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These ocular manifestations may arise during the acute febrile phase or emerge weeks later. Studies from endemic regions report that up to one-quarter of hospitalized patients develop eye-related symptoms. Furthermore, studies confirm a higher risk of new uveitis cases following dengue infection. Breakdown of the blood\u2013ocular barrier\u2014driven by antibody-mediated enhancement, complement activation and release of inflammatory mediators\u2014leads to vascular leakage, tissue injury and ischemia. Diagnosis relies on clinical examination supplemented by imaging (OCT, angiography) and laboratory confirmation of dengue. Mild anterior inflammation often responds to topical steroids, while sight-threatening posterior disease requires systemic corticosteroids and, in refractory cases, immunomodulatory agents. Visual outcomes depend on the initial severity; anterior uveitis typically resolves without sequelae, whereas vasculitis or foveal involvement may leave lasting deficits. This review integrates the current understanding of dengue-related eye disease, emphasizing its varied presentations and the importance of early recognition. Further research into targeted, mechanism-based therapies is needed to optimize visual outcomes.<\/jats:p>","DOI":"10.3390\/pathogens14090872","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:02:57Z","timestamp":1756825377000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dengue-Related Ocular Complications: Spectrum, Diagnosis, and Management"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiaxin","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-8198","authenticated-orcid":false,"given":"Yaru","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-1101","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"},{"name":"Department of Ophthalmology, Zhongshan Torch Development Zone People\u2019s Hospital, Zhongshan 528436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Ohno-Matsui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koju","family":"Kamoi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"eaax4144","DOI":"10.1126\/scitranslmed.aax4144","article-title":"Mapping Global Variation in Dengue Transmission Intensity","volume":"12","author":"Cattarino","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"taaa222","DOI":"10.1093\/jtm\/taaa222","article-title":"Dengue, Chikungunya and Zika in GeoSentinel Surveillance of International Travellers: A Literature Review from 1995 to 2020","volume":"27","author":"Osman","year":"2020","journal-title":"J. Travel Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S1473-3099(16)00026-8","article-title":"The Global Burden of Dengue: An Analysis from the Global Burden of Disease Study 2013","volume":"16","author":"Stanaway","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(23)02576-X","article-title":"Dengue","volume":"403","author":"Adams","year":"2024","journal-title":"Lancet"},{"key":"ref_5","unstructured":"(2025, May 26). Dengue Viruses|Learn Science at Scitable. Available online: https:\/\/www.nature.com\/scitable\/topicpage\/dengue-viruses-22400925\/."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wikramaratna, P.S., Simmons, C.P., Gupta, S., and Recker, M. (2010). The Effects of Tertiary and Quaternary Infections on the Epidemiology of Dengue. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012347"},{"key":"ref_7","unstructured":"(2025, July 04). CDC Clinical Testing Guidance for Dengue, Available online: https:\/\/www.cdc.gov\/dengue\/hcp\/diagnosis-testing\/index.html."},{"key":"ref_8","unstructured":"World Health Organization (WHO) (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control, WHO."},{"key":"ref_9","unstructured":"European Commission (2025, August 27). Commission Implementing Decision (EU) 2018\/945 of 22 June 2018 on the Communicable Diseases and Related Special Health Issues to be Covered by Epidemiological Surveillance as Well as Relevant Case Definitions. Official Journal of the European Union, L 170, 1\u201374. Annex II, Section 3.10 Dengue.. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32018D0945."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3201\/eid1202.050274","article-title":"Ophthalmic Complications of Dengue","volume":"12","author":"Chan","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","first-page":"363","article-title":"Retinal Vasculitis with Macular Infarction: A Dengue-Related Ophthalmic Complication","volume":"13","author":"Agarwal","year":"2020","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_12","first-page":"71","article-title":"Visual Disturbances in Dengue Fever: An Answer at Last","volume":"48","author":"Chang","year":"2007","journal-title":"Singap. Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/eye.2008.124","article-title":"Uveitis Following Dengue Fever","volume":"23","author":"Gupta","year":"2009","journal-title":"Eye"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ophtha.2024.12.028","article-title":"Ocular Manifestations and OCT Findings in Dengue: A Single-Arm Meta-Analysis","volume":"132","author":"Arruda","year":"2025","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e70141","DOI":"10.1002\/jmv.70141","article-title":"Risk of Uveitis in Dengue Fever Patients: A Population-Based Cohort Study in Taiwan","volume":"96","author":"Wu","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/imm.12748","article-title":"Pathogenesis of Vascular Leak in Dengue Virus Infection","volume":"151","author":"Malavige","year":"2017","journal-title":"Immunology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S0140-6736(15)60417-2","article-title":"Microvascular and Endothelial Function for Risk Prediction in Dengue: An Observational Study","volume":"385","author":"Yacoub","year":"2015","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-3156.2011.02793.x","article-title":"Multicentre Prospective Study on Dengue Classification in Four South-East Asian and Three Latin American Countries","volume":"16","author":"Alexander","year":"2011","journal-title":"Trop. Med. Int. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.ophtha.2007.03.054","article-title":"Prevalence of Dengue Maculopathy in Patients Hospitalized for Dengue Fever","volume":"114","author":"Su","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/09273948.2022.2159840","article-title":"Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)\u2013Report 6: Dengue Uveitis at a Tertiary Eye Institution in Singapore","volume":"32","author":"Ng","year":"2024","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.4103\/IJO.IJO_430_24","article-title":"Ocular and Adnexal Manifestations Post Dengue Hemorrhagic Fever","volume":"72","author":"Maan","year":"2024","journal-title":"Indian J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2200769","DOI":"10.2807\/1560-7917.ES.2023.28.29.2200769","article-title":"From Dengue Outbreaks to Endemicity: Reunion Island, France, 2018 to 2021","volume":"28","author":"Vincent","year":"2023","journal-title":"Eurosurveillance"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.oret.2018.09.008","article-title":"Dengue-Induced Inflammatory, Ischemic Foveolitis and Outer Maculopathy: A Swept-Source Imaging Evaluation","volume":"3","author":"Agarwal","year":"2019","journal-title":"Ophthalmol. Retin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/IAE.0b013e3181bd2fc6","article-title":"Optical Coherence Tomography Patterns as Predictors of Visual Outcome in Dengue-Related Maculopathy","volume":"30","author":"Teoh","year":"2010","journal-title":"Retina"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ajo.2009.06.030","article-title":"Comparison of Prevalence of Dengue Maculopathy during Two Epidemics with Differing Predominant Serotypes","volume":"148","author":"Chee","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100049","DOI":"10.1016\/j.aopr.2022.100049","article-title":"Ophthalmic Manifestations in Seropositive Dengue Fever Patients during Epidemics Caused by Predominantly Different Dengue Serotypes","volume":"2","author":"Wagle","year":"2022","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3164375","DOI":"10.1155\/2017\/3164375","article-title":"Molecular Responses of Human Retinal Cells to Infection with Dengue Virus","volume":"2017","author":"Carr","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ashander, L.M., Lumsden, A.L., Dawson, A.C., Ma, Y., Ferreira, L.B., Oliver, G.F., Appukuttan, B., Carr, J.M., and Smith, J.R. (2022). Infection of Human Retinal Pigment Epithelial Cells with Dengue Virus Strains Isolated during Outbreaks in Singapore. Microorganisms, 10.","DOI":"10.3390\/microorganisms10020310"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jcv.2006.11.002","article-title":"Symptoms and Risk Factors of Ocular Complications Following Dengue Infection","volume":"38","author":"Seet","year":"2007","journal-title":"J. Clin. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3181\/0707-MR-198","article-title":"Alternate Hypothesis on the Pathogenesis of Dengue Hemorrhagic Fever (DHF)\/Dengue Shock Syndrome (DSS) in Dengue Virus Infection","volume":"233","author":"Noisakran","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1111\/j.1749-6632.2009.05050.x","article-title":"A Re-Evaluation of the Mechanisms Leading to Dengue Hemorrhagic Fever","volume":"1171","author":"Noisakran","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/09273948.2017.1351571","article-title":"Multimodal Imaging in Dengue-Fever-Associated Maculopathy","volume":"26","author":"Akanda","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1001\/archopht.125.4.501","article-title":"Dengue-Associated Maculopathy","volume":"125","author":"Bacsal","year":"2007","journal-title":"Arch. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.ophtha.2004.03.038","article-title":"Ocular Manifestations of Dengue Fever","volume":"111","author":"Lim","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.4103\/ijo.IJO_387_18","article-title":"An Unusual Occurrence of Stromal Keratitis in Dengue Fever","volume":"66","author":"Bawankar","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-Mediated Cytokine Storm and Its Role in Severe Dengue","volume":"39","author":"Srikiatkhachorn","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3129\/i06-069","article-title":"Ocular Manifestations of Dengue Fever in an East Indian Epidemic","volume":"41","author":"Kapoor","year":"2006","journal-title":"Can. J. Ophthalmol."},{"key":"ref_38","first-page":"31","article-title":"Ophthalmic Manifestations as the First Presenting Feature in Dengue Fever: A 10-Year Study","volume":"68","author":"Mishra","year":"2024","journal-title":"Rom. J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/jmv.10261","article-title":"Antibodies from Dengue Patient Sera Cross-React with Endothelial Cells and Induce Damage","volume":"69","author":"Lin","year":"2003","journal-title":"J. Med. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s12288-018-1058-2","article-title":"Dengue Virus NS1 Exposure Affects von Willebrand Factor Profile and Platelet Adhesion Properties of Cultured Vascular Endothelial Cells","volume":"35","author":"Tadkalkar","year":"2019","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1080\/09273948.2023.2220020","article-title":"Dengue Uveitis\u2014A Major Review","volume":"31","author":"Ng","year":"2023","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_42","first-page":"184","article-title":"A Re-Look at Ocular Complications in Dengue Fever and Dengue Haemorrhagic Fever","volume":"30","author":"Teoh","year":"2006","journal-title":"Dengue Bull."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/tvst.6.4.12","article-title":"Retinal Pigment Epithelial Cells Are a Potential Reservoir for Ebola Virus in the Human Eye","volume":"6","author":"Smith","year":"2017","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"530","DOI":"10.5144\/0256-4947.2012.30.4.1105","article-title":"Dengue Retinochoroiditis","volume":"32","author":"Tabbara","year":"2012","journal-title":"Ann. Saudi Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12348-019-0175-x","article-title":"Secondary Dengue Retinitis with Associated Occlusive Retinal Vasculitis","volume":"9","author":"Koundanya","year":"2019","journal-title":"J. Ophthal Inflamm. Infect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1097\/WNO.0000000000002211","article-title":"Bilateral Optic Neuritis After Dengue Infection Resulting in Legal Blindness in Both Eyes","volume":"45","author":"Hsiao","year":"2025","journal-title":"J. Neuro-Ophthalmol."},{"key":"ref_47","first-page":"32","article-title":"Bilateral Optic Neuritis with Maculopathy: A Rare Manifestation of Dengue Fever","volume":"12","author":"Boo","year":"2017","journal-title":"Malays. Fam. Physician"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.35119\/myjo.v3i1.152","article-title":"Optic Neuritis as the Ocular Manifestation of Dengue Infection: A Case Report","volume":"3","author":"Mahayana","year":"2021","journal-title":"Malays. J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ferreira, B.F.A., Sakuno, G., Kato, J.M., Sato, R.H., Ferreira, \u00c1.F., Missaka, R.F.B.G., and Nakashima, Y. (2024). Paracentral Acute Middle Maculopathy and Henle Fiber Layer Hemorrhage in Dengue Fever: Multimodal Imaging and Review of the Literature. Retin. Cases Brief Rep.","DOI":"10.1097\/ICB.0000000000001684"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40942-016-0057-4","article-title":"Arboviruses and the Eye","volume":"3","author":"Ventura","year":"2017","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4103\/ijo.IJO_1588_20","article-title":"Severe Ocular and Adnexal Complications in Dengue Hemorrhagic Fever: A Report of 29 Eyes","volume":"69","author":"Vijitha","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e11875","DOI":"10.1097\/MD.0000000000011875","article-title":"Dengue Fever-Associated Necrotizing Scleritis","volume":"97","author":"Kamoi","year":"2018","journal-title":"Medicine"},{"key":"ref_53","first-page":"e82119","article-title":"Acute Angle-Closure Glaucoma as an Ocular Complication of Dengue Fever: A Comprehensive Review","volume":"17","year":"2025","journal-title":"Cureus"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"taac106","DOI":"10.1093\/jtm\/taac106","article-title":"Dengue-Related Maculopathy","volume":"30","author":"Richier","year":"2023","journal-title":"J. Travel Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1001\/jamaophthalmol.2015.2687","article-title":"Acute Macular Neuroretinopathy in Dengue Fever: Short-Term Prospectively Followed up Case Series","volume":"133","author":"Li","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101250","DOI":"10.1016\/j.ajoc.2021.101250","article-title":"Acute Macular Neuroretinopathy in Dengue Virus Serotype 1","volume":"25","author":"Guardiola","year":"2022","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4103\/tjo.TJO-D-23-00106","article-title":"An Update on the Ocular Manifestations of Dengue","volume":"14","author":"Wang","year":"2024","journal-title":"Taiwan. J. Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1080\/09273948.2023.2211161","article-title":"Optical Coherence Tomography and Optical Coherence Tomography Angiography in Neglected Diseases","volume":"32","author":"Mahendradas","year":"2024","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4103\/ijo.IJO_113_18","article-title":"Culture-Positiveunilateral Panophthalmitis in a Serology-Positive Case of Dengue Hemorrhagic Fever","volume":"66","author":"Kamal","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/ICO.0000000000001706","article-title":"First Report on Detection of Dengue Virus in the Donor Cornea","volume":"37","author":"Janani","year":"2018","journal-title":"Cornea"},{"key":"ref_61","unstructured":"CDC (2025, August 24). Molecular Tests for Dengue Virus, Available online: https:\/\/www.cdc.gov\/dengue\/hcp\/diagnosis-testing\/molecular-tests-for-dengue-virus.html."},{"key":"ref_62","unstructured":"CDC (2025, July 04). Serologic Tests for Dengue Virus, Available online: https:\/\/www.cdc.gov\/dengue\/hcp\/diagnosis-testing\/serologic-tests-for-dengue-virus.html."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Changal, K.H., Raina, A.H., Raina, A., Raina, M., Bashir, R., Latief, M., Mir, T., and Changal, Q.H. (2016). Differentiating Secondary from Primary Dengue Using IgG to IgM Ratio in Early Dengue: An Observational Hospital Based Clinico-Serological Study from North India. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-2053-6"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/ceo.12269","article-title":"Structure and Function Correlation in a Patient with Dengue-Associated Maculopathy","volume":"42","author":"Tan","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zina, S.M., Hoarau, G., Labetoulle, M., Khairallah, M., and Rousseau, A. (2023). Ocular Manifestations of Flavivirus Infections. Pathogens, 12.","DOI":"10.3390\/pathogens12121457"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12348-019-0190-y","article-title":"Optical Coherence Tomography Angiography in Uveitis","volume":"9","author":"Tranos","year":"2019","journal-title":"J. Ophthalmic Inflamm. Infect."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000144074","article-title":"Foveolitis Associated with Dengue Fever: A Case Series","volume":"222","author":"Loh","year":"2008","journal-title":"Ophthalmologica"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4103\/ijo.IJO_485_17","article-title":"Optical Coherence Tomography Angiography Features of Acute Macular Neuroretinopathy in Dengue Fever","volume":"65","author":"Aggarwal","year":"2017","journal-title":"Indian J. Ophthalmol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3201\/eid1105.040992","article-title":"Retinal Hemorrhages in 4 Patients with Dengue Fever","volume":"11","author":"Chlebicki","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_70","first-page":"151","article-title":"Combination Immunotherapy in the Treatment of Chronic Bilateral Panuveitis and Uveitic Glaucoma during Acute Dengue Fever Infection in the Caribbean","volume":"8","author":"Stewart","year":"2015","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/sj.eye.6701704","article-title":"Bilateral Vitreous Haemorrhage Associated with Dengue Fever","volume":"19","author":"Nainiwal","year":"2005","journal-title":"Eye"},{"key":"ref_72","first-page":"e25916","article-title":"Pars Plana Vitrectomy for a Sub-Internal Limiting Membrane Hemorrhage and Vitreous Hemorrhage Secondary to Dengue Fever: A Case Report","volume":"14","author":"Malek","year":"2022","journal-title":"Cureus"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1080\/09273948.2022.2053548","article-title":"Bilateral Ciliochoroidal Effusion with Secondary Angle Closure and Myopic Shift in Dengue Fever","volume":"31","author":"Dhoot","year":"2023","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/092739490500345","article-title":"Ocular Manifestations in Dengue Fever","volume":"12","author":"Siqueira","year":"2004","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12348-017-0132-5","article-title":"Dengue Associated Choroiditis: A Rare Entity","volume":"7","author":"Yadav","year":"2017","journal-title":"J. Ophthalmic Inflamm. Infect."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/9\/872\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:37:43Z","timestamp":1760035063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/9\/872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":75,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["pathogens14090872"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14090872","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}