{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:46:19Z","timestamp":1792273579903,"version":"4.4.0"},"reference-count":104,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Although the parasite Toxoplasma gondii is one of the most pervasive neurotropic pathogens in the world, the host-parasite interactions during CNS infection and the consequences of neurological infection are just beginning to be unraveled. The chronic stages of infection have been considered dormant, although several studies have found correlations of infection with an array of host behavioral changes. These may facilitate parasite transmission and impact neurological diseases. During infection, in addition to the presence of the parasites within neurons, host-mediated neuroimmune and hormonal responses to infection are also present. T. gondii induces numerous changes to host neurons during infection and globally alters host neurological signaling pathways, as discussed in this review. Understanding the neurophysiological changes in the host brain is imperative to understanding the parasitic mechanisms and to delineate the effects of this single-celled parasite on health and its contribution to neurological disease.<\/jats:p>","DOI":"10.3390\/pathogens6020019","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T11:13:17Z","timestamp":1495019597000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection"],"prefix":"10.3390","volume":"6","author":[{"given":"Ellen","family":"Tedford","sequence":"first","affiliation":[{"name":"Heredity, Disease &amp; Development, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"McConkey","sequence":"additional","affiliation":[{"name":"Heredity, Disease &amp; Development, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"ref_1","unstructured":"Dawkins, R. (1999). The Extended Phenotype: The Long Reach of the Gene, Oxford University Press."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/icb\/icu060","article-title":"What makes a feline fatal in Toxoplasma gondii\u2019s fatal feline attraction? Infected rats choose wild cats","volume":"54","author":"Kaushik","year":"2014","journal-title":"Integr. Comp. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0020-7519(98)00023-X","article-title":"Advances in the life cycle of Toxoplasma gondii","volume":"28","author":"Dubey","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: From animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1038\/nmicrobiol.2016.1","article-title":"Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system","volume":"1","author":"Konradt","year":"2016","journal-title":"Nat. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e01155-15","DOI":"10.1128\/mBio.01155-15","article-title":"Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo","volume":"6","author":"Watts","year":"2015","journal-title":"mBio"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/00034983.1980.11687376","article-title":"Chronic Toxoplasma infections and motor performance in the mouse","volume":"74","author":"Hutchison","year":"1980","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1242\/jeb.074716","article-title":"Toxoplasma gondii infection, from predation to schizophrenia: Can animal behaviour help us understand human behaviour?","volume":"216","author":"Webster","year":"2013","journal-title":"J. Exp. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.4088\/JCP.15m10133","article-title":"Effects of Cumulative Herpesviridae and Toxoplasma gondii Infections on Cognitive Function in Healthy, Bipolar, and Schizophrenia Subjects","volume":"78","author":"Hamdani","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00127-014-0820-5","article-title":"The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis","volume":"49","author":"Pearce","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/schbul\/sbl074","article-title":"Effects of Toxoplasma on human behavior","volume":"33","author":"Flegr","year":"2007","journal-title":"Schizophr. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WAD.0b013e3181f73bc2","article-title":"Could Toxoplasma gondi Have any Role in Alzheimer Disease?","volume":"25","author":"Kusbeci","year":"2011","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Donley, D.W., Olson, A.R., Raisbeck, M.F., Fox, J.H., and Gigley, J.P. (2016). Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162404"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/NMD.0000000000000166","article-title":"Antibodies to Toxoplasma gondii and cognitive functioning in schizophrenia, bipolar disorder, and nonpsychiatric controls","volume":"202","author":"Dickerson","year":"2014","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/2327-6924.12129","article-title":"New findings: Depression, suicide, and Toxoplasma gondii infection","volume":"26","author":"Hsu","year":"2014","journal-title":"J. Am. Assoc. Nurse Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/NMD.0b013e3181c29a23","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders","volume":"197","author":"Arling","year":"2009","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archgenpsychiatry.2012.668","article-title":"Toxoplasma gondii infection and self-directed violence in mothers","volume":"69","author":"Pedersen","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/NMD.0b013e318221416e","article-title":"Toxoplasma gondii seropositivity and suicide rates in women","volume":"199","author":"Ling","year":"2011","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/acps.12423","article-title":"Beyond the association Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis","volume":"132","author":"Sutterland","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/schbul\/sbl050","article-title":"Antibodies to Toxoplasma gondii in patients with schizophrenia: A meta-analysis","volume":"33","author":"Torrey","year":"2007","journal-title":"Schizophr. Bull."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.psc.2007.04.007","article-title":"Epidemiology of schizophrenia: Review of findings and myths","volume":"30","author":"Messias","year":"2007","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2565","article-title":"Regulation of innate immune responses in the brain","volume":"9","author":"Rivest","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_23","first-page":"219","article-title":"Apoptosis and its modulation during infection with Toxoplasma gondii: Molecular mechanisms and role in Pathogenesis","volume":"289","author":"Gross","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10753-015-0262-6","article-title":"Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB\/c Mice","volume":"39","author":"Mahmoudvand","year":"2016","journal-title":"Inflammation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4049\/jimmunol.169.1.315","article-title":"Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis","volume":"169","author":"Meyer","year":"2002","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein","volume":"308","author":"Yarovinsky","year":"2005","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.4049\/jimmunol.168.12.5997","article-title":"Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells","volume":"168","author":"Scanga","year":"2002","journal-title":"J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.4049\/jimmunol.181.12.8478","article-title":"Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology","volume":"181","author":"Yarovinsky","year":"2008","journal-title":"J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gigley, J.P. (2016). The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005396"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/iai.62.7.2818-2824.1994","article-title":"Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: Regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha","volume":"62","author":"Hunter","year":"1994","journal-title":"Infect. Immun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.08.005","article-title":"The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations","volume":"323","author":"Tan","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/IAI.67.5.2233-2240.1999","article-title":"Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: Requirement of a functional JAK\/STAT pathway","volume":"67","author":"Chaves","year":"1999","journal-title":"Infect. Immun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: When physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/ejn.12160","article-title":"Kynurenic acid, by targeting \u03b17 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo","volume":"37","author":"Beggiato","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0006-3223(01)01078-2","article-title":"Increased cortical kynurenate content in schizophrenia","volume":"50","author":"Schwarcz","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuropharm.2016.05.020","article-title":"The kynurenine pathway in schizophrenia and bipolar disorder","volume":"112","author":"Erhardt","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_38","first-page":"589.9","article-title":"Toxoplasma gondii, astrocytes, kynurenic acid and schizophrenia","volume":"32","author":"Guidetti","year":"2006","journal-title":"Soc. Neurosci. Abstr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-2094-5-48","article-title":"Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection","volume":"5","author":"Hermes","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12173","article-title":"Persistence of Toxoplasma gondii in the central nervous system: A fine tuned balance between the parasite, the brain and the immune system","volume":"37","author":"Blanchard","year":"2015","journal-title":"Parasite Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ingram, W.M., Goodrich, L.M., Robey, E.A., and Eisen, M.B. (2013). Mice infected with low-virulence strains of Toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075246"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2012.10.005","article-title":"Sex-dependent neurotransmitter level changes in brains of Toxoplasma gondii infected mice","volume":"133","author":"Gatkowska","year":"2013","journal-title":"Exp. Parasitol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.physbeh.2014.05.036","article-title":"Toxoplasma gondii influences aversive behaviors of female rats in an estrus cycle dependent manner","volume":"135","author":"Golcu","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fimmu.2014.00136","article-title":"The HPA-Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain","volume":"5","author":"Bellavance","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn3138","article-title":"The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission","volume":"13","author":"Popoli","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/156720507780362083","article-title":"A new glucocorticoid hypothesis of brain aging: Implications for Alzheimer\u2019s disease","volume":"4","author":"Landfield","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/00048670802512073","article-title":"Stress and anxiety in schizophrenia and depression: Glucocorticoids, corticotropin-releasing hormone and synapse regression","volume":"42","year":"2008","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"House, P.K., Vyas, A., and Sapolsky, R. (2011). Predator cat odors activate sexual arousal pathways in brains of Toxoplasma gondii infected rats. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023277"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/mec.12042","article-title":"Toxoplasma gondii infection enhances testicular steroidogenesis in rats","volume":"22","author":"Lim","year":"2013","journal-title":"Mol. Ecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1111\/mec.12888","article-title":"Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala","volume":"23","author":"Vyas","year":"2014","journal-title":"Mol. Ecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12639-013-0382-6","article-title":"The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad","volume":"39","author":"Zghair","year":"2015","journal-title":"J. Parasit. Dis."},{"key":"ref_52","first-page":"622","article-title":"Effects of Toxoplasma gondii Infection in Level of Serum Testosterone in Males with Chronic Toxoplasmosis","volume":"8","author":"Eslamirad","year":"2013","journal-title":"Iran. J. Parasitol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0031182007004064","article-title":"Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans","volume":"135","author":"Flegr","year":"2008","journal-title":"Parasitology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/jeb.074153","article-title":"Toxoplasma gondii infection and behaviour\u2014Location, location, location?","volume":"216","author":"McConkey","year":"2013","journal-title":"J. Exp. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Dubey, J.P., Ferreira, L.R., Alsaad, M., Verma, S.K., Alves, D.A., Holland, G.N., and McConkey, G.A. (2016). Experimental Toxoplasmosis in Rats Induced Orally with Eleven Strains of Toxoplasma gondii of Seven Genotypes: Tissue Tropism, Tissue Cyst Size, Neural Lesions, Tissue Cyst Rupture without Reactivation, and Ocular Lesions. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156255"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2013.11.012","article-title":"Patterns of Toxoplasma gondii cyst distribution in the forebrain associate with individual variation in predator odor avoidance and anxiety-related behavior in male Long-Evans rats","volume":"37","author":"Evans","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/BF00535321","article-title":"An ultrastructural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice","volume":"73","author":"Ferguson","year":"1987","journal-title":"Parasitol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Cabral, C.M., Tuladhar, S., Dietrich, H.K., Nguyen, E., MacDonald, W.R., Trivedi, T., and Devineni, A. (2016). Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005447"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Mammari, N., Vignoles, P., Halabi, M.A., Darde, M.L., and Courtioux, B. (2014). In vitro infection of human nervous cells by two strains of Toxoplasma gondii: A kinetic analysis of immune mediators and parasite multiplication. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098491"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nature13800","article-title":"A three-dimensional human neural cell culture model of Alzheimer\u2019s disease","volume":"515","author":"Choi","year":"2014","journal-title":"Nature"},{"key":"ref_61","first-page":"52237","article-title":"3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii","volume":"94","author":"Koshy","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_62","first-page":"459","article-title":"Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity","volume":"7","author":"Parlog","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"ref_63","first-page":"516","article-title":"Toxoplasma gondii infection induces dendritic retraction in basolateral amygdala accompanied by reduced corticosterone secretion","volume":"6","author":"Mitra","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders","volume":"14","author":"Penzes","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/00034983.1985.11811902","article-title":"Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice","volume":"79","author":"Stibbs","year":"1985","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Mahmoud, M.E., Fereig, R., and Nishikawa, Y. (2017). Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice. Infect. Immun., 85.","DOI":"10.1128\/IAI.00007-17"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1128\/IAI.00217-16","article-title":"Toxoplasma gondii Infection in Mice Impairs Long-Term Fear Memory Consolidation through Dysfunction of the Cortex and Amygdala","volume":"84","author":"Ihara","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2015.08.005","article-title":"Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells","volume":"306","author":"Martin","year":"2015","journal-title":"Neuroscience"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Prandovszky, E., Gaskell, E., Martin, H., Dubey, J.P., Webster, J.P., and McConkey, G.A. (2011). The Neurotropic Parasite Toxoplasma gondii Increases Dopamine Metabolism. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023866"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1645\/GE-2760.1","article-title":"Dopamine Stimulates Propagation of Toxoplasma gondii Tachyzoites in Human Fibroblast and Primary Neonatal Rat Astrocyte Cell Cultures","volume":"98","author":"Strobl","year":"2012","journal-title":"J. Parasitol."},{"key":"ref_71","first-page":"1023","article-title":"Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii\u2019s ability to alter host behaviour","volume":"273","author":"Webster","year":"2006","journal-title":"Proc. Biol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1017\/S0031182006000886","article-title":"The role of dopamine in Toxoplasma-induced behavioural alterations in mice: An ethological and ethopharmacological study","volume":"133","author":"Kodym","year":"2006","journal-title":"Parasitology"},{"key":"ref_73","first-page":"IV23","article-title":"L-DOPA treatment from the viewpoint of neuroprotection. Possible mechanism of specific and progressive dopaminergic neuronal death in Parkinson\u2019s disease","volume":"252","author":"Ogawa","year":"2005","journal-title":"J. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1073\/pnas.0702753104","article-title":"Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice","volume":"104","author":"Rommelfanger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mds.870080119","article-title":"Movement disorders with cerebral toxoplasmosis and AIDS","volume":"8","author":"Nath","year":"1993","journal-title":"Mov. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0004801","article-title":"A unique dual activity amino acid hydroxylase in Toxoplasma gondii","volume":"4","author":"Gaskell","year":"2009","journal-title":"PLoS ONE"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2011.12.051","article-title":"Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice","volume":"206","author":"Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Remenyi, J., van den Bosch, M.W.M., Palygin, O., Mistry, R.B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J.S.C., Frenguelli, B.G., and Pankratov, Y. (2013). miR-132\/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062509"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1017\/S003118201400167X","article-title":"Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner","volume":"142","author":"Li","year":"2015","journal-title":"Parasitology"},{"key":"ref_80","first-page":"1673","article-title":"miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression","volume":"125","author":"Yang","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Xiao, J., Li, Y., Prandovszky, E., Kannan, G., Viscidi, R.P., Pletnikov, M.V., and Yolken, R.H. (2016). Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004674"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"David, C.N., Frias, E.S., Szu, J.I., Vieira, P.A., Hubbard, J.A., Lovelace, J., Michael, M., Worth, D., McGovern, K.E., and Ethell, I.M. (2016). GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005643"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e01428-15","DOI":"10.1128\/mBio.01428-15","article-title":"Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System","volume":"6","author":"Brooks","year":"2015","journal-title":"mBio"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.chom.2015.04.003","article-title":"The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole","volume":"17","author":"Gold","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_86","first-page":"183","article-title":"The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids","volume":"7","author":"Diniz","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Koshy, A.A., Dietrich, H.K., Christian, D.A., Melehani, J.H., Shastri, A.J., Hunter, C.A., and Boothroyd, J.C. (2012). Toxoplasma co-opts host cells it does not invade. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002825"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.pt.2011.08.001","article-title":"Toxoplasma gondii effectors are master regulators of the inflammatory response","volume":"27","author":"Melo","year":"2011","journal-title":"Trends Parasitol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Schneider, A.G., Abi Abdallah, D.S., Butcher, B.A., and Denkers, E.Y. (2013). Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFN\u03b3-induced STAT1 transcriptional activity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060215"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1084\/jem.20091703","article-title":"A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3","volume":"206","author":"Yamamoto","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature05395","article-title":"Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue","volume":"445","author":"Saeij","year":"2007","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1074\/jbc.M113.544718","article-title":"Toxoplasma gondii virulence factor ROP18 inhibits the host NF-\u03baB pathway by promoting p65 degradation","volume":"289","author":"Du","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Dvorakova-Hortova, K., Sidlova, A., Ded, L., Hladovcova, D., Vieweg, M., Weidner, W., Steger, K., Stopka, P., and Paradowska-Dogan, A. (2014). Toxoplasma gondii decreases the reproductive fitness in mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096770"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.febslet.2011.03.032","article-title":"Environmental regulation of the neural epigenome","volume":"585","author":"Caldji","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1073\/pnas.1524857113","article-title":"Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus","volume":"113","author":"Saunderson","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.yfrne.2008.03.003","article-title":"Epigenetic mechanisms and the transgenerational effects of maternal care","volume":"29","author":"Champagne","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"430","DOI":"10.31887\/DCNS.2014.16.3\/jmann","article-title":"Increased DNA methylation in the suicide brain","volume":"16","author":"Haghighi","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Teroganova, N., Girshkin, L., Suter, C.M., and Green, M.J. (2016). DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: A systematic review. BMC Genet., 17.","DOI":"10.1186\/s12863-016-0332-2"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e557","DOI":"10.1038\/tp.2015.49","article-title":"Genome-wide methylation study on depression: Differential methylation and variable methylation in monozygotic twins","volume":"5","author":"Navarro","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Eells, J.B., Varela-Stokes, A., Guo-Ross, S.X., Kummari, E., Smith, H.M., Cox, E., and Lindsay, D.S. (2015). Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119280"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nmeth.2481","article-title":"CLARITY for mapping the nervous system","volume":"10","author":"Chung","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_102","first-page":"468","article-title":"Stress and the HPA axis: Role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens","year":"2012","journal-title":"Alcohol Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/157015909790031229","article-title":"Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part I","volume":"7","author":"Miller","year":"2009","journal-title":"Curr. Neuropharmacol."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/6\/2\/19\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:36:09Z","timestamp":1760207769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/6\/2\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":104,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6]]}},"alternative-id":["pathogens6020019"],"URL":"https:\/\/doi.org\/10.3390\/pathogens6020019","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints201705.0071.v1","asserted-by":"object"}]},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}