{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:54:46Z","timestamp":1792079686989,"version":"4.4.0"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Introduction: Mpox virus (MpoxV), an emerging zoonotic pathogen, has recently caused global concern due to increasing outbreaks beyond its traditional endemic regions. While transmission primarily occurs via close contact, fomites are also suspected of contributing. This study aims to evaluate the effectiveness of UV-C irradiation on MpoxV-contaminated surfaces. Methods: the virucidal activity of UV-C (254 nm) irradiation on MpoxV applied to plastic, glass, and stainless-steel surfaces was assessed. Using a viral stock of 2.49 \u00d7 105 TCID50\/mL, the samples were exposed to increasing UV-C doses. Viral titers were quantified through TCID50 and plaque assays. Results: A UV-C dose of 6.34 mJ\/cm2 achieved a &gt;2-log reduction of viral load, below the detection limit (31.6 TCID50\/mL), on all tested surfaces. EC90 values were determined as 3.33 mJ\/cm2 (plastic), 0.81 mJ\/cm2 (stainless steel), and 1.98 mJ\/cm2 (glass). No viable virus was detectable post-treatment at these doses on plastic and stainless steel while the titer was significantly reduced on glass. Conclusions: UV-C irradiation at low doses effectively inactivated MpoxV on various fomites. These findings support UV-C as a rapid and effective environmental disinfection strategy in healthcare and community settings to prevent indirect transmission of MpoxV.<\/jats:p>","DOI":"10.3390\/pathogens15010078","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:13:01Z","timestamp":1768209181000},"page":"78","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["UV-C Irradiation Effectiveness on Mpox-Virus-Contaminated Surfaces"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-6553","authenticated-orcid":false,"given":"Anna","family":"Gidari","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-8325","authenticated-orcid":false,"given":"Samuele","family":"Sabbatini","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-2885","authenticated-orcid":false,"given":"Carlo","family":"Pallotto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-4368","authenticated-orcid":false,"given":"Sabrina","family":"Bastianelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-8169","authenticated-orcid":false,"given":"Sara","family":"Pierucci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Busti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-5721","authenticated-orcid":false,"given":"Alessia","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, University of Milan, 20122 Milan, Italy"},{"name":"Laboratory of Medical Microbiology and Virology, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-4843","authenticated-orcid":false,"given":"Giuseppe Vittorio","family":"De Socio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Francisci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u201cSanta Maria della Misericordia\u201d Hospital, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1099\/vir.0.81215-0","article-title":"A tale of two clades: Monkeypox viruses","volume":"86","author":"Likos","year":"2005","journal-title":"J. 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