{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:23:50Z","timestamp":1791491030351,"version":"4.3.4"},"reference-count":167,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["PI22\/01721"],"award-info":[{"award-number":["PI22\/01721"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["PID2021-127471OB-I00"],"award-info":[{"award-number":["PID2021-127471OB-I00"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union","award":["PI22\/01721"],"award-info":[{"award-number":["PI22\/01721"]}]},{"name":"European Union","award":["PID2021-127471OB-I00"],"award-info":[{"award-number":["PID2021-127471OB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Strongyloidosis is a parasitic disease caused by Strongyloides stercoralis, a nematode with a complex life cycle that facilitates long-term persistence within the host. The infection affects millions of people in tropical and subtropical regions and poses a particular challenge in immunocompromised individuals. Although conventional treatments, such as ivermectin and albendazole, are generally effective, emerging concerns regarding drug resistance and adverse effects have prompted the search for alternative therapeutic options. In this context, natural products\u2014including plant extracts, bioactive phytochemicals, and nanoparticle-based formulations derived from natural sources\u2014are emerging as promising anti-Strongyloides potential. This review summarizes recent studies on natural products with anthelmintic activity against strongyloidiasis, with emphasis on their mechanisms of action, efficacy, and future perspectives. A systematic search of the literature was conducted using terms related to Strongyloides, plant species, extracts, and bioactive compounds with nematocidal activity. Eligible studies included those reporting the activity of plants, plant extracts, and their purified metabolites against Strongyloides spp. Data were compiled into a comprehensive table including year of publication, author, plant species, active principle, application conditions, and target nematode species. The pharmacological treatment of this parasite varies according to its life cycle stage. Various biomolecules, phytoactive compounds, and novel plant-based formulations have demonstrated promising activity and may be considered both for treatment and for inclusion in control programs for strongyloidiasis. This review highlights medicinal plants and phytochemicals with ethnopharmacological background and experimentally validated activity against Strongyloides spp., integrating evidence from in vitro, in vivo, and experimental models, as well as clinical trials.<\/jats:p>","DOI":"10.3390\/pathogens14090842","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:10:36Z","timestamp":1756080636000},"page":"842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Emerging Approaches to Anthelmintic Therapy Using Medicinal Plants and Phytochemicals: A Review of Natural Products Against Strongyloidiasis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-0727","authenticated-orcid":false,"given":"Julio","family":"L\u00f3pez-Ab\u00e1n","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Centre for Tropical Diseases at the University of Salamanca), Faculty of Pharmacy, Universidad de Salamanca, Ldo, Mendez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Vicente-Santiago","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Centre for Tropical Diseases at the University of Salamanca), Faculty of Pharmacy, Universidad de Salamanca, Ldo, Mendez Nieto s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Guti\u00e9rrez-Soto","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Sciences, Biomolecular Innovation Group, Faculty of Agronomy, Campus of Agricultural Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Francisco I. Madero s\/n, Ex Hacienda el Canada, Cd. Gral. Escobedo 66050, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-5437","authenticated-orcid":false,"given":"Nancy Edith","family":"Rodr\u00edguez-Garza","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Centre for Tropical Diseases at the University of Salamanca), Faculty of Pharmacy, Universidad de Salamanca, Ldo, Mendez Nieto s\/n, 37007 Salamanca, Spain"},{"name":"Department of Chemistry, Faculty of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad s\/n, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-0222","authenticated-orcid":false,"given":"Miroslava","family":"Ka\u010d\u00e1niov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Horticulture, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, Slovakia"},{"name":"School of Medical & Health Sciences, VIZJA University, Okopowa 59, 01 043 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosvany","family":"L\u00f3pez-Sandin","sequence":"additional","affiliation":[{"name":"Engineering Department, Universidad Emiliano Zapata, Avenida Rodrigo G\u00f3mez, Sector Heroico s\/n, Monterrey 64260, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-8974","authenticated-orcid":false,"given":"Cesar Iv\u00e1n","family":"Romo-S\u00e1enz","sequence":"additional","affiliation":[{"name":"School of Medicie and Biomedical Sciences, Universidad Aut\u00f3noma de Chihuahua, Circuito Universitario, Campus II, Chihuahua 31109, CH, Mexico"},{"name":"Department of Microbiology and Immunology, Faculty of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad s\/n, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-6671","authenticated-orcid":false,"given":"Juan Manuel","family":"Ballesteros-Torres","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad s\/n, Cd. Universitaria, San Nicol\u00e1s de los Garza 66455, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-6314","authenticated-orcid":false,"given":"Lucio","family":"Galaviz-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Experimental Pathology, Faculty of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Universidad s\/n, Cd. 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