{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:23:33Z","timestamp":1785403413239,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["#19\/23769-4"],"award-info":[{"award-number":["#19\/23769-4"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["#306972\/2020-4"],"award-info":[{"award-number":["#306972\/2020-4"]}]},{"name":"CNPq","award":["#19\/23769-4"],"award-info":[{"award-number":["#19\/23769-4"]}]},{"name":"CNPq","award":["#306972\/2020-4"],"award-info":[{"award-number":["#306972\/2020-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against Leishmania amazonensis. CAPE exhibited IC50 values of 8.07 \u00b5M (95% CI, 6.79\u20139.62 \u00b5M) and 13.51 \u00b5M (95% CI, 10.71\u201317.16 \u00b5M) against L. amazonensis promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited L. amazonensis arginase in a non-competitive manner with a Ki value of 1.51 \u00b1 0.04 \u00b5M. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis.<\/jats:p>","DOI":"10.3390\/pathogens14040384","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T03:59:06Z","timestamp":1744689546000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of Leishmania amazonensis Promastigotes and Intracellular Amastigotes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-4404","authenticated-orcid":false,"given":"Edson Roberto","family":"da Silva","sequence":"first","affiliation":[{"name":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"do Carmo Maquiaveli","sequence":"additional","affiliation":[{"name":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019, June 27). WHO|Leishmaniasis. 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