{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:52:13Z","timestamp":1772711533127,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Astrocytomas are among the most common primary tumors of the central nervous system, arising from astrocytic glial cells and encompassing a wide spectrum of histopathological grades and clinical behaviors. Human immunodeficiency virus (HIV) infection is characterized by chronic immune dysregulation, neuroinflammation, and increased susceptibility to both opportunistic infections and malignancies. The management of astrocytomas in patients living with HIV presents unique clinical challenges but should, whenever feasible, follow standard neuro-oncological principles. We report the case of a 34-year-old man with well-controlled HIV infection who presented in February 2025 with progressive neurological symptoms. Brain imaging revealed a left temporo-insular lesion, and the diagnosis was confirmed by neuronavigation-guided biopsy performed on 31 March 2025. Histopathological and immunohistochemical evaluation established the diagnosis of an isocitrate dehydrogenase (IDH) wild-type astrocytoma, central nervous system (CNS) World Health Organization (WHO) grade 2, according to the 2021 classification of central nervous system tumors.<\/jats:p>","DOI":"10.3390\/pathogens15030284","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:31:14Z","timestamp":1772706674000},"page":"284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Astrocytoma in Patients with HIV\u2014Review of the Literature and Case Report"],"prefix":"10.3390","volume":"15","author":[{"given":"Florentina","family":"Dumitrescu","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"\u201cVictor Babes\u201d, Hospital of Infectious Diseases and Pulmonology from Craiova, 200515 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia-Andreea","family":"Marcu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"\u201cVictor Babes\u201d, Hospital of Infectious Diseases and Pulmonology from Craiova, 200515 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-5689","authenticated-orcid":false,"given":"Vlad","family":"P\u0103dureanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6731-6029","authenticated-orcid":false,"given":"Cristiana-Luiza","family":"R\u0103doi-Troac\u0103","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodica","family":"P\u0103dureanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian","family":"Giubelan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"\u201cVictor Babes\u201d, Hospital of Infectious Diseases and Pulmonology from Craiova, 200515 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro-Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/cid\/cis613","article-title":"The Rising Challenge of Non-AIDS-Defining Cancers in HIV-Infected Patients","volume":"55","author":"Deeken","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.56782\/pps.188","article-title":"Severe Course of HIV-Related Kaposi\u2019s Sarcoma with Cutaneous, Visceral and Oral Manifestations in a Late-Presenting Patient","volume":"22","author":"Barczak","year":"2024","journal-title":"Prospect. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3892\/etm.2024.12380","article-title":"Clinical Characteristics and Prognostic Analysis of Patients with HIV and Glioma: A Case Series and Literature Review","volume":"27","author":"Ding","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9456","DOI":"10.1523\/JNEUROSCI.1460-11.2011","article-title":"Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism","volume":"31","author":"Eugenin","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.10.008","article-title":"Role of the Immune System in HIV-Associated Neuroinflammation and Neurocognitive Implications","volume":"45","author":"Hong","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12987-023-00476-7","article-title":"Occludin: A Gatekeeper of Brain Infection by HIV-1","volume":"20","author":"Torices","year":"2023","journal-title":"Fluids Barriers CNS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11060-022-04095-4","article-title":"Glioblastoma Multiforme in Patients with Human Immunodeficiency Virus: An Integrated Review and Analysis","volume":"159","author":"Lu","year":"2022","journal-title":"J. Neurooncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1016\/j.wneu.2018.02.168","article-title":"Clinical Characteristics and Prognostic Analysis of Glioma in Human Immunodeficiency Virus-Infected Patients","volume":"114","author":"Wang","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.clon.2009.04.006","article-title":"Management of Glioblastoma Multiforme in HIV Patients: A Case Series and Review of Published Studies","volume":"21","author":"Hall","year":"2009","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11904-005-0008-4","article-title":"Non-AIDS-Defining Cancers and HIV Infection","volume":"2","author":"Lim","year":"2005","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_12","unstructured":"(2026, February 01). HIV Infection and Cancer Risk\u2014NCI, Available online: https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/infectious-agents\/hiv-fact-sheet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.5858\/arpa.2021-0295-CP","article-title":"Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas: Guideline from the College of American Pathologists in Collaboration with the American Association of Neuropathologists, Association for Molecular Pathology, and Society for Neuro-Oncology","volume":"146","author":"Brat","year":"2022","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network, Brat, D.J., Verhaak, R.G.W., Aldape, K.D., Yung, W.K.A., Salama, S.R., Cooper, L.A.D., Rheinbay, E., Miller, C.R., and Vitucci, M. (2015). Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N. Engl. J. Med., 372, 2481\u20132498.","DOI":"10.1056\/NEJMoa1402121"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2353\/ajpath.2007.070011","article-title":"Genetic Pathways to Primary and Secondary Glioblastoma","volume":"170","author":"Ohgaki","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"bcr2012008384","DOI":"10.1136\/bcr-2012-008384","article-title":"Brainstem Anaplastic Glioma in Patients with AIDS: A Case Report and Review of the Literature","volume":"2013","author":"Chaudhry","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1407279","article-title":"Glioma Groups Based on 1p\/19q, IDH, and TERT Promoter Mutations in Tumors","volume":"372","author":"Lachance","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-018-1913-0","article-title":"cIMPACT-NOW Update 3: Recommended Diagnostic Criteria for \u201cDiffuse Astrocytic Glioma, IDH-Wildtype, with Molecular Features of Glioblastoma, WHO Grade IV\u201d","volume":"136","author":"Brat","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1097\/QAD.0b013e3283319184","article-title":"HIV infection and the risk of cancers with and without a known infectious cause","volume":"23","author":"Silverberg","year":"2009","journal-title":"AIDS"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1097\/QAD.0000000000000382","article-title":"Risk of Non-AIDS-Defining Cancers among HIV-1-Infected Individuals in France between 1997 and 2009: Results from a French Cohort","volume":"28","author":"Hleyhel","year":"2014","journal-title":"AIDS"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/jnci\/djr076","article-title":"Cancer Burden in the HIV-Infected Population in the United States","volume":"103","author":"Shiels","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/1750743X.2024.2362566","article-title":"Pembrolizumab in an HIV-Infected Patient with Glioblastoma","volume":"16","author":"Yuen","year":"2024","journal-title":"Immunotherapy"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/3\/284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:52:31Z","timestamp":1772707951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/3\/284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["pathogens15030284"],"URL":"https:\/\/doi.org\/10.3390\/pathogens15030284","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}