{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:14:47Z","timestamp":1783354487036,"version":"3.54.6"},"reference-count":22,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Social Development Project of Hailing District, Taizhou city","award":["HLKF-2024-6"],"award-info":[{"award-number":["HLKF-2024-6"]}]},{"name":"International Centre for Genetic Engineering and Biotechnology-Rohonor Clinical Research Fund project","award":["Hxtzsy-2024-01"],"award-info":[{"award-number":["Hxtzsy-2024-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study aimed to investigate the prevalence of human pegivirus type 1 (HPgV-1) among healthy individuals, type 2 diabetes patients, and cancer patients in Taizhou, Jiangsu, China. A total of 2872 participants, including 2052 healthy individuals, 373 type 2 diabetes patients, and 447 cancer patients, were enrolled at Taizhou Fourth People\u2019s Hospital between 2022 and 2024. Serum samples were collected from each participant, and HPgV-1 RNA was detected using a reverse transcription-polymerase chain reaction (RT-PCR) assay. The positive rates were compared across the three groups. The age range of healthy individuals was 5\u201391 years, while that of type 2 diabetes and cancer patients was 25\u201385 years and 34\u201391 years, respectively. The prevalence of HPgV-1 among healthy individuals was 15.3% (313\/2052), which was significantly higher than that in type 2 diabetes patients (11.0%, 41\/373, p &lt; 0.05) and cancer patients (9.2%, 41\/447, p &lt; 0.001). In healthy individuals, the prevalence of HPgV-1 increased from childhood to young adulthood, peaking in the 19\u201340 years age group, followed by a decline after 40 years of age, indicating an age-related pattern. Similarly, HPgV-1 load increased from childhood to adulthood. No significant gender differences in HPgV-1 prevalence were observed across the three cohorts. In conclusion, HPgV-1 infection exhibits an age-dependent prevalence, with the lowest rate in children and adolescents and the highest in young adults (19\u201340 years). The significantly lower prevalence of HPgV-1 in type 2 diabetes and cancer patients raises the intriguing question of whether HPgV-1 infection may play a protective or contributory role in the pathogenesis of diabetes and cancers.<\/jats:p>","DOI":"10.3390\/pathogens15070706","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:01:08Z","timestamp":1783346468000},"page":"706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Pegivirus Type 1 Prevalence in the General Population, Type 2 Diabetes and Cancer Patients in Taizhou, Jiangsu, China"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiuli","family":"Zhao","sequence":"first","affiliation":[{"name":"Medical Laboratory of Taizhou Fourth People\u2019s Hospital, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinling","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Laboratory of Taizhou Fourth People\u2019s Hospital, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Laboratory of Taizhou Fourth People\u2019s Hospital, Taizhou 225300, China"},{"name":"Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China"},{"name":"School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-4226","authenticated-orcid":false,"given":"Zhenzhou","family":"Wan","sequence":"additional","affiliation":[{"name":"Medical Laboratory of Taizhou Fourth People\u2019s Hospital, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-9857","authenticated-orcid":false,"given":"Chiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1099\/vir.0.027490-0","article-title":"The GB viruses: A review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae","volume":"92","author":"Stapleton","year":"2011","journal-title":"J. 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Ed.)"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/7\/706\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:21:57Z","timestamp":1783351317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/7\/706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["pathogens15070706"],"URL":"https:\/\/doi.org\/10.3390\/pathogens15070706","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]}}}