{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:07:00Z","timestamp":1792620420402,"version":"4.5.0"},"reference-count":233,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Medical Research Council","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Medical Research Council","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Medical Research Council","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Medical Research Council","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Medical Research Council","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Medical Research Council","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Medical Research Council","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Medical Research Council","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Medical Research Council","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Kidney Research UK","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Kidney Research UK","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Kidney Research UK","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Kidney Research UK","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Kidney Research UK","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Kidney Research UK","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Kidney Research UK","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Kidney Research UK","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Kidney Research UK","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Kidney Research UK","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Wellcome Trust","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Wellcome Trust","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Wellcome Trust","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Wellcome Trust","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Wellcome Trust","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Wellcome Trust","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Wellcome Trust","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Wellcome Trust","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Wellcome Trust","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Wellcome Trust","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Health Care Research Wales (HCRW) PhD studentship","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Kidney Research UK PhD Studentship","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Kidney Research UK PhD Studentship","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Kidney Research UK PhD Studentship","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Kidney Research UK PhD Studentship","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Kidney Research UK PhD Studentship","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Kidney Research UK PhD Studentship","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Kidney Research UK PhD Studentship","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Kidney Research UK PhD Studentship","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Kidney Research UK PhD Studentship","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Kidney Research UK PhD Studentship","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"GW4 Biomed MRC DTP PhD studentship","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Kidney Research UK Stoneygate Fellowship","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Wales Cancer Research Centre","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Wales Cancer Research Centre","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Wales Cancer Research Centre","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Wales Cancer Research Centre","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Wales Cancer Research Centre","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Wales Cancer Research Centre","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Wales Cancer Research Centre","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Wales Cancer Research Centre","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Wales Cancer Research Centre","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Wales Cancer Research Centre","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Systems Immunity Research Institute (Cardiff University)","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["MR\/L018373\/1"],"award-info":[{"award-number":["MR\/L018373\/1"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["MR\/L008734\/1"],"award-info":[{"award-number":["MR\/L008734\/1"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["MR\/P001602\/1"],"award-info":[{"award-number":["MR\/P001602\/1"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["MR\/V000489\/1"],"award-info":[{"award-number":["MR\/V000489\/1"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["MR\/S00971X\/1"],"award-info":[{"award-number":["MR\/S00971X\/1"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["RP_008_20210729"],"award-info":[{"award-number":["RP_008_20210729"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["204870\/Z\/16\/Z"],"award-info":[{"award-number":["204870\/Z\/16\/Z"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["226615\/Z\/22\/Z"],"award-info":[{"award-number":["226615\/Z\/22\/Z"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["HS-22-32"],"award-info":[{"award-number":["HS-22-32"]}]},{"name":"Academy of Medical Sciences Springboard Award and Cancer Research Wales","award":["TF_006 20191202"],"award-info":[{"award-number":["TF_006 20191202"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Human cytomegalovirus (HCMV) is a ubiquitous member of the herpesvirus family, of significant clinical importance, and highly adapted to its host, resulting from millions of years of co-evolution. As a result, the virus systematically subverts almost all aspects of antiviral immune defence to successfully establish a lifelong persistent infection, and in the process, dramatically reshapes the phenotype and function of host immunity to both HCMV and other diseases. Natural killer (NK) cells are a critical component of successful herpesvirus control. Here, we discuss their role in modulating HCMV disease and the multitude of ways that HCMV has evolved to prevent and manipulate this process. We also consider how antibody-dependent cellular cytotoxicity by NK cells directed against HCMV might overcome NK immune evasion mechanisms and be useful therapeutically.<\/jats:p>","DOI":"10.3390\/pathogens14070629","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:05:40Z","timestamp":1750766740000},"page":"629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons?"],"prefix":"10.3390","volume":"14","author":[{"given":"Hannah","family":"Preston","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-4331","authenticated-orcid":false,"given":"Rowan","family":"Casey","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ferris","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4676-9958","authenticated-orcid":false,"given":"Lauren","family":"Kerr-Jones","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-9623","authenticated-orcid":false,"given":"Farah","family":"Latif","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Clement","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9991-5686","authenticated-orcid":false,"given":"Rebecca J.","family":"Aicheler","sequence":"additional","affiliation":[{"name":"School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2243-4964","authenticated-orcid":false,"given":"Eddie C. Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-1182","authenticated-orcid":false,"given":"Richard J.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5817-3153","authenticated-orcid":false,"given":"Ceri A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK"},{"name":"Systems Immunity University Research Institute (SIURI), Cardiff University, Cardiff CF14 4XN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0264-410X(00)00377-7","article-title":"Encouraging prospects for immunisation against primary cytomegalovirus infection","volume":"19","author":"Griffiths","year":"2001","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/jpids\/piw015","article-title":"Increased Cytomegalovirus Secretion and Risks of Infant Infection by Breastfeeding Duration From Maternal Human Immunodeficiency Virus Positive Compared to Negative Mothers in Sub-Saharan Africa","volume":"5","author":"Musonda","year":"2016","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2034","DOI":"10.1002\/rmv.2034","article-title":"Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis","volume":"29","author":"Zuhair","year":"2019","journal-title":"Rev. Med. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Stowell, J.D., Mask, K., Amin, M., Clark, R., Levis, D., Hendley, W., Lanzieri, T.M., Dollard, S.C., and Cannon, M.J. (2014). Cross-sectional study of cytomegalovirus shedding and immunological markers among seropositive children and their mothers. BMC Infect. Dis., 14.","DOI":"10.1186\/s12879-014-0568-2"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcv.2008.07.012","article-title":"Cytomegalovirus seroprevalence and childhood sources of infection: A population-based study among pre-adolescents in the United States","volume":"43","author":"Staras","year":"2008","journal-title":"J. Clin. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/OLQ.0b013e3181644b70","article-title":"Influence of sexual activity on cytomegalovirus seroprevalence in the United States, 1988\u20131994","volume":"35","author":"Staras","year":"2008","journal-title":"Sex. Transm. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cmi.2014.75","article-title":"The immunology of human cytomegalovirus latency: Could latent infection be cleared by novel immunotherapeutic strategies?","volume":"12","author":"Wills","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/infdis\/150.6.953","article-title":"Identification of multiple cytomegalovirus strains in homosexual men with acquired immunodeficiency syndrome","volume":"150","author":"Spector","year":"1984","journal-title":"J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/infdis\/155.4.655","article-title":"Isolation of multiple strains of cytomegalovirus from women attending a clinic for sexually transmitted disease","volume":"155","author":"Chandler","year":"1987","journal-title":"J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jmv.1890280305","article-title":"Characterization of cytomegalovirus isolates recovered during repeated infection in renal transplant recipients","volume":"28","author":"Kanesaki","year":"1989","journal-title":"J. Med. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1185350","article-title":"Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus","volume":"328","author":"Hansen","year":"2010","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1073\/pnas.1818130116","article-title":"Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination","volume":"116","author":"Cudini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41579-021-00582-z","article-title":"Pathogenesis of human cytomegalovirus in the immunocompromised host","volume":"19","author":"Griffiths","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e2120736","DOI":"10.1001\/jamanetworkopen.2021.20736","article-title":"Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening: A Systematic Review and Meta-analysis","volume":"4","author":"Ssentongo","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.vaccine.2013.09.042","article-title":"Priorities for CMV vaccine development","volume":"32","author":"Krause","year":"2013","journal-title":"Vaccine"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pinninti, S.G., Britt, W.J., and Boppana, S.B. (2024). Auditory and Vestibular Involvement in Congenital Cytomegalovirus Infection. Pathogens, 13.","DOI":"10.3390\/pathogens13111019"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJM196411122712001","article-title":"Infectious Pulmonary Disease in Patients Receiving Immunosuppressive Therapy for Organ Transplantation","volume":"271","author":"Hill","year":"1964","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","article-title":"Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation","volume":"377","author":"Marty","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Herbein, G. (2018). The Human Cytomegalovirus, from Oncomodulation to Oncogenesis. Viruses, 10.","DOI":"10.3390\/v10080408"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Herbein, G. (2022). Tumors and Cytomegalovirus: An Intimate Interplay. Viruses, 14.","DOI":"10.3390\/v14040812"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.18632\/oncotarget.383","article-title":"Is human cytomegalovirus a target in cancer therapy?","volume":"2","author":"Johnsen","year":"2011","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.virusres.2006.01.002","article-title":"Topics in herpesvirus genomics and evolution","volume":"117","author":"McGeoch","year":"2006","journal-title":"Virus Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"veab025","DOI":"10.1093\/ve\/veab025","article-title":"Intrahost speciations and host switches played an important role in the evolution of herpesviruses","volume":"7","author":"Brito","year":"2021","journal-title":"Virus Evol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1099\/vir.0.79888-0","article-title":"Genetic content of wild-type human cytomegalovirus","volume":"85","author":"Dolan","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1073\/pnas.2334032100","article-title":"Functional profiling of a human cytomegalovirus genome","volume":"100","author":"Dunn","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1084\/jem.20050882","article-title":"Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects","volume":"202","author":"Sylwester","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcv.2007.10.027","article-title":"Modulation of natural killer cells by human cytomegalovirus","volume":"41","author":"Wilkinson","year":"2008","journal-title":"J. Clin. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev-immunol-082619-124440","article-title":"Mechanisms of Natural Killer Cell Evasion Through Viral Adaptation","volume":"38","author":"Mancini","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Dell\u2019Oste, V., Biolatti, M., Galitska, G., Griffante, G., Gugliesi, F., Pasquero, S., Zingoni, A., Cerboni, C., and De Andrea, M. (2020). Tuning the Orchestra: HCMV vs. Innate Immunity. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00661"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41577-019-0225-5","article-title":"Modulation of innate and adaptive immunity by cytomegaloviruses","volume":"20","author":"Berry","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cytogfr.2014.11.003","article-title":"NK cells and interferons","volume":"26","author":"Paolini","year":"2015","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1182\/blood-2002-09-2876","article-title":"CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: A potential new link between adaptive and innate immunity","volume":"101","author":"Fehniger","year":"2003","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.170.3.827","article-title":"Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes","volume":"170","author":"Kobayashi","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.180.4.1395","article-title":"Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor","volume":"180","author":"Carson","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Wu, Y., Tian, Z., and Wei, H. (2017). Developmental and Functional Control of Natural Killer Cells by Cytokines. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00930"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/35040504","article-title":"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function","volume":"408","author":"Dillon","year":"2000","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/eji.201444699","article-title":"IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness","volume":"45","author":"Ziblat","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pende, D., Falco, M., Vitale, M., Cantoni, C., Vitale, C., Munari, E., Bertaina, A., Moretta, F., Del Zotto, G., and Pietra, G. (2019). Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01179"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.178.2.597","article-title":"P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities","volume":"178","author":"Moretta","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.20090681","article-title":"The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans","volume":"206","author":"Brandt","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/s41590-019-0448-4","article-title":"A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44","volume":"20","author":"Niehrs","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1470730","DOI":"10.1080\/2162402X.2018.1470730","article-title":"Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor","volume":"7","author":"Gaggero","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1248\/bpb.b18-00312","article-title":"Globo-A Binds to the Recombinant Natural Cytotoxicity Receptor NKp44","volume":"41","author":"Ito","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Shemesh, A., Kundu, K., Peleg, R., Yossef, R., Kaplanov, I., Ghosh, S., Khrapunsky, Y., Gershoni-Yahalom, O., Rabinski, T., and Cerwenka, A. (2018). NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01114"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1182\/blood-2013-03-489054","article-title":"Identification of a cellular ligand for the natural cytotoxicity receptor NKp44","volume":"122","author":"Baychelier","year":"2013","journal-title":"Blood"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.4049\/jimmunol.1102267","article-title":"Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44","volume":"187","author":"Rosental","year":"2011","journal-title":"J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"208ra145","DOI":"10.1126\/scitranslmed.3006702","article-title":"Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry","volume":"5","author":"Horowitz","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/JLB.4MR0620-091R","article-title":"Unraveling exhaustion in adaptive and conventional NK cells","volume":"108","author":"Merino","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00020","DOI":"10.1097\/IN9.0000000000000020","article-title":"Metabolic regulation of NK cell function: Implications for immunotherapy","volume":"5","author":"Sohn","year":"2023","journal-title":"Immunometabolism"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s41467-023-37181-w","article-title":"Control of human cytomegalovirus replication by liver resident natural killer cells","volume":"14","author":"Forrest","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Amand, M., Iserentant, G., Poli, A., Sleiman, M., Fievez, V., Sanchez, I.P., Sauvageot, N., Michel, T., Aouali, N., and Janji, B. (2017). Human CD56(dim)CD16(dim) Cells As an Individualized Natural Killer Cell Subset. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00699"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/JLB.MR0718-269R","article-title":"Mechanisms of natural killer cell-mediated cellular cytotoxicity","volume":"105","author":"Prager","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1376595","DOI":"10.1155\/2016\/1376595","article-title":"The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk","volume":"2016","author":"Gabrielli","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wang, W., Erbe, A.K., Hank, J.A., Morris, Z.S., and Sondel, P.M. (2015). NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00368"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sanseviero, E. (2019). NK Cell-Fc Receptors Advance Tumor Immunotherapy. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101667"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood-2005-04-1351","article-title":"Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion","volume":"107","author":"Bryceson","year":"2006","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2567.2009.03123.x","article-title":"Natural killer cell cytotoxicity: How do they pull the trigger?","volume":"128","author":"Topham","year":"2009","journal-title":"Immunology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/eji.202149188","article-title":"Identification of the predominant human NK cell effector subset mediating ADCC against HIV-infected targets coated with BNAbs or plasma from PLWH","volume":"51","author":"Tomescu","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e005577","DOI":"10.1136\/jitc-2022-005577","article-title":"Adaptive single-KIR(+)NKG2C(+) NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia","volume":"10","author":"Vincenti","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cei\/uxac082","article-title":"Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals","volume":"210","author":"Kristensen","year":"2022","journal-title":"Clin. Exp. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1086\/504719","article-title":"Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94\/NKG2C receptor in aviremic HIV-1-positive patients","volume":"194","author":"Guma","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Jiang, P., Jing, S., Sheng, G., and Jia, F. (2024). The basic biology of NK cells and its application in tumor immunotherapy. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1420205"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ma, S.B., Yu, J.H., and Caligiuri, M.A. (2025). Natural killer cell-based immunotherapy for cancer. J. Immunol., vkaf036.","DOI":"10.1093\/jimmun\/vkaf036"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/infdis\/jix608","article-title":"NKG2C Deletion Is a Risk Factor for Human Cytomegalovirus Viremia and Disease After Lung Transplantation","volume":"217","author":"Vietzen","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1182\/blood-2011-10-386995","article-title":"Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function","volume":"119","author":"Foley","year":"2012","journal-title":"Blood"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Giordano, C., Carlomagno, S., Falco, M., Cantoni, C., Vitale, M., Caruana, I., Dirks, J., Serio, A., Muccio, L., and Bartalucci, G. (2025). CD94-driven in vitro expansion of highly functional adaptive NKG2C(+) NKG2A(-) CD57(+) NK cells from CMV(+) healthy donors. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1481745"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood-2004-05-2058","article-title":"Imprint of human cytomegalovirus infection on the NK cell receptor repertoire","volume":"104","author":"Guma","year":"2004","journal-title":"Blood"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41409-022-01603-y","article-title":"Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays","volume":"57","author":"Venturini","year":"2022","journal-title":"Bone Marrow Transpl."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Medjouel Khlifi, H., Guia, S., Vivier, E., and Narni-Mancinelli, E. (2022). Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.898745"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Luetke-Eversloh, M., Hammer, Q., Durek, P., Nordstr\u00f6m, K., Gasparoni, G., Pink, M., Hamann, A., Walter, J., Chang, H.-D., and Dong, J. (2014). Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells. PLOS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004441"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2015.02.008","article-title":"Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function","volume":"42","author":"Schlums","year":"2015","journal-title":"Immunity"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.4049\/jimmunol.1203034","article-title":"Cutting edge: Antibody-dependent memory-like NK cells distinguished by FcR\u03b3 deficiency","volume":"190","author":"Zhang","year":"2013","journal-title":"J. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/intimm\/dxs080","article-title":"Identification of human NK cells that are deficient for signaling adaptor FcR\u03b3 and specialized for antibody-dependent immune functions","volume":"24","author":"Hwang","year":"2012","journal-title":"Int. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1182\/blood-2005-09-3682","article-title":"Expansion of CD94\/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts","volume":"107","author":"Guma","year":"2006","journal-title":"Blood"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41590-018-0082-6","article-title":"Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells","volume":"19","author":"Hammer","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Mace, E.M., and Orange, J.S. (2016). Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00545"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI61014","article-title":"Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency","volume":"122","author":"Gineau","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.4049\/jimmunol.1201964","article-title":"Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen","volume":"189","author":"Foley","year":"2012","journal-title":"J. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"357ra123","DOI":"10.1126\/scitranslmed.aaf2341","article-title":"Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia","volume":"8","author":"Romee","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bbmt.2018.03.019","article-title":"A Phase 1 Trial of CNDO-109-Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia","volume":"24","author":"Fehniger","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kottaridis, P.D., North, J., Tsirogianni, M., Marden, C., Samuel, E.R., Jide-Banwo, S., Grace, S., and Lowdell, M.W. (2015). Two-Stage Priming of Allogeneic Natural Killer Cells for the Treatment of Patients with Acute Myeloid Leukemia: A Phase I Trial. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123416"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1182\/blood-2008-05-157354","article-title":"Human NK cells can control CMV infection in the absence of T cells","volume":"112","author":"Kuijpers","year":"2008","journal-title":"Blood"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4049\/jimmunol.1601236","article-title":"Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients","volume":"198","author":"Crespo","year":"2017","journal-title":"J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/ajt.15658","article-title":"Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients","volume":"20","author":"Ataya","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/TP.0000000000002545","article-title":"Enrichment of Cytomegalovirus-induced NKG2C+ Natural Killer Cells in the Lung Allograft","volume":"103","author":"Harpur","year":"2019","journal-title":"Transplantation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e149120","DOI":"10.1172\/jci.insight.149120","article-title":"Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation","volume":"7","author":"Yu","year":"2022","journal-title":"JCI Insight"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.bbmt.2015.05.025","article-title":"Adaptive Natural Killer Cell and Killer Cell Immunoglobulin\u2013Like Receptor\u2013Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation","volume":"21","author":"Davis","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3324\/haematol.2014.108407","article-title":"Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation","volume":"99","author":"Kheav","year":"2014","journal-title":"Haematologica"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1002\/eji.201242752","article-title":"Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children","volume":"42","author":"Noyola","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.humimm.2015.01.017","article-title":"Dynamics of the NK-cell subset redistribution induced by cytomegalovirus infection in preterm infants","volume":"76","author":"Noyola","year":"2015","journal-title":"Hum. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/infdis\/jiac307","article-title":"In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection","volume":"226","author":"Vaaben","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jama.289.8.1008","article-title":"Maternal immunity and prevention of congenital cytomegalovirus infection","volume":"289","author":"Fowler","year":"2003","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000477168","article-title":"Perinatal Outcomes of Non-Primary Maternal Cytomegalovirus Infection: A 15-Year Experience","volume":"43","author":"Simonazzi","year":"2018","journal-title":"Fetal Diagn. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Pighi, C., Rotili, A., De Luca, M., Chiurchi\u00f9, S., Cal\u00f2 Carducci, F.I., Rossetti, C., Cifaldi, L., Bei, R., Caforio, L., and Bernardi, S. (2024). Characterization of Natural Killer Cell Profile in a Cohort of Infected Pregnant Women and Their Babies and Its Relation to CMV Transmission. Viruses, 16.","DOI":"10.3390\/v16050780"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1074-7613(00)80529-4","article-title":"A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules","volume":"7","author":"Cosman","year":"1997","journal-title":"Immunity"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.4049\/jimmunol.178.7.4473","article-title":"The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1- NK cells","volume":"178","author":"Griffin","year":"2007","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/331269a0","article-title":"Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens","volume":"331","author":"Beck","year":"1988","journal-title":"Nature"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/347770a0","article-title":"A complex between the MHC class I homologue encoded by human cytomegalovirus and beta 2 microglobulin","volume":"347","author":"Browne","year":"1990","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1099\/vir.0.81126-0","article-title":"Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18","volume":"86","author":"Griffin","year":"2005","journal-title":"J. Gen. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2004.01.027","article-title":"Human cytomegalovirus UL18 alleviated human NK-mediated swine endothelial cell lysis","volume":"315","author":"Kim","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ni961","article-title":"Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor","volume":"4","author":"Willcox","year":"2003","journal-title":"Nat. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"10095","DOI":"10.1073\/pnas.0804551105","article-title":"Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor","volume":"105","author":"Yang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/JVI.79.4.2251-2260.2005","article-title":"Genetic variability of the major histocompatibility complex class I homologue encoded by human cytomegalovirus leads to differential binding to the inhibitory receptor ILT2","volume":"79","author":"Shiroishi","year":"2005","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1093\/hmg\/ddi247","article-title":"Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis","volume":"14","author":"Kuroki","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/eji.200425220","article-title":"Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1\/ILT2\/CD85j","volume":"36","author":"Cerboni","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1172\/JCI96174","article-title":"LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions","volume":"128","author":"Yu","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.187.10.1681","article-title":"Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I major histocompatibility complex and a viral class I homolog","volume":"187","author":"Leong","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.287.5455.1031","article-title":"Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40","volume":"287","author":"Tomasec","year":"2000","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.4049\/jimmunol.164.10.5019","article-title":"Cutting edge: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis","volume":"164","author":"Ulbrecht","year":"2000","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1073\/pnas.112680099","article-title":"UL40-mediated NK evasion during productive infection with human cytomegalovirus","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1182\/blood-2012-10-459545","article-title":"NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs","volume":"121","author":"Beziat","year":"2013","journal-title":"Blood"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/tan.14734","article-title":"Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3\u2032-untranslated regions","volume":"100","author":"Asenjo","year":"2022","journal-title":"HLA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1074\/jbc.M208268200","article-title":"HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities","volume":"278","author":"Strong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8679","DOI":"10.1074\/jbc.M112.409672","article-title":"Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells","volume":"288","author":"Heatley","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.4049\/jimmunol.1103434","article-title":"Host genetic factors in susceptibility to herpes simplex type 1 virus infection: Contribution of polymorphic genes at the interface of innate and adaptive immunity","volume":"188","author":"Moraru","year":"2012","journal-title":"J. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.4049\/jimmunol.1502438","article-title":"Relationship of NKG2C Copy Number with the Distribution of Distinct Cytomegalovirus-Induced Adaptive NK Cell Subsets","volume":"196","author":"Muntasell","year":"2016","journal-title":"J. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.gene.6363940","article-title":"Variations of human killer cell lectin-like receptors: Common occurrence of NKG2-C deletion in the general population","volume":"4","author":"Hikami","year":"2003","journal-title":"Genes. Immun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/intimm\/dxh013","article-title":"Molecular genetic analyses of human NKG2C (KLRC2) gene deletion","volume":"16","author":"Miyashita","year":"2004","journal-title":"Int. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1399-0039.2012.01911.x","article-title":"Assessment of copy-number variation in the NKG2C receptor gene in a single-tube and characterization of a reference cell panel, using standard polymerase chain reaction","volume":"80","author":"Moraru","year":"2012","journal-title":"Tissue Antigens"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/eji.201243117","article-title":"Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: A different perspective of the host-pathogen interaction","volume":"43","author":"Muntasell","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e1359","DOI":"10.1002\/cti2.1359","article-title":"Impact of adaptive natural killer cells, KLRC2 genotype and cytomegalovirus reactivation on late mortality in patients with severe COVID-19 lung disease","volume":"11","author":"Jaiswal","year":"2022","journal-title":"Clin. Transl. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imr.12600","article-title":"Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells","volume":"280","author":"Raulet","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Fielding, C.A., Aicheler, R., Stanton, R.J., Wang, E.C., Han, S., Seirafian, S., Davies, J., McSharry, B.P., Weekes, M.P., and Antrobus, P.R. (2014). Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004058"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.4049\/jimmunol.1502527","article-title":"Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR\/CD155 Expression","volume":"197","author":"Pignoloni","year":"2016","journal-title":"J. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1074-7613(01)00095-4","article-title":"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor","volume":"14","author":"Cosman","year":"2001","journal-title":"Immunity"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/1521-4141(200105)31:5<1428::AID-IMMU1428>3.0.CO;2-4","article-title":"ULBP1, 2, 3: Novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells","volume":"31","author":"Kubin","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4049\/jimmunol.171.2.902","article-title":"Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: Up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein","volume":"171","author":"Rolle","year":"2003","journal-title":"J. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/immu.200390022","article-title":"Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein","volume":"33","author":"Welte","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.1140956","article-title":"Host immune system gene targeting by a viral miRNA","volume":"317","author":"Elefant","year":"2007","journal-title":"Science"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s002510050655","article-title":"Population study of allelic diversity in the human MHC class I-related MIC-A gene","volume":"49","author":"Petersdorf","year":"1999","journal-title":"Immunogenetics"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0198-8859(01)00241-5","article-title":"Typing for all known MICA alleles by group-specific PCR and SSOP","volume":"62","author":"Zhang","year":"2001","journal-title":"Hum. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s00251-001-0426-4","article-title":"MICA polymorphism in South American Indians","volume":"53","author":"Zhang","year":"2002","journal-title":"Immunogenetics"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BJ20130194","article-title":"A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008","volume":"454","author":"Ashiru","year":"2013","journal-title":"Biochem. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.4049\/jimmunol.175.11.7457","article-title":"Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis","volume":"175","author":"Wills","year":"2005","journal-title":"J. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"12345","DOI":"10.1128\/JVI.01175-09","article-title":"NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142","volume":"83","author":"Ashiru","year":"2009","journal-title":"J. Virol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.4049\/jimmunol.1000789","article-title":"Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus","volume":"185","author":"Bennett","year":"2010","journal-title":"J. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2006.05.092","article-title":"Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142","volume":"346","author":"Chalupny","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e22206","DOI":"10.7554\/eLife.22206","article-title":"Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation","volume":"6","author":"Fielding","year":"2017","journal-title":"Elife"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e00162-18","DOI":"10.1128\/JVI.00162-18","article-title":"The Human Cytomegalovirus Protein UL148A Downregulates the NK Cell-Activating Ligand MICA To Avoid NK Cell Attack","volume":"92","author":"Dassa","year":"2018","journal-title":"J. Virol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.celrep.2015.01.029","article-title":"Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA *008 to Escape Elimination by NK Cells","volume":"10","author":"Seidel","year":"2015","journal-title":"Cell Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/s41467-021-21983-x","article-title":"A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain","volume":"12","author":"Seidel","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Kol, I., Rishiq, A., Cohen, M., Kahlon, S., Pick, O., Dassa, L., Stein, N., Bar-On, Y., Wolf, D.G., and Seidel, E. (2023). CLPTM1L is a GPI-anchoring pathway component targeted by HCMV. J. Cell Biol., 222.","DOI":"10.1083\/jcb.202207104"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Seidel, E., Dassa, L., Schuler, C., Oiknine-Djian, E., Wolf, D.G., Le-Trilling, V.T.K., and Mandelboim, O. (2021). The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing. PLoS Pathog., 17.","DOI":"10.1101\/2020.07.17.208462"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Sanchez-Correa, B., Valhondo, I., Hassouneh, F., Lopez-Sejas, N., Pera, A., Bergua, J.M., Arcos, M.J., Banas, H., Casas-Aviles, I., and Duran, E. (2019). DNAM-1 and the TIGIT\/PVRIG\/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy. Cancers, 11.","DOI":"10.3390\/cancers11060877"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(00)70060-4","article-title":"DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes","volume":"4","author":"Shibuya","year":"1996","journal-title":"Immunity"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ni1156","article-title":"Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141","volume":"6","author":"Tomasec","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1099\/vir.0.021931-0","article-title":"Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112","volume":"91","author":"Sugrue","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Hsu, J.L., van den Boomen, D.J., Tomasec, P., Weekes, M.P., Antrobus, R., Stanton, R.J., Ruckova, E., Sugrue, D., Wilkie, G.S., and Davison, A.J. (2015). Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004811"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Barrow, A.D., Martin, C.J., and Colonna, M. (2019). The Natural Cytotoxicity Receptors in Health and Disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00909"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2007.10.010","article-title":"Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells","volume":"27","author":"Simhadri","year":"2007","journal-title":"Immunity"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"33311","DOI":"10.1074\/jbc.M114.603464","article-title":"Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ni1190","article-title":"Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus","volume":"6","author":"Arnon","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Penner, I., Buscher, N., Dejung, M., Freiwald, A., Butter, F., and Plachter, B. (2022). Subviral Dense Bodies of Human Cytomegalovirus Induce an Antiviral Type I Interferon Response. Cells, 11.","DOI":"10.3390\/cells11244028"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Charpak-Amikam, Y., Kubsch, T., Seidel, E., Oiknine-Djian, E., Cavaletto, N., Yamin, R., Schmiedel, D., Wolf, D., Gribaudo, G., and Messerle, M. (2017). Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-08866-2"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e54133","DOI":"10.15252\/embr.202154133","article-title":"Engagement of TRAIL triggers degranulation and IFNgamma production in human natural killer cells","volume":"23","author":"Hofle","year":"2022","journal-title":"EMBO Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2013.02.003","article-title":"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses","volume":"13","author":"Smith","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.141108798","article-title":"A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation","volume":"98","author":"Skaletskaya","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e2309077120","DOI":"10.1073\/pnas.2309077120","article-title":"HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation","volume":"120","author":"Vlachava","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Nemcovicova, I., Benedict, C.A., and Zajonc, D.M. (2013). Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003224"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1099\/vir.0.058313-0","article-title":"Human cytomegalovirus suppresses Fas expression and function","volume":"95","author":"Seirafian","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"7988","DOI":"10.1073\/pnas.0401897101","article-title":"Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria","volume":"101","author":"Arnoult","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1099\/vir.0.19452-0","article-title":"The human cytomegalovirus UL45 gene product is a late, virion-associated protein and influences virus growth at low multiplicities of infection","volume":"84","author":"Patrone","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.4049\/jimmunol.177.9.6199","article-title":"The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression","volume":"177","author":"Chiou","year":"2006","journal-title":"J. Immunol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.20050499","article-title":"Understanding how combinations of HLA and KIR genes influence disease","volume":"201","author":"Rajagopalan","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival","volume":"5","author":"Parham","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/infdis\/jiu226","article-title":"HLA and killer cell immunoglobulin-like receptors influence the natural course of CMV infection","volume":"210","author":"Scafidi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1600-6143.2011.03516.x","article-title":"Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation","volume":"11","author":"Stern","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1073\/pnas.96.10.5674","article-title":"Inhibitory receptors sensing HLA-G1 molecules in pregnancy: Decidua-associated natural killer cells express LIR-1 and CD94\/NKG2A and acquire p49, an HLA-G1-specific receptor","volume":"96","author":"Ponte","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng934","article-title":"Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS","volume":"31","author":"Martin","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.trim.2014.08.002","article-title":"Expression of killer cell immunoglobulin-like receptors (KIRs) by natural killer cells during acute CMV infection after kidney transplantation","volume":"31","author":"Hadaya","year":"2014","journal-title":"Transpl. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/gene.2014.53","article-title":"Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients","volume":"15","author":"Jones","year":"2014","journal-title":"Genes. Immun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"102171","DOI":"10.1016\/j.trim.2024.102171","article-title":"Immunoglobulin-like receptor genotype-associated protection from cytomegalovirus infection after liver transplantation","volume":"88","author":"Wang","year":"2025","journal-title":"Transpl. Immunol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e15320","DOI":"10.1111\/tan.15320","article-title":"Donor aKIR genes influence the risk of EBV and CMV reactivation after anti-thymocyte globulin-based haploidentical hematopoietic stem cell transplantation","volume":"103","author":"Gao","year":"2024","journal-title":"HLA"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1182\/blood-2005-03-1039","article-title":"Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation","volume":"107","author":"Cook","year":"2006","journal-title":"Blood"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Deborska-Materkowska, D., Perkowska-Ptasinska, A., Sadowska-Jakubowicz, A., Gozdowska, J., Ciszek, M., Pazik, J., Ostaszewska, A., Kosieradzki, M., Nowak, J., and Durlik, M. (2019). Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030546"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"van der Ploeg, K., Chang, C., Ivarsson, M.A., Moffett, A., Wills, M.R., and Trowsdale, J. (2017). Modulation of Human Leukocyte Antigen-C by Human Cytomegalovirus Stimulates KIR2DS1 Recognition by Natural Killer Cells. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00298"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Santoni, G., Amantini, C., Santoni, M., Maggi, F., Morelli, M.B., and Santoni, A. (2021). Mechanosensation and Mechanotransduction in Natural Killer Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.688918"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.chom.2014.07.005","article-title":"HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells","volume":"16","author":"Stanton","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1073\/pnas.1720950115","article-title":"Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e63877","DOI":"10.7554\/eLife.63877","article-title":"Human cytomegalovirus antagonizes activation of Fc\u03b3 receptors by distinct and synergizing modes of IgG manipulation","volume":"10","author":"Kolb","year":"2021","journal-title":"eLife"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Cortese, M., Calo, S., D\u2019Aurizio, R., Lilja, A., Pacchiani, N., and Merola, M. (2012). Recombinant human cytomegalovirus (HCMV) RL13 binds human immunoglobulin G Fc. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050166"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Corrales-Aguilar, E., Trilling, M., Hunold, K., Fiedler, M., Le, V.T., Reinhard, H., Ehrhardt, K., Merce-Maldonado, E., Aliyev, E., and Zimmermann, A. (2014). Human cytomegalovirus Fcgamma binding proteins gp34 and gp68 antagonize Fcgamma receptors I, II and III. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004131"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Bentley, K., Statkute, E., Murrell, I., Fielding, C., Antrobus, R., Preston, H., Kerr-Jones, L., Cochrane, D., Brizic, I., and Lehner, P.J. (bioRxiv, 2024). Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity, bioRxiv.","DOI":"10.1101\/2024.11.29.626001"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Davies, E.L., Noor, M., Lim, E.Y., Houldcroft, C.J., Okecha, G., Atkinson, C., Reeves, M.B., Jackson, S.E., and Wills, M.R. (2022). HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1083230"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"558","DOI":"10.12659\/AOT.898050","article-title":"Functional Properties of Human Cytomegalovirus Hyperimmunoglobulin and Standard Immunoglobulin Preparations","volume":"21","author":"Germer","year":"2016","journal-title":"Ann. Transplant."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/AAC.00382-16","article-title":"in vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539","volume":"60","author":"Patel","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"E4997","DOI":"10.1073\/pnas.1316517110","article-title":"Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine","volume":"110","author":"Freed","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/JVI.01809-09","article-title":"Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH\/gL\/UL128-131A complex","volume":"84","author":"Macagno","year":"2010","journal-title":"J. Virol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.vaccine.2014.05.004","article-title":"Human cytomegalovirus gH\/gL\/UL128\/UL130\/UL131A complex elicits potently neutralizing antibodies in mice","volume":"32","author":"Wen","year":"2014","journal-title":"Vaccine"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Wussow, F., Chiuppesi, F., Martinez, J., Campo, J., Johnson, E., Flechsig, C., Newell, M., Tran, E., Ortiz, J., and La Rosa, C. (2014). Human Cytomegalovirus Vaccine Based on the Envelope gH\/gL Pentamer Complex. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004524"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1128\/JVI.01669-12","article-title":"A vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques","volume":"87","author":"Wussow","year":"2013","journal-title":"J. Virol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"17965","DOI":"10.1073\/pnas.1415310111","article-title":"Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies","volume":"111","author":"Kabanova","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Barten, M.J., Baldanti, F., Staus, A., H\u00fcber, C.M., Glynou, K., and Zuckermann, A. (2022). Effectiveness of Prophylactic Human Cytomegalovirus Hyperimmunoglobulin in Preventing Cytomegalovirus Infection following Transplantation: A Systematic Review and Meta-Analysis. Life, 12.","DOI":"10.3390\/life12030361"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)60136-0","article-title":"Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: A phase 2 randomised placebo-controlled trial","volume":"377","author":"Griffiths","year":"2011","journal-title":"Lancet"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1016\/j.vaccine.2008.07.092","article-title":"Cytomegalovirus vaccines fail to induce epithelial entry neutralizing antibodies comparable to natural infection","volume":"26","author":"Cui","year":"2008","journal-title":"Vaccine"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e668","DOI":"10.1093\/infdis\/jiae114","article-title":"Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1 Randomized Clinical Trial","volume":"230","author":"Fierro","year":"2024","journal-title":"J. Infect. Dis."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1073\/pnas.1800177115","article-title":"HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions","volume":"115","author":"Nelson","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"e981","DOI":"10.1093\/cid\/ciab099","article-title":"In Utero Human Cytomegalovirus Infection Is Associated With Increased Levels of Putatively Protective Maternal Antibodies in Nonprimary Infection: Evidence for Boosting but Not Protection","volume":"73","author":"Dorfman","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1073\/pnas.1814835116","article-title":"HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission","volume":"116","author":"Vanarsdall","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJMoa1913569","article-title":"A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection","volume":"385","author":"Hughes","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1056\/NEJMoa1310214","article-title":"A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus","volume":"370","author":"Revello","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"10.1128","DOI":"10.1128\/AAC.02467-19","article-title":"Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation","volume":"64","author":"Maertens","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e01794-16","DOI":"10.1128\/AAC.01794-16","article-title":"Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients","volume":"61","author":"Ishida","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/00002030-200204120-00007","article-title":"HIV and cytomegalovirus viral load and clinical outcomes in AIDS and cytomegalovirus retinitis patients: Monoclonal Antibody Cytomegalovirus Retinitis Trial","volume":"16","author":"Jabs","year":"2002","journal-title":"AIDS"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/uog.19164","article-title":"Prevention of maternal-fetal transmission of cytomegalovirus after primary maternal infection in the first trimester by biweekly hyperimmunoglobulin administration","volume":"53","author":"Kagan","year":"2019","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1099\/vir.0.018994-0","article-title":"Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture","volume":"91","author":"Dargan","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000357102","article-title":"Prevention of Transfusion-Transmitted Cytomegalovirus Infections: Which is the Optimal Strategy?","volume":"41","author":"Ziemann","year":"2014","journal-title":"Transfus. Med. Hemother."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Jackson, J.W., and Sparer, T. (2018). There Is Always Another Way! Cytomegalovirus\u2019 Multifaceted Dissemination Schemes. Viruses, 10.","DOI":"10.20944\/preprints201807.0013.v1"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nrmicro1972","article-title":"Avoiding the void: Cell-to-cell spread of human viruses","volume":"6","author":"Sattentau","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1073\/pnas.1704809114","article-title":"The pentameric complex drives immunologically covert cell\u2013cell transmission of wild-type human cytomegalovirus","volume":"114","author":"Murrell","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/infdis\/jiad593","article-title":"Human Cytomegalovirus mRNA-1647 Vaccine Candidate Elicits Potent and Broad Neutralization and Higher Antibody-Dependent Cellular Cytotoxicity Responses Than the gB\/MF59 Vaccine","volume":"230","author":"Hu","year":"2024","journal-title":"J. Infect. Dis."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.cell.2014.04.028","article-title":"Quantitative temporal viromics: An approach to investigate host-pathogen interaction","volume":"157","author":"Weekes","year":"2014","journal-title":"Cell"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"e139296","DOI":"10.1172\/JCI139296","article-title":"Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus","volume":"131","author":"Vlahava","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1073\/pnas.0508123103","article-title":"Engineered antibody Fc variants with enhanced effector function","volume":"103","author":"Lazar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e167768","DOI":"10.1172\/jci.insight.167768","article-title":"ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission","volume":"8","author":"Semmes","year":"2023","journal-title":"JCI Insight"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cell.2019.05.044","article-title":"Fc Glycan-Mediated Regulation of Placental Antibody Transfer","volume":"178","author":"Jennewein","year":"2019","journal-title":"Cell"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cell.2019.05.046","article-title":"Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women","volume":"178","author":"Martinez","year":"2019","journal-title":"Cell"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"e181342","DOI":"10.1172\/JCI181342","article-title":"In utero human cytomegalovirus infection expands NK-like Fc\u03b3RIII+CD8+ T cells that mediate Fc antibody functions","volume":"135","author":"Semmes","year":"2025","journal-title":"J. Clin. Investig."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Sinclair, J., and Reeves, M. (2014). The intimate relationship between human cytomegalovirus and the dendritic cell lineage. Front. Microbiol., 5.","DOI":"10.3389\/fmicb.2014.00389"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00430-015-0401-6","article-title":"Sleepless latency of human cytomegalovirus","volume":"204","author":"Poole","year":"2015","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41590-020-0643-3","article-title":"Sestrins induce natural killer function in senescent-like CD8(+) T cells","volume":"21","author":"Pereira","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Houldcroft, C.J., Jackson, S.E., Lim, E.Y., Sedikides, G.X., Davies, E.L., Atkinson, C., McIntosh, M., Remmerswaal, E.B.M., Okecha, G., and Bemelman, F.J. (2020). Assessing Anti-HCMV Cell Mediated Immune Responses in Transplant Recipients and Healthy Controls Using a Novel Functional Assay. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00275"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"e2303155120","DOI":"10.1073\/pnas.2303155120","article-title":"ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways","volume":"120","author":"Rubina","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Venturini, C., and Breuer, J. (2025). Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis. Pathogens, 14.","DOI":"10.3390\/pathogens14010050"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1128\/JVI.00578-15","article-title":"High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination","volume":"89","author":"Sijmons","year":"2015","journal-title":"J. Virol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/infdis\/jiz208","article-title":"Human Cytomegalovirus Genomes Sequenced Directly From Clinical Material: Variation, Multiple-Strain Infection, Recombination, and Gene Loss","volume":"220","author":"Suarez","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e156827","DOI":"10.1172\/JCI156827","article-title":"Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection","volume":"132","author":"Semmes","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1073\/pnas.1800224115","article-title":"Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies","volume":"115","author":"Baraniak","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/infdis\/jiac308","article-title":"Human Cytomegalovirus Infection Primes Fetal Natural Killer Cells for Fc-Mediated Antiviral Defense","volume":"227","author":"Semmes","year":"2023","journal-title":"J. Infect. Dis."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/7\/629\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:58:02Z","timestamp":1760032682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/7\/629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":233,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["pathogens14070629"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14070629","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}