{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:04:06Z","timestamp":1785387846097,"version":"3.55.0"},"reference-count":102,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Unit of Adana \u00c7ukurova University","award":["TYL-2023-16378"],"award-info":[{"award-number":["TYL-2023-16378"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Salmonella species isolated from chicken meat pose an increasing threat to public health. According to ECDC data, salmonellosis cases have shown a significant upward trend in many European countries between 2019 and 2023, almost reaching pre-pandemic levels. EFSA reported 77,486 confirmed human cases in the EU in 2023. This corresponds to a notification rate of 18 cases per 100,000 people, compared to 15.4 cases per 100,000 in 2022. This study evaluated the prevalence of Salmonella spp., antimicrobial resistance (AMR) profiles, and the effectiveness of natural biological preservatives in raw chicken meat obtained from retail outlets in Southeast Turkey. Among 100 samples analyzed according to ISO 6579-1:2017, suspicious colonies were detected after selective enrichment in XLD and n = 3 isolates were confirmed to be Salmonella enterica subsp. enterica serovar Infantis by real-time PCR. Disk diffusion tests performed in accordance with EUCAST showed that all isolates were resistant to beta-lactam, tetracycline, trimethoprim, sulfonomid and aminoglycoside groups. All isolates were classified as multidrug-resistant. PCR detected blaTEM-1 (all isolates), aphA1-IAB (all isolates), aadA1 (two isolates), and sul1 (all isolates), while tetA\/tetB genes were not detected. Among the natural compounds tested, carvacrol showed the strongest antimicrobial activity (MIC 1.56 \u00b5L\/mL; MBC 3.125\u20136.25 \u00b5L\/mL; inhibition zones 32\u201335 mm). Eugenol showed moderate effects with higher MIC\/MBC values (3.125\u20136.25 \u00b5L\/mL\/12.25 \u00b5L\/mL), while \u03b1-terpineol was effective only at higher concentrations. These findings are consistent with the global increase in Salmonella Infantis and AMR, supporting carvacrol followed by eugenol and \u03b1-terpineol as promising natural alternatives for controlling MDR Salmonella spp. in food safety applications.<\/jats:p>","DOI":"10.3390\/pathogens14111178","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:05:31Z","timestamp":1763463931000},"page":"1178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integrated Analysis of Salmonella Infantis in Chicken Meat: Epidemiological Surveillance, Antibiotic Resistance, and Potential Bioactive Control Agents"],"prefix":"10.3390","volume":"14","author":[{"given":"Yasin","family":"Tekin","sequence":"first","affiliation":[{"name":"General Directory of Meat and Milk Board, Adana Meat Directory, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-3342","authenticated-orcid":false,"given":"Hatice","family":"Yazgan","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Technology, Faculty of Ceyhan Veterinary Medicine, Cukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin Guven","family":"Gokmen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Ceyhan Veterinary, Cukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Gungor","sequence":"additional","affiliation":[{"name":"General Directory of Meat and Milk Board, Adana Meat Directory, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Sima","family":"Uprak","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Ceyhan Veterinary, Cukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s44197-023-00160-x","article-title":"Prevalence and antimicrobial resistance profile of Salmonella isolated from human, animal and environment samples in South Asia: A 10-year Meta-analysis","volume":"13","author":"Talukder","year":"2023","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chanam\u2019e Pinedo, L., Mughini-Gras, L., Franz, E., Hald, T., and Pires, S.M. (2022). Sources and trends of human salmonellosis in Europe, 2015\u20132019: An analysis of outbreak data. Int. J. Food Microbiol., 379.","DOI":"10.1016\/j.ijfoodmicro.2022.109850"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111275","DOI":"10.1016\/j.foodcont.2025.111275","article-title":"Economic evidence for the control of Salmonella in animal-derived food systems: A scoping review","volume":"175","author":"Alvseike","year":"2025","journal-title":"Food Control"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lamichhane, B., Mawad, A.M.M., Saleh, M., Kelley, W.G., Harrington, P.J., Lovestad, C.W., Amezcua, J., Sarhan, M.M., El Zowalaty, M.E., and Ramadan, H. (2024). Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections. Antibiotics, 13.","DOI":"10.3390\/antibiotics13010076"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e70202","DOI":"10.1111\/1541-4337.70202","article-title":"An investigation about the historic global foodborne outbreaks of Salmonella spp. in eggs: From hatcheries to tables","volume":"24","author":"Carter","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Adley, C.C., and Ryan, M.P. (2025). The nature and extent of foodborne disease. Antimicrobial Food Packaging, Academic Press.","DOI":"10.1016\/B978-0-323-90747-7.00002-8"},{"key":"ref_7","unstructured":"European Food Safety Agency\/European Centre for Disease Prevention and Control (EFSA\/ECDC) (2022). Rapid Outbreak Assessment: Multi- CountryOutbreak of Salmonella Enteritidis Sequence Type (ST)11 Infections Linked to Eggs and Egg Products, Third Update."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S1473-3099(19)30418-9","article-title":"The global burden of non-typhoidal salmonella invasive disease: A systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"Stanaway","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cawthraw, S., Wales, A., Guzinski, J., Trew, J., Ring, I., Huby, T., Hussaini, A., Petrovska, L., and Martelli, F. (2025). Salmonella Infantis outbreak on six broiler units in Great Britain: Investigation, epidemiology, and control. J. Appl. Microbiol., 136.","DOI":"10.1093\/jambio\/lxaf040"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nazari Moghadam, M., Rahimi, E., Shakerian, A., and Momtaz, H. (2023). Prevalence of Salmonella typhimurium and Salmonella Enteritidis isolated from poultry meat: Virulence and antimicrobial-resistant genes. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-02908-8"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100071","DOI":"10.1016\/j.jfp.2023.100071","article-title":"Salmonella outbreaks linked to beef, United States, 2012\u20132019","volume":"86","author":"Canning","year":"2023","journal-title":"J. Food Prot."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.jfp.2023.100093","article-title":"Quantitative risk assessment of salmonella in ground beef products and the resulting impact of risk mitigation strategies on public health","volume":"86","author":"Strickland","year":"2023","journal-title":"J. Food Prot."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Campos, J., Mour\u00e3o, J., Peixe, L., and Antunes, P. (2019). Non-typhoidal Salmonella in the pig production chain: A comprehensive analysis of its impact on human health. Pathogens, 8.","DOI":"10.3390\/pathogens8010019"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/fpd.2020.2853","article-title":"Prevalence and antimicrobial susceptibility of Salmonella Serovars isolated from U.S. retail ground pork","volume":"18","author":"Broadway","year":"2021","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"EFSA (2007). Report of the task force on zoonoses data collection on the analysis of the baseline survey on the prevalence of Salmonella in broiler flocks of Gallus gallus, in the EU, 2005\u20132006. EFSA J., 98, 1\u201385.","DOI":"10.2903\/j.efsa.2007.98r"},{"key":"ref_16","first-page":"115","article-title":"Genetic Characteristics of Antimicrobial Resistance of Salmonella Isolated from Chicken in Japan","volume":"68","author":"Shahada","year":"2006","journal-title":"J. Vet. Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA) (2023). The EU Summary Report on AMR in Zoonotic and Indicator Bacteria from Humans, Animals and Food in 2021. EFSA J., 21, e07784.","DOI":"10.2903\/j.efsa.2023.7867"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1111\/ijfs.17097","article-title":"Comprehensive analysis of Salmonella in poultry meat and products in T\u00fcrkiye: Prevalence, antibiotic susceptibility and genomic characterisation","volume":"59","author":"Dishan","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_19","unstructured":"USDA (2025, August 18). Cost Estimates of Foodborne Illnesses, Available online: https:\/\/www.usda.gov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e70075","DOI":"10.1111\/1541-4337.70075","article-title":"Ensuring Egg Safety: Salmonella Survival, Control, and Virulence in the Supply Chain","volume":"24","author":"Li","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Simpson, K.M.J., Hill-Cawthorne, G.A., Ward, M.P., and Mor, S.M. (2018). Diversity of Salmonella Serotypes From Humans, Food, Domestic Animals and Wildlife in New South Wales, Australia. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3563-1"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kumar, G., Kumar, S., Jangid, H., Dutta, J., and Shidiki, A. (2025). The rise of non-typhoidal Salmonella: An emerging global public health concern. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1524287"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Osivand, Z., Rahimi, E., Shakerian, A., and Khamesipour, F. (2025). Prevalence, Antibiotic Resistance, Virulence and Antimicrobial Resistance Gene Profiles of Salmonella Species Recovered from Retail Beef and Poultry Processing Environments. BMC Microbiol., 25.","DOI":"10.1186\/s12866-025-03871-2"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1089\/mdr.2019.0475","article-title":"Antimicrobial resistance in nontyphoidal Salmonella isolates from human and swine sources in Brazil: A systematic review of the past three decades","volume":"26","author":"Rodrigues","year":"2020","journal-title":"Microb. Drug Resist."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e03364-22","DOI":"10.1128\/spectrum.03364-22","article-title":"Antimicrobial resistance and mechanisms of azithromycin resistance in nontyphoidal Salmonella isolates in Taiwan, 2017 to 2018","volume":"11","author":"Chiou","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/fpd.2022.0080","article-title":"An overview of antimicrobial resistance profiles of publicly available Salmonella genomes with sufficient quality and metadata","volume":"20","author":"Nuanmuang","year":"2023","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/10942912.2019.1582541","article-title":"Antioxidant and Antibacterial Activity of Seven Predominant Terpenoids","volume":"22","author":"Wang","year":"2019","journal-title":"Int. J. Food Prop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16673","DOI":"10.1007\/s13399-022-03625-4","article-title":"Investigation of Bioactive Compounds and Antimicrobial Properties of Aqueous Garlic Extracts","volume":"14","author":"Yazgan","year":"2024","journal-title":"Biomass Convers. Biorefin."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1002\/fsn3.2994","article-title":"Therapeutic application of carvacrol: A comprehensive review","volume":"10","author":"Imran","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"M\u0105czka, W., Twardawska, M., Grabarczyk, M., and Wi\u0144ska, K. (2023). Carvacrol\u2014A natural phenolic compound with antimicrobial properties. Antibiotics, 12.","DOI":"10.3390\/antibiotics12050824"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1007\/s11947-025-03759-z","article-title":"Enhanced pathogen control through thymol and carvacrol nanoemulsions: A microfluidization approach","volume":"18","author":"Ozogul","year":"2025","journal-title":"Food Bioprocess Technol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ulanowska, M., and Olas, B. (2021). Biological Properties and Prospects for the Application of Eugenol\u2014A Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073671"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1742-7843.2012.00875.x","article-title":"\u03b1-Terpineol Reduces Mechanical Hypernociception and Inflammatory Response","volume":"111","author":"Marques","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/13880200601028388","article-title":"Evaluation of the Anticonvulsant Activity of \u03b1-Terpineol","volume":"45","author":"Quintans","year":"2007","journal-title":"Pharm. Biol."},{"key":"ref_35","first-page":"1911","article-title":"Alpha-Terpineol: A Potential Anticancer Agent","volume":"30","author":"Hassan","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hussein, K.N., Csehi, B., J\u00f3zsef, S., Ferenc, H., Kisk\u00f3, G., Dalmadi, I., and Friedrich, L. (2021). Effect of \u03b1-Terpineol on Chicken Meat Quality during Refrigerated Conditions. Foods, 10.","DOI":"10.3390\/foods10081855"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/chem-2018-0040","article-title":"\u03b1-Terpineol, a natural monoterpene: A review of its biological properties","volume":"16","author":"Khaleel","year":"2018","journal-title":"Open Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Knez Hrn\u010di\u010d, M., C\u00f6r, D., Knez, \u017d., and Hrn\u010di\u010d, M.K. (2020). Extraction techniques and analytical methods for characterization of active compounds in Origanum species. Molecules, 25.","DOI":"10.3390\/molecules25204735"},{"key":"ref_39","unstructured":"(2017). Microbiology of the Food Chain\u2014Horizontal Method for the Detection, Enumeration and Serotyping of Salmonella\u2014Part 1: Detection of Salmonella spp. (Standard No. ISO 6579-1:2017). Available online: https:\/\/www.eucast.org."},{"key":"ref_40","unstructured":"EUCAST (European Committee on Antimicrobial Susceptibility Testing) (2025, September 23). Breakpoint Tables for Interpretation of MICs and Zone Diameters, Version 15.0. Available online: https:\/\/www.eucast.org\/clinical_breakpoints."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/mcpr.2001.0363","article-title":"Multiplex PCR for the Detection of Tetracycline Resistant Genes","volume":"15","author":"Ng","year":"2001","journal-title":"Mol. Cell. Probes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for Rapid Detection of Genes Encoding CTX-M ESBLs","volume":"57","author":"Woodford","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jac\/dkp498","article-title":"Development of a Set of Multiplex PCR Assays for the Detection of Genes Encoding Important \u03b2-Lactamases in Enterobacteriaceae","volume":"65","author":"Dallenne","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1128\/JCM.38.6.2429-2433.2000","article-title":"Rapid Identification of MRSA and Species Confirmation Using Real-Time Fluorescence PCR","volume":"38","author":"Reischl","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"ref_45","first-page":"7386","article-title":"Expression of Antibiotic Resistance Genes in Salmonella Isolates from Poultry","volume":"73","author":"Xu","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/jac\/dkm204","article-title":"Multiplex PCR for Detection of Plasmid-Mediated qnr Genes in ESBL-Producing Enterobacterial Isolates","volume":"60","author":"Cattoir","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_47","first-page":"304","article-title":"Quinolone-Resistant Salmonella Hadar\/Enteritidis from Danish Poultry","volume":"64","author":"Cavaco","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1128\/AAC.47.7.2242-2248.2003","article-title":"Plasmid-Mediated Quinolone Resistance in Clinical Escherichia coli from Shanghai, China","volume":"47","author":"Wang","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_49","first-page":"1025","article-title":"Characterization of Antimicrobial Resistance and Class 1 and 2 Integrons in Salmonella enterica Isolates from Different Sources in Portugal","volume":"56","author":"Antunes","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1128\/AAC.40.11.2562","article-title":"Detection of Erythromycin-Resistant Determinants by PCR","volume":"40","author":"Sutcliffe","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_51","unstructured":"CLSI (Clinical and Laboratory Standards Institute) (2024). Performance Standards for Antimicrobial Susceptibility Testing, CLSI. [34th ed.]. CLSI Supplement M100."},{"key":"ref_52","unstructured":"Aytar, F. (2019). Do\u011fal Bile\u015fiklerin Antibakteriyel Etkisinin Salmonella spp. \u00dczerine Kar\u015f\u0131la\u015ft\u0131rmal\u0131 Olarak Ara\u015ft\u0131r\u0131lmas\u0131. [Master\u2019s Thesis, \u0130stanbul \u00dcniversitesi]."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmi.2015.12.004","article-title":"Salmonellosis: The Role of Poultry Meat","volume":"22","author":"Antunes","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3201\/eid3004.231031","article-title":"A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen","volume":"30","author":"Mattock","year":"2024","journal-title":"Emerg. Infect. Dis."},{"key":"ref_55","first-page":"73","article-title":"Salmonella infantis","volume":"94","year":"2023","journal-title":"J. Turk. Vet. Med. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8872137","DOI":"10.1155\/2021\/8872137","article-title":"Salmonella Serovars, Antibiotic Resistance, and Virulence Factors Isolated from Chickens and Ready-to-Eat Gizzards in Nigeria","volume":"2021","author":"Raji","year":"2021","journal-title":"Int. J. Food Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15312\/EurasianJVetSci.2018.196","article-title":"Presence and Antibiotic Resistance of Salmonella spp. Isolated from Chicken Meat and Giblets Consumed in Konya, Turkey","volume":"34","author":"Telli","year":"2018","journal-title":"Eurasian J. Vet. Sci."},{"key":"ref_58","first-page":"1320","article-title":"Identification of Virulence Genes, \u03b2-Lactams and Quinolone Resistance Genes, and Integrons in Salmonella from Retail Chicken in Egypt","volume":"10","author":"Hassan","year":"2021","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"ref_59","first-page":"M1044","article-title":"Prevalence and Characterization of Salmonella Isolated from Chicken Meat in Turkey","volume":"80","author":"Erol","year":"2015","journal-title":"J. Food Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.33188\/vetheder.497569","article-title":"\u00c7i\u011f Tavuk Etlerinden \u0130zole Edilen Salmonella spp. Su\u015flar\u0131n\u0131n Antibiyotik Duyarl\u0131l\u0131klar\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131","volume":"90","author":"Babacan","year":"2019","journal-title":"Vet. Hekimler Derne\u011fi Derg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1292\/jvms.19-0677","article-title":"Effects of Climatic Elements on Salmonella Contamination in Broiler Meat in Japan","volume":"82","author":"Ishihara","year":"2020","journal-title":"J. Vet. Med. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.14202\/vetworld.2021.3138-3143","article-title":"Detection of Microbial Contamination in Chicken Meat from Local Markets in Surabaya, Indonesia","volume":"14","author":"Wardhana","year":"2021","journal-title":"Vet. World"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA), and European Centre for Disease Prevention and Control (ECDC) (2019). The European Union One Health 2018 Zoonoses Report. EFSA J., 17, e05926.","DOI":"10.2903\/j.efsa.2019.5926"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"102655","DOI":"10.1016\/j.psj.2023.102655","article-title":"Comparison of Antimicrobial Resistance among Salmonella enterica Serovars Isolated from Canadian Turkey Flocks, 2013\u20132021","volume":"102","author":"Sodagari","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated Functional Classification of \u03b2-Lactamases. Antimicrob","volume":"54","author":"Bush","year":"2010","journal-title":"Agents Chemother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/CMR.14.4.933-951.2001","article-title":"Extended-Spectrum \u03b2-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection","volume":"14","author":"Bradford","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1128\/AAC.01707-08","article-title":"Resistance Plasmid Families in Enterobacteriaceae","volume":"53","author":"Carattoli","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jac\/dkg362","article-title":"Phenotypic and Genotypic Characterization of Antimicrobial Resistance in German Escherichia coli Isolates from Cattle, Swine and Poultry","volume":"52","author":"Guerra","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1089\/mdr.2017.0148","article-title":"Antimicrobial Resistance in Commensal Escherichia coli and Salmonella enterica from Food Animals in Poland","volume":"24","author":"Wasyl","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Acar, S., Bulut, E., Stasiewicz, M.J., and Soyer, Y. (2019). Genome Analysis of Antimicrobial Resistance, Virulence, and Plasmid Presence in Turkish Salmonella Serovar Infantis Isolates. Int. J. Food Microbiol., 307.","DOI":"10.1016\/j.ijfoodmicro.2019.108275"},{"key":"ref_71","first-page":"387","article-title":"Multidrug-Resistant Salmonella Infantis in Broiler Chickens and Humans in Hungary: The Need for Coordinated Monitoring","volume":"45","author":"Davies","year":"2012","journal-title":"Food Res. Int."},{"key":"ref_72","first-page":"19","article-title":"Salmonella enterica subsp. enterica Serovar Infantis from Meat Products and Human Infections in Switzerland: Phenotypic and Genotypic Antimicrobial Resistance and Phylogenetic Analysis","volume":"73","author":"Hindermann","year":"2017","journal-title":"Food Control"},{"key":"ref_73","first-page":"157","article-title":"Antimicrobial Resistance Patterns and Distribution of Resistance Genes in Salmonella Isolates from Iranian Poultry Farms","volume":"4","author":"Rahmani","year":"2013","journal-title":"Vet. Res. Forum"},{"key":"ref_74","first-page":"146","article-title":"Resistance Genes in Salmonella Isolates from Food and Human Sources in Denmark","volume":"20","author":"Bacci","year":"2014","journal-title":"Microb. Drug Resist."},{"key":"ref_75","unstructured":"Archer, J.R., Otchere, J., Osei, G.Y., Pappoe, M.K., Agyapong, A., Newman, M.J., Andoh, L.A., Dickens, C., Asante-Poku, A., and Harrison, E.M. (2023). Prevalence and Resistance Genes of Salmonella spp. Isolated from Poultry in Ghana. Front. Microbiol., 14."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2958.1995.tb02368.x","article-title":"Mobile Gene Cassettes and Integrons: Capture and Spread of Genes by Site-Specific Recombination","volume":"15","author":"Hall","year":"1995","journal-title":"Mol. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.drup.2012.12.001","article-title":"Extended-Spectrum Cephalosporin-Resistant Gram-Negative Organisms in Livestock: An Emerging Problem for Human Health?","volume":"16","author":"Seiffert","year":"2013","journal-title":"Drug Resist. Updates"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside Modifying Enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updates"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/mr.57.1.138-163.1993","article-title":"Molecular Genetics of Aminoglycoside Resistance Genes and Familial Relationships of the Aminoglycoside-Modifying Enzymes","volume":"57","author":"Shaw","year":"1993","journal-title":"Microbiol. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"van Hoek, A.H., Mevius, D., Guerra, B., Mullany, P., Roberts, A.P., and Aarts, H.J. (2011). Acquired Antibiotic Resistance Genes: An Overview. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00203"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2478\/s11756-011-0051-0","article-title":"Phenotypic and Genetic Characterization of Multidrug-Resistant Salmonella Infantis Strains Isolated from Broiler Chicken Meats in Turkey","volume":"66","year":"2011","journal-title":"Biologia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1086\/345880","article-title":"Multidrug Resistance among Enterobacteriaceae Is Strongly Associated with the Presence of Integrons","volume":"187","author":"Blok","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_83","first-page":"102567","article-title":"Antimicrobial Resistance in Salmonella Isolated from Frozen Chicken Meat in China","volume":"103","author":"Peng","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"708","DOI":"10.55730\/1300-0128.4245","article-title":"Prevalence and Antibiotic Resistance Profiles of Salmonella spp. in Chicken Meat","volume":"46","author":"Tuncay","year":"2022","journal-title":"Turk. J. Vet. Anim. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., and Mnif, W. (2016). Essential Oils\u2019 Chemical Characterization and Investigation of Some Biological Activities: A Critical Review. Medicines, 3.","DOI":"10.3390\/medicines3040025"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Angane, M., Swift, S., Huang, K., Butts, C.A., and Quek, S.Y. (2022). Essential Oils and Their Major Components: Updated Review on Antimicrobial Activities, Mechanism of Action and Potential Food Industry Applications. Foods, 11.","DOI":"10.3390\/foods11030464"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"108480","DOI":"10.1016\/j.foodcont.2021.108480","article-title":"Synergistic Effects of Monocaprin and Carvacrol against Escherichia coli O157:H7 and Salmonella Typhimurium in Chicken Meat Preservation","volume":"132","author":"Ma","year":"2022","journal-title":"Food Control"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"104046","DOI":"10.1016\/j.micpath.2020.104046","article-title":"Antimicrobial Potential of Carvacrol against Uropathogenic E. coli","volume":"142","author":"Khan","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e20210550","DOI":"10.1590\/0001-3765202120210550","article-title":"Combined Effect of Carvacrol, Thymol and Nisin against Staphylococcus aureus and Salmonella Enteritidis","volume":"93","author":"Heckler","year":"2021","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_90","first-page":"149","article-title":"Determination of Time-Dependent Antibacterial Activities of Curcumin, Carvacrol and Styrax Liquidus on Salmonella Enteritidis. Ankara Univ","volume":"69","author":"Keyvan","year":"2022","journal-title":"Vet. Fak. Derg."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Boyer, E., Gal\u00e1n-Rela\u00f1o, \u00c1., Romero-Salmoral, A., Barraza, P., G\u00f3mez-Gasc\u00f3n, L., Tarradas, C., Luque, I., de Aguiar, F.C., and Lorenzo, B.H. (2024). Post-Antibiotic and Post-Sub-MIC Effects of Carvacrol against Salmonella Typhimurium. Animals, 14.","DOI":"10.3390\/ani14182631"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cui, H., Chen, X., Aziz, T., Mohamed, R.A.E.H., Al-Asmari, F., Alshammari, J.M., Al-Joufi, F.A., Shi, C., and Lin, L. (2025). Inactivation Mechanisms of Carvacrol on Salmonella Typhimurium and Its Combined Inhibitory Effects with 405 nm Blue Light. Int. J. Food Microbiol., 414.","DOI":"10.1016\/j.ijfoodmicro.2025.111276"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.psj.2022.101801","article-title":"The Protective Effect and Potential Mechanisms of Eugenol against Salmonella Infections","volume":"101","author":"Zhao","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105314","DOI":"10.1016\/j.micpath.2021.105314","article-title":"Eugenol Exposure in vitro Inhibits T3SS and TIF Virulence Genes in Salmonella Typhimurium","volume":"162","author":"Zhao","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"109764","DOI":"10.1016\/j.foodcont.2023.109764","article-title":"Synergistic Antibacterial Effect of DNase I and Eugenol against Salmonella Enteritidis Biofilm","volume":"150","author":"Kim","year":"2023","journal-title":"Food Control"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"111348","DOI":"10.1016\/j.foodcont.2025.111348","article-title":"Innovative Food Safety Strategy: Eugenol Nanoemulsion with Post-Biotic Biopolymer for Biofilm Inhibition","volume":"176","author":"Balyan","year":"2025","journal-title":"Food Control"},{"key":"ref_97","first-page":"1625","article-title":"Investigation of Antibacterial Activity of Carvacrol, Alpha-Terpineol and Eugenol on ESBL-Producing Escherichia coli Strains Isolated from Chicken Meat","volume":"13","year":"2025","journal-title":"Turk. J. Agric. Food Sci. Technol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Akermi, S., Smaoui, S., Chaari, M., Elhadef, K., Gentile, R., Hait, M., Roymahapatra, G., and Mellouli, L. (2024). Combined In Vitro\/In Silico Approaches and Safety Assessment of Thymol and Carvacrol. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202301575"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Asadi, S., Nayeri-Fasaei, B., Zahraei-Salehi, T., Yahya-Rayat, R., Shams, N., and Sharifi, A. (2023). Antibacterial and Anti-Biofilm Properties of Carvacrol Alone and in Combination with Cefixime against E. coli. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-02797-x"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2010.04.025","article-title":"Eugenol (an Essential Oil of Clove) Acts as an Antibacterial Agent against Salmonella Typhi","volume":"130","author":"Devi","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijfoodmicro.2015.02.030","article-title":"Empirical Prediction and Validation of Antibacterial Inhibitory Effects of Various Plant Essential Oils on Common Pathogenic Bacteria","volume":"202","author":"Evrendilek","year":"2015","journal-title":"Int. J. Food Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100406","DOI":"10.1016\/j.hermed.2020.100406","article-title":"Mechanisms of Bactericidal Action of Eugenol against Escherichia coli","volume":"26","author":"Jeyakumar","year":"2021","journal-title":"J. Herb. Med."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:27:13Z","timestamp":1763465233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/11\/1178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":102,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["pathogens14111178"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14111178","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]}}}