{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:48:32Z","timestamp":1791355712280,"version":"4.3.1"},"reference-count":141,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes for Health Research"},{"name":"Fons de la Recherche du Quebec - Sante"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus.<\/jats:p>","DOI":"10.3390\/pathogens4040793","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T05:40:47Z","timestamp":1447652447000},"page":"793-815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Immunomodulation and Disease Tolerance to Staphylococcus aureus"],"prefix":"10.3390","volume":"4","author":[{"given":"Zhigang","family":"Li","sequence":"first","affiliation":[{"name":"Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Peres","sequence":"additional","affiliation":[{"name":"Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Damian","sequence":"additional","affiliation":[{"name":"Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Madrenas","sequence":"additional","affiliation":[{"name":"Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montr\u00e9al, QC, H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N. 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