{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:49:38Z","timestamp":1762256978626,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006345","name":"Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University","doi-asserted-by":"publisher","award":["WF PDB 839"],"award-info":[{"award-number":["WF PDB 839"]}],"id":[{"id":"10.13039\/501100006345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Polyomaviruses (BKPyV and JCPyV) and herpesviruses (EBV, CMV) usually infect people during childhood, and may be associated, in some clinical states, with immunocompromised individuals. The aim of this study was to investigate the occurrence and coexistence of polyomavirus (BKPyV and JCPyV) and herpesvirus (CMV and EBV) DNAemia in pediatric hematology\/oncology patients, including HCT recipients, and to assess the clinical relevance of polyomaviruses DNAemia. Whole blood samples of 99 children (including 71 patients undergoing HCT) were analyzed for the DNA of the herpes- and polyomaviruses. Co-existence of herpesvirus DNAemia was checked for the patients and clinically analyzed in detail, especially for those positive for BKPyV DNA. BKPyV DNAemia was detected in 15 (15.2%) patients, with viral loads ranging from 1.2 \u00d7 103\u20131.7 \u00d7 107 DNA IU\/mL. No JCPyV DNA was detected in any of the samples. Coinfections with EBV or CMV DNAemia were observed in a subset of BKPyV-positive patients. BKPyV DNAemia was more frequent among children with leukemia and in those undergoing HCT. Our findings highlight the clinical associations between BKPyV and herpesvirus DNAemia in immunocompromised pediatric patients. Routine BKPyV DNA monitoring, alongside standard herpesvirus screening, may provide clinically valuable insights in high-risk pediatric cohorts, particularly those with hematologic malignancies and post-HCT status.<\/jats:p>","DOI":"10.3390\/pathogens14111122","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:11:16Z","timestamp":1762254676000},"page":"1122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Associations and Coexistence of Polyomavirus DNAemia with EBV and CMV in Pediatric Hematology\/Oncology Patients, Including HCT Recipients\u2014A Pilot Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-1378","authenticated-orcid":false,"given":"Tomasz","family":"Bogiel","sequence":"first","affiliation":[{"name":"Department of Propaedeutics of Medicine and Infection Prevention, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinical Microbiology Laboratory, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-3505","authenticated-orcid":false,"given":"Mateusz","family":"Rzepka","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"},{"name":"Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-9778","authenticated-orcid":false,"given":"Dagmara","family":"Depka-Radzikowska","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"},{"name":"Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-6850","authenticated-orcid":false,"given":"Patrycja","family":"Zalas-Wi\u0119cek","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"},{"name":"Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-7518","authenticated-orcid":false,"given":"Krzysztof","family":"Czy\u017cewski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinic of Pediatric, Hematology and Oncology, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Richert-Przygo\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinic of Pediatric, Hematology and Oncology, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-119X","authenticated-orcid":false,"given":"Jan","family":"Styczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinic of Pediatric, Hematology and Oncology, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"D\u0119bski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinic of Pediatric, Hematology and Oncology, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-4952","authenticated-orcid":false,"given":"El\u017cbieta","family":"Grze\u015bk","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology, Immunology and Transplantology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Clinic of Pediatric, Hematology and Oncology, Dr. Antoni Jurasz University Hospital No. 1, 85-094 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-5931","authenticated-orcid":false,"given":"Grzegorz","family":"Grze\u015bk","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Pharmacology Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-168 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-2804","authenticated-orcid":false,"given":"Piotr","family":"Kanarek","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Plant Ecology, Faculty of Agriculture and Biotechnology, Bydgoszcz University of Science and Technology, 85-029 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-9663","authenticated-orcid":false,"given":"Agnieszka","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Medical Microbiology, Chair of Microbiology, Jagiellonian University Medical College, 31-007 Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prezioso, C., and Pietropaolo, V. 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