{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:22:32Z","timestamp":1789435352057,"version":"build-2803163510"},"reference-count":75,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Toxocariasis, a geohelminthiasis caused by Toxocara canis and Toxocara cati nematodes, has an estimated 19% seroprevalence worldwide. Although children have been considered more prone to infection, adults and the elderly may also be considered at risk. Accordingly, the present study aimed to assess the associated risk factors for Toxocara spp. seropositivity in a population of 290 individuals over 50 years old, attended by the Public Health System in western S\u00e3o Paulo state. Socioepidemiological information was obtained by a semi-structured questionnaire, a blood (serum) sample, and a neurocognitive function assessment by the 10-point cognitive screener (10-CS). Overall, 89\/290 (30.7%; 95% CI: 25.7\u201336.2%) individuals presented anti-Toxocara spp. IgG antibodies by ELISA. Multivariate analysis revealed that individuals raising both dogs and cats were 3-fold more likely to be seropositive than the ones without any pet (p = 0.002), while educational level resulted in an associated protective factor (p = 0.001). No seropositivity influence was observed for the other evaluated variables, including age, gender, monthly income, consumption of drinkable water or raw\/undercooked meat, having a dirty floor at home, contact with soil, washing vegetables and hands before meals, and onychophagy. Although seropositivity was not statistically associated with dementia (p = 0.198) and neuropsychiatric disorder (p = 0.440), results herein indicated toxocariasis as a likely under-reported and neglected infection in the older human population. As an immunosenescence risk group that should be continuously monitored, elderly pet owners may be at risk and should be extra careful with self-hygiene and pet deworming, particularly when owning multiple pet species, to reduce the risk of toxocariasis infection.<\/jats:p>","DOI":"10.3390\/pathogens14111095","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:16:07Z","timestamp":1761642967000},"page":"1095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toxocariasis as an Elderly Zoonosis: Seroprevalence, Neurocognitive Assessment, and Associated Risk Factors in Persons 50 Years and Older"],"prefix":"10.3390","volume":"14","author":[{"given":"Gabriela Geraldi","family":"da Silva Rapchan","sequence":"first","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Braghin","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane dos Santos Vaccaro","family":"Lima","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4263-690X","authenticated-orcid":false,"given":"Susana Ang\u00e9lica Zevallos","family":"Lescano","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of S\u00e3o Paulo, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Ribelatto","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Cardoso dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Sapucaia Ferreira","family":"Esteves","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano Borges","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Carlos Chagas Institute, Curitiba 81310-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-1278","authenticated-orcid":false,"given":"Louise Bach","family":"Kmetiuk","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Carlos Chagas Institute, Curitiba 81310-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-5821","authenticated-orcid":false,"given":"Alexander Welker","family":"Biondo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Paran\u00e1 (UFPR), Curitiba 80035-050, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-4349","authenticated-orcid":false,"given":"Rogerio","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7065-1138","authenticated-orcid":false,"given":"Vamilton Alvares","family":"Santarem","sequence":"additional","affiliation":[{"name":"Graduate College in Animal Sciences and Health Sciences, University of Western S\u00e3o Paulo (UNOESTE), Presidente Prudente 19067-175, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104002","DOI":"10.1016\/j.meegid.2019.104002","article-title":"Human toxocariasis\u2014A look at a neglected disease through an epidemiological \u201cprism\u201d","volume":"74","author":"Rostami","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_2","unstructured":"Centers for Disease Control and Prevention (CDC) (2025, July 21). Toxocariasis, Available online: https:\/\/www.cdc.gov\/dpdx\/toxocariasis\/index.html."},{"key":"ref_3","unstructured":"Winders, W.T., and Menkin-Smith, L. (2025). Toxocara canis. StatPearls, StatPearls Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/S1473-3099(17)30331-6","article-title":"Human toxocariasis","volume":"18","author":"Ma","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jech-2022-219772","article-title":"Association of infection with Toxoplasma gondii and Toxocara on cognitive function among US adults aged 60 and over, NHANES 2011\u20132014","volume":"77","author":"Brody","year":"2023","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e068974","DOI":"10.1136\/bmjopen-2022-068974","article-title":"Association between seropositivity for toxocariasis and cognitive functioning in older adults: An analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES), 2011\u20132014","volume":"13","author":"Song","year":"2023","journal-title":"BMJ Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s001150001028","article-title":"Cerebral toxocariasis: A rare cause of cognitive disorders. A contribution to differential dementia diagnosis","volume":"73","author":"Richartz","year":"2002","journal-title":"Nervenarzt"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.clineuro.2008.06.014","article-title":"Cognitive dysfunction, urinary retention, and a lesion in the thalamus\u2014Beware of possible toxocariasis of the central nervous system","volume":"110","author":"Scheid","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jfma.2021.01.025","article-title":"The first two cases of neurotoxocariasis in Taiwan","volume":"120","author":"Lee","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/trstmh\/trae039","article-title":"Association between Alzheimer\u2019s Disease and Toxocara infection\/exposure: A case-control study","volume":"118","author":"Khatir","year":"2024","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/parasite\/2025019","article-title":"No evidence of Alzheimer\u2019s Disease pathology in mice infected with Toxocara canis","volume":"32","author":"Svoboda","year":"2025","journal-title":"Parasite"},{"key":"ref_12","unstructured":"(2025, January 08). Alzheimer\u2019s Disease International (ADI)\u2014Dementia Statistics. Available online: https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/gerona\/glad025","article-title":"Prevalence of dementia and cognitive impairment no dementia in a large and diverse nationally representative sample: The ELSI-Brazil study","volume":"78","author":"Bertola","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1590\/1980-57642020dn14-030001","article-title":"Challenges in the diagnosis of dementia: Insights from the United Kingdom-Brazil dementia workshop","volume":"14","author":"Calil","year":"2020","journal-title":"Dement. neuropsychol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e971","DOI":"10.6061\/clinics\/2019\/e971","article-title":"Dementia Screening in Brazil: A systematic review of normative data for the Mini-Mental State Examination","volume":"74","author":"Sudo","year":"2019","journal-title":"Clinics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: Review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"JAMA"},{"key":"ref_17","unstructured":"Emmady, P.D., Schoo, C., and Tadi, P. (2025). Major Neurocognitive Disorder (Dementia). StatPearls, StatPearls Publishing."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Breijyeh, Z., and Karaman, R. (2020). Comprehensive review on Alzheimer\u2019s Disease: Causes and treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_19","unstructured":"(2025, September 04). Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE)\u2014Estimativas Populacionais por Munic\u00edpio, Idade e Sexo: 2000\u20132024. Dados B\u00e1sicos, Available online: http:\/\/tabnet.datasus.gov.br\/cgi\/tabcgi.exe?ibge\/cnv\/popsvs2024br.def."},{"key":"ref_20","unstructured":"(2025, February 19). Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE)\u2014Cidades. S\u00e3o Paulo. Presidente Prudente. Panorama, Available online: https:\/\/cidades.ibge.gov.br\/brasil\/sp\/presidente-prudente\/panorama."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S2221-1691(13)60052-0","article-title":"Anti-Toxocara spp. antibodies in an adult healthy population: Serosurvey and risk factors in southeast Brazil","volume":"3","author":"Negri","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Naing, L., Nordin, R.B., Abdul Rahman, H., and Naing, Y.T. (2022). Sample size calculation for prevalence studies using Scalex and ScalaR calculators. BMC Med. Res. Methodol., 22.","DOI":"10.1186\/s12874-022-01694-7"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/gps.4282","article-title":"Using temporal orientation, category fluency, and word recall for detecting cognitive impairment: The 10-Point Cognitive Screener (10-CS)","volume":"31","author":"Apolinario","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jcla.20126","article-title":"A serological follow-up of toxocariasis patients after chemotherapy based on the detection of IgG, IgA, and IgE antibodies by Enzyme-Linked Immunosorbent Assay","volume":"20","author":"Elefant","year":"2006","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"de Oliveira Azevedo, P., Lescano, S.Z., Giuffrida, R., Kmetiuk, L.B., Dos Santos, A.P., Dangoudoubiyam, S., Biondo, A.W., and Santar\u00e9m, V.A. (2021). Serosurvey of anti-Toxocara antibodies and risk factors in adolescent and adult pregnant women of southeastern Brazil. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009571"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1081\/IMM-120022974","article-title":"Diagnosis of parasitic zoonoses by immunoenzymatic assays\u2014Analysis of cross-reactivity among the excretory\/secretory antigens of Fasciola hepatica, Toxocara canis, and Ascaris suum","volume":"32","author":"Romasanta","year":"2003","journal-title":"Immunol. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.vetpar.2012.12.028","article-title":"Laboratory diagnosis of human toxocariasis","volume":"193","author":"Fillaux","year":"2013","journal-title":"Vet. Parasitol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4269\/ajtmh.1978.27.492","article-title":"Evaluation of serodiagnostic tests for visceral larva migrans","volume":"27","author":"Glickman","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_29","first-page":"352","article-title":"Seroprevalence of toxocariasis in children with urticaria: A population-based study","volume":"63","author":"Correa","year":"2017","journal-title":"J. Trop. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fialho, P.M.M., Correa, C.R.S., and Lescano, S.Z. (2018). Asthma and seroconversion from Toxocara spp. infection: Which Comes First?. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/4280792"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Menu, E., Kopec, L., Luciani, L., Legrand, S., and L\u2019Ollivier, C. (2021). Measurement of the IgG avidity index in the diagnosis of clinical toxocariasis patients. Pathogens, 10.","DOI":"10.3390\/pathogens10091086"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-3024.2007.01010.x","article-title":"Determination of the relative avidity of the specific IgG antibodies in human toxocariasis","volume":"30","author":"Dziemian","year":"2008","journal-title":"Parasite Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/cid\/cix784","article-title":"Seroprevalence of antibodies to Toxocara species in the United States and associated risk factors, 2011\u20132014","volume":"66","author":"Liu","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/09720502.2010.10700699","article-title":"Collinearity diagnostics of binary logistic regression model","volume":"13","author":"Midi","year":"2010","journal-title":"J. Interdiscip. Math."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i08","article-title":"Implementing a class of permutation tests: The Coin Package","volume":"28","author":"Hothorn","year":"2008","journal-title":"J. Stat. Soft."},{"key":"ref_36","unstructured":"Hebbali, A. (2025, February 18). blorr: Tools for Developing Binary Logistic Regression Models. R package Version 0.3.1.9000. Available online: https:\/\/github.com\/rsquaredacademy\/blorr."},{"key":"ref_37","unstructured":"R Core Team (2024). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ulloque-Badaracco, J.R., Hernandez-Bustamante, E.A., Alarc\u00f3n-Braga, E.A., Huayta-Cortez, M., Carballo-Tello, X.L., Seminario-Amez, R.A., Rodr\u00edguez-Torres, A., Casas-Pati\u00f1o, D., Herrera-A\u00f1azco, P., and Benites-Zapata, V.A. (2023). Seroprevalence of human toxocariasis in Latin America and the Caribbean: A systematic review and meta-analysis. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1181230"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Santos, P.C., Lehmann, L.M., Lorenzi, C., Hirsch, C., Telmo, P.L., Mattos, G.T., Cadore, P.S., Klafke, G.B., Berne, M.E., and Gon\u00e7alves, C.V. (2015). The seropositivity of Toxocara spp. antibodies in pregnant women attented at the University Hospital in southern Brazil and the factors associated with infection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131058"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101106","DOI":"10.1016\/j.onehlt.2025.101106","article-title":"High toxocariasis seroprevalence in a tri-border indigenous community (Brazil, Paraguay and Argentina): A One Health perspective","volume":"21","author":"Ferreira","year":"2025","journal-title":"One Health"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Santar\u00e9m, V.A., Doline, F.R., Ferreira, I.B., Farinhas, J.H., Biondo, L.M., de Souza Filho, R.T., Pettan-Brewer, C., Giuffrida, R., Lescano, S.A.Z., and Dos Santos, A.P. (2023). One health approach to toxocariasis in Brazilian indigenous populations, their dogs, and soil contamination. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1220001"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.exppara.2015.10.006","article-title":"Immunodiagnostic approaches for the detection of human toxocarosis","volume":"159","author":"Ondriska","year":"2015","journal-title":"Exp. Parasitol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e12400","DOI":"10.1111\/pim.12400","article-title":"Clinical usefulness of Western Blotting and ELISA avidity for the diagnosis of human toxocariasis","volume":"39","author":"Kowalewska","year":"2017","journal-title":"Parasite Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.4269\/ajtmh.17-0542","article-title":"Toxocara seroprevalence and associated risk factors in the United States","volume":"97","author":"Berrett","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Waindok, P., Kann, S., Aristizabal, A., Dib, J.C., and Strube, C. (2021). Toxocara seroprevalence and risk factor analysis in four communities of the Wiwa, an indigenous tribe in Colombia. Microorganisms, 9.","DOI":"10.3390\/microorganisms9081768"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.14411\/fp.2022.011","article-title":"Association between toxocariasis seropositivity and serointensity and cognitive function in older U.S. adults","volume":"69","author":"Erickson","year":"2022","journal-title":"Folia Parasitol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40249-025-01312-w","article-title":"Prevalence of Toxocara infection and associated risk factors: A cross-sectional study in Zhejiang, China","volume":"14","author":"Yang","year":"2025","journal-title":"Infect. Dis. Poverty"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13195-024-01436-5","article-title":"Effects of risk factors on the development and mortality of early- and late-onset dementia: An 11-year longitudinal nationwide population-based cohort study in South Korea","volume":"16","author":"Chun","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"ref_50","first-page":"e28","article-title":"Seroprevalence of Toxoplasma gondii and Toxocara canis in a human rural population of southern Rio Grande do Sul","volume":"60","author":"Villela","year":"2018","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1097\/CM9.0000000000003410","article-title":"Immune Aging and Infectious Diseases","volume":"137","author":"Chen","year":"2024","journal-title":"Chin. Med. J."},{"key":"ref_52","first-page":"103","article-title":"Presumptive pulmonary toxocariasis in a patient affected by acute myeloid leukemia and Hodgkin lymphoma: Case report and review of the literature in immunocompromised hosts","volume":"32","author":"Lupia","year":"2024","journal-title":"Infez. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbi.2015.10.014","article-title":"Infectious disease burden and cognitive function in young to middle-aged adults","volume":"52","author":"Gale","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4246781","DOI":"10.1155\/2024\/4246781","article-title":"Seroprevalence and potential risk factors of toxocariasis among general population in southwest Iran: Implications on the One Health approach","volume":"2024","author":"Foroutan","year":"2024","journal-title":"J. Immunol. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2721202","DOI":"10.1155\/2023\/2721202","article-title":"Seroprevalence of toxocariasis and its associated risk factors among adult population in Kavar District, Fars Province, south of Iran: A cross-sectional community-based seroepidemiological survey","volume":"2023","author":"Pezeshkian","year":"2023","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s13071-023-06010-w","article-title":"One Health approach to toxocariasis in quilombola communities of southern Brazil","volume":"16","author":"Panazzolo","year":"2023","journal-title":"Parasites Vectors"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s13071-022-05499-x","article-title":"Serosurvey of anti-Toxocara canis antibodies in people experiencing homelessness and shelter workers from S\u00e3o Paulo, Brazil","volume":"15","author":"Lescano","year":"2022","journal-title":"Parasit. Vectors"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Santar\u00e9m, V.A., Pinto, G.L.B., De Souza Filho, R.T., Ferreira, I.B., Lescano, S.A.Z., Gonz\u00e1les, W.H.R., Kosloski, J., Ribeiro, J., Giuffrida, R., and Dos Santos, A.P. (2023). Risk factors for toxocariasis during incarceration: The One Health intervention approach. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-45484-7"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100353","DOI":"10.1016\/j.onehlt.2021.100353","article-title":"One Health approach on human seroprevalence of anti-Toxocara antibodies, Toxocara spp. eggs in dogs and sand samples between seashore mainland and island areas of southern Brazil","volume":"13","author":"Delai","year":"2021","journal-title":"One Health"},{"key":"ref_60","first-page":"983","article-title":"Risk factors and prevalence of toxocariasis in pregnant women and diabetic patients compared to healthy adults in Ilam Province, western Iran","volume":"17","author":"Raissi","year":"2018","journal-title":"EXCLI J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s15010-016-0889-8","article-title":"Neurotoxocariasis: A systematic literature review","volume":"44","author":"Deshayes","year":"2016","journal-title":"Infection"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Merigueti, Y.F.F.B., Giuffrida, R., da Silva, R.C., Kmetiuk, L.B., Santos, A.P.D., Biondo, A.W., and Santar\u00e9m, V.A. (2022). Dog and cat contact as risk factor for human toxocariasis: Systematic review and meta-analysis. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.854468"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cong, W., Zhang, X.-X., Zhou, N., Yu, C.-Z., Chen, J., Wang, X.-Y., Li, B., Qian, A.-D., and Zhu, X.-Q. (2014). Toxocara seroprevalence among clinically healthy individuals, pregnant women and psychiatric patients and associated risk factors in Shandong Province, eastern China. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003082"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gee, N.R., Mueller, M.K., and Curl, A.L. (2017). Human-animal interaction and older adults: An overview. Front. Psychol., 8.","DOI":"10.3389\/fpsyg.2017.01416"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/08927936.2024.2351278","article-title":"A scoping review of the risks posed by companion animals to older adults","volume":"37","author":"Zoanetti","year":"2024","journal-title":"Anthrozo\u00f6s"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.vetpar.2010.06.010","article-title":"Contamination of the hair of owned dogs with the eggs of Toxocara spp","volume":"173","author":"Keegan","year":"2010","journal-title":"Vet. Parasitol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.vetpar.2017.07.020","article-title":"Protective and risk factors associated with the presence of Toxocara spp. eggs in dog hair","volume":"244","author":"Merigueti","year":"2017","journal-title":"Vet. Parasitol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1080\/13607863.2019.1633620","article-title":"Pet ownership and its influence on mental health in older adults","volume":"24","author":"Hill","year":"2020","journal-title":"Aging Ment. Health"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Lee, R.M., Moore, L.B., Bottazzi, M.E., and Hotez, P.J. (2014). Toxocariasis in North America: A systematic review. PLOS Neglected Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003116"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/bs.apar.2020.01.021","article-title":"Sources and seroprevalence of toxocariasis in Turkey","volume":"109","year":"2020","journal-title":"Adv. Parasitol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Rostami, A., Riahi, S.M., Holland, C.V., Taghipour, A., Khalili-Fomeshi, M., Fakhri, Y., Omrani, V.F., Hotez, P.J., and Gasser, R.B. (2019). Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007809"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1017\/S0950268816001631","article-title":"Seroprevalence and associated risk factors of Toxocara infection in Korean, Manchu, Mongol, and Han ethnic groups in northern China","volume":"144","author":"Yang","year":"2016","journal-title":"Epidemiol. Infect."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Pereira, E.L.G.M., Ferreira, I.B., Victorino, R.B., Lescano, S.A.Z., Giuffrida, R., Kmetiuk, L.B., Biondo, A.W., and Santar\u00e9m, V.A. (2024). Serosurvey of Toxoplasma gondii and Toxocara spp. co-infection in pregnant women in low-income areas of Brazil. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1340434"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1128\/CMR.00106-14","article-title":"Cerebral toxocariasis: Silent progression to neurodegenerative disorders?","volume":"28","author":"Fan","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0020-7519(92)90067-U","article-title":"Persistence of immune response in human toxocariasis as measured by ELISA","volume":"22","author":"Fenoy","year":"1992","journal-title":"Int. J. Parasitol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1095\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:55:54Z","timestamp":1761645354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":75,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["pathogens14111095"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14111095","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]}}}