{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:53Z","timestamp":1790630453933,"version":"4.1.0"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ferdowsi University of Mashhad","award":["24224"],"award-info":[{"award-number":["24224"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Drug resistance is the main challenge in treating parasitic diseases, including cystic echinococcosis (CE). Hence, the current study aims to investigate the effect of nanocapsules containing albendazole (ABZ), mebendazole (MBZ), and praziquantel (PZQ) on treating hydatid cysts in mice using these high-potency drugs. A total of 78 female white laboratory mice (BALB\/C mice), 8 weeks old and weighing 25 g, were intraperitoneally injected with 1500 live protoscoleces of Echinococcus granulosus. The first group received ABZ nanocapsules, group 2 received MBZ nanocapsules, group 3 received PZQ nanocapsules, group 4 received ABZ + MBZ nanocapsules, group 5 received ABZ + PZQ nanocapsules, and group 6 received MBZ + PZQ nanocapsules. Each group also had a control group, which received the non-nanocapsulated drugs (group 7\u201312). Group 13 received no treatment and served as the negative control, just receiving phosphate-buffered saline (PBS). A thorough examination of the cysts\u2019 physical properties, including size, quantity, and weight, was carried out. According to our results, the polymeric nanocapsules are sphere-like and of different sizes. The total number of cysts in all nanocapsule groups significantly decreased compared to the control group. In the total weight of the cysts, ABZ + MBZ nanocapsules, ABZ + PZQ nanocapsules, and MBZ + PZQ nanocapsules had the least total cyst weight, showing that the use of the medicinal combination had a better effect on the penetration and weight reduction of the cysts. In conclusion, the findings showed that ABZ, MBZ, and PZQ significantly reduced the size, weight, and number of hydatid cysts in the mouse model used in this study.<\/jats:p>","DOI":"10.3390\/pathogens14030240","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T05:52:16Z","timestamp":1740981136000},"page":"240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigating the Therapeutic Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules in Hydatid Cyst-Infected Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Nooshinmehr","family":"Soleymani","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad P.O. Box 9177948974, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-0673","authenticated-orcid":false,"given":"Soheil","family":"Sadr","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad P.O. Box 9177948974, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-3745","authenticated-orcid":false,"given":"Cinzia","family":"Santucciu","sequence":"additional","affiliation":[{"name":"WOAH and NRL for Echinococcosis, Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-9214","authenticated-orcid":false,"given":"Abbas","family":"Rahdar","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Zabol, Zabol P.O. Box 53898615, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Masala","sequence":"additional","affiliation":[{"name":"WOAH and NRL for Echinococcosis, Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-4995","authenticated-orcid":false,"given":"Hassan","family":"Borji","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad P.O. 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Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1051\/parasite\/2020024","article-title":"International consensus on terminology to be used in the field of echinococcoses","volume":"27","author":"Vuitton","year":"2020","journal-title":"Parasite"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e10-1128","DOI":"10.1128\/CMR.00075-18","article-title":"Echinococcosis: Advances in the 21st century","volume":"32","author":"Wen","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.pt.2019.05.006","article-title":"\u00a0Echinococcus granulosus sensu lato","volume":"35","author":"Casulli","year":"2019","journal-title":"Trend. Parasitol."},{"key":"ref_6","first-page":"1","article-title":"Interactions between innate immunity system and Echinococcus granulosus: Permission for vaccine development","volume":"3","author":"Sadr","year":"2022","journal-title":"Ser. Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Santucciu, C., Ferrari, P.A., Grimaldi, G., Murenu, A., Nemolato, S., Bonelli, P., Masala, G., Porcu, G.S., and Cherchi, R. (2023). Environmental influence on the occurrence of multi-organ cystic echinococcosis infection in a patient from Sardinia, Italy. Diseases, 11.","DOI":"10.3390\/diseases11030090"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Umhang, G., Bastien, F., Cartet, A., Ahmad, H., van der Ark, K., Berg, R., Bonelli, P., Davidson, R.K., Deplazes, P., and Deksne, G. (2024). Detection of Echinococcus spp. and other taeniid species in lettuces and berries: Two international multicenter studies from the MEmE project. bioRxiv.","DOI":"10.1101\/2024.06.10.598207"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hou, X., Shi, Y., Kang, X., Rousu, Z., Li, D., Wang, M., Ainiwaer, A., Zheng, X., Wang, M., and Jiensihan, B. (2022). Echinococcus granulosus: The establishment of the metacestode in the liver is associated with control of the CD4+ T-cell-mediated immune response in patients with cystic echinococcosis and a mouse model. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.983119"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/trstmh\/try112","article-title":"Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers","volume":"113","author":"Larrieu","year":"2019","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_11","unstructured":"Long, S.S. (2012). 281\u2014Echinococcus species (agents of cystic, alveolar, and polycystic echinococcosis). Principles and Practice of Pediatric Infectious Diseases, Elsevier. [4th ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s13071-019-3644-z","article-title":"Cystic echinococcosis in Nigeria: First insight into the genotypes of Echinococcus granulosus in animals","volume":"12","author":"Ohiolei","year":"2019","journal-title":"Parasit. Vectors"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Widdicombe, J., Bas\u00e1\u00f1ez, M.-G., Entezami, M., Jackson, D., Larrieu, E., and Prada, J.M. (2022). The economic evaluation of cystic echinococcosis control strategies focused on zoonotic hosts: A scoping review. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010568"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.26855\/ijcemr.2022.04.005","article-title":"Cystic Echincoccoosis: A comprehensive review on life cycle, epidemiology, pathogenesis, clinical Spectrum, diagnosis, public health and economic implications, treatment, and control","volume":"6","author":"Pal","year":"2022","journal-title":"Int. J. Clin. Exp. Med. Res"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"04056","DOI":"10.7189\/jogh.14.04056","article-title":"Changes in the global epidemiological characteristics of cystic echinococcosis over the past 30 years and projections for the next decade: Findings from the Global Burden of Disease Study 2019","volume":"14","author":"Yang","year":"2024","journal-title":"J. Glob. Health"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hogea, M.-O., Ciomaga, B.-F., Muntean, M.-M., Muntean, A.-A., Popa, M.I., and Popa, G.L. (2024). Cystic echinococcosis in the early 2020s: A review. Trop. Med. Infect. Dis., 9.","DOI":"10.3390\/tropicalmed9020036"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/tmi.12647","article-title":"Cystic echinococcosis in South America: Systematic review of species and genotypes of Echinococcus granulosus sensu lato in humans and natural domestic hosts","volume":"21","author":"Cucher","year":"2016","journal-title":"Trop. Med. Int. Health"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Alvi, M.A., and Alsayeqh, A.F. (2022). Food-borne zoonotic echinococcosis: A review with special focus on epidemiology. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.1072730"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tian, T., Miao, L., Wang, W., and Zhou, X. (2024). Global, regional and national burden of human cystic echinococcosis from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Trop. Med. Infect. Dis., 9.","DOI":"10.3390\/tropicalmed9040087"},{"key":"ref_20","first-page":"59","article-title":"Prevalence and associated risk factors of cystic echinococcosis in food animals--A neglected and prevailing zoonosis","volume":"42","author":"Mahmood","year":"2022","journal-title":"Pak. Vet. J."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Borhani, M., Fathi, S., Lahmar, S., Ahmed, H., Abdulhameed, M.F., and Fasihi Harandi, M. (2020). Cystic echinococcosis in the Eastern Mediterranean region: Neglected and prevailing!. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008114"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Saadi, A., Amarir, F., Filali, H., Thys, S., Rhalem, A., Kirschvink, N., Raes, M., Marcotty, T., Oukessou, M., and Duchateau, L. (2020). The socio-economic burden of cystic echinococcosis in Morocco: A combination of estimation method. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008410"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100061","DOI":"10.1016\/j.crpvbd.2021.100061","article-title":"Cystic echinococcosis in humans and animals in Egypt: An epidemiological overview","volume":"1","author":"Abdelbaset","year":"2021","journal-title":"Cur. Res. Parasitol. Vector-Borne Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/S1473-3099(22)00638-7","article-title":"Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: A systematic review from the MEmE project","volume":"23","author":"Casulli","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.5152\/tjg.2014.7112","article-title":"Diagnostics in cystic echinococcosis: Serology versus ultrasonography","volume":"25","author":"Wuestenberg","year":"2014","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Stojkovic, M., Rosenberger, K., Kauczor, H.-U., Junghanss, T., and Hosch, W. (2012). Diagnosing and staging of cystic echinococcosis: How do CT and MRI perform in comparison to ultrasound?. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001880"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Manzano-Rom\u00e1n, R., S\u00e1nchez-Ovejero, C., Hern\u00e1ndez-Gonz\u00e1lez, A., Casulli, A., and Siles-Lucas, M. (2015). Serological diagnosis and follow-up of human cystic echinococcosis: A new hope for the future?. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/428205"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e3866","DOI":"10.1136\/bmj.e3866","article-title":"Diagnosis, treatment, and management of echinococcosis","volume":"344","author":"McManus","year":"2012","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1995-7645(12)60035-2","article-title":"Human cystic echinococcosis: Epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects","volume":"5","author":"Mandal","year":"2012","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/ans.14117","article-title":"Hepatic cystic echinococcosis in Australia: An update on diagnosis and management","volume":"88","author":"Keong","year":"2018","journal-title":"ANZ J. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1051\/parasite\/2014073","article-title":"Treatment of echinococcosis: Albendazole and mebendazole\u2013what else?","volume":"21","author":"Hemphill","year":"2014","journal-title":"Parasite"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Velasco-Tirado, V., Alonso-Sard\u00f3n, M., Lopez-Bernus, A., Romero-Alegr\u00eda, \u00c1., Burguillo, F.J., Muro, A., Carpio-P\u00e9rez, A., Munoz Bellido, J.L., Pardo-Lledias, J., and Cordero, M. (2018). Medical treatment of cystic echinococcosis: Systematic review and meta-analysis. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3201-y"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MAJ.0b013e31814252f8","article-title":"Albendazole for the treatment of human echinococcosis: A review of comparative clinical trials","volume":"334","author":"Falagas","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gavidia, C.M., Gonzalez, A.E., Barron, E.A., Ninaquispe, B., Llamosas, M., Verastegui, M.R., Robinson, C., and Gilman, R.H. (2010). Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: A randomized clinical trial in naturally infected sheep. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000616"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s00436-015-4412-4","article-title":"In vivo and in vitro efficacies of mebendazole, mefloquine and nitazoxanide against cyst echinococcosis","volume":"114","author":"Liu","year":"2015","journal-title":"Parasitol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Nogueira, R.A., Lira, M.G.S., Lic\u00e1, I.C.L., Fraz\u00e3o, G.C.C.G., Dos Santos, V.A.F., Mendes Filho, A.C.C., Rodrigues, J.G.M., Miranda, G.S., Carvalho, R.C., and Nascimento, F.R.F. (2022). Praziquantel: An update on the mechanism of its action against schistosomiasis and new therapeutic perspectives. Mol. Biochem. Parasitol., 252.","DOI":"10.1016\/j.molbiopara.2022.111531"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e01895","DOI":"10.1016\/j.idcr.2023.e01895","article-title":"Severe adverse reaction induced by albendazole and praziquantel for cystic echinococcosis","volume":"34","author":"Zhao","year":"2023","journal-title":"IDCases"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/vms3.1221","article-title":"Current status of nano-vaccinology in veterinary medicine science","volume":"9","author":"Sadr","year":"2023","journal-title":"Vet. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hajjafari, A., Sadr, S., Santucciu, C., Masala, G., Bayat, M., Lotfalizadeh, N., Borji, H., Partovi Moghaddam, S., and Hajjafari, K. (2024). Advances in detecting cystic echinococcosis in intermediate hosts and new diagnostic tools: A literature review. Vet. Sci., 11.","DOI":"10.3390\/vetsci11060227"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sadr, S., Lotfalizadeh, N., Abbasi, A.M., Soleymani, N., Hajjafari, A., Roohbaksh Amooli Moghadam, E., and Borji, H. (2023). Challenges and prospective of enhancing hydatid cyst chemotherapy by nanotechnology and the future of nanobiosensors for diagnosis. Trop. Med. Infect. Dis., 8.","DOI":"10.3390\/tropicalmed8110494"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00436-018-5849-z","article-title":"In-vitro and in-vivo effects of chitosan-praziquantel and chitosan-albendazole nanoparticles on Echinococcus granulosus Metacestodes","volume":"117","author":"Torabi","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.33899\/ijvs.2022.135838.2535","article-title":"Effect of selenium nanoparticles against protoscoleces of Echinococcus granulosus in vitro and hydatid cysts in mice","volume":"36","author":"Mohammed","year":"2022","journal-title":"Iraqi J. Vet. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/surfaces5010004","article-title":"Assessment of the therapeutic efficacy of silver nanoparticles against secondary cystic echinococcosis in BALB\/c mice","volume":"5","author":"Hamad","year":"2022","journal-title":"Surfaces"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1007\/s00436-020-06901-2","article-title":"Evaluation of the efficacy of albendazole sulfoxide (ABZ-SO)\u2013loaded chitosan-PLGA nanoparticles in the treatment of cystic echinococcosis in laboratory mice","volume":"119","author":"Darvishi","year":"2020","journal-title":"Parasitol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Navvabi, A., Homaei, A., Khademvatan, S., Ansari, M.H.K., and Keshavarz, M. (2019). Combination of TiO2 nanoparticles and Echinometra mathaeis gonad extracts: In-vitro and in-vivo scolicidal activity against hydatid cysts. Biocatal. Agric. Biotechnol., 22.","DOI":"10.1016\/j.bcab.2019.101432"},{"key":"ref_46","first-page":"269","article-title":"In vitro and in-vivo scolicidal activities of Holothuria leucospilota extract and CeO2 nanoparticles against hydatid cyst","volume":"14","author":"Aryamand","year":"2019","journal-title":"Iran. J. Parasitol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s12639-019-01145-z","article-title":"Evaluation of the therapeutic efficacy of albendazole-loaded silver nanoparticles against Echinococcus granulosus infection in experimental mice","volume":"43","author":"Nassef","year":"2019","journal-title":"J. Parasit. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.exppara.2019.02.002","article-title":"Albendazole-lipid nanocapsules: Optimization, characterization and chemoprophylactic efficacy in mice infected with Echinococcus granulosus","volume":"198","author":"Gamboa","year":"2019","journal-title":"Exp. Parasitol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.actatropica.2018.08.010","article-title":"Efficiency of flubendazole-loaded mPEG-PCL nanoparticles: A promising formulation against the protoscoleces and cysts of Echinococcus granulosus","volume":"187","author":"Farhadi","year":"2018","journal-title":"Acta Trop."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.apjtb.2017.05.011","article-title":"Efficacy of combined albendazol and praziquntel and their loaded solid lipid nanoparticles components in chemoprophylaxis of experimental hydatidosis","volume":"7","author":"Jelowdar","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.actatropica.2015.09.016","article-title":"Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice","volume":"152","author":"Pensel","year":"2015","journal-title":"Acta Trop."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.exppara.2013.07.017","article-title":"In vivo evaluation of the efficacy of albendazole sulfoxide and albendazole sulfoxide loaded solid lipid nanoparticles against hydatid cyst","volume":"135","author":"Ahmadnia","year":"2013","journal-title":"Exp. Parasitol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108860","DOI":"10.1016\/j.exppara.2024.108860","article-title":"Investigating the therapeutic effects of curcumin nanocapsules in hydatid cyst-infected mice","volume":"267","author":"Sorouri","year":"2024","journal-title":"Exp. Parasitol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Soleymani, N., Sadr, S., Santucciu, C., Rahdar, A., Masala, G., and Borji, H. (2024). Evaluation of the in-vitro effects of albendazole, mebendazole, and praziquantel nanocapsules against protoscolices of hydatid cyst. Pathogens, 13.","DOI":"10.3390\/pathogens13090790"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2016.05.004","article-title":"Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus","volume":"167","author":"Shi","year":"2016","journal-title":"Exp. Parasitol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/fpd.2024.0045","article-title":"Effect of temperature and salinity on survival of protoscoleces of hydatid cyst in liver in-vitro","volume":"21","author":"Zabihian","year":"2024","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00423-003-0397-z","article-title":"Echinococcus granulosus infection: The challenge of surgical treatment","volume":"388","author":"Buttenschoen","year":"2003","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Al-Saeedi, M., Ramouz, A., Khajeh, E., El Rafidi, A., Ghamarnejad, O., Shafiei, S., Ali-Hasan-Al-Saegh, S., Probst, P., Stojkovic, M., and Weber, T.F. (2021). Endocystectomy as a conservative surgical treatment for hepatic cystic echinococcosis: A systematic review with single-arm meta-analysis. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009365"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Albalawi, A.E., Alanazi, A.D., Baharvand, P., Sepahvand, M., and Mahmoudvand, H. (2020). High potency of organic and inorganic nanoparticles to treat cystic echinococcosis: An evidence-based review. Nanomaterials, 10.","DOI":"10.3390\/nano10122538"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/JPRI\/2018\/44642","article-title":"Advances in the use of nanoparticles as anti-cystic echinococcosis agents: A review article","volume":"24","author":"Shnawa","year":"2018","journal-title":"J. Pharm. Res. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1051\/parasite\/2014071","article-title":"Non-surgical and non-chemical attempts to treat echinococcosis: Do they work?","volume":"21","author":"Tamarozzi","year":"2014","journal-title":"Parasite"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/trstmh\/try050","article-title":"Management of cystic echinococcosis in the last two decades: What have we learned?","volume":"112","author":"Sampedro","year":"2018","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/14787210.2024.2360684","article-title":"Anti-inflammatory and immunomodulatory effects of mesenchymal stem cell therapy on parasitic drug resistance","volume":"22","author":"Sadr","year":"2024","journal-title":"Exp. Rev. Anti-Infect. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"106252","DOI":"10.1016\/j.actatropica.2021.106252","article-title":"Status and prospect of novel treatment options toward alveolar and cystic echinococcosis","volume":"226","author":"Wang","year":"2022","journal-title":"Acta Trop."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Huayu, M., Mu, Y., Tang, F., and Ge, R.-L. (2024). Ubenimex combined with albendazole for the treatment of Echinococcus multilocularis-induced alveolar echinococcosis in mice. Front. Vet. Sci., 11.","DOI":"10.3389\/fvets.2024.1320308"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4254\/wjh.v16.i11.1243","article-title":"Current status of drug therapy for alveolar echinococcosis","volume":"16","author":"Jing","year":"2024","journal-title":"World J. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"38745","DOI":"10.1021\/acsami.1c11179","article-title":"Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis","volume":"13","author":"Permana","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/jctb.6633","article-title":"Overcoming multi-resistant leishmania treatment by nanoencapsulation of potent antimicrobials","volume":"96","author":"Oliveira","year":"2021","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Bouaouina, S., Aouf, A., Touati, A., Ali, H., Elkhadragy, M., Yehia, H., and Farouk, A. (2022). Effect of nanoencapsulation on the antimicrobial and antibiofilm activities of algerian Origanum glandulosum Desf. against multidrug-resistant clinical isolates. Nanomaterials, 12.","DOI":"10.3390\/nano12152630"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1080\/10408398.2020.1755950","article-title":"Micro\/nanoencapsulation strategy to improve the efficiency of natural antimicrobials against Listeria monocytogenes in food products","volume":"61","author":"Bahrami","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Opatha, S.A.T., Titapiwatanakun, V., and Chutoprapat, R. (2020). Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090855"},{"key":"ref_72","first-page":"77","article-title":"Nanoencapsulation of polyphenols as drugs and supplements for enhancing therapeutic profile-a review","volume":"15","author":"Khatoon","year":"2022","journal-title":"Cur. Mol. Pharmacol."},{"key":"ref_73","first-page":"180","article-title":"Nanoparticles as a new approach for treating hydatid cyst disease","volume":"1","author":"SShnawa","year":"2021","journal-title":"Vet. Pathobiol. Public Health"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1007\/s00436-021-07343-0","article-title":"In-vitro evaluation of albendazole-loaded nanostructured lipid carriers on Echinococcus granulosus microcysts and their prophylactic efficacy on experimental secondary hydatidosis","volume":"120","author":"Farhadi","year":"2021","journal-title":"Parasitol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1080\/10717544.2019.1692968","article-title":"Nanoparticles for antiparasitic drug delivery","volume":"26","author":"Sun","year":"2019","journal-title":"Drug Deliv."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2174\/1567201820666230223085403","article-title":"Nanomaterials as a potential target for infectious parasitic agents","volume":"21","author":"Alsharedeh","year":"2024","journal-title":"Cur. 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