{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:54:55Z","timestamp":1792641295367,"version":"4.5.0"},"reference-count":115,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Tuberculosis (TB) poses serious challenges to healthcare personnel as it continues to be highly prevalent in a developing country like India. Several prominent strategies have been adopted to control this contagious infection, but the incidence rate remains high. Many studies have linked fungal infections to TB, apparently elevating concerns in the TB elimination program. Hence, it is essential to understand the mechanisms underlying TB co-infection and pulmonary mycoses to combat the problems caused by these diseases successfully. In addition, differential diagnosis of TB and fungal infections is equally essential to initiate appropriate treatment. This review attempts to describe misdiagnosis of TB and fungal disease and their relative coexistence in the context of the Indian perspective.<\/jats:p>","DOI":"10.3390\/pathogens14050435","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:44:58Z","timestamp":1746171898000},"page":"435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is Pulmonary Mycoses Shadowed by Tuberculosis? Mandate to Hit the Bull\u2019s Eye\u2014An Indian Perspective"],"prefix":"10.3390","volume":"14","author":[{"given":"Jeevarahini","family":"Regupathy","sequence":"first","affiliation":[{"name":"ICMR National Institute for Research in Tuberculosis, Chennai 600031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Rajendran","sequence":"additional","affiliation":[{"name":"ICMR National Institute for Research in Tuberculosis, Chennai 600031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-1538","authenticated-orcid":false,"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Thoracic Medicine, Madras Medical College, Chennai 600003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivakumar","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"ICMR National Institute for Research in Tuberculosis, Chennai 600031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","unstructured":"WHO (2023). Global Tuberculosis Report."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/ijmy.ijmy_242_21","article-title":"Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India","volume":"11","author":"Singh","year":"2022","journal-title":"Int. J. Mycobacteriol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/21505594.2021.2019950","article-title":"Pathogenesis and virulence of Candida albicans","volume":"13","author":"Lopes","year":"2022","journal-title":"Virulence"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20503121211056164","DOI":"10.1177\/20503121211056163","article-title":"Profiling of potential pulmonary fungal pathogens and the prevalence of the association between pulmonary tuberculosis and potential fungal pathogens in presumptive tuberculosis patients referred to Saint Peter\u2019s Specialized Tuberculosis Referral Hospital, Addis Ababa, Ethiopia","volume":"9","author":"Bitew","year":"2021","journal-title":"SAGE Open Med."},{"key":"ref_5","first-page":"e37664","article-title":"Identification of fungal isolates in patients with pulmonary tuberculosis treated at a tertiary care hospital","volume":"15","author":"Muni","year":"2023","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.3389\/fimmu.2019.01524","article-title":"Pathogenic fungal infection in the lung","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/17476348.2020.1753506","article-title":"Advances in the diagnosis of fungal pneumonias","volume":"14","author":"Kelly","year":"2020","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11046-016-9999-1","article-title":"Pulmonary Fungal Diseases in Immunocompetent Hosts: A Single-Center Retrospective Analysis of 35 Subjects","volume":"181","author":"Yan","year":"2016","journal-title":"Mycopathologia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s00247-023-05636-3","article-title":"Endemic mycoses in children in North America: A review of radiologic findings","volume":"53","author":"Campbell","year":"2023","journal-title":"Pediatr Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3904\/kjim.2023.395","article-title":"Long term management of people with post-tuberculosis lung disease","volume":"39","author":"Seo","year":"2024","journal-title":"Korean J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ekeng, B.E., Davies, A.A., Osaigbovo, I.I., Warris, A., Oladele, R.O., and Denning, D.W. (2022). Pulmonary and extrapulmonary manifestations of fungal infections misdiagnosed as tuberculosis: The need for prompt diagnosis and management. J. Fungi, 8.","DOI":"10.3390\/jof8050460"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/QCO.0000000000000937","article-title":"Radiology-based diagnosis of fungal pulmonary infections in high-risk hematology patients: Are we making progress?","volume":"36","author":"Lewis","year":"2023","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S259","DOI":"10.1093\/infdis\/jiad067","article-title":"Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future","volume":"228","author":"Lai","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.rmed.2018.06.029","article-title":"The spectrum of pulmonary aspergillosis","volume":"141","author":"Kanj","year":"2018","journal-title":"Respir. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4103\/ijmr.IJMR_1187_19","article-title":"Allergic bronchopulmonary aspergillosis","volume":"151","author":"Agarwal","year":"2020","journal-title":"Indian J. Med. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ueki, S., Hebisawa, A., Kitani, M., Asano, K., and Neves, J.S. (2018). Allergic Bronchopulmonary Aspergillosis-A Luminal Hypereosinophilic Disease With Extracellular Trap Cell Death. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02346"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1007\/s00330-023-10334-7","article-title":"Primary immunodeficiency diseases of adults: A review of pulmonary complication imaging findings","volume":"34","author":"Grenier","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_18","first-page":"20499361241252536","article-title":"Distribution of Aspergillus species and risk factors for aspergillosis in mainland China: A systematic review","volume":"11","author":"Khan","year":"2024","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0043-1777769","article-title":"Acute invasive pulmonary aspergillosis: Clinical presentation and treatment","volume":"45","author":"Heylen","year":"2024","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/cid\/civ216","article-title":"Invasive Pulmonary Aspergillosis-mimicking Tuberculosis","volume":"61","author":"Kim","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"van der Torre, M.H., Shen, H., Rautemaa-Richardson, R., Richardson, M.D., and Novak-Frazer, L. (2021). Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients. J. Fungi, 7.","DOI":"10.3390\/jof7020152"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kosmidis, C. (2022). Special issue: Chronic pulmonary aspergillosis. J. Fungi, 8.","DOI":"10.3390\/jof8070714"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijregi.2022.11.005","article-title":"New estimation of the prevalence of chronic pulmonary aspergillosis (CPA) related to pulmonary TB\u2014A revised burden for India","volume":"6","author":"Denning","year":"2022","journal-title":"IJID Reg."},{"key":"ref_24","first-page":"673","article-title":"Chronic pulmonary aspergillosis: A brief review","volume":"94","author":"Zarif","year":"2021","journal-title":"Yale J. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13747","DOI":"10.1111\/myc.13747","article-title":"Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow-up","volume":"67","author":"Jha","year":"2024","journal-title":"Mycoses"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/jfmpc.jfmpc_846_22","article-title":"Prevalence of chronic pulmonary aspergillosis in fibrocavitary pulmonary tuberculosis patients","volume":"12","author":"Rajpurohit","year":"2023","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/lungindia.lungindia_103_21","article-title":"Diagnostic utility of chest computerized tomography in the diagnosis of recurrence among sputum scarce and sputum negative previously treated pulmonary tuberculosis suspects","volume":"39","author":"Bharath","year":"2022","journal-title":"Lung India"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11046-023-00756-8","article-title":"Role of C-Reactive Protein and Erythrocyte Sedimentation Rate in the Diagnosis and Monitoring of Treatment Response in Treatment Na\u00efve Subjects with Chronic Pulmonary Aspergillosis","volume":"188","author":"Sehgal","year":"2023","journal-title":"Mycopathologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e254621","DOI":"10.1136\/bcr-2023-254621","article-title":"Successful management of delayed postoperative lung collapse secondary to spillage of aspergilloma","volume":"16","author":"Lahiri","year":"2023","journal-title":"BMJ Case Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jceh.2021.12.002","article-title":"Invasive Pulmonary Aspergillosis and Tuberculosis Complicated by Hemophagocytic Lymphohistiocytosis\u2014Sequelae of COVID-19 in a Liver Transplant Recipient","volume":"12","author":"Gandotra","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4269\/ajtmh.21-0701","article-title":"Case Report: Chronic Cavitatory Pulmonary Aspergillosis after COVID-19","volume":"106","author":"Chaurasia","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_32","first-page":"26330040241252450","article-title":"Five cases of pulmonary Aspergillus nodules diagnosed at surgery and by pathology in immunocompetent patients, with a literature review","volume":"5","author":"Dong","year":"2024","journal-title":"Ther. Adv. Rare Dis."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhong, H., Wang, Y., Gu, Y., Ni, Y., Wang, Y., Shen, K., Shi, Y., and Su, X. (2022). Clinical features, diagnostic test performance, and prognosis in different subtypes of chronic pulmonary aspergillosis. Front. Med., 9.","DOI":"10.3389\/fmed.2022.811807"},{"key":"ref_34","unstructured":"Chakraborty, R.K., Gilotra, T.S., Tobin, E.H., and Baradhi, K.M. (2024). Aspergilloma, StatPearls Pulishing."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"220114","DOI":"10.1183\/16000617.0114-2022","article-title":"Pulmonary aspergillosis: Diagnosis and treatment","volume":"31","author":"Lamoth","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5606\/tgkdc.dergisi.2022.21406","article-title":"Is there any change in disease presentation and surgical outcomes in patients with pulmonary aspergilloma? An evaluation of the time trend","volume":"30","author":"Aksoy","year":"2022","journal-title":"Turk. J. Thorac. Cardiovasc. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2050313X241251777","DOI":"10.1177\/2050313X241251777","article-title":"Chronic cavitary pulmonary aspergillosis as a sequela of pulmonary tuberculosis: A case report from Pakistan","volume":"12","author":"Uzair","year":"2024","journal-title":"SAGE Open Med Case Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jiac.2013.10.016","article-title":"Pathogenesis and clinical features of chronic pulmonary aspergillosis\u2014Is it possible to distinguish CNPA and CCPA clinically?","volume":"20","author":"Izumikawa","year":"2014","journal-title":"J. Infect. Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4269\/ajtmh.22-0366","article-title":"Imaging spectrum in chronic pulmonary aspergillosis","volume":"108","author":"Garg","year":"2023","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Huang, S.-F., Huang, C.-C., Chou, K.-T., Chan, Y.-J., Yang, Y.-Y., and Wang, F.-D. (2021). Chronic Pulmonary Aspergillosis: Disease Severity Using Image Analysis and Correlation with Systemic Proinflammation and Predictors of Clinical Outcome. J. Fungi, 7.","DOI":"10.3390\/jof7100842"},{"key":"ref_41","first-page":"7981472","article-title":"Clinical diagnosis, treatment, and laboratory detection of 50 cases of pulmonary cryptococcosis","volume":"2022","author":"Wang","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"ofac559","DOI":"10.1093\/ofid\/ofac559","article-title":"Fungal nomenclature: Managing change is the name of the game","volume":"10","author":"Kidd","year":"2023","journal-title":"Open Forum Infect Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"a019760","DOI":"10.1101\/cshperspect.a019760","article-title":"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis","volume":"4","author":"Fraser","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hu, Y., Ren, S.-Y., Xiao, P., Yu, F.-L., and Liu, W.-L. (2021). The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients. BMC Pulm. Med., 21.","DOI":"10.1186\/s12890-021-01630-3"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Xiong, C., Lu, J., Chen, T., and Xu, R. (2022). Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: A systematic review and meta-analysis. BMC Pulm. Med., 22.","DOI":"10.1186\/s12890-022-02175-9"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Qu, J., Zhang, X., Lu, Y., Liu, X., and Lv, X. (2020). Clinical analysis in immunocompetent and immunocompromised patients with pulmonary cryptococcosis in western China. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-66094-7"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4103\/1319-2442.270278","article-title":"Cryptococcosis masquerading as disseminated tuberculosis in a patient on chronic hemodialysis","volume":"30","author":"Meena","year":"2019","journal-title":"Saudi J. Kidney Dis. Transplant."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/tropej\/fmx083","article-title":"Disseminated cryptococcosis presenting as miliary lung shadows in an immunocompetent child","volume":"64","author":"Ismail","year":"2018","journal-title":"J. Trop. Pediatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijtb.2016.09.016","article-title":"Unusual case of coexistent pulmonary cryptococcosis and tuberculosis in an immuno-competent host","volume":"64","author":"Jain","year":"2017","journal-title":"Indian J. Tuberc."},{"key":"ref_50","first-page":"66","article-title":"Pulmonary cryptococcoma masquerading as lung cancer","volume":"64","author":"Pawar","year":"2016","journal-title":"J. Assoc. Physicians India"},{"key":"ref_51","first-page":"OD04-5","article-title":"Disseminated cryptococcosis with adrenal and lung involvement in an immunocompetent patient","volume":"9","author":"Ranjan","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_52","first-page":"518","article-title":"The mycological and molecular study of Pneumocystis jiroveci pneumonia among HIV and non-HIV immunocompromised patients hospitalized in pulmonary units in Guilan, Northern Iran","volume":"13","author":"Rafat","year":"2021","journal-title":"Iran. J. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jmii.2019.05.003","article-title":"Pneumocystis jiroveci pneumonia in Taiwan from 2014 to 2017: Clinical manifestations and outcomes between pediatric and adult patients","volume":"52","author":"Lee","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Apostolopoulou, A., and Fishman, J.A. (2022). The Pathogenesis and Diagnosis of Pneumocystis jiroveci Pneumonia. J. Fungi, 8.","DOI":"10.3390\/jof8111167"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/mmy\/myaa024","article-title":"Diagnosing Pneumocystis jirovecii pneumonia: A review of current methods and novel approaches","volume":"58","author":"Bateman","year":"2020","journal-title":"Med. Mycol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/2229-516X.157166","article-title":"Clinical profile of human immunodeficiency virus patients with opportunistic infections: A descriptive case series study","volume":"5","author":"Ramesh","year":"2015","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/0253-7184.176213","article-title":"Clinical manifestations and outcome of patients with human immunodeficiency virus infection at tertiary care teaching hospital","volume":"37","author":"Patil","year":"2016","journal-title":"Indian J. Sex. Transm. Dis. AIDS"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijtb.2019.08.003","article-title":"Pulmonary tuberculosis and pneumocystis jirovecii concurrent pneumonia in HIV infected patients at a resource limited setting in Eastern India: A case series","volume":"67","author":"Pandey","year":"2020","journal-title":"Indian J. Tuberc."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bongomin, F., Ekeng, B.E., Kibone, W., Nsenga, L., Olum, R., Itam-Eyo, A., Kuate, M.P.N., Pebolo, F.P., Davies, A.A., and Manga, M. (2022). Invasive fungal diseases in africa: A critical literature review. J. Fungi, 8.","DOI":"10.3390\/jof8121236"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"omy071","DOI":"10.1093\/omcr\/omy071","article-title":"Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL","volume":"2018","author":"Goico","year":"2018","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e01661-19","DOI":"10.1128\/JCM.01661-19","article-title":"Human Blastomycosis in South Africa Caused by Blastomyces percursus and Blastomyces emzantsi sp. nov., 1967 to 2014","volume":"58","author":"Maphanga","year":"2020","journal-title":"J. Clin. Microbiol"},{"key":"ref_62","first-page":"63","article-title":"Epidemiology of fungal diseases in Africa: A review of diagnostic drivers","volume":"7","author":"Bongomin","year":"2021","journal-title":"Curr. Med. Mycol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.11604\/pamj.2020.36.220.21829","article-title":"Pulmonary blastomycosis","volume":"36","author":"Abdallah","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, N., Luo, Z., Deng, S., and Li, Q. (2020). A young male with chronic nonproductive cough diagnosed with blastomycosis in China: A case report. BMC Pulm. Med., 20.","DOI":"10.1186\/s12890-020-01225-4"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3201\/eid2509.190587","article-title":"Blastomycosis misdiagnosed as tuberculosis, india","volume":"25","author":"Kumar","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Cordeiro, R., Moura, S., Castelo-Branco, D., Rocha, M.F., Lima-Neto, R., and Sidrim, J.J. (2021). Coccidioidomycosis in brazil: Historical challenges of a neglected disease. J. Fungi, 7.","DOI":"10.3390\/jof7020085"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s40121-022-00606-y","article-title":"Coccidioidomycosis: A contemporary review","volume":"11","author":"Crum","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/mmy\/myy039","article-title":"The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species","volume":"57","author":"Taylor","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/jim-2020-001655","article-title":"Coccidioidomycosis: A review","volume":"69","author":"Johnson","year":"2021","journal-title":"J. Investig. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Scott, A.M., Lim, J.R., Randhawa, R., Lee, J., Yaddanapudi, K., Rabe, B., and Malo, J. (2023). Examining Miliary Disease Etiology in a Coccidioides-Endemic Center: A Retrospective Cohort Study. J. Fungi, 10.","DOI":"10.3390\/jof10010029"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e253740","DOI":"10.1136\/bcr-2022-253740","article-title":"Coccidioidomycosis lymphadenopathy: An unusual presentation","volume":"16","author":"Sri","year":"2023","journal-title":"BMJ Case Rep."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Caceres, D.H., and Valdes, A. (2019). Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV. J. Fungi, 5.","DOI":"10.3390\/jof5030073"},{"key":"ref_73","first-page":"20499361211008676","article-title":"Histoplasmosis overlapping with HIV and tuberculosis in sub-Saharan Africa: Challenges and research priorities","volume":"8","author":"Kuate","year":"2021","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"ofaa119","DOI":"10.1093\/ofid\/ofaa119","article-title":"Chronic Pulmonary Histoplasmosis-A Scoping Literature Review","volume":"7","author":"Baker","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Nacher, M., Alsibai, K.D., Epelboin, L., Abboud, P., About, F., Demar, M., Djossou, F., Blaizot, R., Douine, M., and Sabbah, N. (2021). A Simple Predictive Score to Distinguish between Disseminated Histoplasmosis and Tuberculosis in Patients with HIV. J. Fungi, 8.","DOI":"10.3390\/jof8010016"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"ofac368","DOI":"10.1093\/ofid\/ofac368","article-title":"Prevalence of Histoplasmosis and Molecular Characterization of Histoplasma species in Patients with Presumptive Pulmonary Tuberculosis in Calabar, Nigeria","volume":"9","author":"Ekeng","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5603\/ARM.a2021.0051","article-title":"Acute pulmonary histoplasmosis masquerading as miliary tuberculosis in a non-endemic region","volume":"89","author":"Agarwal","year":"2021","journal-title":"Adv. Respir. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e235531","DOI":"10.1136\/bcr-2020-235531","article-title":"Disseminated histoplasmosis and tuberculosis: Dual infection in a non-endemic region","volume":"13","author":"Anot","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mjafi.2018.07.017","article-title":"Solitary pulmonary nodule: An interesting clinical mimicry of pulmonary tuberculosis","volume":"75","author":"Dutta","year":"2018","journal-title":"Med. J. Armed Forces India"},{"key":"ref_80","first-page":"621","article-title":"A challenging case of pyrexia of unknown origin: Adrenal histoplasmosis mimicking tuberculosis in a patient with chronic hepatitis C","volume":"51","author":"Ramesh","year":"2018","journal-title":"Trop. Dr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/0973-029X.185913","article-title":"Prevalence and characterization of opportunistic candidal infections among patients with pulmonary tuberculosis","volume":"20","author":"Astekar","year":"2016","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Azim, A., and Ahmed, A. (2024). Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: A comprehensive review. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1256158"},{"key":"ref_83","first-page":"18","article-title":"Isolated Candida infection of the lung","volume":"16","author":"Shweihat","year":"2015","journal-title":"Respir. Med. Case Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"103898","DOI":"10.1016\/j.micpath.2019.103898","article-title":"Candida coinfection among patients with pulmonary tuberculosis in Asia and Africa; A systematic review and meta-analysis of cross-sectional studies","volume":"139","author":"Shakerimoghaddam","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijtb.2016.09.017","article-title":"Drug-resistant tuberculosis coexisting with invasive candidiasis in an immunocompetent 30-year-old woman: A case report","volume":"64","author":"Khanduri","year":"2017","journal-title":"Indian J. Tuberc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/2249-4863.197320","article-title":"Profile of infections in renal transplant recipients from India","volume":"5","author":"Kumar","year":"2016","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1237125","DOI":"10.1155\/2022\/1237125","article-title":"Clinical Manifestations of Pulmonary Mucormycosis in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A 21-Case Series Report and Literature Review","volume":"2022","author":"Bao","year":"2022","journal-title":"Can. Respir. J."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Prakash, H., and Chakrabarti, A. (2019). Global epidemiology of mucormycosis. J. Fungi, 5.","DOI":"10.3390\/jof5010026"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1148\/rg.2020190156","article-title":"Pulmonary mucormycosis: Risk factors, radiologic findings, and pathologic correlation","volume":"40","author":"Agrawal","year":"2020","journal-title":"Radiographics"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/0970-2113.148452","article-title":"Pulmonary tuberculosis and mucormycosis co-infection in a diabetic patient","volume":"32","author":"Aggarwal","year":"2015","journal-title":"Lung India"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0972-5229.178187","article-title":"Coinfections in Intensive Care Unit with pulmonary tuberculosis and mucormycosis: A clinical dilemma","volume":"20","author":"Dube","year":"2016","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/ijmy.ijmy_186_19","article-title":"Disseminated pulmonary mucormycosis with concomitant tuberculosis infection in a diabetic patient","volume":"9","author":"Ramesh","year":"2020","journal-title":"Int. J. Mycobacteriol."},{"key":"ref_93","unstructured":"(2024, October 05). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240060241."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Mendon\u00e7a, A., Santos, H., Franco-Duarte, R., and Sampaio, P. (2022). Fungal infections diagnosis\u2014Past, present and future. Res. Microbiol., 173.","DOI":"10.1016\/j.resmic.2021.103915"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/S1473-3099(19)30312-3","article-title":"Global guideline for the diagnosis and management of mucormycosis: An initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium","volume":"19","author":"Cornely","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4103\/ijpm.ijpm_663_21","article-title":"Comparative evaluation of histopathological analysis, KOH wet mount and fungal culture to diagnose fungal infections in post-COVID patients","volume":"66","author":"Baxi","year":"2023","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.18203\/2320-6012.ijrms20194986","article-title":"Histomorphological spectrum of fungal infections","volume":"7","author":"Jandial","year":"2019","journal-title":"Int. J. Res. Med. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13312-019-1505-7","article-title":"Diagnosis of invasive fungal infections in children","volume":"56","author":"Seth","year":"2019","journal-title":"Indian Pediatr."},{"key":"ref_99","first-page":"e48756","article-title":"Radiological and imaging evidence in the diagnosis and management of microbial infections: An update","volume":"15","author":"Vaishnav","year":"2023","journal-title":"Cureus"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4103\/ijri.IJRI_357_19","article-title":"Imaging spectrum of pulmonary infections in renal transplant patients","volume":"30","author":"Ahmad","year":"2020","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"081","DOI":"10.1055\/s-0042-1743418","article-title":"Imaging approach to pulmonary infections in the immunocompromised patient","volume":"32","author":"Grover","year":"2022","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ccm.2017.04.013","article-title":"Laboratory diagnostics for fungal infections: A review of current and future diagnostic assays","volume":"38","author":"Ramanan","year":"2017","journal-title":"Clin. Chest Med."},{"key":"ref_103","unstructured":"(2019). Standard Operating Procedures for Fungal Identification and Detection of Antifungal Resistance Antimicrobial Resistance Surveillance and Research Network, Indian Council of Medical Research."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1164\/rccm.201906-1185ST","article-title":"Microbiological laboratory testing in the diagnosis of fungal infections in pulmonary and critical care practice. An official american thoracic society clinical practice guideline","volume":"200","author":"Hage","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0042-1742632","article-title":"Role of (1-3)-\u0392-D-Glucan Test in the Diagnosis of Invasive Fungal Infections among High-Risk Patients in a Tertiary Care Hospital","volume":"14","author":"Sandhar","year":"2022","journal-title":"J. Lab. Physicians"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Liu, A., Chen, W., Wei, Y., Liang, J., Liao, S., Chen, Y., Li, Y., Wang, X., Chen, W., and Qiu, Y. (2023). Comparison of diagnostic efficiency of detecting IgG and IgE with immunoassay method in diagnosing ABPA: A meta-analysis. BMC Pulm. Med., 23.","DOI":"10.1186\/s12890-023-02620-3"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Takazono, T., and Izumikawa, K. (2018). Recent advances in diagnosing chronic pulmonary aspergillosis. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01810"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s11046-020-00452-x","article-title":"Immunodiagnostic assays for the investigation of fungal outbreaks","volume":"185","author":"Caceres","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Gudisa, R., Harchand, R., and Rudramurthy, S.M. (2024). Nucleic-Acid-Based Molecular Fungal Diagnostics: A Way to a Better Future. Diagnostics, 14.","DOI":"10.3390\/diagnostics14050520"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.4103\/jfmpc.jfmpc_2325_20","article-title":"Utility of Panfungal PCR in the diagnosis of invasive fungal infections in febrile neutropenia","volume":"10","author":"Srinivas","year":"2021","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Poplin, V., Smith, C., Milsap, D., Zabel, L., and Bahr, N.C. (2021). Diagnosis of pulmonary infections due to endemic fungi. Diagnostics, 11.","DOI":"10.3390\/diagnostics11050856"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wu, W., Xiao, Y., Zou, H., Hao, S., and Jiang, Y. (2024). Application of metagenomic next-generation sequencing and targeted metagenomic next-generation sequencing in diagnosing pulmonary infections in immunocompetent and immunocompromised patients. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1439472"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Naik, S., Kashyap, D., Deep, J., Darwish, S., Cross, J., Mansoor, E., Garg, V.K., and Honnavar, P. (2024). Utilizing Next-Generation Sequencing: Advancements in the Diagnosis of Fungal Infections. Diagnostics, 14.","DOI":"10.3390\/diagnostics14151664"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cmi.2014.11.009","article-title":"Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the rapid identification of yeasts causing bloodstream infections","volume":"21","author":"Ghosh","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2217\/fmb-2017-0105","article-title":"Matrix-assisted laser desorption\/ionization-time of flight mass spectrometry: Protocol standardization and database expansion for rapid identification of clinically important molds","volume":"12","author":"Paul","year":"2017","journal-title":"Future Microbiol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/5\/435\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:25:28Z","timestamp":1760030728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/5\/435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":115,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["pathogens14050435"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14050435","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}