{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:10:39Z","timestamp":1778155839692,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Objectives: This study investigated the associations of biochemical and body water distribution parameters with dengue status, as well as their discriminatory ability, among hospitalized adults with febrile illnesses and evaluated whether dynamic changes in body water volumes were associated with length of hospital stay (LOS) in dengue patients. Methods: A prospective observational cohort study was conducted at a tertiary care hospital involving 186 hospitalized adults (age \u2265 18 years) with fever onset \u2264 5 days and suspected dengue. Body water parameters were assessed by bioelectrical impedance analysis (BIA) using the InBody S10 body composition analyzer at admission (T1), defervescence (T2), and discharge (T3) in dengue patients and at admission only in other febrile illness (OFI) cases. Laboratory data and LOS were retrieved from the hospital information system. Linear and logistic regression models were used to examine the associations and interactions. Discriminative performance was assessed using a receiver operating characteristic (ROC) curve analysis. Results: The proportion of dengue cases was 55.9% (n = 104). Higher levels of lymphocytes, hematocrit, hemoglobin, AST, and ALT were associated with an increased likelihood of dengue, whereas elevated WBC counts, neutrophils, platelets, CRP, sodium, chloride, and the extracellular water-to-total body water ratio (ECW\/TBW) were associated with a reduced likelihood of dengue. ROC analysis indicated that WBC showed the best diagnostic performance. In dengue patients, a greater increase in ECW volume from admission to defervescence was associated with a longer LOS in males, and ratio-based body water parameters showed longitudinal variation across dengue phases. Conclusions: Several hematologic, biochemical, and BIA-derived body water parameters were associated with dengue status. Among dengue patients, dynamic ECW changes were associated with longer LOS in males, and ratio-based fluid indices were more sensitive than absolute water volumes in reflecting fluid redistribution throughout the dengue course.<\/jats:p>","DOI":"10.3390\/pathogens15050501","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:39:47Z","timestamp":1778150387000},"page":"501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Biomarkers and Body Water with Dengue Status and Length of Hospital Stay: A Single-Center Observational Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-0472","authenticated-orcid":false,"given":"Thang Van","family":"Dao","sequence":"first","affiliation":[{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi 12108, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh Nhu","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi 12108, Vietnam"},{"name":"Department of Military Science, Vietnam Military Medical University, Hanoi 12108, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-7410","authenticated-orcid":false,"given":"Minh Duc","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Military Hospital 103, Vietnam Military Medical University, Hanoi 12108, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Minh","family":"Cap","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Haiphong University of Medicine and Pharmacy, Haiphong 04212, Vietnam"},{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-8055","authenticated-orcid":false,"given":"Kien Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Faculty of Social and Behavioral Sciences, Hanoi University of Public Health, Hanoi 11910, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-0723","authenticated-orcid":false,"given":"Tuyen Van","family":"Duong","sequence":"additional","affiliation":[{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, September 02). 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