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The aim of this study was to highlight the epidemiological aspects of the prevalence rate in Europe, and we found that the distribution of Toxocara infection is uneven, depending on geographical, climatic and socio-economic factors. Currently, there is a continuous spread of this parasite in many regions, including economically developed countries, but the exact prevalence is not known because there are no regular reports and statistical evidence regarding toxocarosis. The presence of nonspecific symptoms and subclinical disease may delay diagnosis and treatment, with long-term implications for the patient, and because of this, we discussed the possible Toxocara detection methods, with several novel and interesting approaches. Toxocarosis is included among the neglected parasitic diseases, requiring seroprevalence studies to be carried out to develop programs to reduce the frequency of this parasitosis.<\/jats:p>","DOI":"10.3390\/pathogens14111117","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:14Z","timestamp":1762175714000},"page":"1117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Toxocara Seroprevalence in Europe and Considerations for Future Research"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3856-1413","authenticated-orcid":false,"given":"Roxana Gabriela","family":"Cobzaru","sequence":"first","affiliation":[{"name":"Grigore T. 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Helminth Infections and Their Impact on Global Public Health, Springer.","DOI":"10.1007\/978-3-7091-1782-8"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3347\/kjp.2001.39.1.1","article-title":"Highlights of Human Toxocariasis","volume":"39","author":"Magnaval","year":"2001","journal-title":"Korean J. Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/oxfordjournals.epirev.a036235","article-title":"Epidemiology and Pathogenesis of Zoonotic Toxocariasis","volume":"3","author":"Glickman","year":"1981","journal-title":"Epidemiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104002","DOI":"10.1016\/j.meegid.2019.104002","article-title":"Human Toxocariasis\u2013A Look at a Neglected Disease through an Epidemiological \u2018Prism\u2019","volume":"74","author":"Rostami","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.vetpar.2012.12.033","article-title":"Toxocara spp. Infections in Paratenic Hosts","volume":"193","author":"Strube","year":"2013","journal-title":"Vet. Parasitol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1128\/CMR.16.2.265-272.2003","article-title":"Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects","volume":"16","author":"Despommier","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/S1473-3099(17)30331-6","article-title":"Human Toxocariasis","volume":"18","author":"Ma","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.4269\/ajtmh.15-0733","article-title":"A Systematic Review of Toxocariasis: A Neglected but High-Prevalence Disease in Brazil","volume":"94","author":"Fialho","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Raissi, V., Masoumi, M.T., Ibrahim, A., Etemadi, S., Getso, M., Jalali, P., Babaei Pouya, N., Zareie, M., Ehsani Amraei, F., and Raiesi, O. (2021). Spatial Analysis of Toxocara spp. Eggs in Soil as a Potential for Serious Human Infection. Comp. Immunol. Microbiol. Infect. Dis., 75.","DOI":"10.1016\/j.cimid.2021.101619"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2222.2008.02934.x","article-title":"Toxocara Canis Infection: An Important and Neglected Environmental Risk Factor for Asthma?","volume":"38","author":"Cooper","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.pt.2014.07.003","article-title":"Human Toxocariasis: Current Advances in Diagnostics, Treatment, and Interventions","volume":"30","author":"Moreira","year":"2014","journal-title":"Trends Parasitol."},{"key":"ref_12","first-page":"81","article-title":"dos Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers","volume":"12","author":"Chieffi","year":"2021","journal-title":"Res. Rep. Trop. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Smith, H., and Noordin, R. (2006). Diagnostic Limitations and Future Trends in the Serodiagnosis of Human Toxocariasis. Toxocara Enigm. Parasite, 89\u2013112.","DOI":"10.1079\/9781845930264.0089"},{"key":"ref_14","unstructured":"Meyers, W.M., Neafie, R.C., Marty, A.M., and Wear, D.J. (2000). Toxocariasis. Pathology of Infectious Diseases, Volume 1: Helminthiases, Armed Forces Institute of Pathology, American Registry of Pathology."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2012.03.011","article-title":"Association between Contamination of Public Squares and Seropositivity for Toxocara spp. in Children","volume":"188","author":"Manini","year":"2012","journal-title":"Vet. Parasitol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1590\/S0037-86822011000400024","article-title":"Prevalence and Risk Factors of Human Infection by Toxocara Canis in Salvador, State of Bahia, Brazil","volume":"44","author":"Souza","year":"2011","journal-title":"Rev. Da Soc. Bras. De Med. Trop."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.actatropica.2013.06.018","article-title":"Seroprevalence and Risk Factors for Toxocara Infection in Children from an Urban Large Setting in Northeast Brazil","volume":"128","author":"Figueiredo","year":"2013","journal-title":"Acta Trop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cimid.2019.02.002","article-title":"A Survey on Toxocara Cati Eggs on the Hair of Stray Cats: A Potential Risk Factor for Human Toxocariasis in Northeastern Iran","volume":"64","author":"Bakhshani","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.vetpar.2014.10.005","article-title":"Comparison of Toxocara Eggs in Hair and Faecal Samples from Owned Dogs and Cats Collected in Ankara, Turkey","volume":"206","year":"2014","journal-title":"Vet. Parasitol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/bs.apar.2020.01.025","article-title":"Global Prevalence of Toxocara Infection in Cats","volume":"Volume 109","author":"Rostami","year":"2020","journal-title":"Advances in Parasitology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1590\/S0036-46652009000600001","article-title":"Human Toxocariasis: Contribution by Brazilian Researchers","volume":"51","author":"Chieffi","year":"2009","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"109133","DOI":"10.1016\/j.vetpar.2020.109133","article-title":"Phylogenetic Relationships among Toxocara spp. and Toxascaris sp. from Different Regions of the World","volume":"282","author":"Fava","year":"2020","journal-title":"Vet. Parasitol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1111\/tmi.12607","article-title":"Identification of Immunodominant Antigens for the Laboratory Diagnosis of Toxocariasis","volume":"20","author":"Zhan","year":"2015","journal-title":"Trop. Med. Int. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1590\/S0036-46652011000200001","article-title":"Potential Immunological Markers for Diagnosis and Therapeutic Assessment of Toxocariasis","volume":"53","author":"Jacob","year":"2011","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Magnaval, J.-F., Bouhsira, E., and Fillaux, J. (2022). Therapy and Prevention for Human Toxocariasis. Microorganisms, 10.","DOI":"10.3390\/microorganisms10020241"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"34752","DOI":"10.1038\/s41598-025-18345-8","article-title":"Visceral Larva Migrans among Hospitalized Patients in Poland: Analysis of National Hospital Discharge Data from 2014 to 2023","volume":"15","author":"Kanecki","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00436-025-08557-2","article-title":"Toxocariasis, Risk and Protective Factors, and Mental Health Difficulties in Early Childhood: A Comparison of Marginalised Roma Communities and the Majority Population","volume":"124","author":"Kalinova","year":"2025","journal-title":"Parasitol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ardelean, A.A., Lighezan, R., Ursoniu, S., Sprintar, S.A., Oatis, D.A., Mihu, A.G., Lupu, M.A., and Olariu, T.R. (2025). First Report on the Seroprevalence and Risk Factors Associated with Toxocara Infection in Blood Donors from Romania. Pathogens, 14.","DOI":"10.3390\/pathogens14090857"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1017\/S0950268825000330","article-title":"Modelling the Risk of Food-Borne Transmission of Toxocara spp. to Humans","volume":"153","author":"Healy","year":"2025","journal-title":"Epidemiol. Infect."},{"key":"ref_30","first-page":"e77965","article-title":"Eosinophilia and IgE Elevation: An Uncommon Toxocara Infection","volume":"17","author":"Reis","year":"2025","journal-title":"Cureus"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijpara.2024.02.003","article-title":"First Use of Tissue Exudate Serology to Identify Toxocara spp. Infection in Food Animals","volume":"54","author":"Healy","year":"2024","journal-title":"Int. J. Parasitol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102288","DOI":"10.1016\/j.tmaid.2022.102288","article-title":"Toxocariasis in Migrant Children: A 6 Years\u2019 Experience in a Reference Pediatric Unit in Spain","volume":"47","author":"Bustamante","year":"2022","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e13651","DOI":"10.1111\/tid.13651","article-title":"Splenic Abscess Caused by Toxocara spp. in a Lung Transplant Recipient, Marseille, France","volume":"23","author":"Balacheff","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jiph.2020.04.006","article-title":"Seroepidemiology of Human Toxocariasis in Selected Population Groups in Slovakia: A Cross-Sectional Study","volume":"13","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kantarakia, C., Tsoumani, M.E., Galanos, A., Mathioudakis, A.G., Giannoulaki, E., Beloukas, A., and Voyiatzaki, C. (2020). Comparison of the Level of Awareness about the Transmission of Echinococcosis and Toxocariasis between Pet Owners and Non-Pet Owners in Greece. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155292"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Macejova, Z., Kristian, P., Janicko, M., Halanova, M., Drazilova, S., Antolova, D., Marekova, M., Pella, D., Madarasova-Geckova, A., and Jarcuska, P. (2020). The Roma Population Living in Segregated Settlements in Eastern Slovakia Has a Higher Prevalence of Metabolic Syndrome, Kidney Disease, Viral Hepatitis B and E, and Some Parasitic Diseases Compared to the Majority Population. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17093112"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13071-020-04086-2","article-title":"Survey of UK Pet Owners Quantifying Internal Parasite Infection Risk and Deworming Recommendation Implications","volume":"13","author":"Pennelegion","year":"2020","journal-title":"Parasit. Vectors"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2478\/s11686-019-00121-0","article-title":"Seroprevalence of Larval Toxocarosis in the Czech Republic","volume":"65","author":"Skulinova","year":"2020","journal-title":"Acta Parasitol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1051\/parasite\/2020029","article-title":"Human Toxocariasis and Atopy","volume":"27","author":"Magnaval","year":"2020","journal-title":"Parasite"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/bs.apar.2020.01.014","article-title":"Seroprevalence of Human Toxocarosis in Europe: A Review and Meta-Analysis","volume":"109","author":"Strube","year":"2020","journal-title":"Adv. Parasitol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10072-019-04017-9","article-title":"Lack of Evidence for Toxocara Infection in Italian Myelitis Patients","volume":"41","author":"Nicoletti","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.12659\/MSM.910749","article-title":"A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe","volume":"24","author":"Moskal","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Peju, M., Deroux, A., Pelloux, H., Bouillet, L., and Epaulard, O. (2018). Hypereosinophilia: Biological Investigations and Etiologies in a French Metropolitan University Hospital, and Proposed Approach for Diagnostic Evaluation. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204468"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Overbosch, F.W., van Gool, T., Matser, A., and Sonder, G.J.B. (2018). Low Incidence of Helminth Infections (Schistosomiasis, Strongyloidiasis, Filariasis, Toxocariasis) among Dutch Long-Term Travelers: A Prospective Study, 2008-2011. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197770"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s00436-018-5833-7","article-title":"Toxocarosis in Children: Poor Hygiene Habits and Contact with Dogs Is Related to Longer Treatment","volume":"117","author":"Kroten","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12223-017-0572-1","article-title":"Assessment of the Diagnostic Value of Specific Anti-Toxocara IgA in Slovakian Patients Suspected to Have Toxocarosis","volume":"63","author":"Ondriska","year":"2018","journal-title":"Folia Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/cea.13055","article-title":"Zoonotic Helminth Exposure and Risk of Allergic Diseases: A Study of Two Generations in Norway","volume":"48","author":"Svanes","year":"2018","journal-title":"Clin. Exp. Allergy"},{"key":"ref_48","first-page":"124","article-title":"Toxocara spp. Seronegativity in Czech Patients with Early Form of Multiple Sclerosis\u2013Clinically Isolated Syndrome","volume":"66","year":"2017","journal-title":"Epidemiol. Mikrobiol. Imunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"335.e1","DOI":"10.1016\/j.cmi.2017.02.024","article-title":"Seroprevalence of Five Neglected Parasitic Diseases among Immigrants Accessing Five Infectious and Tropical Diseases Units in Italy: A Cross-Sectional Study","volume":"23","author":"Martelli","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/fpd.2016.2190","article-title":"Seroprevalence and Risk Factors for Toxocara canis Infection in Serbia During 2015","volume":"14","author":"Gabrielli","year":"2017","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/zph.12259","article-title":"Epidemiology of Toxocariasis in England and Wales","volume":"63","author":"Halsby","year":"2016","journal-title":"Zoonoses Public Health"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lassen, B., Janson, M., Viltrop, A., Neare, K., H\u00fctt, P., Golovljova, I., Tummeleht, L., and Jokelainen, P. (2016). Serological Evidence of Exposure to Globally Relevant Zoonotic Parasites in the Estonian Population. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164142"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1007\/s00436-016-5139-6","article-title":"Seroepidemiology of Human Toxocara and Ascaris Infections in the Netherlands","volume":"115","author":"Harms","year":"2016","journal-title":"Parasitol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"384","DOI":"10.12891\/ceog2100.2016","article-title":"Seroepidemiological Investigation of Toxocara canis in a Female Greek Pregnant Population in the Area of Athens","volume":"43","author":"Papavasilopoulos","year":"2016","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.exppara.2015.10.006","article-title":"Immunodiagnostic Approaches for the Detection of Human Toxocarosis","volume":"159","author":"Ondriska","year":"2015","journal-title":"Exp. Parasitol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lee, R.M., Moore, L.B., Bottazzi, M.E., and Hotez, P.J. (2014). Toxocariasis in North America: A Systematic Review. PLoS Neglected Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003116"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4269\/ajtmh.13-0727","article-title":"Neglected Parasitic Infections in the United States: Needs and Opportunities","volume":"90","author":"Parise","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"810","DOI":"10.4269\/ajtmh.13-0725","article-title":"Neglected Parasitic Infections in the United States: Toxocariasis","volume":"90","author":"Woodhall","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2133.2009.09411.x","article-title":"Comparative Assessment of Enzyme-Linked Immunosorbent Assay and Western Blot for the Diagnosis of Toxocariasis in Patients with Skin Disorders","volume":"162","author":"Bellanger","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s40475-013-0001-8","article-title":"Immunodiagnosis of Human Toxocariasis and Prospects for Improved Diagnostics","volume":"1","author":"Wilkins","year":"2014","journal-title":"Curr. Trop. Med. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.apar.2020.01.003","article-title":"Chapter Seven\u2013Serodiagnostic Methods for Diagnosing Larval Toxocariasis","volume":"Volume 109","author":"Bowman","year":"2020","journal-title":"Advances in Parasitology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40249-018-0437-0","article-title":"Toxocariasis: A Silent Threat with a Progressive Public Health Impact","volume":"7","author":"Chen","year":"2018","journal-title":"Infect. Dis. Poverty"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Baharudeen, Z., Noordin, R., Soon, L.T., Balachandra, D., Anuar, N.S., Mustafa, F.H., and Rahumatullah, A. (2022). Isolation and Production of Human Monoclonal Antibody Proteins against a Toxocara Canis Excretory-Secretory Recombinant Antigen. Pathogens, 11.","DOI":"10.3390\/pathogens11111232"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"13606","DOI":"10.1021\/acs.analchem.1c02876","article-title":"Nanobody-Based Immunosensor Detection Enhanced by Photocatalytic-Electrochemical Redox Cycling","volume":"93","author":"Trashin","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13071-020-04113-2","article-title":"Electrochemical Detection of Toxocara Canis Excretory-Secretory Antigens in Children from Rural Communities in Esmeraldas Province, Ecuador: Association between Active Infection and High Eosinophilia","volume":"13","author":"Trashin","year":"2020","journal-title":"Parasit. Vectors"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11582","DOI":"10.1021\/acs.analchem.9b01687","article-title":"Fast One-Step Ultrasensitive Detection of Toxocara Canis Antigens by a Nanobody-Based Electrochemical Magnetosensor","volume":"91","author":"Trashin","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zibaei, M., Rokni, M.B., Sohrabi, N., Sepahvand, A., Raiesi, O., Getso, M.I., Alizadeh, G., Ibrahim, A., Yarahmadi, M., and Raissi, V. (2022). Changes in the Expression of miR-103a and miR-21: A Functional Diagnosis of Toxocariasis in Rats. J. Med. Microbiol., 71.","DOI":"10.1099\/jmm.0.001532"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1017\/S0031182021000342","article-title":"Development of a Low-Cost Copro-LAMP Assay for Simultaneous Copro-Detection of Toxocara Canis and Toxocara Cati","volume":"148","author":"Avila","year":"2021","journal-title":"Parasitology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/vms3.431","article-title":"Molecular Evaluation of Toxocara Species in Stray Cats Using Loop-Mediated Isothermal Amplification (Lamp) Technique as a Rapid, Sensitive and Simple Screening Assay","volume":"7","author":"Azimian","year":"2021","journal-title":"Vet. Med. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.1016\/j.parint.2020.102134","article-title":"Quantification of Toxocara Canis DNA by qPCR in Mice Inoculated with Different Infective Doses","volume":"78","author":"Terto","year":"2020","journal-title":"Parasitol. Int."},{"key":"ref_71","first-page":"e70","article-title":"Visceral Larva Migrans Detection Using PCR-RFLP in BALB\/c Mice Infected with Toxocara Canis","volume":"94","year":"2019","journal-title":"J. Helminthol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0031182020002085","article-title":"A New ELISA and Western Blot Technique Based on Recombinant TES Antigen and\/or Larval Antigen for the Detection of Toxocariasis in Humans","volume":"148","author":"Raulf","year":"2021","journal-title":"Parasitology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijpara.2019.03.004","article-title":"An Innovative Approach in the Detection of Toxocara canis Excretory\/Secretory Antigens Using Specific Nanobodies","volume":"49","author":"Sariego","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e11144","DOI":"10.1016\/j.heliyon.2022.e11144","article-title":"Evaluation of New Toxocara Canis Chimeric Antigens as an Alternative to Conventional TES-Ag for Anti-Toxocara Antibodies Detection","volume":"8","author":"Alzate","year":"2022","journal-title":"Heliyon"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-3024.2007.01010.x","article-title":"Determination of the Relative Avidity of the Specific IgG Antibodies in Human Toxocariasis","volume":"30","author":"Dziemian","year":"2008","journal-title":"Parasite Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e12400","DOI":"10.1111\/pim.12400","article-title":"Clinical Usefulness of Western Blotting and ELISA Avidity for the Diagnosis of Human Toxocariasis","volume":"39","author":"Kowalewska","year":"2017","journal-title":"Parasite Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1087057114548065","article-title":"Diagnosis of Parasitic Infections: What\u2019s Going On?","volume":"20","author":"Ricciardi","year":"2015","journal-title":"SLAS Discov."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1167\/tvst.10.8.33","article-title":"Diagnosis of Ocular Toxocariasis by Serum and Aqueous Humor IgG ELISA","volume":"10","author":"Huang","year":"2021","journal-title":"Transl. Vis. Sci. Technol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1117\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:43:27Z","timestamp":1762256607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":78,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["pathogens14111117"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14111117","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}