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This study evaluated the biological effects of standardized Apis mellifera propolis extract (EPP-AF\u00ae) in experimental murine schistosomiasis. In vitro, EPP-AF\u00ae reduced adult worm viability and motility. In vivo, Swiss mice were allocated to four groups: EPP-AF\u00ae (4.5 mg\/kg\/day, orally, for 30 days), Praziquantel (PZQ; 50 mg\/kg, days 45\u201351 post-infection), infected untreated control, and uninfected untreated SHAM control. EPP-AF\u00ae delayed oviposition and reduced egg production and tissue retention, granuloma formation, hepatic fibrosis, and eosinophilia. It also modulated splenic cytokine production, reducing inflammatory mediators and increasing IL-10. Molecular docking indicated favorable interactions between propolis phenolic compounds and SmCB1. Collectively, EPP-AF\u00ae exhibited antiparasitic and tissue-protective effects during experimental S. mansoni infection, supporting its pharmacological potential against schistosomiasis.<\/jats:p>","DOI":"10.3390\/pathogens15090980","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:57:34Z","timestamp":1789473454000},"page":"980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Standardized Apis mellifera Propolis Extract (EPP-AF\u00ae) Reduces Egg Burden and Granulomatous Inflammation in Experimental Schistosoma mansoni Infection"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-4337","authenticated-orcid":false,"given":"Vitor Augusto Ferreira","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Immunophysiology, Center for Biological and Health Sciences, Federal University of Maranh\u00e3o, Saint Louis 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