{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:14:04Z","timestamp":1783602844468,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: Melioidosis correlates strongly with rainfall, and there is substantial diversity in climate between melioidosis-endemic locations. The Northern Territory of Australia epitomises the \u201cwet\/dry\u201d tropics, with a prolonged dry season from May to October. We analysed dry season cases of melioidosis during 35 consecutive years and compared these with wet season cases. We aimed to provide insights into how dry season cases of melioidosis may occur in this region and explore non-rainfall exposures that are usually not considered in the wet season. Methods: Case epidemiological and clinical data were extracted from the Darwin Prospective Melioidosis Study. Weather parameters, including daily rainfall, were analysed using generalised additive models and conditional logistic regressions to assess associations between dry season cases and preceding rainfall. Results: Of 1520 melioidosis cases between 1989 and 2024, there were 325 (21%) in the dry season. While the well-recognised clinical diversity of melioidosis was also seen amongst dry season cases, pneumonia was proportionally less common and cutaneous melioidosis was more common than in the wet season. A total of 23% of dry season patients had no identified clinical risk factors for melioidosis, compared to 14% in the wet season. Mortality was 8% in the dry season and 11% in the wet season. There was a range of plausible explanations for many of the dry season cases, including unseasonal rainfall prior to infection. Infections in urban settings were notable, with anthropogenic factors such as irrigation and construction resulting in persistence of Burkholderia pseudomallei in the environment during the dry season. A total of 3% of cases remained unexplained. Conclusions: Not all dry season cases are explained by infection occurring the previous wet season or by unseasonal rainfall in the dry. Identification of cases in the dry season support the need for year-round prevention strategies during potential exposure to contaminated water or soil. Further prospective studies are needed to better define the infecting events resulting in melioidosis, especially in the dry season. These studies should include timely history taking from the case and their family and selected environmental sampling for B. pseudomallei.<\/jats:p>","DOI":"10.3390\/pathogens15070726","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:55:32Z","timestamp":1783598132000},"page":"726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dry Season Melioidosis in the Tropical North of Australia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7877-2774","authenticated-orcid":false,"given":"Marisia","family":"Madrigal-Solis","sequence":"first","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Kaestli","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Territory Pathology, Royal Darwin Hospital, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mayo","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Woerle","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-820X","authenticated-orcid":false,"given":"Ella M.","family":"Meumann","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Territory Pathology, Royal Darwin Hospital, Darwin, NT 0810, Australia"},{"name":"Department of Infectious Diseases, Royal Darwin Hospital, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-8837","authenticated-orcid":false,"given":"Bart J.","family":"Currie","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Department of Infectious Diseases, Royal Darwin Hospital, Darwin, NT 0810, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa2306448","article-title":"Locally Acquired Melioidosis Linked to Environment\u2014Mississippi, 2020\u20132023","volume":"389","author":"Petras","year":"2023","journal-title":"N. 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