{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:14:19Z","timestamp":1785428059886,"version":"3.56.0"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"crossref","award":["V294"],"award-info":[{"award-number":["V294"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"crossref"}]},{"award":["V294"],"award-info":[{"award-number":["V294"]}],"id":[{"id":"https:\/\/ror.org\/01tjs6929","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["EX-2019-45545263-APN-GDCT#CONICET"],"award-info":[{"award-number":["EX-2019-45545263-APN-GDCT#CONICET"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"award":["EX-2019-45545263-APN-GDCT#CONICET"],"award-info":[{"award-number":["EX-2019-45545263-APN-GDCT#CONICET"]}],"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}]},{"name":"UK Department of Health and Social Care as part of the Global Antimicrobial Resistance (AMR) Innovation Fund","award":["BB\/T004592\/1"],"award-info":[{"award-number":["BB\/T004592\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The occurrence of Escherichia coli resistant to high-priority critically important antimicrobials (HPCIA) in the food chain is a growing concern for food safety and public health. This study aimed to evaluate whether HPCIA-resistant E. coli isolated from pork and chicken meat at retail markets in La Plata, Buenos Aires, Argentina, exhibit source-associated genomic differentiation through whole-genome sequencing. The isolates displayed a polyclonal population structure, encompassing multiple phylogenetic groups and sequence types. Virulence gene profiles were highly diverse, with chicken-derived isolates harbouring a substantially higher number of virulence genes than pork isolates. Notably, one pork isolate carried a complete set of virulence genes characteristic of diarrheagenic E. coli. Single Nucleotide Polymorphism-based phylogenetic analysis revealed several closely related subclusters, including strains recovered from both pork and chicken meat from the same retail markets, suggesting recent clonal sharing or cross-contamination at the point of sale. These findings highlight the circulation of genetically diverse HPCIA-resistant E. coli in retail meat, underscoring the potential public health risk and the importance of monitoring resistance and virulence determinants throughout the food production chain.<\/jats:p>","DOI":"10.3390\/pathogens15040438","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:37:42Z","timestamp":1776677862000},"page":"438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Diversity and Virulence Potential of High-Priority Critically Important Antimicrobial-Resistant Escherichia coli from Pork and Chicken Retail Meat"],"prefix":"10.3390","volume":"15","author":[{"given":"Hern\u00e1n D.","family":"Nievas","sequence":"first","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda y Antimicrobianos, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Aurnague","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda y Antimicrobianos, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-0334","authenticated-orcid":false,"given":"Elisa","family":"Helman","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunoparasitolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4293-3244","authenticated-orcid":false,"given":"Ra\u00fal E.","family":"Iza","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda y Antimicrobianos, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-4073","authenticated-orcid":false,"given":"Magdalena","family":"Costa","sequence":"additional","affiliation":[{"name":"IGEVET\u2014Instituto de Gen\u00e9tica Veterinaria \u201cIng. Fernando N. Dulout\u201d (UNLP-CONICET La Plata), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Mounsey","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Avison","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-6387","authenticated-orcid":false,"given":"Luc\u00eda","family":"Galli","sequence":"additional","affiliation":[{"name":"IGEVET\u2014Instituto de Gen\u00e9tica Veterinaria \u201cIng. Fernando N. 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