{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:37:27Z","timestamp":1790271447015,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["17-20286S"],"award-info":[{"award-number":["17-20286S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010653","name":"Masaryk University","doi-asserted-by":"publisher","award":["MUNI\/A\/1098\/2019"],"award-info":[{"award-number":["MUNI\/A\/1098\/2019"]}],"id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["ID:90254"],"award-info":[{"award-number":["ID:90254"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["No 857560"],"award-info":[{"award-number":["No 857560"]}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education, Youth and Sports","doi-asserted-by":"crossref","award":["No LM2023069"],"award-info":[{"award-number":["No LM2023069"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Czech Academy of Sciences, project MycoLife\u2014world of fungi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Hibernation profoundly alters host\u2013pathogen dynamics by suppressing metabolism and immune function, posing unique challenges for infection control. In this study, we examined how genomic variation modulates infection and physiological traits in temperate bats during hibernation. We combined infection screening, haematology, blood biochemistry, and whole-genome sequencing across five vespertilionid species, identifying over 170,000 single nucleotide variants (SNVs) and assessing their associations with 23 health-related variables. Using the phylogenetically informed treeWAS framework, we detected 515 significant SNVs linked to traits including fungal, protozoan and bacterial infections, acid\u2013base balance, and blood cell indices. These SNVs mapped to 137 unique genes, which were enriched for functional domains related to cytoskeletal dynamics, membrane trafficking, and intracellular signalling (e.g., SH3, C2, BAR, semaphorin). Notably, canonical immune effector genes were underrepresented, and several trait-associated SNVs appeared in blocks across multiple scaffolds, pointing to regulatory loci as key modulators of hibernator health. Our findings support the hypothesis that bats rely on infection tolerance rather than resistance during hibernation, with genomic variation in regulatory and signalling pathways shaping their physiological responses to infection under energy-limited conditions.<\/jats:p>","DOI":"10.3390\/pathogens15020149","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:35:46Z","timestamp":1769783746000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-Wide Association Reveals Signalling-Linked Infection Tolerance in Hibernating Bats"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-7589","authenticated-orcid":false,"given":"Mark\u00e9ta","family":"Harazim","sequence":"first","affiliation":[{"name":"Institute of Vertebrate Biology, Czech Academy of Sciences, Kv\u011btn\u00e1 8, 60300 Brno, Czech Republic"},{"name":"Department of Botany and Zoology, Faculty of Sciences, Masaryk University, Kotl\u00e1\u0159sk\u00e1 2, 61137 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubom\u00edr","family":"Pi\u00e1lek","sequence":"additional","affiliation":[{"name":"Institute of Vertebrate Biology, Czech Academy of Sciences, Kv\u011btn\u00e1 8, 60300 Brno, Czech Republic"},{"name":"Department of Zoology, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice, Brani\u0161ovsk\u00e1 31, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0373-7940","authenticated-orcid":false,"given":"Hana","family":"Bandouchova","sequence":"additional","affiliation":[{"name":"Avian and Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Palack\u00e9ho t\u0159\u00edda 1946\/1, 61242 Brno, Czech 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Sciences, Kv\u011btn\u00e1 8, 60300 Brno, Czech Republic"},{"name":"Department of Botany and Zoology, Faculty of Sciences, Masaryk University, Kotl\u00e1\u0159sk\u00e1 2, 61137 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-2956","authenticated-orcid":false,"given":"Monika","family":"N\u011bmcov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Ecology and Diseases of Zoo Animals, Game, Fish and Bees, University of Veterinary Sciences Brno, Palack\u00e9ho t\u0159\u00edda 1946\/1, 61242 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Heger","sequence":"additional","affiliation":[{"name":"Department of Ecology and Diseases of Zoo Animals, Game, Fish and Bees, University of Veterinary Sciences Brno, Palack\u00e9ho t\u0159\u00edda 1946\/1, 61242 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Linhart","sequence":"additional","affiliation":[{"name":"Department of Animal Protection and Welfare & Veterinary Public Health, University of Veterinary Sciences Brno, Palack\u00e9ho t\u0159\u00edda 1946\/1, 61242 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-3801","authenticated-orcid":false,"given":"Vladim\u00edr","family":"Pia\u010dek","sequence":"additional","affiliation":[{"name":"Department of Ecology and Diseases of Zoo Animals, Game, Fish and Bees, University of Veterinary Sciences Brno, Palack\u00e9ho t\u0159\u00edda 1946\/1, 61242 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-2124","authenticated-orcid":false,"given":"Tomasz","family":"Kokurewicz","sequence":"additional","affiliation":[{"name":"Institute of Biology, Department of Vertebrate Ecology and Paleontology, Wroc\u0142aw University of Environmental and Life Sciences, 51-631 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg L.","family":"Orlov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Tyumen State Medical University, Odesskaya St. 54, 625023 Tyumen, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-118X","authenticated-orcid":false,"suffix":"Jr.","given":"Alexandra","family":"Zahradn\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Cellular Cardiology, Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Dubravska cesta 9, 84545 Bratislava, 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