{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:28:13Z","timestamp":1792794493623,"version":"4.5.0"},"reference-count":141,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Candida albicans is a fungal commensal and a major colonizer of the human skin, as well as of the gastrointestinal and genitourinary tracts. It is also one of the leading causes of opportunistic microbial infections in cancer patients, often presenting in a life-threatening, systemic form. Increased susceptibility to such infections in cancer patients is attributed primarily to chemotherapy-induced depression of innate immune cells and weakened epithelial barriers, which are the body\u2019s first-line defenses against fungal infections. Moreover, classical chemotherapeutic agents also have a detrimental effect on components of the adaptive immune system, which further play important roles in the antifungal response. In this review, we discuss the current paradigm regarding the mechanisms behind the increased risk of systemic candidiasis in cancer patients. We also highlight some recent findings, which suggest that chemotherapy may have more extensive effects beyond the human host, in particular towards C. albicans itself and the bacterial microbiota. The extent to which these additional effects contribute towards the development of candidiasis in chemotherapy-treated patients remains to be investigated.<\/jats:p>","DOI":"10.3390\/pathogens5010006","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T03:30:25Z","timestamp":1452915025000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-2582","authenticated-orcid":false,"given":"Flora","family":"Teoh","sequence":"first","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos Building, Singapore 138648, Singapore"},{"name":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4542-9970","authenticated-orcid":false,"given":"Norman","family":"Pavelka","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos Building, Singapore 138648, Singapore"},{"name":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2014). World Cancer Report, International Agency for Research on Cancer."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1182\/blood.V26.5.642.642","article-title":"The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia","volume":"26","author":"Frei","year":"1965","journal-title":"Blood"},{"key":"ref_3","first-page":"1258","article-title":"Intensive combination chemotherapy and X-irradiation in Hodgkin\u2019s disease","volume":"27","author":"Moxley","year":"1967","journal-title":"Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1056\/NEJM199002083220602","article-title":"Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma","volume":"322","author":"Moertel","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/cncr.10630","article-title":"Changing patient perceptions of the side effects of cancer chemotherapy","volume":"95","author":"Carelle","year":"2002","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"iv329","DOI":"10.1093\/annonc\/mdh947","article-title":"Opportunistic infections in patients with cancer","volume":"15","author":"Klastersky","year":"2004","journal-title":"Ann. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1473-3099(09)70175-6","article-title":"Influenza in immunosuppressed populations: A review of infection frequency, morbidity, mortality, and vaccine responses","volume":"9","author":"Kunisaki","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/cncr.11671","article-title":"The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis","volume":"98","author":"Elting","year":"2003","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Khan, S.A., and Wingard, J.R. (2001). Infection and mucosal injury in cancer treatment. J. Natl. Cancer Inst. Monogr., 31\u201336.","DOI":"10.1093\/oxfordjournals.jncimonographs.a003437"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.diagmicrobio.2012.10.003","article-title":"Epidemiology and outcomes of candidemia in 3648 patients: Data from the Prospective Antifungal Therapy (PATH Alliance(R)) registry, 2004-2008","volume":"74","author":"Pfaller","year":"2012","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijantimicag.2013.09.005","article-title":"Nosocomial bloodstream infections due to Candida spp. in the USA: Species distribution, clinical features and antifungal susceptibilities","volume":"43","author":"Wisplinghoff","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12539","article-title":"Global trends in the distribution of Candida species causing candidemia","volume":"20","author":"Guinea","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bassetti, M., Merelli, M., Ansaldi, F., de Florentiis, D., Sartor, A., Scarparo, C., Callegari, A., and Righi, E. (2015). Clinical and therapeutic aspects of candidemia: A five year single centre study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127534"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1016\/j.ijid.2011.06.006","article-title":"Epidemiology, clinical characteristics, and outcome of candidemia: Experience in a tertiary referral center in the UK","volume":"15","author":"Das","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jhin.2010.09.026","article-title":"Candida species bloodstream infection: Epidemiology and outcome in a single institution from 1991 to 2008","volume":"77","author":"Ortega","year":"2011","journal-title":"J. Hosp. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jmii.2010.08.010","article-title":"Candida albicans versus non-albicans bloodstream infections: The comparison of risk factors and outcome","volume":"44","author":"Chi","year":"2011","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nucci, M., Queiroz-Telles, F., Alvarado-Matute, T., Tiraboschi, I.N., Cortes, J., Zurita, J., Guzman-Blanco, M., Santolaya, M.E., Thompson, L., and Sifuentes-Osornio, J. (2013). Epidemiology of candidemia in Latin America: A laboratory-based survey. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059373"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nri3684","article-title":"The mycobiota: Interactions between commensal fungi and the host immune system","volume":"14","author":"Underhill","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1086\/323759","article-title":"Revisiting the source of candidemia: Skin or gut?","volume":"33","author":"Nucci","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jhin.2009.02.009","article-title":"Candida colonisation as a source for candidaemia","volume":"72","author":"Miranda","year":"2009","journal-title":"J. Hosp. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1128\/JCM.01998-13","article-title":"Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia across five sites in Italy and Spain","volume":"51","author":"Bassetti","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: Human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/514955","article-title":"The impact of candidemia on length of hospital stay, outcome, and overall cost of illness","volume":"27","author":"Rentz","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajic.2009.06.014","article-title":"Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections","volume":"38","author":"Moran","year":"2010","journal-title":"Am. J. Infect. Control"},{"key":"ref_26","first-page":"1","article-title":"Candida albicans and cancer: Can this yeast induce cancer development or progression?","volume":"20","author":"Rementeria","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1086\/313450","article-title":"The epidemiology of candidemia in two United States cities: Results of a population-based active surveillance","volume":"29","author":"Kao","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(03)00801-6","article-title":"Epidemiology of Candida species infections in critically ill non-immunosuppressed patients","volume":"3","author":"Eggimann","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: A persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1309\/AJCP50AEEYGREWUZ","article-title":"The differential diagnosis and bone marrow evaluation of new-onset pancytopenia","volume":"139","author":"Weinzierl","year":"2013","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/cncr.11882","article-title":"Chemotherapy-induced neutropenia: Risks, consequences, and new directions for its management","volume":"100","author":"Crawford","year":"2004","journal-title":"Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s15010-013-0525-9","article-title":"The current spectrum of infection in cancer patients with chemotherapy related neutropenia","volume":"42","author":"Nesher","year":"2014","journal-title":"Infection"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ccc.2009.09.005","article-title":"Mechanical ventilation in cancer patients: Clinical characteristics and outcomes","volume":"26","author":"Soares","year":"2010","journal-title":"Crit. Care Clin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","article-title":"Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005\u20132006)","volume":"37","author":"Leroy","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1681\/ASN.2004100843","article-title":"Renal failure associated with cancer and its treatment: An update","volume":"16","author":"Humphreys","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e00810","DOI":"10.1128\/mBio.00810-13","article-title":"Altered dynamics of Candida albicans phagocytosis by macrophages and PMNs when both phagocyte subsets are present","volume":"4","author":"Rudkin","year":"2013","journal-title":"MBio"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1462-5822.2005.00659.x","article-title":"Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms","volume":"8","author":"Urban","year":"2006","journal-title":"Cell Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1242\/jcs.112.19.3237","article-title":"Rapid recruitment of late endosomes and lysosomes in mouse macrophages ingesting Candida albicans","volume":"112 Pt 19","author":"Kaposzta","year":"1999","journal-title":"J. Cell Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1099\/13500872-142-12-3487","article-title":"Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance","volume":"142 Pt 12","author":"Fulurija","year":"1996","journal-title":"Microbiology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Koh, A.Y., Kohler, J.R., Coggshall, K.T., van Rooijen, N., and Pier, G.B. (2008). Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.0040035"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/CMR.16.4.597-621.2003","article-title":"Infections in patients with inherited defects in phagocytic function","volume":"16","author":"Andrews","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1136\/jcp.36.10.1120","article-title":"Defective neutrophil function and microbicidal mechanisms in the myelodysplastic disorders","volume":"36","author":"Martin","year":"1983","journal-title":"J. Clin. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/bjc.1981.285","article-title":"Neutrophil function during chemotherapy for Hodgkin's disease","volume":"44","author":"Gandossini","year":"1981","journal-title":"Br. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0014-4827(03)00253-2","article-title":"Microfilaments and microtubules regulate recycling from phagosomes","volume":"289","author":"Damiani","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1083\/jcb.75.3.666","article-title":"Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis","volume":"75","author":"Malech","year":"1977","journal-title":"J. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Stroka, K.M., Hayenga, H.N., and Aranda-Espinoza, H. (2013). Human neutrophil cytoskeletal dynamics and contractility actively contribute to trans-endothelial migration. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061377"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00280-013-2348-x","article-title":"Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy","volume":"73","author":"Mendonca","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1111\/j.1538-7836.2011.04465.x","article-title":"Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus","volume":"9","author":"Swystun","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Halverson, T.W., Wilton, M., Poon, K.K., Petri, B., and Lewenza, S. (2015). DNA is an antimicrobial component of neutrophil extracellular traps. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004593"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.4049\/jimmunol.152.10.5000","article-title":"Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis","volume":"152","author":"Qian","year":"1994","journal-title":"J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/infdis\/jit413","article-title":"Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis","volume":"209","author":"Ngo","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chom.2012.06.006","article-title":"Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes","volume":"12","author":"Quintin","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cheng, S.C., Quintin, J., Cramer, R.A., Shepardson, K.M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E.J., Martens, J.H., Rao, N.A., and Aghajanirefah, A. (2014). mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science, 345.","DOI":"10.1126\/science.1250684"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Saeed, S., Quintin, J., Kerstens, H.H., Rao, N.A., Aghajanirefah, A., Matarese, F., Cheng, S.C., Ratter, J., Berentsen, K., and van der Ent, M.A. (2014). Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science, 345.","DOI":"10.1126\/science.1251086"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00000421-199902000-00025","article-title":"Early monocytopenia after chemotherapy as a risk factor for neutropenia","volume":"22","author":"Kondo","year":"1999","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood-2013-01-480749","article-title":"CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice","volume":"122","author":"Jacquelin","year":"2013","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1172\/JCI71307","article-title":"CX3CR1-dependent renal macrophage survival promotes Candida control and host survival","volume":"123","author":"Lionakis","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/infdis\/jit574","article-title":"Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity","volume":"209","author":"Voigt","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1002\/eji.201343828","article-title":"Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice","volume":"44","author":"Quintin","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.immuni.2013.12.002","article-title":"IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells","volume":"40","author":"Bar","year":"2014","journal-title":"Immunity"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1158\/1078-0432.CCR-10-2084","article-title":"Unique functional status of natural killer cells in metastatic stage IV melanoma patients and its modulation by chemotherapy","volume":"17","author":"Fregni","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1128\/EC.00093-14","article-title":"Interplay between Candida albicans and the antimicrobial peptide armory","volume":"13","author":"Swidergall","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ni797","article-title":"Paneth cell trypsin is the processing enzyme for human defensin-5","volume":"3","author":"Ghosh","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(93)81160-2","article-title":"Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel","volume":"315","author":"Jones","year":"1993","journal-title":"FEBS Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1128\/iai.65.6.2396-2401.1997","article-title":"Broad-spectrum antimicrobial activity of human intestinal defensin 5","volume":"65","author":"Porter","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/08959374000140010201","article-title":"Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva","volume":"14","author":"Edgerton","year":"2000","journal-title":"Adv. Dent. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/AAC.50.1.324-331.2006","article-title":"Distinct antifungal mechanisms: Beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides","volume":"50","author":"Vylkova","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/AAC.00478-06","article-title":"Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption","volume":"51","author":"Vylkova","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_73","first-page":"1025","article-title":"Human beta-defensin-2 in oral cancer with opportunistic Candida infection","volume":"24","author":"Meyer","year":"2004","journal-title":"Anticancer Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/annonc\/mdl347","article-title":"Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: Dosing, efficacy, and tolerability analysis","volume":"18","author":"Grunberg","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1081-1206(10)60078-6","article-title":"Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents","volume":"102","author":"Lee","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1182\/blood.V84.7.2221.2221","article-title":"Lymphocyte depletion during treatment with intensive chemotherapy for cancer","volume":"84","author":"Mackall","year":"1994","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/CJI.0b013e3181ea7e6e","article-title":"Impact of 3 different short-term chemotherapy regimens on lymphocyte-depletion and reconstitution in melanoma patients","volume":"33","author":"Laurent","year":"2010","journal-title":"J. Immunother."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0022034511399284","article-title":"Candida-host interactions in HIV disease: Implications for oropharyngeal candidiasis","volume":"23","author":"Fidel","year":"2011","journal-title":"Adv. Dent. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1172\/JCI116498","article-title":"Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors","volume":"91","author":"Marodi","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1073\/pnas.85.13.4874","article-title":"Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of childhood","volume":"85","author":"Sechler","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4049\/jimmunol.150.3.925","article-title":"CD4+ subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance","volume":"150","author":"Romani","year":"1993","journal-title":"J. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1128\/iai.59.12.4647-4654.1991","article-title":"Th1 and Th2 cytokine secretion patterns in murine candidiasis: Association of Th1 responses with acquired resistance","volume":"59","author":"Romani","year":"1991","journal-title":"Infect. Immun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","author":"Laan","year":"1999","journal-title":"J. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20081463","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis","volume":"206","author":"Conti","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","article-title":"Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells","volume":"8","author":"Rivino","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/eji.201041197","article-title":"IL-22 and TNF-alpha represent a key cytokine combination for epidermal integrity during infection with Candida albicans","volume":"41","author":"Eyerich","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20021345","article-title":"CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms","volume":"197","author":"Maloy","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.179.9.5999","article-title":"Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc","volume":"179","author":"Montagnoli","year":"2007","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1182\/blood.V77.8.1845.1845","article-title":"Clonal analysis of T-cell deficiencies in autotransplant recipients","volume":"77","author":"Miller","year":"1991","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1084\/jem.20042167","article-title":"Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response","volume":"201","author":"Ercolini","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/iai.40.1.46-55.1983","article-title":"Correlation between in vivo and in vitro studies of modulation of resistance to experimental Candida albicans infection by cyclophosphamide in mice","volume":"40","author":"Bistoni","year":"1983","journal-title":"Infect. Immun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.4049\/jimmunol.1203539","article-title":"Profound impairment of adaptive immune responses by alkylating chemotherapy","volume":"190","author":"Litterman","year":"2013","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/IAI.73.2.999-1005.2005","article-title":"Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity","volume":"73","author":"Ibrahim","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"13526","DOI":"10.1073\/pnas.0803195105","article-title":"Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis","volume":"105","author":"Xin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20050749","article-title":"A novel glyco-conjugate vaccine against fungal pathogens","volume":"202","author":"Torosantucci","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mib.2012.04.004","article-title":"Recent progress in vaccines against fungal diseases","volume":"15","author":"Cassone","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1016\/j.vaccine.2012.10.038","article-title":"NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults","volume":"30","author":"Schmidt","year":"2012","journal-title":"Vaccine"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1016\/j.vaccine.2012.04.069","article-title":"A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models","volume":"30","author":"Amacker","year":"2012","journal-title":"Vaccine"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Lin, L., Ibrahim, A.S., Xu, X., Farber, J.M., Avanesian, V., Baquir, B., Fu, Y., French, S.W., Edwards, J.E., and Spellberg, B. (2009). Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000703"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(88)92547-0","article-title":"Candida and AIDS: evidence for protective antibody","volume":"2","author":"Matthews","year":"1988","journal-title":"Lancet"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1016\/j.vaccine.2012.08.010","article-title":"A beta-mannan trisaccharide conjugate vaccine aids clearance of Candida albicans in immunocompromised rabbits","volume":"30","author":"Lipinski","year":"2012","journal-title":"Vaccine"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Nilsson, A., De Milito, A., Engstrom, P., Nordin, M., Narita, M., Grillner, L., Chiodi, F., and Bjork, O. (2002). Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens. Pediatrics, 109.","DOI":"10.1542\/peds.109.6.e91"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/cncr.20384","article-title":"Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy","volume":"101","author":"Zignol","year":"2004","journal-title":"Cancer"},{"key":"ref_106","first-page":"420","article-title":"The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission","volume":"31","author":"Borella","year":"1971","journal-title":"Cancer Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/S1470-2045(12)70553-3","article-title":"Pathobiology of chemotherapy-induced hair loss","volume":"14","author":"Paus","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jaad.2008.01.001","article-title":"Chemotherapeutic agents and the skin: An update","volume":"58","author":"Heidary","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/bjc.1983.25","article-title":"Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation","volume":"47","author":"Ijiri","year":"1983","journal-title":"Br. J. Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1524-4725.1981.tb00208.x","article-title":"Alterations in the oral mucosa caused by chemotherapeutic agents. A histologic study","volume":"7","author":"Lockhart","year":"1981","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/gut.47.5.632","article-title":"Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans","volume":"47","author":"Keefe","year":"2000","journal-title":"Gut"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/SPC.0b013e32835f3e8c","article-title":"Chemotherapy-induced mucosal barrier dysfunction: An updated review on the role of intestinal tight junctions","volume":"7","author":"Wardill","year":"2013","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/MPG.0b013e318247240d","article-title":"Methotrexate modulates tight junctions through NF-kappaB, MEK, and JNK pathways","volume":"54","author":"Belmonte","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00280-010-1253-9","article-title":"Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats","volume":"66","author":"Hamada","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","article-title":"The role of the gut microbiota in nutrition and health","volume":"9","author":"Flint","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12026-012-8265-y","article-title":"Complexity and dynamics of host-fungal interactions","volume":"53","author":"Cottier","year":"2012","journal-title":"Immunol. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1128\/IAI.72.11.6206-6210.2004","article-title":"Regulation of Candida albicans morphogenesis by fatty acid metabolites","volume":"72","author":"Noverr","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1534\/g3.114.015941","article-title":"The transcriptional stress response of Candida albicans to weak organic acids","volume":"5","author":"Cottier","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","article-title":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22","volume":"39","author":"Zelante","year":"2013","journal-title":"Immunity"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.3871","article-title":"Activation of HIF-1alpha and LL-37 by commensal bacteria inhibits Candida albicans colonization","volume":"21","author":"Fan","year":"2015","journal-title":"Nat. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1128\/AAC.38.3.602","article-title":"Effects of broad-spectrum antibiotics on colonization of gastrointestinal tracts of mice by Candida albicans","volume":"38","author":"Samonis","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0732-8893(97)00068-0","article-title":"Candidemia in a Canadian tertiary care hospital from 1976 to 1996","volume":"29","author":"Karlowsky","year":"1997","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"van Vliet, M.J., Harmsen, H.J., de Bont, E.S., and Tissing, W.J. (2010). The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000879"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zwielehner, J., Lassl, C., Hippe, B., Pointner, A., Switzeny, O.J., Remely, M., Kitzweger, E., Ruckser, R., and Haslberger, A.G. (2011). Changes in human fecal microbiota due to chemotherapy analyzed by TaqMan-PCR, 454 sequencing and PCR-DGGE fingerprinting. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028654"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lin, X.B., Dieleman, L.A., Ketabi, A., Bibova, I., Sawyer, M.B., Xue, H., Field, C.J., Baracos, V.E., and Ganzle, M.G. (2012). Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039764"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/599346","article-title":"Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut","volume":"49","author":"Tissing","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","article-title":"The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide","volume":"342","author":"Viaud","year":"2013","journal-title":"Science"},{"key":"ref_131","unstructured":"Bristol-Myers Squibb (2011). Hydrea (Hydroxyurea Capsules, USP) Prescribing Information, Bristol-Myers Squibb."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hoffmann, C., Dollive, S., Grunberg, S., Chen, J., Li, H., Wu, G.D., Lewis, J.D., and Bushman, F.D. (2013). Archaea and fungi of the human gut microbiome: Correlations with diet and bacterial residents. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066019"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0966-842X(01)02094-7","article-title":"Virulence factors of Candida albicans","volume":"9","author":"Calderone","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1034\/j.1399-302X.2001.160408.x","article-title":"Increase of Candida cell virulence by anticancer drugs and irradiation","volume":"16","author":"Ueta","year":"2001","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1091\/mbc.e06-05-0442","article-title":"Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans","volume":"18","author":"Shi","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1091\/mbc.e09-01-0040","article-title":"Stress-induced phenotypic switching in Candida albicans","volume":"20","author":"Alby","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/genetics\/162.2.737","article-title":"In Candida albicans, white-opaque switchers are homozygous for mating type","volume":"162","author":"Lockhart","year":"2002","journal-title":"Genetics"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1038\/sj.emboj.7601099","article-title":"Opaque cells signal white cells to form biofilms in Candida albicans","volume":"25","author":"Daniels","year":"2006","journal-title":"EMBO J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14907","DOI":"10.1073\/pnas.232566499","article-title":"Metabolic specialization associated with phenotypic switching in Candida albicans","volume":"99","author":"Lan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/IAI.72.2.667-677.2004","article-title":"Release of a potent polymorphonuclear leukocyte chemoattractant is regulated by white-opaque switching in Candida albicans","volume":"72","author":"Geiger","year":"2004","journal-title":"Infect. Immun."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/5\/1\/6\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:17:47Z","timestamp":1760210267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/5\/1\/6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":141,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3]]}},"alternative-id":["pathogens5010006"],"URL":"https:\/\/doi.org\/10.3390\/pathogens5010006","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]}}}