Leclercia adecarboxylata. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-05923-0"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1055\/s-0040-1721162","article-title":"Leclercia adecarboxylata Causing Spontaneous Bacterial Peritonitis in a Child with Nephrotic Syndrome: A Case Report and Review of Literature","volume":"12","author":"Hassan","year":"2020","journal-title":"J. Lab. Physicians"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e929537-1","DOI":"10.12659\/AJCR.929537","article-title":"Leclercia adecarboxylata Bacteremia without a Focus in a Non-Immunosuppressed Patient","volume":"22","author":"Shaikhain","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jmoldx.2011.07.004","article-title":"Novel, Improved Sample Preparation for Rapid, Direct Identification from Positive Blood Cultures Using Matrix-Assisted Laser Desorption\/Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry","volume":"13","author":"Schubert","year":"2011","journal-title":"J. Mol. Diagn. JMD"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Machen, A.J., Drake, T., and Wang, Y.F. (2014). (Wayne) Same Day Identification and Full Panel Antimicrobial Susceptibility Testing of Bacteria from Positive Blood Culture Bottles Made Possible by a Combined Lysis-Filtration Method with MALDI-TOF VITEK Mass Spectrometry and the VITEK2 System. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087870"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1469-0691.2004.00892.x","article-title":"Natural Antimicrobial Susceptibility Patterns and Biochemical Profiles of Leclercia adecarboxylata Strains","volume":"10","author":"Stock","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yescas-Zazueta, V., Rocha-Gracia, R.D.C., Gonz\u00e1lez-Bonilla, C.R., Ayala-Zavala, J.F., Enciso-Mart\u00ednez, Y., Carre\u00f3n-Le\u00f3n, E.A., Gonz\u00e1lez Corona, B.A., Valencia, D., Ballesteros-Monrreal, M.G., and Barrios-Villa, E. (2024). Resistance Phenotype and Virulence Potential of Leclercia adecarboxylata Strains Isolated from Different Sources. Microbiology, 170.","DOI":"10.1099\/mic.0.001457"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3855\/jidc.12598","article-title":"Leclercia adecarboxylata as an Emerging Pathogen in Human Infections: A 13-Year Retrospective Analysis in Southern Hungary","volume":"14","author":"Lazar","year":"2020","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zayet, S., Lang, S., Garnier, P., Pierron, A., Plantin, J., Toko, L., Royer, P.-Y., Villemain, M., Klopfenstein, T., and Gendrin, V. (2021). Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing. Pathogens, 10.","DOI":"10.3390\/pathogens10111399"},{"key":"ref_16","unstructured":"Aky\u00fcz, A.K. (2024). A Rare Agent in Wound Infection: Leclercia adecarboxylata. Life Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.2217\/fmb-2022-0067","article-title":"Matrix-Assisted Laser Desorption\/Ionization Time-of-Flight Mass Spectrometry in the Diagnosis of Microorganisms","volume":"17","author":"Evangelista","year":"2022","journal-title":"Future Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, X., Hou, X., Xiao, M., Zhang, L., Cheng, J., Zhou, M., Huang, J., Zhang, J., Xu, Y., and Hsueh, P.-R. (2021). Matrix-Assisted Laser Desorption\/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) Analysis for the Identification of Pathogenic Microorganisms: A Review. Microorganisms, 9.","DOI":"10.3390\/microorganisms9071536"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.17533\/udea.iatreia.62","article-title":"Claves diagn\u00f3sticas en el paciente adulto con derrame pleural: Revisi\u00f3n narrativa","volume":"33","year":"2020","journal-title":"Iatreia"},{"key":"ref_20","first-page":"DD03","article-title":"Leclercia adecarboxylata Isolation: Case Reports and Review","volume":"8","author":"Anuradha","year":"2014","journal-title":"JCDR"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/qjmed\/hcy131","article-title":"Sepsis and Leclercia adecarboxylata","volume":"111","author":"Matsuura","year":"2018","journal-title":"QJM Int. J. Med."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/2\/125\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:39:03Z","timestamp":1759919943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/2\/125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["pathogens14020125"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14020125","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2025,1,30]]}}}