{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:47:50Z","timestamp":1792003670287,"version":"4.4.0"},"reference-count":181,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The gastrointestinal (GI) tract contributes significantly to the pathogenesis of acute respiratory distress syndrome (ARDS) by influencing systemic inflammation and sepsis, which are key factors in the development of multiple organ dysfunction syndrome (MODS), while the significant impact of gut microbiota in critically ill patients, including those with sepsis and ARDS, further underscores its importance. The intestinal microbiota is vital to immune system function, responsible for triggering around 80% of immune responses. Therefore, it may be hypothesized that modifying fecal microbiota, such as through fecal microbiota transplantation (FMT), could serve as a valuable therapeutic approach for managing inflammatory diseases like lung injury (LI)\/ARDS. Indeed, emerging experimental research suggests that FMT may have beneficial effects in ARDS models by improving inflammation, oxidative stress, LI, and oxygenation. However, well-designed randomized clinical trials in patients with ARDS are still lacking. Our study seeks to examine how therapeutic interventions such as FMT might benefit LI\/ARDS patients by exploring the interactions between the gut and lungs in this context.<\/jats:p>","DOI":"10.3390\/pathogens14121206","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:39:43Z","timestamp":1764167983000},"page":"1206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting Gut\u2013Lung Crosstalk in Acute Respiratory Distress Syndrome: Exploring the Therapeutic Potential of Fecal Microbiota Transplantation"],"prefix":"10.3390","volume":"14","author":[{"given":"Mairi","family":"Ziaka","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Inselspital, University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients with Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"ref_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin Definition","volume":"307","author":"Force","year":"2012","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13054-018-2126-6","article-title":"Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries","volume":"22","author":"Abe","year":"2018","journal-title":"Crit. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1164\/rccm.200909-1427SO","article-title":"Innate immune recognition in infectious and noninfectious diseases of the lung","volume":"181","author":"Opitz","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury","volume":"133","author":"Imai","year":"2008","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm.163.6.2004035","article-title":"Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome","volume":"163","author":"Ware","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1165\/rcmb.F305","article-title":"Acute lung injury and the acute respiratory distress syndrome: Four decades of inquiry into pathogenesis and rational management","volume":"33","author":"Matthay","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_10","first-page":"23","article-title":"Organ crosstalk during acute lung injury, acute respiratory distress syndrome, and mechanical ventilation","volume":"18","author":"Quilez","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13054-024-04966-4","article-title":"Exploring the lung-gut direction of the gut-lung axis in patients with ARDS","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"key":"ref_12","first-page":"160","article-title":"The effects of mechanical ventilation on the gut and abdomen","volume":"12","author":"Putensen","year":"2006","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1067\/msy.2002.116408","article-title":"Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings?","volume":"131","author":"Deitch","year":"2002","journal-title":"Surgery"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molmed.2013.08.004","article-title":"Redefining the gut as the motor of critical illness","volume":"20","author":"Mittal","year":"2014","journal-title":"Trends Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1365-2036.2006.03174.x","article-title":"Review article: Bacterial translocation in the critically ill-evidence and methods of prevention","volume":"25","author":"Gatt","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1179\/acb.2007.62.s1.022","article-title":"Defining gastrointestinal failure","volume":"62","author":"Reintam","year":"2007","journal-title":"Acta Clin. Belg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jss.2013.01.064","article-title":"Bacterial translocation in an experimental model of multiple organ dysfunctions","volume":"183","author":"Louis","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Dickson, R.P., Singer, B.H., Newstead, M.W., Falkowski, N.R., Erb-Downward, J.R., Standiford, T.J., and Huffnagle, G.B. (2016). Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat. Microbiol., 1.","DOI":"10.1038\/nmicrobiol.2016.113"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF00254795","article-title":"Prevention of colonization and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis","volume":"13","author":"Unertl","year":"1987","journal-title":"Intensive Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1007\/s00134-012-2690-1","article-title":"Selective decontamination of the digestive tract: The mechanism of action is control of gut overgrowth","volume":"38","author":"Silvestri","year":"2012","journal-title":"Intensive Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/CCM.0b013e3181d9db8c","article-title":"Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: Systematic review of randomized controlled trials","volume":"38","author":"Silvestri","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S2213-2600(15)00427-0","article-title":"The microbiome and critical illness","volume":"4","author":"Dickson","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.173.6.4137","article-title":"The essential role of the intestinal microbiota in facilitating acute inflammatory responses","volume":"173","author":"Souza","year":"2004","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature15367","article-title":"Neutrophil ageing is regulated by the microbiome","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00000658-198909000-00010","article-title":"Does the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals","volume":"210","author":"Rush","year":"1989","journal-title":"Ann. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/archsurg.1972.04180030067015","article-title":"The lung lesion in four different types of shock in rabbits","volume":"104","author":"Cuevas","year":"1972","journal-title":"Arch. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wiertsema, S.P., van Bergenhenegouwen, J., Garssen, J., and Knippels, L.M.J. (2021). The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients, 13.","DOI":"10.3390\/nu13030886"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13054-024-05006-x","article-title":"Gut-derived immune cells and the gut-lung axis in ARDS","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"110727","DOI":"10.1016\/j.nut.2020.110727","article-title":"Protective effects of fecal microbiota transplantation in sepsis are independent of the modulation of the intestinal flora","volume":"73","author":"Avila","year":"2020","journal-title":"Nutrition"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4014\/jmb.2002.02044","article-title":"Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation","volume":"30","author":"Zhang","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2018.20046","article-title":"Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients with Ulcerative Colitis: A Randomized Clinical Trial","volume":"321","author":"Costello","year":"2019","journal-title":"JAMA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.3748\/wjg.v20.i35.12687","article-title":"A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation","volume":"20","author":"Kim","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gai, X., Wang, H., Li, Y., Zhao, H., He, C., Wang, Z., and Zhao, H. (2021). Fecal Microbiota Transplantation Protects the Intestinal Mucosal Barrier by Reconstructing the Gut Microbiota in a Murine Model of Sepsis. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.736204"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1205037","article-title":"Duodenal infusion of donor feces for recurrent Clostridium difficile","volume":"368","author":"Vrieze","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/1751-2980.12750","article-title":"Safety and efficacy of fecal microbiota transplant in 9 critically ill patients with severe and complicated Clostridium difficile infection with impending colectomy","volume":"20","author":"Alukal","year":"2019","journal-title":"J. Dig. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e600","DOI":"10.1097\/CCM.0000000000002310","article-title":"Antibiotic-Associated Apoptotic Enterocolitis in the Absence of a Defined Pathogen: The Role of Intestinal Microbiota Depletion","volume":"45","author":"Wurm","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13054-015-0738-7","article-title":"Successful treatment of severe sepsis and diarrhea after vagotomy utilizing fecal microbiota transplantation: A case report","volume":"19","author":"Li","year":"2015","journal-title":"Crit. Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13054-016-1491-2","article-title":"Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis","volume":"20","author":"Wei","year":"2016","journal-title":"Crit. Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13054-019-2604-5","article-title":"Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients","volume":"23","author":"Dai","year":"2019","journal-title":"Crit. Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e164572","DOI":"10.1172\/jci.insight.164572","article-title":"Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis","volume":"9","author":"Gurczynski","year":"2023","journal-title":"JCI Insight"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2353396","DOI":"10.1080\/19490976.2024.2353396","article-title":"Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis","volume":"16","author":"Yan","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaci.2014.06.027","article-title":"Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases","volume":"135","author":"Russell","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Negi, S., Pahari, S., Bashir, H., and Agrewala, J.N. (2019). Gut Microbiota Regulates Mincle Mediated Activation of Lung Dendritic Cells to Protect Against Mycobacterium tuberculosis. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01142"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2020.06.006","article-title":"Anti-fungal T cell responses in the lung and modulation by the gut-lung axis","volume":"56","author":"Scheffold","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Enaud, R., Prevel, R., Ciarlo, E., Beaufils, F., Wieers, G., Guery, B., and Delhaes, L. (2020). The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00009"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Winglee, K., Eloe-Fadrosh, E., Gupta, S., Guo, H., Fraser, C., and Bishai, W. (2014). Aerosol Mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097048"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/s41590-019-0451-9","article-title":"The influence of the microbiome on respiratory health","volume":"20","author":"Wypych","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1513\/AnnalsATS.201503-133AW","article-title":"The Gut-Lung Axis in Respiratory Disease","volume":"12","author":"Marsland","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13054-024-04855-w","article-title":"Pathophysiology of acute lung injury in patients with acute brain injury: The triple-hit hypothesis","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"He, S., Lin, F., Hu, X., and Pan, P. (2023). Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients-A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15224734"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ney, L.M., Wipplinger, M., Grossmann, M., Engert, N., Wegner, V.D., and Mosig, A.S. (2023). Short chain fatty acids: Key regulators of the local and systemic immune response in inflammatory diseases and infections. Open Biol., 13.","DOI":"10.1098\/rsob.230014"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Golpour, F., Abbasi-Alaei, M., Babaei, F., Mirzababaei, M., Parvardeh, S., Mohammadi, G., and Nassiri-Asl, M. (2023). Short chain fatty acids, a possible treatment option for autoimmune diseases. Biomed. Pharmacother., 163.","DOI":"10.1016\/j.biopha.2023.114763"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-clinpsy-050718-095432","article-title":"Man and the Microbiome: A New Theory of Everything?","volume":"15","author":"Butler","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41586-022-04427-4","article-title":"The lung microbiome regulates brain autoimmunity","volume":"603","author":"Hosang","year":"2022","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e01361-14","DOI":"10.1128\/mBio.01361-14","article-title":"Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness","volume":"5","author":"Zaborin","year":"2014","journal-title":"mBio"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10-1128","DOI":"10.1128\/mSphere.00199-16","article-title":"Extreme Dysbiosis of the Microbiome in Critical Illness","volume":"1","author":"McDonald","year":"2016","journal-title":"mSphere"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1189\/jlb.0607372","article-title":"The re-emerging role of the intestinal microflora in critical illness and inflammation: Why the gut hypothesis of sepsis syndrome will not go away","volume":"83","author":"Alverdy","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.3748\/wjg.v21.i37.10487","article-title":"Microbiome as mediator: Do systemic infections start in the gut?","volume":"21","author":"Latorre","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ccc.2015.11.004","article-title":"The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness","volume":"32","author":"Klingensmith","year":"2016","journal-title":"Crit. Care Clin."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2018.02.016","article-title":"Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection","volume":"218","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_62","first-page":"143","article-title":"New insights into the gut as the driver of critical illness and organ failure","volume":"23","author":"Meng","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ","volume":"7","author":"Shanahan","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","article-title":"Bifidobacterium mechanisms of immune modulation and tolerance","volume":"15","author":"Gavzy","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"104344","DOI":"10.1016\/j.micpath.2020.104344","article-title":"The critical role of Faecalibacterium prausnitzii in human health: An overview","volume":"149","author":"Leylabadlo","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/SHK.0000000000000565","article-title":"Mechanisms of Intestinal Barrier Dysfunction in Sepsis","volume":"46","author":"Yoseph","year":"2016","journal-title":"Shock"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhou, X., and Liao, Y. (2021). Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.779620"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/path.2525","article-title":"Disruption of tight junctions during polymicrobial sepsis in vivo","volume":"218","author":"Li","year":"2009","journal-title":"J. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00424-016-1909-3","article-title":"Claudins: Vital partners in transcellular and paracellular transport coupling","volume":"469","author":"Gunzel","year":"2017","journal-title":"Pflugers Arch."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00134-016-4613-z","article-title":"Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: A pilot study","volume":"43","author":"Lankelma","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/acs.jafc.8b06359","article-title":"Sodium Butyrate Inhibits the Inflammation of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Regulating the Toll-Like Receptor 4\/Nuclear Factor kappaB Signaling Pathway","volume":"67","author":"Liu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s10753-012-9484-z","article-title":"Short-chain fatty acids suppress lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines through inhibition of NF-kappaB pathway in RAW264.7 cells","volume":"35","author":"Liu","year":"2012","journal-title":"Inflammation"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2018.05.003","article-title":"Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells","volume":"831","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1039\/D3FO04051H","article-title":"Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice","volume":"14","author":"Shen","year":"2023","journal-title":"Food Funct."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/rccm.201702-0441OC","article-title":"Lung Microbiota is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients","volume":"197","author":"Panzer","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_76","first-page":"143","article-title":"More of the Gut in the Lung: How Two Microbiomes Meet in ARDS","volume":"91","author":"Mukherjee","year":"2018","journal-title":"Yale J. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1165\/rcmb.2020-0196TR","article-title":"The Gut-Lung Axis in Systemic Inflammation. Role of Mesenteric Lymph as a Conduit","volume":"64","author":"Ma","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eaav1080","DOI":"10.1126\/sciimmunol.aav1080","article-title":"IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis","volume":"5","author":"Bauche","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e24032","DOI":"10.1016\/j.heliyon.2024.e24032","article-title":"Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay","volume":"10","author":"Eladham","year":"2024","journal-title":"Heliyon"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5217\/ir.2018.16.1.26","article-title":"Immunological pathogenesis of inflammatory bowel disease","volume":"16","author":"Lee","year":"2018","journal-title":"Intest. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/thorax.58.12.1066","article-title":"Idiopathic chronic cough: Association with organ specific autoimmune disease and bronchoalveolar lymphocytosis","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12017-020-08633-z","article-title":"The Gut Ecosystem: A Critical Player in Stroke","volume":"23","author":"Benakis","year":"2021","journal-title":"Neuromolecular Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Thomas, R., Qiao, S., and Yang, X. (2023). Th17\/Treg Imbalance: Implications in Lung Inflammatory Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054865"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5607\/en20033","article-title":"Immunosuppression and Neuroinflammation in Stroke Pathobiology","volume":"30","author":"Jiang","year":"2021","journal-title":"Exp. Neurobiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbi.2016.11.001","article-title":"Role of microglia in a mouse model of paediatric traumatic brain injury","volume":"63","author":"Chhor","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., and Li, L. (2023). Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review. Biomed. Pharmacother., 164.","DOI":"10.1016\/j.biopha.2023.114985"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1523\/JNEUROSCI.1114-16.2016","article-title":"Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke","volume":"36","author":"Singh","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1186\/s13054-020-03320-8","article-title":"Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice","volume":"24","author":"Dessein","year":"2020","journal-title":"Crit. Care"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wang, Z., Bai, C., Hu, T., Luo, C., Yu, H., Ma, X., Liu, T., and Gu, X. (2022). Emerging trends and hotspot in gut-lung axis research from 2011 to 2021: A bibliometrics analysis. Biomed. Eng. OnLine, 21.","DOI":"10.1186\/s12938-022-00987-8"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40560-019-0372-6","article-title":"Gut integrity in critical illness","volume":"7","author":"Otani","year":"2019","journal-title":"J. Intensive Care"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.1111\/j.1749-6632.2010.05713.x","article-title":"Gut lymph and lymphatics: A source of factors leading to organ injury and dysfunction","volume":"1207","author":"Deitch","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.amjsurg.2010.05.010","article-title":"Claude H. Organ, Jr. Memorial Lecture: Splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase\u2013dependent mechanism","volume":"200","author":"Moore","year":"2010","journal-title":"Am. J. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10620-010-1418-8","article-title":"Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome","volume":"56","author":"Shimizu","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"F456","DOI":"10.1136\/fetalneonatal-2011-301373","article-title":"Gut microbial colonisation in premature neonates predicts neonatal sepsis","volume":"97","author":"Madan","year":"2012","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.ta.0000197374.99755.fe","article-title":"Altered gut flora and environment in patients with severe SIRS","volume":"60","author":"Shimizu","year":"2006","journal-title":"J. Trauma."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13054-019-2488-4","article-title":"Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death","volume":"23","author":"Xu","year":"2019","journal-title":"Crit. Care"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1707610","DOI":"10.1080\/19490976.2019.1707610","article-title":"Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis","volume":"12","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Zhang, D.W., Lu, J.L., Dong, B.Y., Fang, M.Y., Xiong, X., Qin, X.J., and Fan, X.M. (2024). Gut microbiota and its metabolic products in acute respiratory distress syndrome. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1330021"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Hu, X., Han, Z., Zhou, R., Su, W., Gong, L., Yang, Z., Song, X., Zhang, S., Shu, H., and Wu, D. (2023). Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1127369"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1053\/j.gastro.2020.05.048","article-title":"Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization","volume":"159","author":"Zuo","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/gutjnl-2020-323020","article-title":"Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19","volume":"70","author":"Yeoh","year":"2021","journal-title":"Gut"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1080\/07315724.2020.1727379","article-title":"Stool Short-Chain Fatty Acids in Critically Ill Patients with Sepsis","volume":"39","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10620-012-2334-x","article-title":"Probiotic\/synbiotic therapy for treating critically ill patients from a gut microbiota perspective","volume":"58","author":"Shimizu","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1186\/cc11413","article-title":"Prognostic impact of fecal pH in critically ill patients","volume":"16","author":"Osuka","year":"2012","journal-title":"Crit. Care"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13054-022-04127-5","article-title":"The central and biodynamic role of gut microbiota in critically ill patients","volume":"26","author":"Wozniak","year":"2022","journal-title":"Crit. Care"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/1574-6976.12075","article-title":"The first 1000 cultured species of the human gastrointestinal microbiota","volume":"38","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.clnu.2020.12.017","article-title":"Prevalence of hypophosphatemia in the ICU\u2014Results of an international one-day point prevalence survey","volume":"40","author":"Berger","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3109\/08916934.2014.938322","article-title":"The effects of the microbiota on the host immune system","volume":"47","author":"Karczewski","year":"2014","journal-title":"Autoimmunity"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free Fatty Acid Receptors in Health and Disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/mi.2016.108","article-title":"The respiratory tract microbiome and lung inflammation: A two-way street","volume":"10","author":"Huffnagle","year":"2017","journal-title":"Mucosal Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021115-105238","article-title":"The Microbiome and the Respiratory Tract","volume":"78","author":"Dickson","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7861\/clinmedicine.17-6-525","article-title":"The lung microbiome in health and disease","volume":"17","author":"Moffatt","year":"2017","journal-title":"Clin. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1164\/rccm.201710-2118OC","article-title":"Airway Microbiota is Associated with Upregulation of the PI3K Pathway in Lung Cancer","volume":"198","author":"Tsay","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"26ra25","DOI":"10.1126\/scitranslmed.3000251","article-title":"Airway PI3K pathway activation is an early and reversible event in lung cancer development","volume":"2","author":"Gustafson","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrmicro2848","article-title":"Microbial translocation in HIV infection: Causes, consequences and treatment opportunities","volume":"10","author":"Sandler","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1440-1746.2007.04933.x","article-title":"Bacterial translocation: Overview of mechanisms and clinical impact","volume":"22","author":"Balzan","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1164\/rccm.201907-1487OC","article-title":"Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients","volume":"201","author":"Dickson","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jhin.2020.04.028","article-title":"Pulmonary microbiome patterns correlate with the course of the disease in patients with sepsis-induced ARDS following major abdominal surgery","volume":"105","author":"Schmitt","year":"2020","journal-title":"J. Hosp. Infect."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Qin, N., Zheng, B., Yao, J., Guo, L., Zuo, J., Wu, L., Zhou, J., Liu, L., Guo, J., and Ni, S. (2015). Influence of H7N9 virus infection and associated treatment on human gut microbiota. Sci. Rep., 5.","DOI":"10.1038\/srep14771"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/cid\/ciaa709","article-title":"Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza","volume":"71","author":"Gu","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Sun, M., Lu, F., Yu, D., Wang, Y., Chen, P., and Liu, S. (2024). Respiratory diseases and gut microbiota: Relevance, pathogenesis, and treatment. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1358597"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e12356","DOI":"10.1002\/clt2.12356","article-title":"Gut-lung axis and asthma: A historical review on mechanism and future perspective","volume":"14","author":"Song","year":"2024","journal-title":"Clin. Transl. Allergy"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/gutjnl-2020-322599","article-title":"Gut microbiota modulates COPD pathogenesis: Role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide","volume":"71","author":"Lai","year":"2022","journal-title":"Gut"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s11864-022-01027-2","article-title":"Cancer Immunotherapy: Fecal Microbiota Transplantation Brings Light","volume":"23","author":"Zhang","year":"2022","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s12276-020-0469-y","article-title":"Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis","volume":"52","author":"Jang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s10753-024-02233-w","article-title":"Fecal Microbiota Transplantation Alleviates Airway Inflammation in Asthmatic Rats by Increasing the Level of Short-Chain Fatty Acids in the Intestine","volume":"48","author":"Lai","year":"2025","journal-title":"Inflammation"},{"key":"ref_131","first-page":"352","article-title":"A preliminary study on the effects of fecal microbiota transplantation on the intestinal microecology of patients with severe pneumonia during the convalescence period","volume":"35","author":"Zhong","year":"2023","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zhuang, L., You, Y., Zeng, S., Yu, Z., Wang, H., Chen, M., and Wen, W. (2024). Fecal microbiota transplantation in severe pneumonia: A case report on overcoming pan-drug resistant Klebsiella pneumoniae infection. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1451751"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Zhang, D., Dong, B., Chen, J., Zhang, Z., Zeng, W., Liao, L., Xiong, X., Qin, X., and Fan, X. (2025). Fecal Microbiota Transplantation Modulates Th17\/Treg Balance via JAK\/STAT Pathway in ARDS Rats. Adv. Biol., 9.","DOI":"10.1002\/adbi.202500028"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gutjnl-2016-313017","article-title":"European consensus conference on faecal microbiota transplantation in clinical practice","volume":"66","author":"Cammarota","year":"2017","journal-title":"Gut"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/gutjnl-2023-329948","article-title":"The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease","volume":"72","author":"Lopetuso","year":"2023","journal-title":"Gut"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/CCM.0000000000002382","article-title":"Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology","volume":"45","author":"Gaines","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1177\/2050640618780762","article-title":"Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: A systematic review and meta-analysis","volume":"6","author":"Ianiro","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/apt.14201","article-title":"Systematic review with meta-analysis: The efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection","volume":"46","author":"Quraishi","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/1751-2980.12933","article-title":"Efficacy and safety of fecal microbiota transplantation for treating patients with ulcerative colitis: A systematic review and meta-analysis","volume":"21","author":"Zhao","year":"2020","journal-title":"J. Dig. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"104403","DOI":"10.1016\/j.phrs.2019.104403","article-title":"Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota","volume":"148","author":"Chen","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Kang, D.W., Adams, J.B., Gregory, A.C., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., and McDonough-Means, S. (2017). Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: An open-label study. Microbiome, 5.","DOI":"10.1186\/s40168-016-0225-7"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Kang, D.W., Adams, J.B., Coleman, D.M., Pollard, E.L., Maldonado, J., McDonough-Means, S., Caporaso, J.G., and Krajmalnik-Brown, R. (2019). Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-42183-0"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson\u2019s disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Boicean, A., Neamtu, B., Birsan, S., Batar, F., Tanasescu, C., Dura, H., Roman, M.D., Hasegan, A., Bratu, D., and Mihetiu, A. (2022). Fecal Microbiota Transplantation in Patients Co-Infected with SARS-CoV2 and Clostridioides difficile. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010007"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Li, B., Yin, G.F., Wang, Y.L., Tan, Y.M., Huang, C.L., and Fan, X.M. (2020). Impact of fecal microbiota transplantation on TGF-beta1\/Smads\/ERK signaling pathway of endotoxic acute lung injury in rats. 3 Biotech, 10.","DOI":"10.1007\/s13205-020-2062-4"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"107272","DOI":"10.1016\/j.intimp.2020.107272","article-title":"Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4\/NF-kB signaling pathway","volume":"91","author":"Tang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1186\/s12967-024-05376-4","article-title":"Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions","volume":"22","author":"Hu","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_148","first-page":"1582","article-title":"Effects and mechanism of fecal transplantation on acute lung injury induced by lipopolysaccharide in rats","volume":"99","author":"Yin","year":"2019","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Hua, F., Cui, E., Lv, L., Wang, B., Li, L., Lu, H., Chen, N., and Chen, W. (2023). Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1243102"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3946320251333982","DOI":"10.1177\/03946320251333982","article-title":"Impact of fecal microbiota transplantation on lung function and gut microbiome in an ARDS rat model: A multi-omics analysis including 16S rRNA sequencing, metabolomics, and transcriptomics","volume":"39","author":"Zhang","year":"2025","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Wen, L., Shi, L., Kong, X.L., Li, K.Y., Li, H., Jiang, D.X., Zhang, F., and Zhou, Z.G. (2022). Gut Microbiota Protected Against pseudomonas aeruginosa Pneumonia via Restoring Treg\/Th17 Balance and Metabolism. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.856633"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Feng, R., Zhu, Q., Wang, A., Wang, H., Wang, J., Chen, P., Zhang, R., Liang, D., Teng, J., and Ma, M. (2024). Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: A randomized, double-blind, placebo-controlled trial. BMC Med., 22.","DOI":"10.1186\/s12916-024-03781-6"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Fu, W., Peng, N., and Geng, Y. (2025). Fecal microbiota transplantation as salvage therapy for disseminated strongyloidiasis in an immunosuppressed patient: A case report. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1676906"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e18476","DOI":"10.1097\/MD.0000000000018476","article-title":"Effectiveness of fecal microbiota transplantation for severe diarrhea after drug-induced hypersensitivity syndrome","volume":"98","author":"Wei","year":"2019","journal-title":"Medicine"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/ajg.2014.299","article-title":"Therapeutic modulation and reestablishment of the intestinal microbiota with fecal microbiota transplantation resolves sepsis and diarrhea in a patient","volume":"109","author":"Li","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1017\/ice.2017.300","article-title":"Fecal Microbiota Transplant for Multidrug-Resistant Organism Decolonization Administered During Septic Shock","volume":"39","author":"Gopalsamy","year":"2018","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wei, Y., Gong, J., Zhu, W., Guo, D., Gu, L., Li, N., and Li, J. (2015). Fecal microbiota transplantation restores dysbiosis in patients with methicillin resistant Staphylococcus aureus enterocolitis. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0973-1"},{"key":"ref_158","first-page":"8462659","article-title":"Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient","volume":"2020","author":"Ueckermann","year":"2020","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/apt.16148","article-title":"Systematic review: The global incidence of faecal microbiota transplantation-related adverse events from 2000 to 2020","volume":"53","author":"Marcella","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1394379","DOI":"10.1155\/2018\/1394379","article-title":"A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplant for Clostridium difficile Infection in Immunocompromised Patients","volume":"2018","author":"Shogbesan","year":"2018","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bpg.2013.03.003","article-title":"Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?","volume":"27","author":"Vrieze","year":"2013","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41467-020-20240-x","article-title":"Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"a000448","DOI":"10.1101\/mcs.a000448","article-title":"Long-term changes of bacterial and viral compositions in the intestine of a recovered Clostridium difficile patient after fecal microbiota transplantation","volume":"2","author":"Broecker","year":"2016","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Chu, N.D., Crothers, J.W., Nguyen, L.T.T., Kearney, S.M., Smith, M.B., Kassam, Z., Collins, C., Xavier, R., Moses, P.L., and Alm, E.J. (2021). Dynamic Colonization of Microbes and Their Functions after Fecal Microbiota Transplantation for Inflammatory Bowel Disease. mBio, 12.","DOI":"10.1128\/mBio.00975-21"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Song, Y., Garg, S., Girotra, M., Maddox, C., von Rosenvinge, E.C., Dutta, A., Dutta, S., and Fricke, W.F. (2013). Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081330"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"7546047","DOI":"10.1155\/2019\/7546047","article-title":"The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases","volume":"2019","author":"Xu","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e2023062922","DOI":"10.1542\/peds.2023-062922","article-title":"Fecal Microbiota Transplantation: Information for the Pediatrician","volume":"152","author":"Kahn","year":"2023","journal-title":"Pediatrics"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Wang, S., Xu, M., Wang, W., Cao, X., Piao, M., Khan, S., Yan, F., Cao, H., and Wang, B. (2016). Systematic Review: Adverse Events of Fecal Microbiota Transplantation. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161174"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature10571","article-title":"Ecology drives a global network of gene exchange connecting the human microbiome","volume":"480","author":"Smillie","year":"2011","journal-title":"Nature"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ajg.2013.59","article-title":"Fecal microbiota transplantation for Clostridium difficile infection: Systematic review and meta-analysis","volume":"108","author":"Kassam","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1056\/NEJMoa1910437","article-title":"Drug-resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant","volume":"381","author":"DeFilipp","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s13054-025-05548-8","article-title":"Composition and diversity of the pulmonary microbiome in acute respiratory distress syndrome: A systematic review","volume":"29","author":"Schneider","year":"2025","journal-title":"Crit. Care"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Cibulkova, I., Rehorova, V., Hajer, J., and Duska, F. (2021). Fecal Microbial Transplantation in Critically Ill Patients-Structured Review and Perspectives. Biomolecules, 11.","DOI":"10.20944\/preprints202109.0228.v1"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12967-025-06645-6","article-title":"Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: A scoping review","volume":"23","author":"Ruszkowski","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Cibulkova, I., Rehorova, V., Soukupova, H., Waldauf, P., Cahova, M., Manak, J., Matejovic, M., and Duska, F. (2024). Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II). PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0310180"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13054-025-05309-7","article-title":"A review of gut failure as a cause and consequence of critical illness","volume":"29","author":"Soranno","year":"2025","journal-title":"Crit. Care"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/15265161.2017.1299240","article-title":"Ethical Issues in Fecal Microbiota Transplantation in Practice","volume":"17","author":"Ma","year":"2017","journal-title":"Am. J. Bioeth."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s40001-022-00780-2","article-title":"ARDS associated acute brain injury: From the lung to the brain","volume":"27","author":"Ziaka","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1854640","DOI":"10.1080\/19490976.2020.1854640","article-title":"Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: A systematic review and meta-analysis","volume":"12","author":"Green","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Ziaka, M., and Exadaktylos, A. (2025). Acute Respiratory Distress Syndrome: Pathophysiological Insights, Subphenotypes, and Clinical Implications-A Comprehensive Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14155184"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s40001-025-02661-w","article-title":"Fluid management strategies in critically ill patients with ARDS: A narrative review","volume":"30","author":"Ziaka","year":"2025","journal-title":"Eur. J. Med. Res."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/12\/1206\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:53:44Z","timestamp":1764240824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/14\/12\/1206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":181,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["pathogens14121206"],"URL":"https:\/\/doi.org\/10.3390\/pathogens14121206","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}