{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:28:02Z","timestamp":1787225282645,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background\/Objectives: Strongyloides stercoralis may persist through autoinfection and is clinically important before corticosteroid exposure, but its relationship with airway obstruction in children with sickle cell disease (SCD) is uncertain. We examined whether routine-detected S. stercoralis infection was associated with spirometry-defined airway obstruction in children with SCD in French Guiana. Methods: This multicentre cross-sectional secondary analysis used an availability-based sample from a routine respiratory screening database. Eligible children aged 5\u201317 years had SCD, spirometry, and stool parasitology documented during routine care. The primary outcome was FEV1\/FVC &lt; 80%. Logistic regression adjusted for age, sex, genotype, hydroxyurea treatment, previous acute chest syndrome, and atopy. Results: Stool parasitology was available for 160 children; 26 (16.2%) had S. stercoralis detected. Among 138 children with complete spirometry and covariate data, 45 (32.6%) had obstruction. S. stercoralis was not associated with obstruction in univariable analysis (OR 0.75, 95% CI 0.30\u20131.91) or after adjustment (adjusted OR 1.02, 95% CI 0.37\u20132.86; p = 0.964). Male sex was independently associated with obstruction (adjusted OR 2.32, 95% CI 1.11\u20134.83). Conclusions: Routine-detected S. stercoralis infection was not an independent correlate of airway obstruction. The wide confidence interval, limited exposure ascertainment, and small infected subgroup mean that clinically important protective or harmful associations cannot be excluded.<\/jats:p>","DOI":"10.3390\/pathogens15080867","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:12:58Z","timestamp":1787155978000},"page":"867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strongyloides stercoralis Infection and Spirometry-Defined Airway Obstruction in Children with Sickle Cell Disease: A Species-Specific Multicentre Cross-Sectional Study in French Guiana"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5406-3189","authenticated-orcid":false,"given":"Gabriel","family":"Bafunyembaka","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Franck Joly Hospital, Western French Guiana Hospital Center (CHOG), 1465 Boulevard de la Libert\u00e9, 97320 Saint-Laurent-du-Maroni, French Guiana, France"},{"name":"Department of Pediatrics, General Reference Hospital of Bukavu, Bukavu, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chimene","family":"Maniassom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cayenne Hospital, Centre Hospitalier Andr\u00e9e Rosemon, 3 Avenue Alexis Blaise, 97300 Cayenne, French Guiana, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philbert","family":"Furero","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Franck Joly Hospital, Western French Guiana Hospital Center (CHOG), 1465 Boulevard de la Libert\u00e9, 97320 Saint-Laurent-du-Maroni, French Guiana, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-437X","authenticated-orcid":false,"given":"Arriel","family":"Makembi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Franck Joly Hospital, Western French Guiana Hospital Center (CHOG), 1465 Boulevard de la Libert\u00e9, 97320 Saint-Laurent-du-Maroni, French Guiana, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Kuamba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Franck Joly Hospital, Western French Guiana Hospital Center (CHOG), 1465 Boulevard de la Libert\u00e9, 97320 Saint-Laurent-du-Maroni, French Guiana, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0624-4180","authenticated-orcid":false,"given":"Narcisse","family":"Elenga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cayenne Hospital, Centre Hospitalier Andr\u00e9e Rosemon, 3 Avenue Alexis Blaise, 97300 Cayenne, French Guiana, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"240005","DOI":"10.1183\/16000617.0005-2024","article-title":"Respiratory management of acute chest syndrome in children with sickle cell disease","volume":"33","author":"Ahmed","year":"2024","journal-title":"Eur. 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