{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:38Z","timestamp":1787029298667,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: Odontogenic abscesses may significantly affect maternal health during pregnancy. Aim: This study analyzes three cases of pregnant patients with odontogenic infections, comparing them to a control group of non-pregnant women, and reviews recent literature. Materials and Methods: Between January 2020 and April 2025, 3 pregnant and 70 non-pregnant women with odontogenic abscesses were treated. Clinical presentation, pathogens, therapy, and outcomes were compared. Results: Severe sequelae, such as rapid abscess spread and systemic inflammation, were more frequent in pregnant women, though not statistically significant (p = 0.068). Pregnant patients also tended toward prolonged intubation (p = 0.194) and targeted antibiotic use (p = 0.133). Antibiotic selection was based on gestational age, with beta-lactams preferred. Surgical interventions were more extensive, often involving multiple neck spaces. Hospitalization was longer (\u22654 days in most cases) due to maternal\u2013fetal monitoring. Conclusions: Odontogenic abscesses in pregnancy require individualized management and gestation-adjusted antibiotic therapy.<\/jats:p>","DOI":"10.3390\/pathogens14101024","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:54:31Z","timestamp":1760028871000},"page":"1024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Management of Odontogenic Infections in Pregnant Patients: Case-Based Approach and Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5640-1925","authenticated-orcid":false,"given":"Andrei","family":"Hramyka","sequence":"first","affiliation":[{"name":"Students\u2019 Scientific Group, Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5056-1980","authenticated-orcid":false,"given":"Agata","family":"Wieczorkiewicz","sequence":"additional","affiliation":[{"name":"Students\u2019 Scientific Group, Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-3084","authenticated-orcid":false,"given":"Jakub","family":"Bargiel","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"\u015aliwi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-3499","authenticated-orcid":false,"given":"Krzysztof","family":"G\u0105siorowski","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Marecik","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Szczurowski","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-0633","authenticated-orcid":false,"given":"Gra\u017cyna","family":"Wyszy\u0144ska-Pawelec","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Zapa\u0142a","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-948X","authenticated-orcid":false,"given":"Micha\u0142","family":"Gontarz","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1089\/sur.2024.143","article-title":"Severe Deep Fascial Spaces Infections with Pregnancy: A Retrospective Study","volume":"25","author":"Mahran","year":"2024","journal-title":"Surg. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4049\/jimmunol.2200454","article-title":"Impact of Estrogen and Progesterone on Immune Cells and Host-Pathogen Interactions in the Lower Female Reproductive Tract","volume":"209","author":"Collins","year":"2022","journal-title":"J. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lieske, B., Makarova, N., Jagemann, B., Walther, C., Ebinghaus, M., Zyriax, B.-C., and Aarabi, G. (2022). Inflammatory Response in Oral Biofilm during Pregnancy: A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14224894"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pecci-Lloret, M.P., Linares-P\u00e9rez, C., Pecci-Lloret, M.R., Rodr\u00edguez-Lozano, F.J., and O\u00f1ate-S\u00e1nchez, R.E. (2024). Oral Manifestations in Pregnant Women: A Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030707"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Neal, T.W., and Schlieve, T. (2022). Complications of Severe Odontogenic Infections: A Review. Biology, 11.","DOI":"10.3390\/biology11121784"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pucci, R., Cassoni, A., Di Carlo, D., Della Monaca, M., Romeo, U., and Valentini, V. (2021). Severe Odontogenic Infections during Pregnancy and Related Adverse Outcomes. Case Report and Systematic Literature Review. Trop. Med. Infect. Dis., 6.","DOI":"10.3390\/tropicalmed6020106"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chacko, L.K., Shenoy, R.P., and Kalladka, P.K. (2025). Oral health status and quality of life among pregnant women with oral health problems: A descriptive study. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-06654-3"},{"key":"ref_8","first-page":"1139","article-title":"Oral health during pregnancy","volume":"77","author":"Silk","year":"2008","journal-title":"Am. Fam. Physician"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1744-1609.2011.00210.x","article-title":"Periodontal treatment during pregnancy and birth outcomes: A meta-analysis of randomised trials","volume":"9","author":"George","year":"2011","journal-title":"Int. J. Evid.-Based Healthc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1902\/jop.2007.060388","article-title":"Effect of periodontal therapy on pregnancy outcome in women affected by periodontitis","volume":"78","author":"Tarannum","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1471-0528.2005.00827.x","article-title":"Periodontal disease and adverse pregnancy outcomes: A systematic review","volume":"113","author":"Xiong","year":"2006","journal-title":"BJOG"},{"key":"ref_12","first-page":"10813","article-title":"Antibiotic use in endodontic treatment during pregnancy: A narrative review","volume":"32","author":"Aliabadi","year":"2022","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shi, Q., Cai, Y., Wang, X., Liu, G., and Luan, Q. (2024). Nomogram prediction for periodontitis in Chinese pregnant women with different sociodemographic and oral health behavior characteristics: A community-based study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04640-9"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yang, R., Rashwan, N., Al Jallad, N., Wu, Y., Lu, X., Wu, T., and Xiao, J. (2024). Maternal and infant oral health benefits from mothers receiving prenatal total oral rehabilitation: A pilot prospective birth cohort study. Front. Oral Health, 5.","DOI":"10.3389\/froh.2024.1443337"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3109\/14767050902926954","article-title":"Oral health during pregnancy","volume":"22","author":"Morgan","year":"2009","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jogn.2016.04.005","article-title":"Oral Health in Pregnancy","volume":"45","author":"Hartnett","year":"2016","journal-title":"J. Obstet. Gynecol. Neonatal Nurs."},{"key":"ref_17","first-page":"703","article-title":"Immune disorders in sepsis and their treatment as a significant problem of modern intensive care","volume":"71","author":"Nelke","year":"2017","journal-title":"Post\u0119p. Hig. Med. Do\u015bw."},{"key":"ref_18","first-page":"158264","article-title":"Pregnancy complicated by Ludwig\u2019s angina requiring delivery","volume":"2010","author":"Moorhead","year":"2010","journal-title":"Infect. Dis. Obs. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/ijdr.ijdr_839_23","article-title":"Ludwig\u2019s Angina During Pregnancy\u2014A Case Report","volume":"35","author":"Balaji","year":"2024","journal-title":"Indian J. Dent. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jogc.2020.03.014","article-title":"Ludwig\u2019s Angina in Pregnancy: A Case Report","volume":"42","author":"Trahan","year":"2020","journal-title":"J. Obs. Gynaecol. Can."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12663-019-01206-z","article-title":"Delay in the Referral of Pregnant Patients with Fascial Spaces Infection: A Cross-Sectional Observational Study from Khartoum Teaching Dental Hospital, Sudan","volume":"19","author":"Ali","year":"2020","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_22","first-page":"1011","article-title":"Management of difficult airway in a pregnant patient with severely reduced mouth opening","volume":"71","author":"Shamim","year":"2021","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_23","first-page":"66","article-title":"Decompression of Ludwig\u2019s angina in a pregnant patient under bilateral superficial cervical plexus block","volume":"32","author":"Rahman","year":"2022","journal-title":"J. Perioper. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/adj.12189","article-title":"Odontogenic deep neck space infection as life-threatening condition in pregnancy","volume":"59","author":"Burtscher","year":"2014","journal-title":"Aust. Dent. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110131","DOI":"10.1016\/j.ijscr.2024.110131","article-title":"Maternal and Foetal care in odontogenic infections: A well curated management","volume":"123","author":"Jain","year":"2024","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_26","first-page":"1765","article-title":"Oral and general health conditions involved in periodontal status during pregnancy: A prospective cohort study","volume":"308","year":"2023","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_27","first-page":"603","article-title":"Poor dental hygiene in pregnancy leading to submandibular cellulitis and intrauterine fetal demise: Case report and literature review","volume":"4","author":"Mukherjee","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/AOG.0b013e31822468d6","article-title":"Pregnancy complicated by recurrent brain abscess after extraction of an infected tooth","volume":"118","author":"Hobson","year":"2011","journal-title":"Obs. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1834-7819.2012.01728.x","article-title":"Management of severe odontogenic infections in pregnancy","volume":"57","author":"Wong","year":"2012","journal-title":"Aust. Dent. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/adj.12025","article-title":"Acute fetal distress following tooth extraction and abscess drainage in a pregnant patient with maxillofacial infection","volume":"58","author":"Soylu","year":"2013","journal-title":"Aust. Dent. J."},{"key":"ref_31","first-page":"17","article-title":"Odontogenic fascial space infections in pregnancy: A study","volume":"33","author":"Wazir","year":"2013","journal-title":"Pak. Oral Dent. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e748","DOI":"10.1097\/SCS.0000000000003907","article-title":"Dental Infection and Pregnancy: The Lack of Treatment by the Dental Professional Evolving to a Complex Maxillofacial Infection","volume":"28","author":"Pereira","year":"2017","journal-title":"J. Craniofacial Surg."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Figueiredo, M.G.O.P., Takita, S.Y., Dourado, B.M.R., Mendes, H.S., Terakado, E.O., Nunes, H.R.C., and Fonseca, C.R.B.D. (2019). Periodontal disease: Repercussions in pregnant woman and newborn health\u2014A cohort study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225036"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12663-012-0410-6","article-title":"Ludwig\u2019s Angina in Pregnancy Necessitating Pre Mature Delivery","volume":"14","author":"Kamath","year":"2015","journal-title":"J. Maxillofac. Oral. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.11604\/pamj.2020.36.258.24864","article-title":"Odontogenic cervico-facial cellulitis during pregnancy: About 3 cases","volume":"36","author":"Aziz","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/adj.12463","article-title":"Severe odontogenic infection in pregnancy: A timely reminder","volume":"62","author":"Tocaciu","year":"2017","journal-title":"Aust. Dent. J."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/10\/1024\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:51:01Z","timestamp":1760035861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/10\/1024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["pathogens14101024"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14101024","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}