{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:42:53Z","timestamp":1761007373511,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Despite the devastating consequences of fungal disease, research struggles to catch up to present needs. This study aims to give a broad perspective on the situation, investigating patterns and distribution of fungal pathogens and monitoring trends of resistance to antifungal drugs, over an 8-year timeframe, at the National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d in Bucharest, Romania. Samples were inoculated on Sabouraud or Brilliance Candida Agar media; strains were identified using MALDI-TOF MS; and antifungal sensitivity testing was performed using E-Tests strips, VITEK2 Compact and MICRONAUT-AM automatic systems. Candida albicans, accounting for 42% of the positive samples, was the most common pathogen observed, with only 17% of the isolates being susceptible to all antifungals tested, while it was also predominant and deadly in the ICU. The emerging Candidozyma auris, found in 8% of the candidoses, exhibited a fluconazole resistance rate of 96.3%. Of the Aspergillus fumigatus strains, 35.7% showed resistance to azoles, and 25% to amphotericin B. In the ICU, more than half of A. flavus-, A. fumigatus- or A. niger-related cases culminated in death. Antifungal resistance is not to be treated lightly, as it is still a complex and dynamic threat, with devastating consequences.<\/jats:p>","DOI":"10.3390\/pathogens14101061","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:27:29Z","timestamp":1760963249000},"page":"1061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fungus Among Us: An 8-Year Retrospective Study of Fungal Infections at a Tertiary-Care Hospital in Bucharest, Romania"],"prefix":"10.3390","volume":"14","author":[{"given":"Alina Maria","family":"Borcan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"},{"name":"The National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, Doctor Grozovici Street, No. 1, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-2338","authenticated-orcid":false,"given":"Mihaela-Cristina","family":"Olariu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"},{"name":"The National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, Doctor Grozovici Street, No. 1, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora Gabriela","family":"Anghel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5185-3332","authenticated-orcid":false,"given":"Bianca","family":"Secuiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalina","family":"Simoiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"},{"name":"The National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u0219\u201d, Doctor Grozovici Street, No. 1, 021105 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcis","family":"Copca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"},{"name":"St. Mary Clinical Hospital, Department of General Surgery, Ion Mihalache Boulevard, No 37-39, 011172 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-030X","authenticated-orcid":false,"given":"Dragos","family":"Cretoiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"},{"name":"The National Institute of Mother and Child Health \u201cAlessandrescu-Rusescu\u201d, Materno-Fetal Medicine Excellence Center, Lacul Tei Boulevard, No 120, 20382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7756-9670","authenticated-orcid":false,"given":"Laura Georgiana","family":"Caravia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Medicine and Pharmacy \u201cCarol Davila\u201d, Dionisie Lupu Street, No. 37, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jorgensen, J.H., Warnock, D.W., Funke, G., Pfaller, M.A., Landry, M.L., Carroll, K.C., and Richter, S.S. 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