{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:54:30Z","timestamp":1774889670199,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Infective endocarditis (IE) of the tricuspid and pulmonary valve accounts for 5 to 10% of all IE cases and, compared with left-sided IE, is often associated with intravenous (i.v.) drug use, presence of intracardiac devices, and central venous catheters (CVCs), including permanent\u2014Hickman catheter (HC). We report a case of a 71-year-old female patient on a chronic hemodialysis (HD) program who had developed IE. Her first symptoms were fever and malaise. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) examinations were performed, revealing vegetations on the tip of HC and the anterior and posterior leaflets of the tricuspid valve (TV). Three blood culture bottles were positive for Enterococcus spp. The HC was replaced with a new CVC to continue HD. After a six-week antibiotic treatment, most clinical symptoms were resolved, and there was a decrease in vegetation size with normalization of inflammatory markers and negative follow-up blood cultures. After this initial improvement in the patient\u2019s condition, the clinical course was complicated by the development of Citrobacter koseri bacteremia and sepsis. Despite adequate antibiotic therapy, the condition progressed to septic shock, which was soon followed by a fatal outcome. IE treatment in HD patients requires long-term broad-spectrum antibiotic therapy, and also, in patients without arteriovenous fistula (AVF), the CVC should be replaced after each HD during IE and sepsis treatment to minimize the patient\u2019s exposure to a foreign body that is susceptible to bacterial colonization. A colonized foreign body is a focus for sustained and spreading infection, and its presence prevents adequate antibiotic treatment until the focus of infection is removed.<\/jats:p>","DOI":"10.3390\/pathogens14060539","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T08:12:47Z","timestamp":1748419967000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tricuspid Valve Infective Endocarditis in a Chronic Haemodialysis Patient with a Hickman Catheter: A Case Report"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3844-128X","authenticated-orcid":false,"given":"Dalila","family":"\u0160a\u010di\u0107","sequence":"first","affiliation":[{"name":"Clinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3446-4900","authenticated-orcid":false,"given":"Saddam","family":"Shawamri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Jovanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-799X","authenticated-orcid":false,"given":"Marija","family":"Bori\u010di\u0107-Kosti\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8292-4548","authenticated-orcid":false,"given":"Boris","family":"Jegorovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Infectious and Tropical Diseases \u201cProf. dr Kosta Todorovic\u201d, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo\u0161","family":"Mijalkovi\u0107","sequence":"additional","affiliation":[{"name":"Polyclinic Kardio Medika, 18000 Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Fili\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3045-5263","authenticated-orcid":false,"given":"Stefan","family":"Juri\u010di\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3744-1819","authenticated-orcid":false,"given":"Vidna","family":"Karad\u017ei\u0107-Ristanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danka","family":"Bjeli\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-261X","authenticated-orcid":false,"given":"Selena","family":"Gaji\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-9793","authenticated-orcid":false,"given":"Marko","family":"Barali\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Nephrology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0140-6736(24)01098-5","article-title":"Infective endocarditis","volume":"404","author":"Li","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7861\/clinmed.cme.20.1.1","article-title":"Infective endocarditis: A contemporary update","volume":"20","author":"Rajani","year":"2020","journal-title":"Clin. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sangiorgio, G., Calvo, M., Migliorisi, G., Campanile, F., and Stefani, S. (2024). The Impact of Enterococcus spp. in the Immunocompromised Host: A Comprehensive Review. Pathogens, 13.","DOI":"10.3390\/pathogens13050409"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Codelia-Anjum, A., Lerner, L.B., Elterman, D., Zorn, K.C., Bhojani, N., and Chughtai, B. (2023). Enterococcal Urinary Tract Infections: A Review of the Pathogenicity, Epidemiology, and Treatment. Antibiotics, 12.","DOI":"10.3390\/antibiotics12040778"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Herrera-Hidalgo, L., Fern\u00e1ndez-Rubio, B., Luque-M\u00e1rquez, R., L\u00f3pez-Cort\u00e9s, L.E., Gil-Navarro, M.V., and de Alarc\u00f3n, A. (2023). Treatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge. Antibiotics, 12.","DOI":"10.20944\/preprints202303.0033.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ejim.2013.01.010","article-title":"Native valve right sided infective endocarditis","volume":"24","author":"Akinosoglou","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/HCO.0000000000000493","article-title":"Endocarditis in the setting of IDU: Multidisciplinary management","volume":"33","author":"Yanagawa","year":"2018","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Scheggi, V., Merilli, I., Marcucci, R., Del Pace, S., Olivotto, I., Zoppetti, N., Ceschia, N., Andrei, V., Alterini, B., and Stef\u00e0no, P.L. (2021). Predictors of mortality and adverse events in patients with infective endocarditis: A retrospective real world study in a surgical centre. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-01853-6"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mpdhp.2022.01.003","article-title":"Infective endocarditis","volume":"28","author":"Sheppard","year":"2022","journal-title":"Diagn. Histopathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.jacc.2015.03.518","article-title":"Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011","volume":"65","author":"Pant","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","first-page":"981","article-title":"Infectious endocarditis: Diagnosis and treatment","volume":"85","author":"Pierce","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13049-019-0596-4","article-title":"Sepsis: Mechanisms of bacterial injury to the patient","volume":"27","author":"Minasyan","year":"2019","journal-title":"Scand. J. Trauma. Resusc. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCULATIONAHA.106.183095","article-title":"Prevention of infective endocarditis: Guidelines from the American Heart Association: A guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group","volume":"116","author":"Wilson","year":"2007","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0924-8579(98)00038-7","article-title":"Hickman catheter-related infections in patients with cancer","volume":"10","author":"Yip","year":"1998","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_15","first-page":"257","article-title":"An immunocompromised dialysis patient with skin and bone lesions","volume":"3","author":"Ball","year":"2010","journal-title":"NDT Plus"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Nappi, F. (2024). Native Infective Endocarditis: A State-of-the-Art-Review. Microorganisms, 12.","DOI":"10.20944\/preprints202406.0527.v1"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.tcm.2024.01.001","article-title":"Update on the epidemiology, diagnosis, and management of infective endocarditis: A review","volume":"34","author":"Miao","year":"2024","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2217\/fmb.15.46","article-title":"Enterococcal endocarditis revisited","volume":"10","author":"Zboromyrska","year":"2015","journal-title":"Future Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jama.297.12.1354","article-title":"Contemporary clinical profile and outcome of prosthetic valve endocarditis","volume":"297","author":"Wang","year":"2007","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)","volume":"36","author":"Habib","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jmii.2014.08.019","article-title":"Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous drugs: Analysis of risk factors and treatment outcomes","volume":"49","author":"Lin","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tomoaia, R., Oprea, A., Sandu, I., Danu, V., Pop, D., Zdrenghea, D., D\u0103d\u00e2rlat-Pop, A., Minciun\u0103, I.A., Che\u021ban, I.M., and Hada, N.C. (2022). A Rare Case of Successfully Treated Double Valve Infective Endocarditis Caused by Pseudomonas aeruginosa. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911127"},{"key":"ref_24","first-page":"115","article-title":"Severe tricuspid valve endocarditis related to tunneled catheters in chronic hemodialysis patients: When should the catheter be removed?","volume":"6","author":"Bentata","year":"2013","journal-title":"Arab J. Nephrol. Transplant."},{"key":"ref_25","first-page":"1","article-title":"Risk Factors for In-Hospital Mortality in Infective Endocarditis","volume":"114","author":"Marques","year":"2020","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10654-005-4724-2","article-title":"Characteristics and analysis of risk factors for mortality in infective endocarditis","volume":"21","author":"Leblebicioglu","year":"2006","journal-title":"Eur. J. Epidemiol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/6\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:42:13Z","timestamp":1760031733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/6\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["pathogens14060539"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14060539","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}