{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:14:48Z","timestamp":1773098088227,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indian Immunologicals Limited","award":["Nil"],"award-info":[{"award-number":["Nil"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Infectious Bovine Rhinotracheitis (IBR) is endemic in India, causing significant losses to dairy enterprises. Until recently, the unavailability of an indigenously manufactured vaccine and the high cost of imported vaccines limited national vaccination efforts. However, an indigenously developed and manufactured inactivated DIVA vaccine has now become available. The exact strategies that other countries have employed for the successful control of IBR may not be applicable in India due to the differences in the production systems and the social values. Hence, we have employed linear deterministic modeling to study the benefits, both in terms of the protection of the animals from the disease and the costs, of vaccination against IBR towards proposing an optimal strategy for immunization-based control of the disease in India. Our findings emphasize the need for proper vaccination practices, appropriate farm biosecurity measures, and biannual re-vaccinations to achieve the desired endpoints in a vaccination program. Based on our findings, a vaccination program aiming for primary vaccination with two doses followed by continuing bi-annual re-vaccination with a single dose to achieve 70% vaccination coverage in the cattle population can be recommended for the control of IBR in India.<\/jats:p>","DOI":"10.3390\/pathogens14090955","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T17:08:17Z","timestamp":1758560897000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Simple Deterministic Model of Protection and Cost Benefits from Vaccinating Indian Cattle Against Infectious Bovine Rhinotracheitis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-1887","authenticated-orcid":false,"given":"Bhaskar","family":"Ganguly","sequence":"first","affiliation":[{"name":"Indian Immunologicals Limited, Rakshapuram, Hyderabad 500032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarvesh","family":"Tayshete","sequence":"additional","affiliation":[{"name":"Indian Immunologicals Limited, Rakshapuram, Hyderabad 500032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-0052","authenticated-orcid":false,"given":"Priyabrata","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Indian Immunologicals Limited, Rakshapuram, Hyderabad 500032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyayapati Sunil Narayana","family":"Bhargav","sequence":"additional","affiliation":[{"name":"Indian Immunologicals Limited, Rakshapuram, Hyderabad 500032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand Kumar","family":"Kanakasapapathy","sequence":"additional","affiliation":[{"name":"Indian Immunologicals Limited, Rakshapuram, Hyderabad 500032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.3168\/jds.2023-24626","article-title":"Global losses due to dairy cattle diseases: A comorbidity-adjusted economic analysis","volume":"107","author":"Rasmussen","year":"2024","journal-title":"J. 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