{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:03:47Z","timestamp":1785323027559,"version":"3.55.0"},"reference-count":289,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Texas Tech University Association of Biologists and TechASM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Staphylococcus aureus (S. aureus), a leading cause of nosocomial infections, contributes significantly to increased morbidity and mortality, especially when it forms biofilms on medical devices. This pathogen, specifically methicillin-resistant S. aureus (MRSA), remains a challenge to treat due to its ability to form biofilms and rapidly develop resistance against antibiotics. Biofilm formation allows bacteria to adhere to biotic and abiotic surfaces, creating a protective matrix that shields them from immune responses and antibiotic therapies. The widespread prevalence of multidrug-resistant S. aureus biofilms poses a significant therapeutic challenge in clinical settings. Several novel therapeutic strategies have been developed to combat S. aureus biofilm-associated infections. Accumulating evidence suggests that natural plants and their derivatives possess antimicrobial and chemo preventive properties that can disrupt established biofilms. Several plant-derived compounds with anti-biofilm activities have been reported to target the regulatory proteins involved in the Agr quorum sensing (Agr-QS) system, underscoring their potential as therapeutic candidates for the prevention and treatment of biofilm-associated infections. However, despite these encouraging findings, clinical validation of these plant-based agents is essential to ensure their efficacy, safety, and optimal application in treating S. aureus biofilm infections. The continued exploration of natural biofilm inhibitors anticipates the urgent need for new treatments to combat biofilm-associated infections and multidrug-resistant pathogens like MRSA. This review provides a detailed overview of preventive and therapeutic interventions to eradicate biofilm-forming S. aureus infections.<\/jats:p>","DOI":"10.3390\/pathogens15080795","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention and Treatment of Staphylococcus aureus Biofilms Using Promising Agr-QS-Targeting Anti-Biofilm Agents"],"prefix":"10.3390","volume":"15","author":[{"given":"Salma Waheed","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Medical School, Twin Cities Campus, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Anhui Agricultural University, Hefei 230036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-6613","authenticated-orcid":false,"given":"Ting","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Anhui Agricultural University, Hefei 230036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-3359","authenticated-orcid":false,"given":"Lauren","family":"Gollahon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1080\/10408398.2018.1541865","article-title":"Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants","volume":"59","author":"Li","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.meegid.2013.03.020","article-title":"Staphylococcus aureus: Determinants of human carriage","volume":"21","author":"Sollid","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hindieh, P., Yaghi, J., Assaf, J.C., Chokr, A., Atoui, A., Tzenios, N., Louka, N., and Khoury, A.E. (2025). Emerging Multimodal Strategies for Bacterial Biofilm Eradication: A Comprehensive Review. Microorganisms, 13.","DOI":"10.3390\/microorganisms13122796"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1749-6632.2011.06281.x","article-title":"New approaches for treating staphylococcal biofilm infections","volume":"1241","author":"Kiedrowski","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4248\/IJOS11026","article-title":"The clinical impact of bacterial biofilms","volume":"3","author":"Ciofu","year":"2011","journal-title":"Int. J. Oral Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","article-title":"Bacterial biofilm and associated infections","volume":"81","author":"Jamal","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_7","first-page":"1823","article-title":"Staphylococcus aureus adaptation to the host and persistence: Role of loss of capsular polysaccharide expression","volume":"5","author":"Tuchscherr","year":"2010","journal-title":"Future Med."},{"key":"ref_8","first-page":"27","article-title":"Interaction of primary mammary bovine epithelial cells with biofilm-forming staphylococci associated with subclinical bovine mastitis","volume":"20","author":"Zaatout","year":"2019","journal-title":"Iran. J. Vet. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pietrocola, G., Nobile, G., Rindi, S., and Speziale, P. (2017). Staphylococcus aureus manipulates innate immunity through own and host-expressed proteases. Front. Cell. Infect. Microbiol., 7.","DOI":"10.3389\/fcimb.2017.00166"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.arth.2010.04.011","article-title":"Periprosthetic joint infection: The economic impact of methicillin-resistant infections","volume":"25","author":"Parvizi","year":"2010","journal-title":"J. Arthroplast."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1086\/649797","article-title":"Clinical and economic impact of methicillin-resistant Staphylococcus aureus colonization or infection on neonates in intensive care units","volume":"31","author":"Song","year":"2010","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_12","first-page":"1934578X1601100641","article-title":"Essential oil from Origanum vulgare completely inhibits the growth of multidrug-resistant cystic fibrosis pathogens","volume":"11","author":"Pesavento","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.copbio.2011.08.005","article-title":"Essential oils from aromatic herbs as antimicrobial agents","volume":"23","year":"2012","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Tuffs, S.W., Haeryfar, S.M.M., and McCormick, J.K. (2018). Manipulation of innate and adaptive immunity by Staphylococcal superantigens. Pathogens, 7.","DOI":"10.3390\/pathogens7020053"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"827965","DOI":"10.1155\/2014\/827965","article-title":"Staphylococcus aureus and staphylococcal food-borne disease: An ongoing challenge in public health","volume":"2014","author":"Kadariya","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1574-6976.2011.00311.x","article-title":"Staphylococcus aureus and its food poisoning toxins: Characterization and outbreak investigation","volume":"36","author":"Hennekinne","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref_18","unstructured":"WHO (2026, July 12). Sepsis Fact Sheet 2024. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sepsis."},{"key":"ref_19","unstructured":"Tobin, E.H., Jogu, P., and Koirala, J. (2026, January 11). Methicillin-Resistant Staphylococcus aureus, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482221\/."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shoaib, M., Aqib, A.I., Muzammil, I., Majeed, N., Bhutta, Z.A., Kulyar, M.F.-e.-A., Fatima, M., Zaheer, C.-N.F., Muneer, A., and Murtaza, M. (2023). MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1067284"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/jac\/dkx437","article-title":"Telavancin for refractory MRSA bacteraemia in intermittent haemodialysis recipients","volume":"73","author":"Britt","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetmic.2009.12.044","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA) ST398 associated with clinical and subclinical mastitis in Belgian cows","volume":"144","author":"Vanderhaeghen","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.32895\/UMP.MPR.9.2.19","article-title":"A retrospective study of the risk factors for linezolid-induced thrombocytopenia in hospitalized patients","volume":"9","author":"Ha","year":"2025","journal-title":"MedPharmRes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e27597","DOI":"10.1097\/MD.0000000000027597","article-title":"Linezolid for infective endocarditis: A structured approach based on a national database experience","volume":"100","author":"Goenaga","year":"2021","journal-title":"Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13756-020-00714-9","article-title":"The global prevalence of Daptomycin, Tigecycline, Quinupristin\/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase-negative staphylococci strains: A systematic review and meta-analysis","volume":"9","author":"Shariati","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s40119-019-00148-4","article-title":"Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review","volume":"8","author":"Kobayashi","year":"2019","journal-title":"Cardiol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/JCM.44.2.655-656.2006","article-title":"Treatment failure resulting from resistance of Staphylococcus aureus to daptomycin","volume":"44","author":"Skiest","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Fiore, M., Alfieri, A., Fiore, D., Iuliano, P., Spatola, F.G., Limone, A., Pezone, I., and Leone, S. (2025). Use of Daptomycin to Manage Severe MRSA Infections in Humans. Medicine, 14.","DOI":"10.3390\/antibiotics14060617"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1086\/652767","article-title":"Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: Data from a randomized trial of patients with bacteremia and endocarditis","volume":"50","author":"Bhavnani","year":"2010","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jac\/46.4.523","article-title":"Development of daptomycin for gram-positive infections","volume":"46","author":"Tally","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/JCM.44.2.595-597.2006","article-title":"Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis","volume":"44","author":"Marty","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/1440-1681.13066","article-title":"Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice","volume":"46","author":"Zamoner","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_34","first-page":"100021","article-title":"Methicillin-resistant Staphylococcus aureus and Vancomycin Prescribing in the Emergency Department: A Single-center Study Assessing Antibiotic Prescribing","volume":"6","author":"Niforatos","year":"2025","journal-title":"J. Am. Coll. Emerg. Phys. Open"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jgar.2024.02.002","article-title":"Global distribution of heterogeneous vancomycin-intermediate Staphylococcus aureus strains (1997\u20132021): A systematic review and meta-analysis","volume":"37","author":"Keikha","year":"2024","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1086\/527392","article-title":"Vancomycin-resistant Staphylococcus aureus in the United States, 2002\u20132006","volume":"46","author":"Sievert","year":"2008","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhang, S., Sun, X., Chang, W., Dai, Y., and Ma, X. (2015). Systematic review and meta-analysis of the epidemiology of vancomycin-intermediate and heterogeneous vancomycin-intermediate Staphylococcus aureus isolates. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136082"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0255-0857.62488","article-title":"Inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples","volume":"28","author":"Deotale","year":"2010","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_39","first-page":"19","article-title":"Phenotypic detection of constitutive and inducible clindamycin resistance in clinical isolates of Staphylococcus aureus and coagulase negative Staphylococcus on routine susceptibility plate","volume":"42","author":"Fomda","year":"2010","journal-title":"J. Commun. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Addis, Z., Aschale, Y., Fenta, A., Teffera, Z.H., Melkamu, A., Tigab, A., and Dilnessa, T. (2025). Methicillin and inducible clindamycin resistance in clinical Staphylococcus aureus isolates: A cross-sectional study from Northwest Ethiopia. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1569242"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1128\/JCM.39.10.3586-3590.2001","article-title":"Methicillin-resistant, quinupristin-dalfopristin-resistant Staphylococcus aureus with reduced sensitivity to glycopeptides","volume":"39","author":"Werner","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"ref_42","unstructured":"Pharm, U. (2026, June 08). ToExamTable Blog Summary with Recent VISA\/VRSA Data and Therapeutic Options: \u201cVancomycin-Resistant Staphylococcus aureus: Emergence and Treatment Options\u201d. Available online: https:\/\/blog.unmc.edu\/infectious-disease\/2022\/11\/03\/pharmtoexamtable-vancomycin-resistant-staphylococcus-aureus-emergence-and-treatment\/."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10096-017-2915-x","article-title":"Frequent occurrence of trimethoprim-sulfamethoxazole hetero-resistant Staphylococcus aureus isolates in different African countries","volume":"36","author":"Coelho","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis. Off. Publ. Eur. Soc. Clin. Microbiol."},{"key":"ref_44","first-page":"1506","article-title":"What is behind phylogenetic analysis of hospital-, community- and livestock-associated methicillin-resistant Staphylococcus aureus? Transbound","volume":"66","author":"Bendary","year":"2019","journal-title":"Emerg. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tim.2014.02.001","article-title":"Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms","volume":"22","author":"Coenye","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"McCarthy, H., Rudkin, J.K., Black, N.S., Gallagher, L., O\u2019Neill, E., and O\u2019Gara, J.P. (2015). Methicillin resistance and the biofilm phenotype in Staphylococcus aureus. Front. Cell. Infect. Microbiol., 5.","DOI":"10.3389\/fcimb.2015.00001"},{"key":"ref_47","first-page":"107","article-title":"Multidrug tolerance of biofilms and persister cells","volume":"322","author":"Lewis","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/1574-6976.12088","article-title":"Physical stress and bacterial colonization","volume":"38","author":"Otto","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/jam.14706","article-title":"Staphylococcus aureus persistence properties associated with bovine mastitis and alternative therapeutic modalities","volume":"129","author":"Zaatout","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/viru.2.5.17724","article-title":"Staphylococcus aureus biofilms: Properties, regulation, and roles in human disease","volume":"2","author":"Archer","year":"2011","journal-title":"Virulence"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijfoodmicro.2014.06.018","article-title":"First description of PVL-positive methicillin-resistant Staphylococcus aureus (MRSA) in wild boar meat","volume":"186","author":"Kraushaar","year":"2014","journal-title":"Int. J. Food Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Arciola, C.R., Campoccia, D., Ravaioli, S., and Montanaro, L. (2015). Polysaccharide intercellular adhesin in biofilm: Structural and regulatory aspects. Front. Cell. Infect. Microbiol., 5.","DOI":"10.3389\/fcimb.2015.00007"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Boles, B.R., and Horswill, A.R. (2008). Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000052"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tan, L., Li, S.R., Jiang, B., Hu, X.M., and Li, S. (2018). Therapeutic targeting of the Staphylococcus aureus accessory gene regulator (agr) system. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00055"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","article-title":"Agr function in clinical Staphylococcus aureus isolates","volume":"154","author":"Traber","year":"2008","journal-title":"Microbiology"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Le, K.Y., and Otto, M. (2015). Quorum-sensing regulation in staphylococci\u2014An overview. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01174"},{"key":"ref_57","first-page":"187","article-title":"Staphylococcus aureus biofilms and their impact on the medical field","volume":"11","author":"Reffuveille","year":"2017","journal-title":"Rise Virulence Antibiot. Resist. Staphylococcus Aureus"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Josse, J., Velard, F., and Gangloff, S.C. (2015). Staphylococcus aureus vs. osteoblast: Relationship and consequences in osteomyelitis. Front. Cell. Infect. Microbiol., 5.","DOI":"10.3389\/fcimb.2015.00085"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-med-042711-140023","article-title":"Staphylococcal infections: Mechanisms of biofilm maturation and detachment as critical determinants of pathogenicity","volume":"64","author":"Otto","year":"2013","journal-title":"Annu. Rev. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1016\/j.csbj.2020.10.027","article-title":"The staphylococcal exopolysaccharide PIA\u2014Biosynthesis and role in biofilm formation, colonization, and infection","volume":"18","author":"Nguyen","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lister, J.L., and Horswill, A.R. (2014). Staphylococcus aureus biofilms: Recent developments in biofilm dispersal. Front. Cell. Infect. Microbiol., 4.","DOI":"10.3389\/fcimb.2014.00178"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/s41598-018-20485-z","article-title":"Broad impact of extracellular DNA on biofilm formation by clinically isolated Methicillin-resistant and -sensitive strains of Staphylococcus aureus","volume":"8","author":"Sugimoto","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.biomaterials.2006.11.046","article-title":"Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections","volume":"28","author":"Rohde","year":"2007","journal-title":"Biomaterials"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JB.00167-08","article-title":"A Novel Staphylococcus aureus Biofilm Phenotype Mediated by the Fibronectin-Binding Proteins, FnBPA and FnBPB","volume":"190","author":"Pozzi","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1128\/JB.00628-10","article-title":"Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus","volume":"192","author":"Geoghegan","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Speziale, P., Pietrocola, G., Foster, T.J., and Geoghegan, J.A. (2014). Protein-based biofilm matrices in Staphylococci. Front. Cell. Infect. Microbiol., 4.","DOI":"10.3389\/fcimb.2014.00171"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kavanaugh Jeffrey, S., Flack Caralyn, E., Lister, J., Ricker Erica, B., Ibberson Carolyn, B., Jenul, C., Moormeier Derek, E., Delmain Elizabeth, A., Bayles Kenneth, W., and Horswill Alexander, R. (2019). Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix. mBio, 10.","DOI":"10.1128\/mBio.01137-19"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.resmic.2005.11.003","article-title":"Bap: A family of surface proteins involved in biofilm formation","volume":"157","author":"Lasa","year":"2006","journal-title":"Res. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1128\/JB.00913-09","article-title":"Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC","volume":"191","author":"Cue","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e02331-17","DOI":"10.1128\/mBio.02331-17","article-title":"Bacterial quorum sensing and microbial community interactions","volume":"9","author":"Abisado","year":"2018","journal-title":"mBio"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Passos da Silva, D., Schofield, M.C., Parsek, M.R., and Tseng, B.S. (2017). An update on the sociomicrobiology of quorum sensing in gram-negative biofilm development. Pathogens, 6.","DOI":"10.3390\/pathogens6040051"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xie, Y., He, Y., Gehring, A., Hu, Y., Li, Q., Tu, S.-I., and Shi, X. (2011). Genotypes and toxin gene profiles of Staphylococcus aureus clinical isolates from China. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028276"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2016.01.003","article-title":"Existence of two groups of Staphylococcus aureus strains isolated from bovine mastitis based on biofilm formation, intracellular survival, capsular profile and agr-typing","volume":"185","author":"Bardiau","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.febslet.2014.05.037","article-title":"Novel aspects of RNA regulation in Staphylococcus aureus","volume":"588","author":"Fechter","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.diagmicrobio.2010.10.028","article-title":"Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: Results of the CANWARD 2007-2009 study","volume":"69","author":"Nichol","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_76","first-page":"295","article-title":"Frequency of specific agr groups and antibiotic resistance in Staphylococcus aureus isolated from bovine mastitis in the northeast of Iran","volume":"6","author":"Mohsenzadeh","year":"2015","journal-title":"Vet. Res. Forum Int. Q. J."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Xu, D., Shi, L., Cai, R., Li, C., and Yan, H. (2018). Association between agr type, virulence factors, biofilm formation and antibiotic resistance of Staphylococcus aureus isolates from pork production. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01876"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1574-695X.2007.00298.x","article-title":"Agr-Genotyping and transcriptional analysis of biofilm-producing Staphylococcus aureus","volume":"51","author":"Cafiso","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.micpath.2009.09.011","article-title":"Association of biofilm formation and methicillin-resistance with accessory gene regulator (agr) loci in Greek Staphylococcus aureus clones","volume":"47","author":"Ikonomidis","year":"2009","journal-title":"Microb. Pathog."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.micpath.2016.05.022","article-title":"Detection of biofilm related genes, classical enterotoxin genes and agr typing among Staphylococcus aureus isolated from bovine with subclinical mastitis in southwest of Iran","volume":"97","author":"Khoramrooz","year":"2016","journal-title":"Microb. Pathog."},{"key":"ref_81","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_82","unstructured":"(2026, April 22). Seattle. Methicillin-Resistant Staphylococcus aureus Market Size Is Estimated to Reach US$ 1,327.9 Million by 2027-Press Release. Available online: https:\/\/www.pharmiweb.com\/press-release\/2021-03-25\/methicillin-resistant-staphylococcus-aureus-market-size-is-estimated-to-reach-us-1-3279-million-by."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1039\/D0RA09725J","article-title":"Concerted dispersion of Staphylococcus aureus biofilm by bacteriophage and \u2018green synthesized\u2019 silver nanoparticles","volume":"11","author":"Manoharadas","year":"2021","journal-title":"RSC Adv."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wypij, M., J\u0119drzejewski, T., Trzci\u0144ska-Wencel, J., Ostrowski, M., Rai, M., and Goli\u0144ska, P. (2021). Green synthesized silver nanoparticles: Antibacterial and anticancer activities, biocompatibility, and analyses of surface-attached proteins. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.632505"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/mdr.2015.0170","article-title":"Oligomerization of RNAIII-Inhibiting Peptide Inhibits Adherence and Biofilm Formation of Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo","volume":"22","author":"Zhou","year":"2016","journal-title":"Microb. Drug Resist."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"81","DOI":"10.31083\/ph.2015.4750","article-title":"RIP-V improves murine survival in a sepsis model by down-regulating RNAIII expression and \u03b1-hemolysin release of methicillin-resistant Staphylococcus aureus","volume":"70","author":"Ma","year":"2015","journal-title":"Die Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e00500","DOI":"10.1128\/mSphere.00500-17","article-title":"Targeting virulence in Staphylococcus aureus by chemical inhibition of the accessory gene regulator system in vivo","volume":"3","author":"Salam","year":"2018","journal-title":"mSphere"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Sully, E.K., Malachowa, N., Elmore, B.O., Alexander, S.M., Femling, J.K., Gray, B.M., DeLeo, F.R., Otto, M., Cheung, A.L., and Edwards, B.S. (2014). Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004174"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Pant, N., Miranda-Hernandez, S., Rush, C., Warner, J., and Eisen, D.P. (2022). Effect of savirin in the prevention of biofilm-related Staphylococcus aureus prosthetic joint infection. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.989417"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Wallis, J.K., Kr\u00f6mker, V., and Paduch, J.-H. (2019). Biofilm challenge: Lactic acid bacteria isolated from bovine udders versus Staphylococci. Foods, 8.","DOI":"10.3390\/foods8020079"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1128\/AEM.03323-12","article-title":"Inhibition of Staphylococcus aureus invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei","volume":"79","author":"Bouchard","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/microbiolres12040068","article-title":"Probiotics as Therapeutic Tools against Pathogenic Biofilms: Have We Found the Perfect Weapon?","volume":"12","author":"Meroni","year":"2021","journal-title":"Microbiol. Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Asli, A., Brouillette, E., Ster, C., Ghinet, M.G., Brzezinski, R., Lacasse, P., Jacques, M., and Malouin, F. (2017). Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus aureus isolates associated with bovine mastitis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176988"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Canovas, J., Baldry, M., Bojer, M.S., Andersen, P.S., Grzeskowiak, P.K., Stegger, M., Damborg, P., Olsen, C.A., and Ingmer, H. (2016). Cross-talk between Staphylococcus aureus and other Staphylococcal species via the agr quorum sensing system. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01733"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.chembiol.2016.01.004","article-title":"Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles","volume":"23","author":"Wang","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1472-765X.2005.01781.x","article-title":"Isolation and characterization of two anti-staphylococcal bacteriophages specific for pathogenic Staphylococcus aureus associated with bovine infections","volume":"41","author":"Ross","year":"2005","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Iwano, H., Inoue, Y., Takasago, T., Kobayashi, H., Furusawa, T., Taniguchi, K., Fujiki, J., Yokota, H., Usui, M., and Tanji, Y. (2018). Bacteriophage \u03a6SA012 has a broad host range against Staphylococcus aureus and effective lytic capacity in a mouse mastitis model. Biology, 7.","DOI":"10.3390\/biology7010008"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e26825","DOI":"10.4161\/bact.26825","article-title":"Bacteriophage K for reduction of Staphylococcus aureus biofilm on central venous catheter material","volume":"3","author":"Lungren","year":"2013","journal-title":"Bacteriophage"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/jor.70029","article-title":"Activity of Phage and Vancomycin in a Murine Staphylococcus aureus Periprosthetic Joint Infection Model Managed With Debridement and Implant Retention","volume":"43","author":"Herren","year":"2025","journal-title":"J. Orthop. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1128\/AEM.01789-14","article-title":"Combined use of bacteriophage K and a novel bacteriophage to reduce Staphylococcus aureus biofilm formation","volume":"80","author":"Alves","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Klein, R.C., Fabres-Klein, M.H., de Oliveira, L.L., Feio, R.N., Malouin, F., and Ribon Ade, O. (2015). A C-type lectin from Bothrops jararacussu venom disrupts Staphylococcal biofilms. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120514"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e02020-16","DOI":"10.1128\/AAC.02020-16","article-title":"Sustained nitric oxide-releasing nanoparticles interfere with methicillin-resistant Staphylococcus aureus adhesion and biofilm formation in a rat central venous catheter model","volume":"61","author":"Mihu","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1049\/iet-nbt.2011.0061","article-title":"Effect of biologically synthesised silver nanoparticles on Staphylococcus aureus biofilm quenching and prevention of biofilm formation","volume":"6","author":"Masurkar","year":"2012","journal-title":"IET Nanobiotechnol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"18877","DOI":"10.1038\/srep18877","article-title":"Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria","volume":"6","author":"Mu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s11999-016-5211-7","article-title":"Phosphatidylcholine coatings deliver local antimicrobials and reduce infection in a murine model: A preliminary study","volume":"475","author":"Harris","year":"2017","journal-title":"Clin. Orthop. Relat. Res.\u00ae"},{"key":"ref_106","first-page":"5611","article-title":"Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles","volume":"7","author":"Lellouche","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_107","first-page":"1175","article-title":"Antibiofilm surface functionalization of catheters by magnesium fluoride nanoparticles","volume":"7","author":"Lellouche","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_108","first-page":"6120509","article-title":"Anti-inflammatory and antimicrobial effects of estradiol in bovine mammary epithelial cells during Staphylococcus aureus internalization","volume":"2016","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"33857","DOI":"10.1021\/acsnano.5c08838","article-title":"Autoinducing Peptide-Mediated Bacterial Keratitis Therapy by Camouflaged Staphylococcus aureus","volume":"19","author":"Wu","year":"2025","journal-title":"ACS Nano"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4014\/jmb.1609.09053","article-title":"Screening of anti-biofilm compounds from marine-derived fungi and the effects of Secalonic acid D on Staphylococcus aureus biofilm","volume":"27","author":"Wang","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1874285801105010021","article-title":"The use of commercially available alpha-amylase compounds to inhibit and remove Staphylococcus aureus biofilms","volume":"5","author":"Craigen","year":"2011","journal-title":"Open Microbiol. J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jac\/dkp145","article-title":"Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice","volume":"64","author":"Chanturiya","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_113","unstructured":"Index, N. (2026, June 22). Lysostaphin Applications for Staphylococcus aureus Infections. Available online: https:\/\/www.nature.com\/nature-index\/topics\/l4\/lysostaphin-applications-for-staphylococcus-aureus-infections."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s13346-024-01518-9","article-title":"Storage stability of lysostaphin solution and its pulmonary delivery","volume":"14","author":"Zeng","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1128\/IAI.01418-15","article-title":"Hyaluronan modulation impacts Staphylococcus aureus biofilm infection","volume":"84","author":"Ibberson","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"625341","DOI":"10.1155\/2013\/625341","article-title":"Bacteriophage-Derived Peptidase CHAPK Eliminates and Prevents Staphylococcal Biofilms","volume":"2013","author":"Fenton","year":"2013","journal-title":"Int. J. Microbiol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez, D., Ruas-Madiedo, P., Mart\u00ednez, B., Rodr\u00edguez, A., and Garc\u00eda, P. (2014). Effective Removal of Staphylococcal Biofilms by the Endolysin LysH5. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107307"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Nasiri Shoeibi, Z., Rafiee, F., Akrami, S., Ghandehari, Z., and Feizabadi, M.M. (2026). Endolysins, Depolymerases, Holins, and VALs: Phage-Derived Proteins for Combating Antimicrobial Resistance. Microb. Drug Resist., 10766294261441705.","DOI":"10.1177\/10766294261441705"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijmm.2018.11.002","article-title":"An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms","volume":"309","author":"Suresh","year":"2019","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1128\/IAI.00377-13","article-title":"Staphopains modulate Staphylococcus aureus biofilm integrity","volume":"81","author":"Mootz","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/mbo3.214","article-title":"Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants","volume":"3","author":"Loughran","year":"2014","journal-title":"Microbiologyopen"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ja.2011.113","article-title":"Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci","volume":"65","author":"Kaplan","year":"2012","journal-title":"J. Antibiot."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Deng, W., Lei, Y., Tang, X., Li, D., Liang, J., Luo, J., Liu, L., Zhang, W., Ye, L., and Kong, J. (2022). DNase inhibits early biofilm formation in Pseudomonas aeruginosa- or Staphylococcus aureus-induced empyema models. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.917038"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kaplan, J.B., Sukhishvili, S.A., Sailer, M., Kridin, K., and Ramasubbu, N. (2024). Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme. Pathogens, 13.","DOI":"10.20944\/preprints202407.1788.v1"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/lam.12305","article-title":"Effect of proteases against biofilms of Staphylococcus aureus and Staphylococcus epidermidis","volume":"59","author":"Elchinger","year":"2014","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1007\/s00253-020-10561-8","article-title":"Mannosylerythritol lipids: Dual inhibitory modes against Staphylococcus aureus through membrane-mediated apoptosis and biofilm disruption","volume":"104","author":"Shu","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1099\/jmm.0.040758-0","article-title":"Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: Role for clumping factor B","volume":"61","author":"Abraham","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1574-6968.2010.02190.x","article-title":"Sulfhydryl compounds reduce Staphylococcus aureus biofilm formation by inhibiting PIA biosynthesis","volume":"316","author":"Wu","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"172472","DOI":"10.1016\/j.ejphar.2019.172472","article-title":"Alkaloids for cancer prevention and therapy: Current progress and future perspectives","volume":"858","author":"Mondal","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e01728","DOI":"10.1016\/j.heliyon.2019.e01728","article-title":"Anti-biofilm activity of hydromethanolic plant extracts against Staphylococcus aureus isolates from bovine mastitis","volume":"5","author":"Gomes","year":"2019","journal-title":"Heliyon"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phymed.2017.10.018","article-title":"Plant phenolics and terpenoids as adjuvants of antibacterial and antifungal drugs","volume":"37","author":"Zacchino","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Swolana, D., K\u0119pa, M., Kaba\u0142a-Dzik, A., Dzik, R., and Wojtyczka, R.D. (2021). Sensitivity of Staphylococcal biofilm to selected compounds of plant origin. Antibiotics, 10.","DOI":"10.3390\/antibiotics10050607"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1080\/14786419.2017.1366485","article-title":"Antimicrobial and anti-biofilm activity of tannic acid against Staphylococcus aureus","volume":"32","author":"Dong","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Maisetta, G., Batoni, G., Caboni, P., Esin, S., Rinaldi, A.C., and Zucca, P. (2019). Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2487-7"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Schestakow, A., Guth, M.S., Eisenmenger, T.A., and Hannig, M. (2021). Evaluation of anti-biofilm activity of mouthrinses containing tannic acid or chitosan on dentin in situ. Molecules, 26.","DOI":"10.3390\/molecules26051351"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2174\/0929867325666181001104550","article-title":"A Review: The anti-inflammatory, anticancer and antibacterial properties of four kinds of licorice flavonoids isolated from licorice","volume":"27","author":"Jia","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1900380","DOI":"10.1002\/ardp.201900380","article-title":"Coumarin-containing hybrids and their antibacterial activities","volume":"353","author":"Feng","year":"2020","journal-title":"Arch. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e1900496","DOI":"10.1002\/cbdv.201900496","article-title":"Evaluation of antibacterial activity of Lavandulapedunculata subsp. atlantica (Braun-Blanq.) romo essential oil and selected terpenoids against resistant bacteria strains\u2013structure\u2013activity relationships","volume":"17","author":"Sayout","year":"2020","journal-title":"Biochem. Biodivers."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"13195","DOI":"10.1021\/acs.jafc.9b05595","article-title":"Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus","volume":"67","author":"Wu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1080\/14786419.2019.1698575","article-title":"Epigallocatechin gallate has antibacterial and antibiofilm activity in methicillin resistant and susceptible Staphylococcus aureus of different lineages in non-cytotoxic concentrations","volume":"35","author":"Knidel","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Shinde, S., Lee, L.H., and Chu, T. (2021). Inhibition of Biofilm Formation by the Synergistic Action of EGCG-S and Antibiotics. Antibiotics, 10.","DOI":"10.3390\/antibiotics10020102"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Hengge, R. (2019). Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG. Molecules, 24.","DOI":"10.3390\/molecules24132403"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1186\/s40064-016-2759-3","article-title":"Moringa oleifera aqueous leaf extract inhibits reducing monosaccharide-induced protein glycation and oxidation of bovine serum albumin","volume":"5","author":"Nunthanawanich","year":"2016","journal-title":"Springerplus"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/0929866530666230123113007","article-title":"Disruption of Staphylococcus aureus biofilms with purified Moringa Oleifera leaf extract protein","volume":"30","author":"Menon","year":"2023","journal-title":"Protein Pept. Lett."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Kim, S., and Kim, T.J. (2024). Inhibitory Effect of Moringa oleifera Seed Extract and Its Behenic Acid Component on Staphylococcus aureus Biofilm Formation. Antibiotics, 14.","DOI":"10.3390\/antibiotics14010019"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.5455\/OVJ.2025.v15.i11.11","article-title":"Exploring the antibacterial and anti-biofilm properties of Rosmarinus officinalis extracts: A natural strategy against methicillin-resistant Staphylococcus aureus","volume":"15","author":"Ali","year":"2025","journal-title":"Open Vet. J."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Iobbi, V., Parisi, V., Bernab\u00e8, G., De Tommasi, N., Bisio, A., and Brun, P. (2023). Anti-Biofilm Activity of Carnosic Acid from Salvia rosmarinus against Methicillin-Resistant Staphylococcus aureus. Plants, 12.","DOI":"10.3390\/plants12213679"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Nakagawa, S., Hillebrand, G.G., and Nunez, G. (2020). Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence. Antibiotics, 9.","DOI":"10.3390\/antibiotics9040149"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Khan, M.A., Celik, I., Khan, H.M., Shahid, M., Shahzad, A., Kumar, S., and Ahmed, B. (2023). Antibiofilm and anti-quorum sensing activity of Psidium guajava L. leaf extract: In vitro and in silico approach. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0295524"},{"key":"ref_150","first-page":"685","article-title":"Antibacterial Activities of Guava (Psidium guajava) Leaf Aqueous Extract Against Staphylococcus aureus and Escherichia coli","volume":"35","author":"Akter","year":"2026","journal-title":"Mymensingh Med. J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1080\/08927014.2020.1842877","article-title":"Benzyl isocyanate isolated from the leaves of Psidium guajava inhibits Staphylococcus aureus biofilm formation","volume":"36","author":"Dutta","year":"2020","journal-title":"Biofouling"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"39460","DOI":"10.1038\/s41598-025-22965-5","article-title":"Evaluation of antimicrobial efficacy of Psidium guajava L. leaf extract in ketoconazole shampoo","volume":"15","author":"Imtara","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"20250201","DOI":"10.1515\/chem-2025-0201","article-title":"Targeting QS-mediated virulence in Staphylococcus aureus using Eucalyptus globulus essential oil: From chemistry to molecular docking","volume":"24","author":"Tabti","year":"2026","journal-title":"Open Chem."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Elangovan, S., and Mudgil, P. (2023). Antibacterial Properties of Eucalyptus globulus Essential Oil against MRSA: A Systematic Review. Antibiotics, 12.","DOI":"10.3390\/antibiotics12030474"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhang, Z., Li, J., and Qin, G. (2023). New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition. Toxins, 15.","DOI":"10.3390\/toxins15090570"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Okba, M.M., El-Shiekh, R.A., Abu-Elghait, M., Sobeh, M., and Ashour, R.M.S. (2021). HPLC-PDA-ESI-MS\/MS profiling and anti-biofilm potential of Eucalyptussideroxylon flowers. Antibiotics, 10.","DOI":"10.3390\/antibiotics10070761"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/chromsci\/bmz029","article-title":"Eucalyptus Sideroxylon Bark anti-inflammatory potential, its UPLC-PDA-ESI-qTOF-MS profiling, and isolation of a new phloroglucinol","volume":"57","author":"Ashour","year":"2019","journal-title":"J. Chromatogr. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jep.2015.09.026","article-title":"Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant Staphylococcus aureus biofilm formation and Schistosoma mansoni worms","volume":"175","author":"Quelemes","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","first-page":"110","article-title":"Impact of Neem (Azadirachta indica) and Papaya (Carica papaya) Leaves on Staphylococcus aureus Virulence Factors","volume":"11","author":"Shil","year":"2026","journal-title":"Res. Perspect. Biol. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Ziegert, Z., Dietz, M., Hill, M., McBride, M., Painter, E., Elias, M.H., and Staley, C. (2024). Targeting quorum sensing for manipulation of commensal microbiota. BMC Biotechnol., 24.","DOI":"10.1186\/s12896-024-00937-3"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.foodchem.2012.08.002","article-title":"Inhibition of biofilm development of uropathogens by curcumin\u2014An anti-quorum sensing agent from Curcuma longa","volume":"148","author":"Packiavathy","year":"2014","journal-title":"Food Chem."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Adamczak, A., O\u017carowski, M., and Karpi\u0144ski, T.M. (2020). Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity. Pharmaceuticals, 13.","DOI":"10.3390\/ph13070153"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Pu, Z., Tang, H., Long, N., Qiu, M., Gao, M., Sun, F., and Dai, M. (2020). Assessment of the anti-virulence potential of extracts from four plants used in traditional Chinese medicine against multidrug-resistant pathogens. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-03114-z"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"154973","DOI":"10.1016\/j.phymed.2023.154973","article-title":"Evolving biofilm inhibition and eradication in clinical settings through plant-based antibiofilm agents","volume":"119","author":"Silva","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Nair, A., Debprasad, C., and Bhaskar, S. (2019). Plant-derived immunomodulators. New Look to Phytomedicine, Academic Press.","DOI":"10.1016\/B978-0-12-814619-4.00018-5"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4314\/ajtcam.v13i2.21","article-title":"Antiviral effects of green tea (Camellia sinensis) against pathogenic viruses in human and animals (a mini-review)","volume":"13","author":"Mahmood","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fm.2011.08.019","article-title":"AFM study of the differential inhibitory effects of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against Gram-positive and Gram-negative bacteria","volume":"29","author":"Cui","year":"2012","journal-title":"Food Microbiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"110150","DOI":"10.1016\/j.lwt.2020.110150","article-title":"HPLC-DAD phenolic profiles, antibiofilm, anti-quorum sensing and enzyme inhibitory potentials of Camellia sinensis (L.) O. Kuntze and Curcuma longa L","volume":"133","author":"Tamfu","year":"2020","journal-title":"LWT"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"109430","DOI":"10.1016\/j.foodres.2020.109430","article-title":"Optimizing the extraction of bioactive compounds from pu-erh tea (Camellia sinensis var. assamica) and evaluation of antioxidant, cytotoxic, antimicrobial, antihemolytic, and inhibition of \u03b1-amylase and \u03b1-glucosidase activities","volume":"137","author":"Armstrong","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.14260\/jemds\/2021\/338","article-title":"Role of a Miracle Tree (Moringa oleifera) in Healthcare","volume":"10","author":"Yadav","year":"2021","journal-title":"J. Evol. Med. Dent. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11947-020-02521-x","article-title":"Natural extract of moringa oleifera leaves promoting control of Staphylococcus aureus strains biofilm on PVC surface","volume":"13","author":"Bergamasco","year":"2020","journal-title":"Food Bioprocess Technol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Enan, G., Al-Mohammadi, A.-R., Mahgoub, S., Abdel-Shafi, S., Askar, E., Ghaly, M.F., Taha, M.A., and El-Gazzar, N. (2020). Inhibition of Staphylococcus aureus LC 554891 by Moringa oleifera seed extract either singly or in combination with antibiotics. Molecules, 25.","DOI":"10.3390\/molecules25194583"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12929-019-0499-8","article-title":"Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent","volume":"26","author":"Camargo","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12944-017-0580-9","article-title":"Chemical composition, anti-biofilm activity and potential cytotoxic effect on cancer cells of Rosmarinus officinalis L. essential oil from Tunisia","volume":"16","author":"Jardak","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/1535370216688571","article-title":"Biological activities of Rosmarinus officinalis L. (rosemary) extract as analyzed in microorganisms and cells","volume":"242","author":"Figueira","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_176","first-page":"129","article-title":"Antibiofilm and antiviral potential of leaf extracts from Moringa oleifera and rosemary (Rosmarinus officinalis Lam.)","volume":"52","author":"Abdelhamid","year":"2017","journal-title":"Egypt. J. Microbiol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"113965","DOI":"10.1016\/j.jpba.2021.113965","article-title":"Capturing the antimicrobial profile of Rosmarinus officinalis against methicillin-resistant Staphylococcus aureus (MRSA) with bioassay-guided fractionation and bioinformatics","volume":"197","author":"Khin","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e00523","DOI":"10.1016\/j.btre.2020.e00523","article-title":"Investigation on the biofilm eradication potential of selected medicinal plants against methicillin-resistant Staphylococcus aureus","volume":"28","author":"A","year":"2020","journal-title":"Biotechnol. Rep."},{"key":"ref_179","first-page":"134","article-title":"Evaluation of antimicrobial activity of ethanolic extracts of Azadirachta indica and Psidium guajava against clinically important bacteria at varying pH and temperature","volume":"28","author":"Rasool","year":"2017","journal-title":"Biomed. Res.-India"},{"key":"ref_180","unstructured":"Qaralleh, H., Al-Limoun, M., Khlaifat, A., Khleifat, K., Al-Tawarah, N., Alsharafa, K., and Abu-Harirah, H. (2021). Antibacterial and antibiofilm activities of a traditional herbal formula against respiratory infection causing bacteria. arXiv."},{"key":"ref_181","first-page":"71","article-title":"Antibiofilm activity and composition of the petroleum ether soluble fraction of Psidium guajava Linn","volume":"10","author":"Dildar","year":"2020","journal-title":"FUUAST J. Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s43094-020-00056-8","article-title":"Antibiofilm potential of Psidium guajava and Passiflora edulis pulp extracts against Staphylococcus aureus, cytotoxicity, and interference on the activity of antimicrobial drugs","volume":"6","author":"Costa","year":"2020","journal-title":"Future J. Pharm. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41522-019-0108-3","article-title":"Rapid microevolution of biofilm cells in response to antibiotics","volume":"5","author":"Penesyan","year":"2019","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3998\/ark.5550190.0008.f27","article-title":"Eucalyptone G, a new phloroglucinol derivative and other constituents from Eucalyptus Globulus Labill","volume":"15","author":"Mohamed","year":"2007","journal-title":"Arkivoc"},{"key":"ref_185","unstructured":"Brooker, M.I.H. (2019, July 18). Eucalyptus globulus. Royal Botanic Gardens Victoria, Available online: https:\/\/vicflora.rbg.vic.gov.au\/flora\/taxon\/1dfdd922-7fa3-4fc4-bb6e-96cfa112337a."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1590\/S0080-623420150000200005","article-title":"Antimicrobial activity of Eucalyptus globulus oil, xylitol and papain: A pilot study","volume":"49","author":"Mota","year":"2015","journal-title":"Rev. Esc. Enferm. USP"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.micpath.2018.03.006","article-title":"Assessment of the antibiofilm and antiquorum sensing activities of Eucalyptus globulus essential oil and its main component 1,8-cineole against methicillin-resistant Staphylococcus aureus strains","volume":"118","author":"Merghni","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_188","first-page":"425","article-title":"Anti-biofilm potential of aqueous Eucalyptus leaf extract against nosocomial pathogens: Staphylococcus and Pseudomonas aeruginosa","volume":"7","author":"Kaur","year":"2018","journal-title":"Pharma Innovtion"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Santos, B.M.d., Zibrandtsen, J.F.S., Gunbilig, D., S\u00f8rensen, M., Cozzi, F., Boughton, B.A., Heskes, A.M., and Neilson, E.H.J. (2019). Quantification and localization of formylated phloroglucinol compounds (FPCs) in Eucalyptus species. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00186"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Mostafa, I., Abbas, H.A., Ashour, M.L., Yasri, A., El-Shazly, A.M., Wink, M., and Sobeh, M. (2020). Polyphenols from Salix tetrasperma impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa. Molecules, 25.","DOI":"10.3390\/molecules25061341"},{"key":"ref_191","first-page":"7382506","article-title":"Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid.-Based Complement","volume":"2016","author":"Alzohairy","year":"2016","journal-title":"Altern. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5455\/javar.2019.f340","article-title":"Antibacterial efficacy of ethanolic extract of Camellia sinensis and Azadirachta indica leaves on methicillin-resistant Staphylococcus aureus and shiga-toxigenic Escherichia coli","volume":"6","author":"Zihadi","year":"2019","journal-title":"J. Adv. Vet. Anim. Res."},{"key":"ref_193","first-page":"514","article-title":"Anti-biofilm activity of Azadirachta indica and Ocimum sanctum aqueous extract combination against MRSA","volume":"12","author":"Sood","year":"2020","journal-title":"Int. J. Pharm. Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Omosa, L.K., Midiwo, J.O., and Kuete, V. (2017). Curcuma\u00a0longa. Medicinal Spices and Vegetables from Africa, Elsevier.","DOI":"10.1016\/B978-0-12-809286-6.00019-4"},{"key":"ref_195","first-page":"S1","article-title":"A comprehensive review on Curcuma longa Linn.: Phytochemical, pharmacological, and molecular study","volume":"11","author":"Kamran","year":"2017","journal-title":"Int. J. Green Pharm."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/ptr.1553","article-title":"Antioxidant availability of turmeric in relation to its medicinal and culinary uses","volume":"18","author":"Tilak","year":"2004","journal-title":"Phytother. Res. PTR"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10103-012-1064-9","article-title":"Phototoxic effect of curcumin on methicillin-resistant Staphylococcus aureus and L929 fibroblasts","volume":"28","author":"Ribeiro","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.2147\/IJN.S71365","article-title":"Upconversion nanoparticles conjugated with curcumin as a photosensitizer to inhibit methicillin-resistant Staphylococcus aureus in lung under near infrared light","volume":"9","author":"Ye","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_199","unstructured":"(2025, April 04). Sanguisorba officinalis L. Plants of the World Online. Available online: https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:741402-1."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/lam.13417","article-title":"Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus","volume":"72","author":"Wang","year":"2021","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s00217-019-03276-2","article-title":"Characterization of polyphenolic constituents from Sanguisorba officinalis L. and its antibacterial activity","volume":"245","author":"Zhu","year":"2019","journal-title":"Eur. Food Res. Technol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2174\/1381612826666200212121710","article-title":"Inhibition of bacterial biofilm formation by phytotherapeutics with focus on overcoming antimicrobial resistance","volume":"26","author":"Jang","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"8486","DOI":"10.3168\/jds.2015-9899","article-title":"Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formation of methicillin-resistant Staphylococcus aureus in an ica-dependent manner","volume":"98","author":"Chen","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1142\/S0192415X18500155","article-title":"Phytotherapeutic activities of Sanguisorba officinalis and its chemical constituents: A Review","volume":"46","author":"Jang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e03303","DOI":"10.1016\/j.heliyon.2020.e03303","article-title":"In vitro antibacterial activity of medicinal plants against biofilm-forming methicillin-resistant Staphylococcus aureus: Efficacy of Moringa stenopetala and Rosmarinus officinalis extracts","volume":"6","author":"Manilal","year":"2020","journal-title":"Heliyon"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.13005\/bpj\/1978","article-title":"Characterization and identification of methicillin-resistant Staphylococcus aureus (MRSA) producing biofilm: Impacts of garlic extract and Lactobacillus biosurfactants","volume":"13","author":"Mohamed","year":"2020","journal-title":"Biomed. Pharmacol. J."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"104191","DOI":"10.1016\/j.micpath.2020.104191","article-title":"Antibiofilm, antiquorum sensing and antioxidant activity of secondary metabolites from seeds of Annona senegalensis, Persoon","volume":"144","author":"Tamfu","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_208","first-page":"7","article-title":"The Antibiofilm Activity of Jatropha curcas L. Latex on Staphylococcus aureus ATCC 25923","volume":"5","author":"Utami","year":"2019","journal-title":"Nat. B J. Health Environ. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/1995-7645.273573","article-title":"Orostachys japonicus ethyl acetate fraction suppresses MRSA biofilm formation","volume":"13","author":"Kim","year":"2020","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.35500\/jghs.2020.2.e26","article-title":"Potential therapeutic uses of Moringa stenopetala: A scoping review","volume":"2","author":"Hadis","year":"2020","journal-title":"J. Glob. Health Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"114369","DOI":"10.1016\/j.jep.2021.114369","article-title":"Antibacterial and antibiofilm activities of Mayan medicinal plants against methicillin-susceptible and -resistant strains of Staphylococcus aureus","volume":"279","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1080\/14786419.2019.1650352","article-title":"Antibacterial and anti-biofilm activities of walnut pellicle extract (Juglans regia L.) against coagulase-negative staphylococci","volume":"35","author":"Acquaviva","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_213","first-page":"e12337","article-title":"Antimicrobial and anti-biofilm activities of Citrus sinensis and Moringa oleifera against the pathogenic Pseudomonas aeruginosa and Staphylococcus aureus","volume":"12","author":"M","year":"2020","journal-title":"Cureus"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1139\/cjm-2016-0365","article-title":"Effect of Bacoside A on growth and biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa","volume":"63","author":"Parai","year":"2017","journal-title":"Can. J. Microbiol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.2174\/0929867325666180327105842","article-title":"Virtual screening for the development of new effective compounds against Staphylococcus aureus","volume":"25","author":"Diniz","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"39","DOI":"10.35916\/thmr.v1i2.6","article-title":"Effectiveness of Cinnamon (Cinnamomum burmannii) ethanol extract against Staphylococcus aureus growth","volume":"1","author":"Huda","year":"2019","journal-title":"Trop. Health Med. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"e20201507","DOI":"10.1590\/0001-3765202120201507","article-title":"In-vitro antibacterial and antibiofilm activity of Cinnamomum verum leaf oil against Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae","volume":"93","author":"Wijesinghe","year":"2021","journal-title":"An. DA Acad. Bras. DE Ci\u00eanc."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Nu\u021b\u0103, D.C., Limban, C., Chiri\u021b\u0103, C., Chifiriuc, M.C., Costea, T., Ioni\u021b\u0103, P., Nicolau, I., and Zarafu, I. (2021). Contribution of essential oils to the fight against microbial biofilms\u2014A review. Processes, 9.","DOI":"10.3390\/pr9030537"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.foodcont.2015.09.036","article-title":"Antibiofilm activity of essential oils and plant extracts against Staphylococcus aureus and Escherichia coli biofilms","volume":"61","author":"Bazargani","year":"2016","journal-title":"Food Control"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2678924","DOI":"10.1155\/2018\/2678924","article-title":"Phytochemical screening and biological activity of Mentha \u00d7 piperita L. and Lavandula angustifolia Mill. extracts","volume":"2018","author":"Alexa","year":"2018","journal-title":"Anal. Cell. Pathol."},{"key":"ref_221","first-page":"S23","article-title":"Effect of oregano essential oil on biofilms formed by Staphylococci and Escherichia coli","volume":"16","author":"Oral","year":"2010","journal-title":"Kafkas Univ. Vet. Fak. Derg."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jep.2008.05.005","article-title":"Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus","volume":"118","author":"Quave","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_223","first-page":"56","article-title":"Ballota nigra L.\u2014An overview of pharmacological effects and traditional uses","volume":"66","author":"Przerwa","year":"2020","journal-title":"Int. J."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13567-019-0664-9","article-title":"Evaluation of a Rhodomyrtus tomentosa ethanolic extract for its therapeutic potential on Staphylococcus aureus infections using in vitro and in vivo models of mastitis","volume":"50","author":"Mordmuang","year":"2019","journal-title":"Vet. Res."},{"key":"ref_225","first-page":"1","article-title":"Antimicrobial and antibiofilm activities of the methanol extracts of Rosa damascena against S. aureus","volume":"Volume 30163","author":"Ahmad","year":"2019","journal-title":"Proceedings of the 9th Dental Student\u2019s Scientific Symposium"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1016\/j.ijbiomac.2020.09.037","article-title":"The assessment of antibiofilm activity of chitosan-zinc oxide-gentamicin nanocomposite on Pseudomonas aeruginosa and Staphylococcus aureus","volume":"163","author":"Hemmati","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1055\/s-0030-1250145","article-title":"Quorum sensing inhibitors of Staphylococcus aureus from Italian medicinal plants","volume":"77","author":"Quave","year":"2011","journal-title":"Planta Medica"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/2211352518999200622152308","article-title":"Biochemical composition, antibacterial and anti-biofilm activities of Indian medicinal plants","volume":"19","author":"Mulat","year":"2021","journal-title":"Anti-Infect. Agents"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"168","DOI":"10.19184\/ams.v6i3.17541","article-title":"The extract of kemangi leaves as inhibitor of biofilm from Staphylococcus aureus in vitro","volume":"6","author":"Utami","year":"2020","journal-title":"J. Agromedicine Med. Sci."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ptr.6294","article-title":"Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus","volume":"33","author":"Mouwakeh","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"112135","DOI":"10.1016\/j.jep.2019.112135","article-title":"Nigella sativa seed extract applicability in preparations against methicillin-resistant Staphylococcus aureus and effects on human dermal fibroblasts viability","volume":"244","author":"Gawron","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Sequeda, N., C\u00e1ceres, M., Stashenko, E.E., Hidalgo, W., and Ortiz, C. (2020). Antimicrobial and antibiofilm activities of essential oils against Escherichia coli O157: H7 and methicillin-resistant Staphylococcus aureus (MRSA). Antibiotics, 9.","DOI":"10.3390\/antibiotics9110730"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"270","DOI":"10.15421\/011936","article-title":"Antimicrobial, antibiofilm and biochemichal properties of Thymus vulgaris essential oil against clinical isolates of opportunistic infections","volume":"27","author":"Kryvtsova","year":"2019","journal-title":"Biosyst. Divers."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s12026-017-8933-z","article-title":"Thymus vulgaris L. and thymol assist murine macrophages (RAW 264.7) in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans","volume":"65","author":"Figueira","year":"2017","journal-title":"Immunol. Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1055\/s-0032-1315042","article-title":"Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"78","author":"Cech","year":"2012","journal-title":"Planta Medica"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.2174\/1381612822999160629115627","article-title":"Alkaloids: An emerging antibacterial modality against methicillin resistant Staphylococcus aureus","volume":"22","author":"Pervaiz","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1080\/14786419.2015.1110705","article-title":"Chemical constituents of essential oil of endemic Rhanterium suaveolens Desf. growing in Algerian Sahara with antibiofilm, antioxidant and anticholinesterase activities","volume":"30","author":"Chemsa","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Ben Abdallah, F., Lagha, R., and Gaber, A. (2020). Biofilm inhibition and eradication properties of medicinal plant essential oils against methicillin-resistant Staphylococcus aureus clinical isolates. Pharmaceuticals, 13.","DOI":"10.3390\/ph13110369"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.hermed.2018.07.001","article-title":"Anti-biofilm activity of Rosmarinus officinalis, Punica granatum and Tetradenia riparia against methicillin-resistant Staphylococcus aureus (MRSA) and synergic interaction with penicillin","volume":"14","author":"Endo","year":"2018","journal-title":"J. Herb. Med."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"40","DOI":"10.37652\/juaps.2022.171555","article-title":"Effect of alcoholic extracts of Rosmarinus officinalis and Propolis on inhibition of Staphylococcus aureus and Klebsiella pneumoniae biofilm isolate from urinary tract infection","volume":"12","author":"Kodi","year":"2018","journal-title":"J. Univ. Anbar Pure Sci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1039\/C9MD00044E","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA): Antibiotic-resistance and the biofilm phenotype","volume":"10","author":"Craft","year":"2019","journal-title":"MedChemComm"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Quave, C.L., Est\u00e9vez-Carmona, M., Compadre, C.M., Hobby, G., Hendrickson, H., Beenken, K.E., and Smeltzer, M.S. (2012). Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0028737"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/2049-632X.12141","article-title":"Anti-biofilm agents: Recent breakthrough against multi-drug resistant Staphylococcus aureus","volume":"70","author":"Chung","year":"2014","journal-title":"Pathog. Dis."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1615\/JEnvironPatholToxicolOncol.2020032665","article-title":"Going beyond antibiotics: Natural plant extracts as an emergent strategy to combat biofilm-associated infections","volume":"39","author":"Kou","year":"2020","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Ka\u010d\u00e1niov\u00e1, M., Galovi\u010dov\u00e1, L., Ivani\u0161ov\u00e1, E., Vukovic, N.L., \u0160tef\u00e1nikov\u00e1, J., Valkov\u00e1, V., Borotov\u00e1, P., \u017diarovsk\u00e1, J., Terentjeva, M., and Fel\u0161\u00f6ciov\u00e1, S. (2020). Antioxidant, antimicrobial and antibiofilm activity of coriander (Coriandrum sativum L.) essential oil for its application in foods. Foods, 9.","DOI":"10.3390\/foods9030282"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"100401","DOI":"10.1016\/j.hermed.2020.100401","article-title":"Anti-infective effects of traditional household remedies described in the national list of essential medicines, Thailand, on important human pathogens","volume":"26","author":"Yincharoen","year":"2021","journal-title":"J. Herb. Med."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Khan, M.F., Tang, H., Lyles, J.T., Pineau, R., Mashwani, Z.-u.-R., and Quave, C.L. (2018). Antibacterial properties of medicinal plants from Pakistan against multidrug-resistant ESKAPE pathogens. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00815"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.5958\/0976-5506.2019.03838.5","article-title":"Comparative study of antimicrobial activity of seven ficus species cultivated in Egypt","volume":"10","author":"Hassan","year":"2019","journal-title":"Indian J. Public Health Res. Dev."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4314\/ajtcam.v11i3.19","article-title":"Antibacterial and anti-biofilm activity of flavonoids and triterpenes isolated from the extracts of Ficus sansibarica Warb. subsp. sansibarica (Moraceae) extracts","volume":"11","author":"Awolola","year":"2014","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13568-019-0793-6","article-title":"Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics","volume":"9","author":"Haq","year":"2019","journal-title":"AMB Express"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1089\/acm.2013.0173","article-title":"Evaluation of antibacterial activity, phytochemical constituents, and cytotoxicity effects of Thai household ancient remedies","volume":"20","author":"Chusri","year":"2014","journal-title":"J. Altern. Complement. Med."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"263","DOI":"10.22159\/ajpcr.2016.v9i6.14362","article-title":"Antibacterial and antibiofilm activities of crude extracts of Lawsonia inermis against methicillin-resistant Staphylococcus aureus","volume":"9","author":"Triveni","year":"2016","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"e01604","DOI":"10.1016\/j.heliyon.2019.e01604","article-title":"A comparative study on chemical composition, antibiofilm and biological activities of leaves extracts of four Tunisian olive cultivars","volume":"5","author":"Edziri","year":"2019","journal-title":"Heliyon"},{"key":"ref_254","first-page":"1371","article-title":"Evaluation of the antibacterial effects of Eucalyptus camaldulensis L., Glycyrrhiza glabra L. and Morus nigra L. extracts against some pathogenic bacteria in vitro","volume":"58","author":"Sidkey","year":"2017","journal-title":"Iraqi J. Sci."},{"key":"ref_255","first-page":"383","article-title":"Isolation of methyl gallate from mango twigs and its anti-biofilm activity","volume":"6","author":"Subramanian","year":"2016","journal-title":"J. Biol. Act. Prod. Nat."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"142","DOI":"10.36103\/ijas.v49i1.217","article-title":"Evaluation of Phyllanthus emblica extract as antibacterial and antibiofilm against biofilm formation bacteria","volume":"49","author":"Hamzah","year":"2018","journal-title":"Iraqi J. Agric. Sci."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4315\/0362-028X.JFP-19-337","article-title":"Rosemary and tea tree essential oils exert antibiofilm activities in vitro against Staphylococcus aureus and Escherichia coli","volume":"83","author":"Liu","year":"2020","journal-title":"J. Food Prot."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.micpath.2018.07.027","article-title":"Phenotype and RNA-seq-based transcriptome profiling of Staphylococcus aureus biofilms in response to tea tree oil","volume":"123","author":"Zhao","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/1750-3841.14655","article-title":"Composition, antivirulence activity, and active property distribution of the fruit of Terminalia chebula Retz","volume":"84","author":"Li","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Ouyang, P., He, X., Yuan, Z.-W., Yin, Z.-Q., Fu, H., Lin, J., He, C., Liang, X., Lv, C., and Shu, G. (2018). Erianin against Staphylococcus aureus infection via inhibiting sortase A. Toxins, 10.","DOI":"10.3390\/toxins10100385"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijid.2020.09.170","article-title":"Antibiofilm and synergistic antibacterial effect of Garlic (Allium sativum) against Methicillin resistant Staphylococcus aureus (MRSA)","volume":"101","author":"Anupam","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3136\/fstr.25.65","article-title":"Constituents of the essential oils of garlic and citronella and their vapor-phase inhibition mechanism against S. aureus","volume":"25","author":"Zhang","year":"2019","journal-title":"Food Sci. Technol. Res."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/08927014.2014.976207","article-title":"Non-toxic plant metabolites regulate Staphylococcus viability and biofilm formation: A natural therapeutic strategy useful in the treatment and prevention of skin infections","volume":"30","author":"Ferrero","year":"2014","journal-title":"Biofouling"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.fitote.2013.02.001","article-title":"Inhibition of \u03b1-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia","volume":"86","author":"Zhang","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijbiomac.2020.04.231","article-title":"Proteomic profiling unveils citral modulating expression of IsaA, CodY and SaeS to inhibit biofilm and virulence in methicillin-resistant Staphylococcus aureus","volume":"158","author":"Valliammai","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"24","DOI":"10.26605\/medvet-v14n1-3711","article-title":"M\u00e9todos alternativos no tratamento de infec\u00e7\u00f5es causadas por Staphylococcus aureus","volume":"14","author":"Fanin","year":"2020","journal-title":"Med. Veterin\u00e1ria"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.sjbs.2020.04.005","article-title":"In vitro antioxidant and cytotoxic activities of polyherbal extracts from Vetiveria zizanioides, Trichosanthes cucumerina, and Mollugo cerviana on HeLa and MCF-7 cell lines","volume":"27","author":"Seshadri","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.micpath.2017.07.016","article-title":"Antibiofilm activity of Vetiveria zizanioides root extract against methicillin-resistant Staphylococcus aureus","volume":"110","author":"Kannappan","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Song, X., Liu, T., Wang, L., Liu, L., Li, X., and Wu, X. (2020). Antibacterial effects and mechanism of mandarin (Citrus reticulata L.) essential oil against Staphylococcus aureus. Molecules, 25.","DOI":"10.3390\/molecules25214956"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13020-020-00413-y","article-title":"Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: A review","volume":"16","author":"Junren","year":"2021","journal-title":"Chin. Med."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Shahid, A., Rasool, M., Akhter, N., Aslam, B., Hassan, A., Sana, S., Rasool, M.H., and Khurshid, M. (2019). Innovative strategies for the control of biofilm formation in clinical settings. Bacterial Biofilms, IntechOpen.","DOI":"10.5772\/intechopen.89310"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jep.2018.04.031","article-title":"Biofilm inhibition mechanism from extract of Hymenocallis littoralis leaves","volume":"222","author":"Nadaf","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Gao, S., Liu, G., Li, J., Chen, J., Li, L., Li, Z., Zhang, X., Zhang, S., Thorne, R.F., and Zhang, S. (2020). Antimicrobial Activity of Lemongrass Essential Oil (Cymbopogon flexuosus) and Its Active Component Citral Against Dual-Species Biofilms of Staphylococcus aureus and Candida Species. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.603858"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.micpath.2018.03.043","article-title":"Nanoemulsions containing Cymbopogon flexuosus essential oil: Development, characterization, stability study and evaluation of antimicrobial and antibiofilm activities","volume":"118","author":"Quatrin","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Zheng, X., Chen, L., Zeng, W., Liao, W., Wang, Z., Tian, X., Fang, R., Sun, Y., and Zhou, T. (2021). Antibacterial and anti-biofilm efficacy of Chinese Dragon\u2019s Blood against Staphylococcus aureus isolated from infected wounds. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.672943"},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Thu, Z.M., Myo, K.K., Aung, H.T., Armijos, C., and Vidari, G. (2020). Flavonoids and stilbenoids of the genera Dracaena and Sansevieria: Structures and bioactivities. Molecules, 25.","DOI":"10.3390\/molecules25112608"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3329\/bpj.v22i1.40075","article-title":"Phytochemical screenings and bioactivities of Duabanga grandiflora (Roxb. ex DC.) Walp","volume":"22","author":"Akhter","year":"2019","journal-title":"Bangladesh Pharm. J."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.3390\/molecules20034473","article-title":"Inhibitory effect of Duabanga grandiflora on MRSA biofilm formation via prevention of cell-surface attachment and PBP2a production","volume":"20","author":"Santiago","year":"2015","journal-title":"Molecules"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"104577","DOI":"10.1016\/j.archoralbio.2019.104577","article-title":"Cytotoxicity and antimicrobial effects of citronella oil (Cymbopogon nardus) and commercial mouthwashes on S. aureus and C. albicans biofilms in prosthetic materials","volume":"109","author":"Cunha","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20473\/fmi.v55i1.12542","article-title":"Correlation between the bacteriostatic and bactericide effect with antibiofilm and anticolony spreading from javanese citronella oil on methicillin-resistant Staphylococcus aureus (MRSA)","volume":"55","author":"Hidayah","year":"2019","journal-title":"Folia Medica Indones."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"173","DOI":"10.15171\/jhp.2019.27","article-title":"A review on medicinal plant extracts and their active ingredients against methicillin-resistant and methicillin-sensitive Staphylococcus aureus","volume":"8","author":"Askarinia","year":"2019","journal-title":"J. Herbmed Pharmacol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.micpath.2018.03.041","article-title":"Characterization of essential oil from Ocimum gratissimum leaves: Antibacterial and mode of action against selected gastroenteritis pathogens","volume":"118","author":"Chimnoi","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Melo, R.S., Albuquerque Azevedo \u00c1, M., Gomes Pereira, A.M., Rocha, R.R., Bastos Cavalcante, R.M., Carneiro Matos, M.N., Ribeiro Lopes, P.H., Gomes, G.A., Soares Rodrigues, T.H., and Santos, H.S.D. (2019). Chemical composition and antimicrobial effectiveness of Ocimum gratissimum L. essential oil against multidrug-resistant isolates of Staphylococcus aureus and Escherichia coli. Molecules, 24.","DOI":"10.3390\/molecules24213864"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13020-025-01147-5","article-title":"Natural phytochemical-based strategies for antibiofilm applications","volume":"20","author":"Zhou","year":"2025","journal-title":"Chin. Med."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Vaou, N., Stavropoulou, E., Voidarou, C., Tsigalou, C., and Bezirtzoglou, E. (2021). Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms, 9.","DOI":"10.3390\/microorganisms9102041"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"e202402479","DOI":"10.1002\/cbdv.202402479","article-title":"Phytochemicals in Cancer Therapy: A Structured Review of Mechanisms, Challenges, and Progress in Personalized Treatment","volume":"22","author":"Aljabali","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"El-Saadony, M.T.T., Saad, A.M., Mohammed, D.M., Korma, S.A., Alshahrani, M.Y., Ahmed, A.E., Ibrahim, E.H., Salem, H.M., Alkafaas, S.S., and Saif, A.M. (2025). Medicinal plants: Bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits\u2014A comprehensive review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1491777"},{"key":"ref_288","doi-asserted-by":"crossref","unstructured":"Touati, A., Mairi, A., Ibrahim, N.A., and Idres, T. (2025). Essential Oils for Biofilm Control: Mechanisms, Synergies, and Translational Challenges in the Era of Antimicrobial Resistance. Antibiotics, 14.","DOI":"10.3390\/antibiotics14050503"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"100363","DOI":"10.1016\/j.lddd.2026.100363","article-title":"Phytochemicals as promising lead compounds for drug discovery: A comprehensive review of mechanisms and pharmacological potentials","volume":"23","author":"Idakwoji","year":"2026","journal-title":"Lett. Drug Des. Discov."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/8\/795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:30:44Z","timestamp":1785321044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/15\/8\/795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":289,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["pathogens15080795"],"URL":"https:\/\/doi.org\/10.3390\/pathogens15080795","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}