{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:40:18Z","timestamp":1785458418631,"version":"3.56.0"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Parvovirus B19 (B19V) re-emerged across Europe in 2024, raising concerns about vertical transmission and neonatal morbidity. We undertook a prospective, single-centre cohort study to characterise the early clinical course of congenitally infected neonates born between April and December 2024. Seventy-one pregnancies with serologically or PCR-confirmed maternal infection were enrolled; seven neonates met laboratory criteria for congenital B19V infection and were followed with serial clinical, biochemical and imaging assessments through the first year of life. Troponin I and CK-MB were measured on days 1, 3, 7 and 15; electrocardiogram (ECG) and echocardiography were repeated in parallel, and cranial ultrasound (US), ophthalmologic and audiologic screening were scheduled prospectively. Mean troponin rose from 50.7 ng L\u22121 on day 1 to a peak of 120.7 ng L\u22121 on day 7 (p &lt; 0.01), normalising by one month, while echocardiograms remained structurally normal, and only one transient arrhythmia was recorded. CK-MB exceeded the reference range in 29% of infants but showed no clinical sequelae. Multiple periventricular hyperechogenicities were identified in 8\/70 neonates (11%), and moderate anaemia (Hb \u2264 9.8 g\/dL) occurred in 2 cases. Serum PCR detected high-level viraemia (&gt;108 genome equivalents mL\u22121) in 40% of those tested; saliva and urine were consistently negative. No instances of myocarditis or hydrops were observed. Our findings indicate that congenital B19V infection during the current outbreak is marked by transient biochemical myocardial stress and subtle neurosonographic changes rather than overt cardiac disease, supporting an outpatient-focused follow-up strategy incorporating serial biomarkers and targeted neuroimaging.<\/jats:p>","DOI":"10.3390\/pathogens14080798","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:02:09Z","timestamp":1754910129000},"page":"798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Congenital Parvovirus B19 During the 2024 European Resurgence: A Prospective Single-Centre Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-4945","authenticated-orcid":false,"given":"Pasqua","family":"Betta","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospital Policlinico \u201cG. Rodolico San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-4387","authenticated-orcid":false,"given":"Roberta","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospital Policlinico \u201cG. Rodolico San Marco\u201d, University of Catania, 95123 Catania, Italy"},{"name":"Postgraduate Training Programme in Pediatrics, Department of Clinical and Esperimental Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Mattia","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospital Policlinico \u201cG. Rodolico San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Saporito","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospital Policlinico \u201cG. Rodolico San Marco\u201d, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Gentile","sequence":"additional","affiliation":[{"name":"U.O.C. Laboratory Analysis Unit, A.O.U. \u2018Policlinico-Vittorio Emanuele\u2019, University of Catania, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-8545","authenticated-orcid":false,"given":"Laura","family":"Trovato","sequence":"additional","affiliation":[{"name":"U.O.C. Laboratory Analysis Unit, A.O.U. \u2018Policlinico-Vittorio Emanuele\u2019, University of Catania, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta Ilenia","family":"Palermo","sequence":"additional","affiliation":[{"name":"U.O.C. Laboratory Analysis Unit, A.O.U. \u2018Policlinico-Vittorio Emanuele\u2019, University of Catania, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Scalia","sequence":"additional","affiliation":[{"name":"U.O.C. Laboratory Analysis Unit, A.O.U. \u2018Policlinico-Vittorio Emanuele\u2019, University of Catania, 95125 Catania, Italy"},{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virol.2003.09.011","article-title":"Construction and sequencing of an infectious clone of the human parvovirus B19","volume":"318","author":"Zhi","year":"2004","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2217\/fvl.14.103","article-title":"Human Parvovirus B19: A Mechanistic Overview of Infection and DNA Replication","volume":"10","author":"Luo","year":"2015","journal-title":"Future Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1128\/CMR.15.3.485-505.2002","article-title":"Human Parvovirus B19","volume":"15","author":"Heegaard","year":"2002","journal-title":"Clin. 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