{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:47:29Z","timestamp":1791478049240,"version":"4.3.4"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Measles represents a critical public health challenge due to its high transmissibility and the resurgence of outbreaks of the disease, linked to gaps in vaccination coverage. In this study, we analyze the epidemiological dynamics of the outbreak that began in Mexico in 2025 and focus on Jalisco as the epicenter during the first quarter of 2026. A descriptive, retrospective, ecological time-series analysis was conducted using official epidemiological surveillance data, correlating incidence with immunization strategies. The results reveal that 6681 cases were recorded in Jalisco, with the highest prevalence among adults aged 20 to 49 years (41.96%), which highlights the accumulated gaps in immunity coverage. The public health response, comprising the administration of three million doses, focusing on zero-dose children and vaccination blockades, contributed to a notable decrease in infections by epidemiological week 17 of 2026. It was concluded that the outbreak was controlled through intensive and coordinated intervention. However, the proximity of the 2026 International Federation of Association Football (FIFA) World Cup requires vaccination coverage to be maintained at over 95%, in addition to vigilance, to mitigate the risk of viral reintroduction and to safeguard global health security.<\/jats:p>","DOI":"10.3390\/pathogens15060572","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:31:56Z","timestamp":1779885116000},"page":"572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatiotemporal Dynamics of the 2025\u20132026 Measles Outbreak in Mexico: Jalisco as the Emerging Epicenter and the Impact of Intensive Immunization Efforts"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-6309","authenticated-orcid":false,"given":"Elena","family":"Sandoval-Pinto","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Molecular, Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad de Guadalajara, Zapopan 45200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-8593","authenticated-orcid":false,"given":"Rosa","family":"Cremades","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-119X","authenticated-orcid":false,"given":"H\u00e9ctor Ra\u00fal","family":"P\u00e9rez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud Jalisco, Guadalajara 44100, Mexico"},{"name":"Instituto de Patolog\u00eda Infecciosa y Experimental, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44280, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Carlos","family":"Rivera-\u00c1vila","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud Jalisco, Guadalajara 44100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto Dom\u00ednguez","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud Jalisco, Guadalajara 44100, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-1350","authenticated-orcid":false,"given":"Lakshmanane","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-9012","authenticated-orcid":false,"given":"Erick","family":"Sierra-D\u00edaz","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Epidemiolog\u00eda, Unidades M\u00e9dicas de Alta Especialidad, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-4870","authenticated-orcid":false,"given":"Diana Emilia","family":"Mart\u00ednez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Transdisciplinario de Investigaci\u00f3n y Servicios (ITRANS), Universidad de Guadalajara, Zapopan 45150, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4152-2757","authenticated-orcid":false,"given":"Jos\u00e9 \u00c1ngel","family":"Regla-Nava","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1056\/NEJMra2504516","article-title":"Measles 2025","volume":"393","author":"Mulholland","year":"2025","journal-title":"N. 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