{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:37:18Z","timestamp":1792107438349,"version":"4.4.0"},"reference-count":202,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Chagas disease, caused by Trypanosoma cruzi, remains a significant public health challenge, particularly in Latin America, where it is one of the most neglected diseases and is primarily transmitted by triatomine insects. The disease exhibits complexity due to its diverse transmission routes, including vectorial and non-vectorial mechanisms such as blood transfusions and congenital transmission. Effective monitoring and control strategies are critical to mitigating its impact. This review focuses on current monitoring and control efforts, emphasizing the importance of enhanced surveillance systems, improved risk assessments, and integrated vector control programs. Surveillance plays a pivotal role in early detection and timely intervention, particularly in endemic regions, while vector control remains central to reducing transmission. Moreover, the development of novel diagnostic tools, treatments, and vaccines is a crucial step in advancing control efforts. This review also highlights the involvement of local governments, international organizations, and civil society in executing these strategies, stressing the need for sustained political commitment to ensure the success of public health programs. By addressing key challenges in monitoring, control, and prevention, this review aims to provide insights and recommendations to further global efforts in reducing the burden of Chagas disease.<\/jats:p>","DOI":"10.3390\/pathogens14020183","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:25:57Z","timestamp":1739355957000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fighting Strategies Against Chagas\u2019 Disease: A Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4867-5533","authenticated-orcid":false,"given":"Andrea","family":"Hern\u00e1ndez-Flores","sequence":"first","affiliation":[{"name":"Departamento de Etolog\u00eda, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad Universitaria, Av. Universidad #3000, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-3875","authenticated-orcid":false,"given":"Debora","family":"El\u00edas-D\u00edaz","sequence":"additional","affiliation":[{"name":"Sistema de Estudios de Posgrado Posgrado en Biolog\u00eda, Universidad de Costa Rica, San Jos\u00e9 11501-206, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadeth","family":"Cubillo-Cervantes","sequence":"additional","affiliation":[{"name":"Sistema de Estudios de Posgrado Posgrado en Biolog\u00eda, Universidad de Costa Rica, San Jos\u00e9 11501-206, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-4344","authenticated-orcid":false,"given":"Carlos N.","family":"Ibarra-Cerde\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda Humana, Centro de Investigaci\u00f3n y de Estudios Avanzados (Cinvestav), Unidad M\u00e9rida, Merida 97205, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Ecolog\u00eda y Epidemiolog\u00eda, Programa Arbovirus y Zoonoses, Centro para Estudios de Salud, Universidad del Valle de Guatemala, Guatemala City 01015, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-8816","authenticated-orcid":false,"given":"Audrey","family":"Arnal","sequence":"additional","affiliation":[{"name":"Departamento de Etolog\u00eda, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad Universitaria, Av. 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