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This strategy saves time and money by passing early-stage safety testing for established human compounds. Although advances in genomics and proteomics have greatly expanded our understanding of parasite biology and facilitated the identification of potential therapeutic targets, they have translated into relatively few new antiparasitic drugs. This limitation highlights the need for alternative strategies such as drug repurposing. The basic biology of the host\u2013parasite interface has not been thoroughly investigated despite its importance. The multifaceted immune\u2013endocrine interplay may also help clarify the frequently inconsistent observations associated with host age and sex during infections, while providing insights that extend beyond current parasite management approaches. This review summarizes the potential uses and applications of old drugs as antiparasites, including, for example, the use of hormone agonists and antagonists and hormone analogues, while also discussing other drugs that have been isolated from natural products that are not used in the field.<\/jats:p>","DOI":"10.3390\/pathogens15090900","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:05:46Z","timestamp":1787735146000},"page":"900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug Repurposing in Parasitology: New Uses for Old Drugs to Be Used Through the Host\u2013Parasite Interface"],"prefix":"10.3390","volume":"15","author":[{"given":"V\u00edctor Hugo","family":"Del R\u00edo-Araiza","sequence":"first","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melod\u00eda Rub\u00ed","family":"Castro-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romel","family":"Hern\u00e1ndez-Bello","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64460, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-610X","authenticated-orcid":false,"given":"Jorge","family":"Morales-Montor","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4269\/ajtmh.2003.68.382","article-title":"Nitazoxanide: An Important Advance in Anti-Parasitic Therapy","volume":"68","author":"White","year":"2003","journal-title":"Am. 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