{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:52:32Z","timestamp":1779904352960,"version":"3.53.1"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Several indirect findings suggest that host-related factors influence susceptibility to Coxiella burnetii infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.<\/jats:p>","DOI":"10.3390\/pathogens14040394","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:07:38Z","timestamp":1744934858000},"page":"394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Host Genetic Factors in Q Fever Susceptibility"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-6901","authenticated-orcid":false,"given":"Jos\u00e9-Mar\u00eda","family":"Robaina Bord\u00f3n","sequence":"first","affiliation":[{"name":"Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, Spain"},{"name":"Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negr\u00edn, 35010 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Luis","family":"P\u00e9rez-Arellano","sequence":"additional","affiliation":[{"name":"University Institute of Biomedical and Health Research [IUIBS], University of Las Palmas de Gran Canaria [ULPGC], 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Montes-Ares","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Torio-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital General Universitario de Albacete, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Hern\u00e1ndez-Cabrera","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, Spain"},{"name":"Unit of Infectious and Tropical Diseases, Complejo Hospitalario Universitario Insular, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-6586","authenticated-orcid":false,"given":"Elena","family":"Pisos-\u00c1lamo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, Spain"},{"name":"Unit of Infectious and Tropical Diseases, Complejo Hospitalario Universitario Insular, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Carranza-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria [ULPGC], 35001 Las Palmas de Gran Canaria, Spain"},{"name":"University Institute of Biomedical and Health Research [IUIBS], University of Las Palmas de Gran Canaria [ULPGC], 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ullah, Q., Jamil, T., Saqib, M., Iqbal, M., and Neubauer, H. 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