{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:44:14Z","timestamp":1760060654985,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Adhesion of different microorganisms to the surface of dental materials has generated significant interest since one of the most important requirements of biomaterials to be considered successful is their ability to withstand the damage caused by microorganisms that may lead to failure and the onset of different pathologies, such as caries. In vitro testing has demonstrated that surface modification is an alternative approach to reduce the adhesion of microorganisms to surfaces. The objective of this work was to assess the adhesion of Streptococcus mitis, Streptococcus mutans, and Candida albicans to a dental composite surface modified following a biomimetic approach and coated with salivary proteins. Soft lithography was used to copy the topography from the Crocosmia aurea leaf and then transfer it to the surface of dental composite discs that were coated with saliva proteins. Surfaces were characterized by contact angle and atomic force microscopy. S. mitis, S. mutans, and C. albicans were used to assess bacterial and fungal adhesion in monoculture and co-culture. The topographic modification of the surface of a dental composite reduced the adhesion of assessed microorganisms and the adhesion of these species in monoculture and co-culture on saliva-coated surfaces was higher than on topographically modified surfaces.<\/jats:p>","DOI":"10.3390\/pathogens14090909","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:04:55Z","timestamp":1757505895000},"page":"909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Surface Modification of a Dental Composite on the Adhesion of Streptococcus mitis, Streptococcus mutans, and Candida albicans: An In Vitro Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-9895","authenticated-orcid":false,"given":"Santiago","family":"Arango-Santander","sequence":"first","affiliation":[{"name":"GIOM Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Medellin 055421, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Mar\u00eda","family":"Bedoya-Correa","sequence":"additional","affiliation":[{"name":"GIOM Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Medellin 055421, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Soto","sequence":"additional","affiliation":[{"name":"GIOM Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Medellin 055421, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Bustamante","sequence":"additional","affiliation":[{"name":"GIOM Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Medellin 055421, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Franco","sequence":"additional","affiliation":[{"name":"GIOM Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Medellin 055421, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103317","DOI":"10.1016\/j.jdent.2020.103317","article-title":"Surface properties and bacterial adhesion of bulk-fill composite resins","volume":"95","author":"Bilgili","year":"2020","journal-title":"J. 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