{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:14:54Z","timestamp":1791389694169,"version":"4.3.3"},"reference-count":71,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Coinfection rates of candidiasis in patients affected by COVID-19 had a significantly increase during the sanitary contingency. The objective of this scoping review is to analyze the available scientific evidence around the coinfection of invasive candidiasis in hospitalized patients with severe COVID-19 disease. Online databases such as PubMed, EBSCO, SciFinder, Scopus, and SciELO were used to analyze the different scientific studies published from January 2020 to December 2022, selecting 48 publications that reported comorbidity between invasive candidiasis and COVID-19 as a study variable. Based on the PRISMA-ScR extension for scoping reviews, we identified more than half of the publications (57%) as observational, descriptive, and analytic studies, while 43% were systematic reviews. Overall, up to 169,468 adult patients admitted to the intensive care unit were examined. Coinfection was due mainly to Candida albicans (75%), but some more species were reported such as Meyerozyma parapsilosis (formerly Candida parapsilosis); Meyerozyma guilliermondii (formerly Candida guilliermondii); Nakaseomyces glabratus (formerly Candida glabrata); Candida tropicalis; Candida dubliniensis; Clavispora lusitaniae (formerly Candida lusitaniae); and Pichia kudriavzevii (formerly Candida krusei). We concluded that patients infected by SARS-CoV-2 had a higher incidence of fungal coinfections, thus increasing the mortality rate, disease severity, and length of hospital stay in the intensive care unit.<\/jats:p>","DOI":"10.3390\/pathogens14050466","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:58:07Z","timestamp":1747047487000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Invasive Candidiasis Coinfection in Patients with Severe COVID-19 Disease: Scoping Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Omar Esteban","family":"Valencia-Ledezma","sequence":"first","affiliation":[{"name":"Departamento de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Servicios de Salud del Instituto Mexicano de Seguro Social para el Bienestar (IMSS-BIENESTAR), Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-9995","authenticated-orcid":false,"given":"Mar\u00eda del Roc\u00edo","family":"Reyes-Montes","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Acosta-Altamirano","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n del Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-8698","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Fr\u00edas-De-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n, Hospital Regional de Alta 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Pediatr. (Engl. Ed.)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/cid\/ciab562","article-title":"The Landscape of Candidemia During the Coronavirus Disease 2019 (COVID-19) Pandemic","volume":"74","author":"Seagle","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Machado, M., Est\u00e9vez, A., S\u00e1nchez-Carrillo, C., Guinea, J., Escribano, P., Alonso, R., Valerio, M., Padilla, B., Bouza, E., and Mu\u00f1oz, P. (2022). Incidence of Candidemia Is Higher in COVID-19 versus Non-COVID-19 Patients, but Not Driven by Intrahospital Transmission. J. Fungi, 8.","DOI":"10.3390\/jof8030305"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12281-022-00434-0","article-title":"Overview of COVID-19-Associated Invasive Fungal Infection","volume":"16","author":"Shishido","year":"2022","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101198","DOI":"10.1016\/j.mycmed.2021.101198","article-title":"Invasive fungal infections among critically ill adult COVID-19 patients: First experiences from the national centre in Hungary","volume":"31","author":"Szabo","year":"2021","journal-title":"J. Mycol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Koukaki, E., Rovina, N., Tzannis, K., Sotiropoulou, Z., Loverdos, K., Koutsoukou, A., and Dimopoulos, G. (2022). Fungal Infections in the ICU during the COVID-19 Era: Descriptive and Comparative Analysis of 178 Patients. J. Fungi, 8.","DOI":"10.3390\/jof8080881"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1002\/jmv.27198","article-title":"Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19","volume":"93","author":"Kayaaslan","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Moser, D., Biere, K., Han, B., Hoerl, M., Schelling, G., Chouk\u00e9r, A., and Woehrle, T. (2021). COVID-19 Impairs Immune Response to Candida albicans. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.640644"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ahmed, N., Mahmood, M.S., Ullah, M.d.A., Araf, Y., Rahaman, T.I., Moin, A.T., and Hosen, M.J. (2022). COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies. Curr. Microbiol., 79.","DOI":"10.1007\/s00284-022-02824-6"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41564-022-01172-2","article-title":"COVID-19-associated fungal infections","volume":"7","author":"Hoenigl","year":"2022","journal-title":"Nat. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PRS.0b013e318219c171","article-title":"The Levels of Evidence and Their Role in Evidence-Based Medicine","volume":"128","author":"Burns","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"106619","DOI":"10.1016\/j.rmed.2021.106619","article-title":"Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factors","volume":"188","author":"Carrillo","year":"2021","journal-title":"Respir. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jeong, S., Lee, N., Park, Y., Kim, J., Jeon, K., Park, M.-J., and Song, W. (2022). Prevalence and Clinical Impact of Coinfection in Patients with Coronavirus Disease 2019 in Korea. Viruses, 14.","DOI":"10.3390\/v14020446"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1017\/ice.2022.65","article-title":"Healthcare-associated infections on the intensive care unit in 21 Brazilian hospitals during the early months of the coronavirus disease 2019 (COVID-19) pandemic: An ecological study","volume":"44","author":"Porto","year":"2023","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/myc.13225","article-title":"Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic","volume":"64","author":"Nucci","year":"2021","journal-title":"Mycoses"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.riam.2020.07.001","article-title":"Fungal co-infection in COVID-19 patients: Should we be concerned?","volume":"37","author":"Salavert","year":"2020","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10238-021-00751-7","article-title":"COVID-19-associated opportunistic infections: A snapshot on the current reports","volume":"22","author":"Abdoli","year":"2021","journal-title":"Clin. Exp. Med."},{"key":"ref_20","first-page":"71","article-title":"Invasive fungal infections in patients with COVID-19: A review on pathogenesis, epidemiology, clinical features, treatment, and outcomes","volume":"44","author":"Chiurlo","year":"2021","journal-title":"New Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s42399-021-00873-9","article-title":"Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19","volume":"3","author":"Muddana","year":"2021","journal-title":"SN Compr. Clin. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Hilmio\u011flu-Polat, S., Daneshnia, F., Pan, W., Hafez, A., Fang, W., Liao, W., \u015eahbudak-Bal, Z., Metin, D., and Junior, J.M. (2021). Clonal Candidemia Outbreak by Candida parapsilosis Carrying Y132F in Turkey: Evolution of a Persisting Challenge. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.676177"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Fr\u00edas-De-Le\u00f3n, M.G., Pinto-Almaz\u00e1n, R., Hern\u00e1ndez-Castro, R., Garc\u00eda-Salazar, E., Meza-Meneses, P., Rodr\u00edguez-Cerdeira, C., Arenas, R., Conde-Cuevas, E., Acosta-Altamirano, G., and Mart\u00ednez-Herrera, E. (2021). Epidemiology of Systemic Mycoses in the COVID-19 Pandemic. J. Fungi, 7.","DOI":"10.3390\/jof7070556"},{"key":"ref_24","first-page":"714","article-title":"Prevalence of candidiasis and oral candidiasis in COVID-19 patients: A cross-sectional pilot study from the patients\u2019 registry in a large health center","volume":"52","author":"Katz","year":"2021","journal-title":"Quintessence Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.33073\/pjm-2021-039","article-title":"Fungal Infections in COVID-19 Intensive Care Patients","volume":"70","author":"Coskun","year":"2021","journal-title":"Pol. J. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Erami, M., Mirhendi, H., Momen-Heravi, M., Hezaveh, S.J.H., Ahsaniarani, A.H., Sabet, S.S., and Aboutalebian, S. (2022). A case of COVID-19-associated rhino-orbito-cerebral mucormycosis caused by Apophysomyces variabilis with a review of the literature. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.898477"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s11046-020-00472-7","article-title":"Opportunistic Fungal Infections in the Epidemic Area of COVID-19: A Clinical and Diagnostic Perspective from Iran","volume":"185","author":"Salehi","year":"2020","journal-title":"Mycopathologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s42770-022-00704-6","article-title":"An overview of COVID-19 related to fungal infections: What do we know after the first year of pandemic?","volume":"53","author":"Vitale","year":"2022","journal-title":"Braz. J. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12281-021-00421-x","article-title":"Molecular Diagnosis of Yeast Infections","volume":"15","author":"White","year":"2021","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/myc.13137","article-title":"Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern","volume":"63","author":"Salehi","year":"2020","journal-title":"Mycoses"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2147\/IDR.S314029","article-title":"Coinfections in Patients Hospitalized with COVID-19: A Descriptive Study from the United Arab Emirates","volume":"14","author":"Senok","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.21037\/apm-21-833","article-title":"Secondary infection in severe and critical COVID-19 patients in China: A multicenter retrospective study","volume":"10","author":"Sang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2838","DOI":"10.1093\/cid\/ciaa1594","article-title":"Candidemia in Coronavirus Disease 2019 (COVID-19) Patients: Incidence and Characteristics in a Prospective Cohort Compared with Historical Non\u2013COVID-19 Controls","volume":"73","author":"Mastrangelo","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1177\/00220345211029637","article-title":"Oral Manifestations in Patients with COVID-19: A 6-Month Update","volume":"100","author":"Normando","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Roudbary, M., Kumar, S., Kumar, A., \u010cern\u00e1kov\u00e1, L., Nikoomanesh, F., and Rodrigues, C.F. (2021). Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients. J. Fungi, 7.","DOI":"10.3390\/jof7090720"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jinf.2021.02.020","article-title":"A retrospective multicenter analysis of candidaemia among COVID-19 patients during the first UK pandemic wave","volume":"82","author":"Denny","year":"2021","journal-title":"J. Infect."},{"key":"ref_37","first-page":"48","article-title":"Candida infections associated with COVID-19: An underestimated risk","volume":"10","author":"Norberg","year":"2021","journal-title":"WJPPS"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/odi.13916","article-title":"Coronavirus disease 2019 (COVID-19) vaccines: A concise review","volume":"28","author":"Samaranayake","year":"2022","journal-title":"Oral. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Brandi, N., Ciccarese, F., Balacchi, C., Rimondi, M.R., Modolon, C., Sportoletti, C., Capozzi, C., Renzulli, M., Paccapelo, A., and Castelli, A. (2022). Co-Infections and Superinfections in COVID-19 Critically Ill Patients Are Associated with CT Imaging Abnormalities and the Worst Outcomes. Diagnostics, 12.","DOI":"10.3390\/diagnostics12071617"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101588","DOI":"10.1016\/j.genrep.2022.101588","article-title":"Fungal and bacterial co-infections of the respiratory tract among patients with COVID-19 hospitalized in intensive care units","volume":"27","author":"Rafat","year":"2022","journal-title":"Gene Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154004","DOI":"10.1016\/j.jcrc.2022.154004","article-title":"Invasive fungal infections in critically ill COVID-19 patients in a large tertiary university hospital in Israel","volume":"69","author":"Ayalon","year":"2022","journal-title":"J. Crit. Care"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Soltani, S., Zakeri, A., Zandi, M., Kesheh, M.M., Tabibzadeh, A., Dastranj, M., Faramarzi, S., Didehdar, M., Hafezi, H., and Hosseini, P. (2021). The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6670798"},{"key":"ref_43","first-page":"12","article-title":"Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-19","volume":"7","author":"Mahmoudi","year":"2022","journal-title":"Curr. Med. Mycol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"ofab201","DOI":"10.1093\/ofid\/ofab201","article-title":"Characterization of Bacterial and Fungal Infections in Hospitalized Patients with Coronavirus Disease 2019 and Factors Associated with Health Care-Associated Infections","volume":"8","author":"Kubin","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jgar.2020.10.004","article-title":"Incidence of bacterial and fungal bloodstream infections in COVID-19 patients in intensive care: An alarming \u201ccollateral effect\u201d","volume":"23","author":"Cataldo","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101012","DOI":"10.1016\/j.mycmed.2020.101012","article-title":"Critically ill patients with COVID-19 and candidaemia: We must keep this in mind","volume":"30","author":"Agrifoglio","year":"2020","journal-title":"J. Mycol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.cmi.2020.06.025","article-title":"Bacterial and fungal coinfection among hospitalized patients with COVID-19: A retrospective cohort study in a UK secondary-care setting","volume":"26","author":"Hughes","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"102564","DOI":"10.1016\/j.autrev.2020.102564","article-title":"Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: An increased risk for candidemia?","volume":"19","author":"Antinori","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102353","DOI":"10.1016\/j.bjid.2022.102353","article-title":"Increased incidence of candidemia in critically ill patients during the Coronavirus Disease 2019 (COVID-19) pandemic","volume":"26","author":"Kolonitsiou","year":"2022","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"ofab510","DOI":"10.1093\/ofid\/ofab510","article-title":"Coronavirus Disease 2019\u2013Associated Invasive Fungal Infection","volume":"8","author":"Baddley","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijid.2020.08.051","article-title":"Corticosteroids in the Treatment of Severe COVID-19 Lung Disease: The Pulmonology Perspective from the First United States Epicenter","volume":"100","author":"Macauley","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Basile, K., Halliday, C., Kok, J., and Chen, S.C.-A. (2022). Fungal Infections Other Than Invasive Aspergillosis in COVID-19 Patients. J. Fungi, 8.","DOI":"10.3390\/jof8010058"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Elbaz, M., Korem, M., Ayalon, O., Wiener-Well, Y., Shachor-Meyouhas, Y., Cohen, R., Bishara, J., Atamna, A., Brosh-Nissimov, T., and Maaravi, N. (2022). Invasive Fungal Diseases in Hospitalized Patients with COVID-19 in Israel: A Multicenter Cohort Study. J. Fungi, 8.","DOI":"10.3390\/jof8070721"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s42399-021-01033-9","article-title":"Response to Commentary: Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19","volume":"3","author":"Santosh","year":"2021","journal-title":"SN Compr. Clin. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Carvalho, A., Nguyen, M.H., Hedayati, M.T., Netea, M.G., Perlin, D.S., and Hoenigl, M. (2020). COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions?. J. Fungi, 6.","DOI":"10.3390\/jof6040211"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abc1669","article-title":"SARS-CoV-2 productively infects human gut enterocytes","volume":"369","author":"Lamers","year":"2020","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Torres-Estrella, C.U., Reyes-Montes Mdel, R., Duarte-Escalante, E., Sierra Mart\u00ednez, M., Fr\u00edas-De-Le\u00f3n, M.G., and Acosta-Altamirano, G. (2022). Vaccines Against COVID-19: A Review. Vaccines, 10.","DOI":"10.3390\/vaccines10030414"},{"key":"ref_58","first-page":"27018","article-title":"Nasal Mask: An Alternative to Prevent Contagion during Essential Activities","volume":"34","year":"2021","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1164\/rccm.202002-0445OC","article-title":"COVID-19 with Different Severities: A Multicenter Study of Clinical Features","volume":"201","author":"Feng","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/0022034520957289","article-title":"Oral Manifestations in Patients with COVID-19: A Living Systematic Review","volume":"100","author":"Normando","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Denny, S., Rawson, T.M., Hart, P., Satta, G., Abdulaal, A., Hughes, S., Gilchrist, M., Mughal, N., and Moore, L. (2021). Bacteraemia variation during the COVID-19 pandemic; A multi-centre UK secondary care ecological analysis. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06159-8"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Daneshnia, F., Najafzadeh, M.J., Hagen, F., Mahmoudi, S., Salehi, M., Zarrinfar, H., Namvar, Z., Zareshahrabadi, Z., and Khodavaisy, S. (2020). Evaluation of Molecular Epidemiology, Clinical Characteristics, Antifungal Susceptibility Profiles, and Molecular Mechanisms of Antifungal Resistance of Iranian Candida parapsilosis Species Complex Blood Isolates. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00206"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Daneshnia, F., Farahyar, S., Fang, W., Salimi, M., Salehi, M., Hagen, F., Weihua, P., Roudbary, M., and Boekhout, T. (2019). Incidence and spectrum of yeast species isolated from the oral cavity of Iranian patients suffering from hematological malignancies. J. Oral. Microbiol., 11.","DOI":"10.1080\/20002297.2019.1601061"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/mmy\/myab056","article-title":"Clinical characteristics and risk factors for COVID-19-associated Candidemia","volume":"59","author":"Omrani","year":"2021","journal-title":"Med. Mycol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"105520","DOI":"10.1016\/j.micpath.2022.105520","article-title":"Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia","volume":"166","author":"Erami","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1002\/jmv.26633","article-title":"Fungemia in COVID-19 ICU patients, a single medical center experience","volume":"93","author":"Bishburg","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cannon, R.D. (2022). Oral Fungal Infections: Past, Present, and Future. Front. Oral Health., 3.","DOI":"10.3389\/froh.2022.838639"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.idc.2021.08.002","article-title":"Nosocomial Fungal Infections: Epidemiology, Infection Control, and Prevention","volume":"35","author":"Suleyman","year":"2021","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3855\/jidc.16256","article-title":"Fatal invasive candidiasis in COVID-19 patient with severe bleeding and extensively drug-resistant Klebsiella enterobacter","volume":"16","author":"Velickovic","year":"2022","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.7196\/SAMJ.2020.v110i11.15248","article-title":"Opportunistic pathogenic fungal co-infections are prevalent in critically ill COVID-19 patients: Are they risk factors for disease severity?","volume":"110","author":"Ezeokoli","year":"2020","journal-title":"S. Afr. Med. J."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/5\/466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:30:35Z","timestamp":1760031035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/5\/466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":71,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["pathogens14050466"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14050466","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]}}}