{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:12:01Z","timestamp":1775081521918,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This research addresses IL-28B gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1\u2019s impact on immunity, this study seeks biomarkers for early diagnosis and intervention. A systematic search met inclusion criteria, such as open access bibliographic and experimental studies published in English between 2010 and 2024, and genetic factors linked to susceptibility to pathologies. Regarding exclusion criteria, bibliographic or experimental studies in organisms other than humans, unofficial sources, non-indexed journals, and scientific articles in languages other than English were ruled out. Statistical data analyses were assessed using meta-analysis, including forest plot and Q test of heterogeneity based on the I2 statistics. The analyzed data indicate associations between genotypes, such as CT, GG, CC, and TT of the rs12979890 and rs8099917 polymorphisms and the predisposition to various diseases, such as HCV, arthropathy, HAM\/TSP, cytomegalovirus and Crimean\u2013Congo hemorrhagic fever associated with HTLV-1; however, the observed inconsistencies, such as high heterogeneity, and deficiency of related information limit the consolidation of the findings. Further research is needed to clarify IL-28B genotype interactions and disease susceptibility in HTLV-1 infections.<\/jats:p>","DOI":"10.3390\/pathogens14050470","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:59:26Z","timestamp":1747108766000},"page":"470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between IL-28B (rs8099917) and IL-28B (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9574-0604","authenticated-orcid":false,"given":"Naomi","family":"Cuenca","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Aplicaciones Biotecnol\u00f3gicas (GIAB), Universidad Polit\u00e9cnica Salesiana (UPS), Carrera de Biotecnolog\u00eda, Campus Mar\u00eda Auxiliadora, Kil\u00f3metro 19.5 V\u00eda a La Costa, Guayaquil P.O. Box 09-01-2074, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damarys","family":"Cordero","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Aplicaciones Biotecnol\u00f3gicas (GIAB), Universidad Polit\u00e9cnica Salesiana (UPS), Carrera de Biotecnolog\u00eda, Campus Mar\u00eda Auxiliadora, Kil\u00f3metro 19.5 V\u00eda a La Costa, Guayaquil P.O. Box 09-01-2074, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3023-3038","authenticated-orcid":false,"given":"Brenda","family":"L\u00f3pez-Ulloa","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Aplicaciones Biotecnol\u00f3gicas (GIAB), Universidad Polit\u00e9cnica Salesiana (UPS), Carrera de Biotecnolog\u00eda, Campus Mar\u00eda Auxiliadora, Kil\u00f3metro 19.5 V\u00eda a La Costa, Guayaquil P.O. Box 09-01-2074, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, March 12). Fact Sheets: Human T-Lymphotropic Virus Type 1. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/human-t-lymphotropic-virus-type-1."},{"key":"ref_2","unstructured":"WHO (2019). Public Health Impact And Implications For Future Actions: Who Global Consultation On The Human T-Lymphotropic Virus Type 1, WHO."},{"key":"ref_3","unstructured":"WHO (2020). Human T-Lymphotropic Virus Type 1: Technical Report February 2020, WHO."},{"key":"ref_4","unstructured":"Organizaci\u00f3n Panamericana de la Salud (2025, March 12). Hoja Informativa: Virus linfotr\u00f3pico T humano (HTLV). 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