{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:48:40Z","timestamp":1760057320612,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of India\u2019s (GOI) Department of Biotechnology (DBT)","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"Indian Council of Medical Research (ICMR)","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"United States National Institutes of Health (NIH)","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID)","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"Office of AIDS Research (OAR)","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"CRDF Global","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"CRDF Global RePORT India Consortium Supplemental Funding","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]},{"name":"Division of Intramural Research, NIAID, NIH","award":["USB1-31149-XX-13","OISE-17-62911-1"],"award-info":[{"award-number":["USB1-31149-XX-13","OISE-17-62911-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Tuberculosis (TB) treatment monitoring is an essential tool for effective TB treatment management. Identifying parameters that predict adverse TB treatment outcomes could significantly improve clinical management. The association of hematological parameters with poor TB treatment outcomes is not well defined. To study the relationship of hematological parameters with TB treatment outcomes, we examined data from pulmonary tuberculosis (PTB) patients with successful (controls) and unsuccessful (cases) treatment outcomes. We enrolled 68 cases and 133 controls through a nested 1:2 case\u2013control study, matching for age, sex, body mass index, diabetes status, alcohol and smoking. Hematological profiling showed significant difference in the absolute counts of white blood cells, lymphocytes, neutrophils and monocytes between cases and controls. In addition, increased neutrophil to lymphocyte ratio (NL) ratio and monocyte to lymphocyte (ML) ratio were present in cases in comparison to controls. Similarly, decreased hematocrit and red blood cell counts were detected in cases when compared with controls. Univariate and multivariate analysis demonstrated a significant association of absolute counts of WBC, neutrophils, monocytes, NL and ML ratios with poor treatment outcomes. The altered baseline hematological parameters are clearly associated with the poor TB treatment outcomes, showing potential for clinical prediction to enhance management of at-risk cases.<\/jats:p>","DOI":"10.3390\/pathogens14020146","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:13:43Z","timestamp":1738646023000},"page":"146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Altered Baseline Hematological Parameters with Adverse Tuberculosis Treatment Outcomes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9561-8967","authenticated-orcid":false,"given":"Arul","family":"Nancy Pandiarajan","sequence":"first","affiliation":[{"name":"National Institutes of Health-NIRT\u2014International Center for Excellence in Research, Chennai 600 031, India"},{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-2621","authenticated-orcid":false,"given":"Nathella Pavan","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201 002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadar","family":"Moideen","sequence":"additional","affiliation":[{"name":"National Institutes of Health-NIRT\u2014International Center for Excellence in Research, Chennai 600 031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-1094","authenticated-orcid":false,"given":"Kannan","family":"Thiruvengadam","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-1552","authenticated-orcid":false,"given":"Syed","family":"Hissar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-2664","authenticated-orcid":false,"given":"Shanmugam","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201 002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-5233","authenticated-orcid":false,"given":"Ramalingam","family":"Bethunaickan","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for Research in Tuberculosis, Chennai 600 031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad 201 002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Prof. M. Viswanathan Diabetes Research Center, Chennai 600 013, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardy","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School, Worcester, MA 01655, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-8042","authenticated-orcid":false,"given":"Subash","family":"Babu","sequence":"additional","affiliation":[{"name":"National Institutes of Health-NIRT\u2014International Center for Excellence in Research, Chennai 600 031, India"},{"name":"Laboratory of Parasitic Diseases (LPD), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022). Global Tuberculosis Report 2022, WHO. 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