{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:38Z","timestamp":1787029298085,"version":"build-2736575974"},"reference-count":263,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Rodents are recognized as significant reservoirs for a broad range of zoonotic pathogens, including bacteria, viruses, and parasites, many of which have substantial implications for human and animal health. The intensifying interaction between humans and rodent populations, fuelled by urbanization, climate change, and global trade, has amplified the risk of zoonotic disease transmission. This review compiles and examines current knowledge on key rodent-borne bacterial diseases, including leptospirosis, rat-bite fever, plague, salmonellosis, tularemia, Lyme disease, rickettsioses, Babesiosis, and associated parasitic infections such as toxoplasmosis and Chagas disease. Each disease is analyzed in terms of its etiology, transmission, clinical manifestations, diagnostic tools, and treatment options, with a particular focus on the impact of environmental changes. Emphasizing a One Health perspective, this work highlights the importance of interdisciplinary approaches to the surveillance, prevention, and control of rodent-borne zoonoses, particularly in the context of increasing climate variability and anthropogenic pressures.<\/jats:p>","DOI":"10.3390\/pathogens14090928","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:56:46Z","timestamp":1758013006000},"page":"928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Silent Carriers: The Role of Rodents in the Emergence of Zoonotic Bacterial Threats"],"prefix":"10.3390","volume":"14","author":[{"given":"Shereen","family":"Basiouni","sequence":"first","affiliation":[{"name":"Center for Preclinical Research, German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2192","authenticated-orcid":false,"given":"Alfonso J.","family":"Rodriguez-Morales","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Universidad Cient\u00edfica del Sur, Lima 15307, Peru"},{"name":"Grupo de Investigaci\u00f3n Biomedicina, Faculty of Medicine, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas-Instituci\u00f3n Universitaria Visi\u00f3n de las Am\u00e9ricas, Pereira 660003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-0778","authenticated-orcid":false,"given":"Awad A.","family":"Shehata","sequence":"additional","affiliation":[{"name":"TUM School of Natural Sciences, Bavarian NMR Center (BNMRZ), Structural Membrane Biochemistry, Technical University of Munich, 85748 Garching, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-3576","authenticated-orcid":false,"given":"Phelipe Magalh\u00e3es","family":"Duarte","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Bioscience, Federal Rural University of Pernambuco (UFRPE), Recife 52171-900, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.adq7993","article-title":"Emerging Patterns in Rodent-Borne Zoonotic Diseases","volume":"385","author":"Keesing","year":"2024","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/10408410902989837","article-title":"Rodent-Borne Diseases and Their Risks for Public Health","volume":"35","author":"Meerburg","year":"2009","journal-title":"Crit. 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