{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:44:54Z","timestamp":1761194694861,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82360388"],"award-info":[{"award-number":["82360388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kunming University of Science and Technology & the First People\u2019s Hospital of Yunnan Province Joint Special Project on Medical Research","award":["KUST-KH2022002Y"],"award-info":[{"award-number":["KUST-KH2022002Y"]}]},{"name":"Key Research and Development Program of Yunnan Province","award":["202403AC100006"],"award-info":[{"award-number":["202403AC100006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Hand\u2013foot\u2013mouth disease (HFMD), primarily caused by human enteroviruses (EVs), poses a public health challenge, particularly among infants, due to a lack of effective therapies. Elucidating the molecular interplay between EVs and the host immune response is crucial for developing antiviral treatments. Recent studies have highlighted the significance of long non-coding RNAs (lncRNAs) in regulating host\u2013pathogen interactions; however, the mechanisms of lncRNAs in EV infection remain poorly unexplored. Here, we identified a highly inducible nuclear lncRNA, LINC1467, that is upregulated in response to HFMD-related EV infection. Functional analyses revealed that LINC1467 suppresses viral replication. Mechanistically, LINC1467 interacts with nuclear import receptor Importin 8 (IPO8) to form the LINC1467\/IPO8\/p65 complex, facilitating the phosphorylation and nuclear translocation of p65, thus promoting the expression of pro-inflammatory cytokines and activating the NF-\u03baB pathway. The antiviral function of LINC1467 was further validated in a mouse model of viral infection. These findings uncover a novel lncRNA-mediated regulatory mechanism in the innate immune response and highlight LINC1467 as a promising target for future antiviral strategies against HFMD-related EVs.<\/jats:p>","DOI":"10.3390\/pathogens14101071","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:36:31Z","timestamp":1761060991000},"page":"1071","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LINC1467 Activates the IPO8\u2013p65 Axis to Restrict Hand, Foot, and Mouth Disease Virus Replication"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaokui","family":"Zhang","sequence":"first","affiliation":[{"name":"Medical School, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical School, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Yunnan Province, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical School, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical School, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghan","family":"Luo","sequence":"additional","affiliation":[{"name":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-4277","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical School, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12929-023-00908-4","article-title":"Current status of hand-foot-and-mouth disease","volume":"30","author":"Zhu","year":"2023","journal-title":"J. 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