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Infectious prion agents are considered to comprise solely of abnormally folded isoforms of the cellular prion protein known as PrPSc. Pathology during prion disease is restricted to the central nervous system where it causes extensive neurodegeneration and ultimately leads to the death of the host. The first half of this review provides a thorough account of our understanding of the various ways in which PrPSc prions may spread between individuals within a population, both horizontally and vertically. Many natural prion diseases are acquired peripherally, such as by oral exposure, lesions to skin or mucous membranes, and possibly also via the nasal cavity. Following peripheral exposure, some prions accumulate to high levels within the secondary lymphoid organs as they make their journey from the site of infection to the brain, a process termed neuroinvasion. The replication of PrPSc prions within secondary lymphoid organs is important for their efficient spread to the brain. The second half of this review describes the key tissues, cells and molecules which are involved in the propagation of PrPSc prions from peripheral sites of exposure (such as the lumen of the intestine) to the brain. This section also considers how additional factors such as inflammation and aging might influence prion disease susceptibility.<\/jats:p>","DOI":"10.3390\/pathogens6040060","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T11:29:33Z","timestamp":1511522973000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["How do PrPSc Prions Spread between Host Species, and within Hosts?"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-1796","authenticated-orcid":false,"given":"Neil","family":"Mabbott","sequence":"first","affiliation":[{"name":"The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.6815801","article-title":"Identification of a protein that purifies with the scrapie prion","volume":"218","author":"Bolton","year":"1982","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.1100195","article-title":"Synthetic mammalian prions","volume":"305","author":"Legname","year":"2004","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/ncomms6821","article-title":"Evidence for zoonotic potential of ovine scrapie prions","volume":"5","author":"Cassard","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1098\/rstb.1999.0427","article-title":"Population dynamics of scrapie in a flock","volume":"354","author":"Woolhouse","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/425035a","article-title":"Prion disease: Horizontal prion transmission in mule deer","volume":"425","author":"Miller","year":"2003","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3201\/eid2212.160635","article-title":"Horizontal transmission of chronic wasting disease","volume":"22","author":"Moore","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1098\/rstb.1997.0063","article-title":"The epidemiology of BSE in cattle herds in Great Britain. II. Model construction and analysis of transmission dynamics","volume":"352","author":"Ferguson","year":"1997","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1098\/rstb.1997.0062","article-title":"The epidemiology of BSE in cattle herds in Great Britain. I. Epidemiological processes, demography of cattle and approaches to control by culling","volume":"352","author":"Donnelly","year":"1997","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/39057","article-title":"Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent","volume":"389","author":"Bruce","year":"1997","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/38925","article-title":"The same prion strain causes vCJD and BSE","volume":"389","author":"Hill","year":"1997","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/vr.134.17.449","article-title":"Transmission of feline spongiform encephalopathy to mice","volume":"134","author":"Fraser","year":"1994","journal-title":"Vet. Rec."},{"key":"ref_12","first-page":"418","article-title":"Spongiform encephalopathy in an arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros)","volume":"127","author":"Kirkwood","year":"1990","journal-title":"Vet. Rec."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF00304476","article-title":"Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae","volume":"84","author":"Jeffrey","year":"1992","journal-title":"Acta Neuropathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/pri.24430","article-title":"Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced coversion assay","volume":"7","author":"John","year":"2013","journal-title":"Prion"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1128\/JVI.00425-11","article-title":"Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: Potential mechanisms of prion shedding and transmission","volume":"85","author":"Haley","year":"2011","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3201\/eid1409.080259","article-title":"Excretion of transmissible spongiform encephalopathy infectivity in urine","volume":"14","author":"Gregori","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1099\/vir.0.82786-0","article-title":"Urinary excretion and blood level of prions in scrapie-infected hamsters","volume":"88","author":"Murayama","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ligios, C., Cancedda, G.M., Margalith, I., Santucciu, C., Madau, L., Maestrale, C., Basagni, M., Saba, M., and Heikenwalder, M. (2007). Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000859"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08289","article-title":"Asymptomatic deer excrete infectious prions in faeces","volume":"461","author":"Tamguney","year":"2009","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/588193","article-title":"Transmission and detection of prions in feces","volume":"198","author":"Safar","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4161\/pri.6.1.16984","article-title":"Salivary prions in sheep and deer","volume":"6","author":"Tamguney","year":"2012","journal-title":"Prion"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1128\/JVI.05579-11","article-title":"The oral secretion of infectious scrapie prions occurs in preclinical sheep with a range of PRNP genotypes","volume":"86","author":"Gough","year":"2012","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1128\/JVI.02148-06","article-title":"PrPSc in salivary glands of scrapie-affected sheep","volume":"81","author":"Vascellari","year":"2007","journal-title":"J. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bessen, R.A., Shearin, H., Martinka, S., Boharski, R., Lowe, D., Wilham, J.M., Caughey, B., and Wiley, J.A. (2010). Prion shedding from olfactory neurons into nasal secretions. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000837"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1128\/JVI.06626-11","article-title":"Accelerated shedding of prions following damage to the olfactory epithelium","volume":"86","author":"Bessen","year":"2012","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1099\/jgv.0.000845","article-title":"Temporal patterns of chronic wasting disease prion excretion in three cervid species","volume":"98","author":"Plummer","year":"2017","journal-title":"J. Gen. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1126\/science.1118829","article-title":"Coincident scrapie infection and nephritis lead to urinary prion excretion","volume":"310","author":"Seeger","year":"2005","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1128\/JVI.01133-10","article-title":"Environmental sources of scrapie prions","volume":"84","author":"Maddison","year":"2010","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1021\/es101591a","article-title":"The interaction of ruminant PrP(Sc) with soils is influenced by prion source and soil type","volume":"44","author":"Maddison","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3389\/fmicb.2016.01885","article-title":"Clay components in soil dictate environmental stability and bioavailability of cervid prions in mice","volume":"7","author":"Wyckoff","year":"2016","journal-title":"Front. Microb."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.celrep.2015.04.036","article-title":"Grass plants bind, retain, uptake, and transport infectious prions","volume":"11","author":"Pritzkow","year":"2015","journal-title":"Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Johnson, C.J., Pedersen, J.A., Chappell, R.J., McKenzie, D., and Aiken, J.M. (2007). Oral transmissibility of prion disease is enhanced by binding soil particles. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030093"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/JVI.02649-06","article-title":"The nasal cavity is a route for prion infection in hamsters","volume":"81","author":"Kincaid","year":"2007","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1354\/vp.45-1-7","article-title":"Experimental transmission of US scrapie agent by nasal, peritoneal, and conjuctival routes to genetically susceptible sheep","volume":"45","author":"Hamir","year":"2008","journal-title":"Vet. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1128\/JVI.00018-09","article-title":"Role of the lymphoreticular system in prion neuroinvasion from the oral and nasal mucosa","volume":"83","author":"Bessen","year":"2009","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1099\/vir.0.017335-0","article-title":"Aerosol and nasal transmission of chronic wasting disease in cervidized mice","volume":"91","author":"Denkers","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Haybaeck, J., Heikenwalder, M., Klevenz, B., Schwarz, P., Margalith, I., Bridel, C., Mertz, K., Zirdum, E., Petsch, B., and Fuchs, T.J. (2011). Aerosols transmit prions to immunocompetent and immunodeficient mice. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1001257"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1128\/JVI.01103-16","article-title":"Specificity, size and frequency of spaces that characterize the mechanism of bulk transepithelial transport of prions in the nasal cavities of hamsters and mice","volume":"90","author":"Kincaid","year":"2016","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1099\/0022-1317-77-7-1595","article-title":"Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice","volume":"77","author":"Taylor","year":"1996","journal-title":"J. Gen. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.vetimm.2005.08.021","article-title":"Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin","volume":"109","author":"Gossner","year":"2005","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/JVI.77.1.583-591.2003","article-title":"Rapid prion neuroinvasion following tongue infection","volume":"77","author":"Bartz","year":"2003","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(82)90421-4","article-title":"Transmission of scrapie by oral route: Effect of gingival scarification","volume":"1","author":"Carp","year":"1982","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1128\/JVI.01655-10","article-title":"Minor oral lesions facilitate transmission of chronic wasting disease","volume":"85","author":"Denkers","year":"2011","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Crowell, J., Wiley, J.A., and Bessen, R.A. (2015). Lesion of the alfactory epithelium accelerates prion neuroinvasion and disease onset when prion replication is restricted to neurons. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119863"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0140-6736(92)92431-E","article-title":"\u201cFriendly fire\u201d in medicine: Hormones, homografts and Creutzfeldt-Jakob disease","volume":"340","author":"Brown","year":"1992","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1080\/19336896.2015.1121356","article-title":"Iatrogenic and sporadic Creutzfeldt-Jakob disease in 2 sisters without mutation in the prion protein gene","volume":"9","author":"Frontzek","year":"2015","journal-title":"Prion"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcpa.2010.01.015","article-title":"Disease-associated prion protein in the dental tissue of mice infected with scrapie","volume":"143","author":"Okada","year":"2010","journal-title":"J. Comp. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1038\/bdj.2007.126","article-title":"Dental treatment and risk of variant CJD\u2014A case control study","volume":"202","author":"Everington","year":"2007","journal-title":"Br. Dent. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1046\/j.1537-2995.1998.38998408999.x","article-title":"The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy","volume":"38","author":"Brown","year":"1998","journal-title":"Transfusion"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1046\/j.1537-2995.1999.39111169.x","article-title":"Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans","volume":"39","author":"Brown","year":"1999","journal-title":"Transfusion"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0037-1963(01)90130-1","article-title":"Creutzfeldt-Jakob disease: Blood infectivity and screeing tests","volume":"38","author":"Brown","year":"2001","journal-title":"Semin. Hematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1046\/j.0041-1132.2003.00586.x","article-title":"Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy","volume":"43","author":"Cervenakova","year":"2003","journal-title":"Transfusion"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1128\/JVI.76.9.4649-4650.2002","article-title":"Scrapie infectivity in hamster blood is not associated with platelets","volume":"76","author":"Holada","year":"2002","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(00)02719-7","article-title":"Transmission of BSE by blood transfusion in sheep","volume":"356","author":"Houston","year":"2000","journal-title":"Lancet"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1099\/0022-1317-83-11-2897","article-title":"Transmission of prion diseases by blood transfusion","volume":"83","author":"Hunter","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_56","unstructured":"Court, L., and Dodet, B. (1996). The risk of blood-borne Creutzfeldt-Jakob Disease. Transmissible Subacute Spongiform Encephalopathies: Prion Diseases, Elsevier."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1212\/WNL.46.5.1287","article-title":"Risk factors for Creutzfeldt-Jakob disease: A reanalysis of case-control studies","volume":"47","author":"Wietjens","year":"1996","journal-title":"Neurology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(97)09468-3","article-title":"Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993\u20131995","volume":"351","author":"Masullo","year":"1998","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0140-6736(98)08138-0","article-title":"Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: A case-control study","volume":"353","author":"Collins","year":"1999","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/vox.12371","article-title":"Creutzfeldt-Jakob disease and blood transfusion: Updated results of the UK transfusion medicine epidemiology review study","volume":"110","author":"Unwin","year":"2016","journal-title":"Vox Sang."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3201\/eid2001.130353","article-title":"Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease","volume":"20","author":"Douet","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(04)15486-X","article-title":"Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion","volume":"363","author":"Llewelyn","year":"2004","journal-title":"Lancet"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0140-6736(04)16811-6","article-title":"Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient","volume":"354","author":"Peden","year":"2004","journal-title":"Lancet"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/S0140-6736(06)69835-8","article-title":"Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: A case report","volume":"368","author":"Wroe","year":"2006","journal-title":"Lancet"},{"key":"ref_65","unstructured":"Health Protection Agency (2017, November 23). vCJD Abnormal Protein Found in a Patient with Haemophilia at Post Mortem, Available online: http:\/\/webarchive.nationalarchives.gov.uk\/20140714094822tf_\/http:\/\/www.hpa.org.uk\/NewsCentre\/NationalPressReleases\/2009PressReleases\/090217vCJDABNORMALPRIONPROTEINFOUNDINAPATIENTWITH\/."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(97)24002-X","article-title":"Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy","volume":"349","author":"Hill","year":"1997","journal-title":"Lancet"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(98)12075-5","article-title":"Investigation of variant Creutzfeldt-Jakob disease and other prion diseases with tonsil biopsy samples","volume":"353","author":"Hill","year":"1999","journal-title":"Lancet"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0140-6736(04)16812-8","article-title":"Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathy","volume":"364","author":"Gregori","year":"2004","journal-title":"Lancet"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.prevetmed.2009.10.013","article-title":"Evidence for maternal transmission of scrapie in naturally affected flocks","volume":"93","author":"Hoinville","year":"2010","journal-title":"Prev. Vet. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1530\/REP-07-0388","article-title":"Semen from scrapie-infected rams does not transmit prion infection to transgenic mice","volume":"135","author":"Sarradin","year":"2008","journal-title":"Reproduction"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nalls, A.V., McNulty, E., Powers, J., Seelig, D.M., Hoover, C., Haley, N.J., Hayes-Klug, J., Anderson, K., Stewart, P., and Goldmann, W. (2013). Mother to offspring transmission of chronic wasting disease in reeves\u2019 muntjac deer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071844"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1099\/jgv.0.000281","article-title":"In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk","volume":"96","author":"Selariu","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/vr.150.12.365","article-title":"Studies of embryo transfer from cattle clinically affected by bovine spongiform encephalopathy (BSE)","volume":"150","author":"Wrathall","year":"2002","journal-title":"Vet. Rec."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1128\/JVI.79.13.8665-8668.2005","article-title":"Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model","volume":"79","author":"Castilla","year":"2005","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/vr.141.10.239","article-title":"A cohort study to examine maternally-associated risk factors for bovine spongiform encephalopathy","volume":"141","author":"Wilesmith","year":"1997","journal-title":"Vet. Rec."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1098\/rspb.1997.0229","article-title":"Analysis of dam-calf pairs of BSE cases: Confirmation of maternal risk enhancement","volume":"264","author":"Donnelly","year":"1997","journal-title":"Proc. R. Soc. Lond. B"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1099\/0022-1317-80-2-517","article-title":"Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos","volume":"80","author":"Foster","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1099\/vir.0.80099-0","article-title":"Maternal transmission studies of BSE in sheep","volume":"85","author":"Foster","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2460\/ajvr.1993.54.11.1863","article-title":"Prevention of scrapie transmission in sheep, using embryo transfer","volume":"54","author":"Foote","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0093-691X(01)00566-0","article-title":"Preventing experimental vertical transmission of scrapie by embryo transfer","volume":"56","author":"Wang","year":"2001","journal-title":"Theriogenology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.theriogenology.2009.05.017","article-title":"Failure to transmit scrapie infection by transferring preimplantation embryos from naturally infected donor sheep","volume":"72","author":"Low","year":"2009","journal-title":"Theriogenology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/S0093-691X(02)00673-8","article-title":"Polymorphic distribution of the ovine prion protein (PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmission of scrapie","volume":"57","author":"Wang","year":"2002","journal-title":"Theriogenology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1099\/0022-1317-83-10-2607","article-title":"PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: Influence of foetal PrP genotype and effect on ewe-to-lamb transmission","volume":"83","author":"Lacroux","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1099\/vir.0.000151","article-title":"The placenta shed from goats with classical scrapie is infectious to goat kids and lambs","volume":"96","author":"Schneider","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1099\/vir.0.034652-0","article-title":"Factors influencing temporal variation of scrapie incidence within a clsoed Suffolk sheep flock","volume":"93","author":"Gonzalez","year":"2012","journal-title":"J. Gen. Virol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/vr.138.23.559","article-title":"Observations on the transmission of scrapie in experiments using embryo transfer","volume":"138","author":"Foster","year":"1996","journal-title":"Vet. Rec."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/vr.130.16.341","article-title":"Studies on maternal transmission of scarpie in sheep by embryo transfer","volume":"130","author":"Foster","year":"1992","journal-title":"Vet. Rec."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Foster, J.D., Goldmann, W., and Hunter, N. (2013). Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079433"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Garza, M.C., Fernandez-Borges, N., Bolea, R., Badiola, J.J., Castilla, J., and Monleon, E. (2011). Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027525"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1128\/JVI.03264-13","article-title":"Evidence of in utero transmission of classical scrapie in sheep","volume":"88","author":"Spiropoulos","year":"2014","journal-title":"J. Virol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1099\/vir.0.81418-0","article-title":"PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus","volume":"87","author":"Alverson","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jnnp.2009.172148","article-title":"Is there evidence of vertical transmission of variant Creutzfeldt-Jakob disease","volume":"82","author":"Murray","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3181\/00379727-166-41092","article-title":"Absence of vertical transmission of subacute spongiform viral encephalopathies in experimental primates","volume":"166","author":"Amyx","year":"1981","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.2353\/ajpath.2009.081045","article-title":"Failure to detect the presence of prions in the uterine and gestational tissues from a Gravida with Creutzfeldt-Jakob disease","volume":"174","author":"Xiao","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Garza, M.C., Monzon, M., Marin, B., Badiola, J.J., and Monleon, E. (2014). Distribution of peripheral PrP(Sc) in sheep with naturally acquired scrapie. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097768"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Maestrale, C., Di Guardo, G., Cancedda, M.G., Marruchella, G., Masia, M., Sechi, S., Macciocu, S., Santucciu, C., Petruzzi, M., and Ligios, C. (2013). A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062830"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/JVI.02022-10","article-title":"Sheep with scrapie and mastitis transmit infectious prions through the milk","volume":"85","author":"Ligios","year":"2011","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1051\/vetres\/2010030","article-title":"Detection of PrPSc in lung and mammary gland is favoured by the presence of Visna\/maedi virus lesions in naturally coinfected sheep","volume":"41","author":"Salazar","year":"2010","journal-title":"Vet. Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Konold, T., Moore, S.J., Bellworthy, S.J., Terry, L.A., Thorne, L., Ramsay, A., Salguerro, F.J., Simmons, M.M., and Simmons, H.A. (2013). Evidence of effective scrapie transmission via colostrum and milk in sheep. BMC Vet. Res., 9.","DOI":"10.1186\/1746-6148-9-99"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Lacroux, C., Simon, S., Benenstad, S.L., Maillet, S., Mathey, J., Lugan, S., Corbiere, F., Cassard, H., Costes, P., and Bergonier, D. (2008). Prions in milk from ewes incubating natural scrapie. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000238"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1099\/vir.0.81491-0","article-title":"No abnormal prion protein detected in the milk of cattle infected with the bovine spongiform encephalopathy agent","volume":"87","author":"Everest","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_102","first-page":"331","article-title":"PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology","volume":"3","author":"Manson","year":"1994","journal-title":"Neurodegeneration"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1073\/pnas.90.22.10608","article-title":"Ablation of the Prion Protein (PrP) Gene in Mice Prevents Scrapie and Facilitates Production of Anti-PrP Antibodies","volume":"90","author":"Prusiner","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1183748","article-title":"Generating a prion with bacterially expressed recombinant prion protein","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(87)90150-4","article-title":"Scrapie prion protein contains a phosphatidylinositol gylcolipid","volume":"51","author":"Stahl","year":"1987","journal-title":"Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1073\/pnas.90.23.10962","article-title":"Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion protein","volume":"90","author":"Pan","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0014-5793(97)00920-4","article-title":"NMR characterization of the full-length recombinant murine prion protein, mPrP","volume":"413","author":"Riek","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1021\/bi00245a003","article-title":"Secondary structure analysis of the scrapie-associated protein PrP 27\u201330 in water by infrared spectroscopy","volume":"30","author":"Caughey","year":"1991","journal-title":"Biochemistry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature01979","article-title":"RNA molecules stimulate prion protein conversion","volume":"425","author":"Deleault","year":"2003","journal-title":"Nature"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ma, J. (2012). The role of cofactors in prion propagation and infectivity. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002589"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature19312","article-title":"The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6","volume":"536","author":"Lakkraju","year":"2016","journal-title":"Nature"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/380639a0","article-title":"Altered circadian activity rythyms and sleep in mice devoid of prion protein","volume":"380","author":"Tobler","year":"1996","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/370295a0","article-title":"Prion protein is necessary for normal synaptic function","volume":"370","author":"Collinge","year":"1994","journal-title":"Nature"},{"key":"ref_115","first-page":"1375","article-title":"Cellular prion protein ablation impairs behaviour as a function of age","volume":"14","author":"Coitinho","year":"2003","journal-title":"Neuroreport"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/j.1528-1157.1999.tb01583.x","article-title":"Increased sensitivity to seizures in mice lacking cellular prion protein","volume":"40","author":"Walz","year":"1999","journal-title":"Epilesia"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1126\/science.289.5486.1925","article-title":"Signal transduction through prion protein","volume":"289","author":"Ermonval","year":"2000","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"44604","DOI":"10.1074\/jbc.M103289200","article-title":"PrPC directly interacts with proteins involved in signalling pathways","volume":"276","author":"Spielhaupter","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"39145","DOI":"10.1074\/jbc.C100443200","article-title":"Prion protein protects human neurons against Bax-mediated apoptosis","volume":"276","author":"Bounar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1750-3639.2007.00061.x","article-title":"The role of the octarepeat region in neuroprotective function of the cellular prion protein","volume":"17","author":"Mitteregger","year":"2007","journal-title":"Brain Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1128\/JVI.77.12.6845-6854.2003","article-title":"Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility","volume":"77","author":"Mabbott","year":"2003","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0002-9440(10)63907-7","article-title":"Oral prion infection requires normal numbers of Peyer\u2019s patches but not of enteric lymphocytes","volume":"162","author":"Prinz","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.4049\/jimmunol.178.6.3757","article-title":"Role of the GALT in scrapie agent neuroinvasion from the intestine","volume":"178","author":"Glaysher","year":"2007","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1099\/0022-1317-80-10-2757","article-title":"Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)","volume":"80","author":"Sigurdson","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1099\/0022-1317-81-12-3115","article-title":"Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie","volume":"81","author":"Andreoletti","year":"2000","journal-title":"J. Gen. Virol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1099\/0022-1317-81-9-2327","article-title":"Distribution of prion protein in the ileal Peyer\u2019s patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent","volume":"81","author":"Press","year":"2000","journal-title":"J. Gen. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/jcpa.1998.0300","article-title":"Scrapie-associated prion protein in the gastro-intestinal tract of sheep with scrapie","volume":"121","author":"Schreuder","year":"1999","journal-title":"J. Comp. Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imm.12031","article-title":"Ablation of the cellular prion protein, PrPC, specifcally on follicular dendritic cells has no effect on their maturation or function","volume":"138","author":"McCulloch","year":"2013","journal-title":"Immunology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(90)90225-4","article-title":"Cellular isoform of the scrapie agent protein participates in lymphocyte activation","volume":"61","author":"Cashman","year":"1990","journal-title":"Cell"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2567.1997.00331.x","article-title":"T lymphocyte activation and the cellular form of the prion protein","volume":"92","author":"Mabbott","year":"1997","journal-title":"Immunology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.4049\/jimmunol.177.9.6137","article-title":"Prion protein expression by mouse dendritic cells is restricted to the nonplasmacytoid subsets and correlates with the maturation state","volume":"177","author":"Metharom","year":"2006","journal-title":"J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.4049\/jimmunol.176.6.3490","article-title":"Overexpression of cellular prion protein induces and antioxidant environment altering T cell development in the thymus","volume":"176","author":"Rachidi","year":"2006","journal-title":"J. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.4049\/jimmunol.176.12.7254","article-title":"Funcitonal implication of cellular prion protein in antigen-driven interactions between T cells and dendritic cells","volume":"176","author":"Ballerini","year":"2006","journal-title":"J. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4049\/jimmunol.1103332","article-title":"Cutting edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor","volume":"189","author":"Nakato","year":"2012","journal-title":"J. Immunol."},{"key":"ref_135","first-page":"238","article-title":"The cellular prion protein modulates phagocytosis and inflammatory response","volume":"77","author":"Chiarini","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1620\/tjem.146.483","article-title":"Absence of autoantibodies against neurofilament proteins in the sera of scarpie infected mice","volume":"4","author":"Tsukamoto","year":"1985","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/vr.78.19.647","article-title":"Attempts to demonstrate neutralising antibodies in the sera of scrapie-infected animals","volume":"19","author":"Clarke","year":"1966","journal-title":"Vet. Rec."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cellimm.2010.03.018","article-title":"Anti-PrP antibodies detected at terminal stage of prion-affected mouse","volume":"263","author":"Sassa","year":"2010","journal-title":"Cell. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/bmb\/66.1.71","article-title":"Trafficking, turnover and membrane topology of PrP","volume":"66","author":"Harris","year":"2003","journal-title":"Br. Med. Bull."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tcb.2004.12.002","article-title":"The highways and byways of prion protein trafficking","volume":"15","author":"Campana","year":"2005","journal-title":"Trends Cell Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0021-9258(18)41985-0","article-title":"Evidence for synthesis of scrapie prion proteins in the endocytic pathway","volume":"267","author":"Borchelt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/path.1711760412","article-title":"The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain","volume":"176","author":"Arnold","year":"1995","journal-title":"J. Pathol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Marijanovic, Z., Caputo, A., Campana, V., and Zurzolo, C. (2009). Identification of an intracellular site of prion conversion. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000426"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"12489","DOI":"10.1523\/JNEUROSCI.4474-08.2008","article-title":"Cryo-immunogold EM for prions: Towards identification of a conversion site","volume":"28","author":"Godsave","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"38972","DOI":"10.1074\/jbc.M205110200","article-title":"Stimulation of PrPC retrograde transport toward the endoplasmic reticulum increases accumulation of PrPSc in prion -infected cells","volume":"277","author":"Beranger","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Kujala, P., Raymond, C.R., Romeijn, M., Godsave, S.F., van Kasteren, S.I., Wille, H., Prusiner, S.B., Mabbott, N.A., and Peters, P.J. (2011). Prion uptake in the gut: Identification of the first uptake and replication sites. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002449"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"McGovern, G., Mabbott, N.A., and Jeffrey, M. (2009). Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in mice. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008186"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ncomms1282","article-title":"Rapid cell-surface prion protein conversion revealed using a novel cell system","volume":"2","author":"Goold","year":"2011","journal-title":"Nat. Commun"},{"key":"ref_149","first-page":"3552","article-title":"Alternative sites of newly formed PrPSc upon prion conversion on the plasma membrane","volume":"126","author":"Goold","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/226462a0","article-title":"Pathogenesis of scrapie in the mouse: The role of the spleen","volume":"226","author":"Fraser","year":"1970","journal-title":"Nature"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0021-9975(78)90010-5","article-title":"Studies on the lymphoreticular system in the pathogenesis of scrapie: The role of spleen and thymus","volume":"88","author":"Fraser","year":"1978","journal-title":"J. Comp. Pathol."},{"key":"ref_152","first-page":"149","article-title":"Alymphoplasia mice are resistant to prion infection via oral route","volume":"53","author":"Horiuchi","year":"2006","journal-title":"Jpn. J. Vet. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9532","DOI":"10.1128\/JVI.01544-15","article-title":"The gut-associated lymphoid tissues in the small intestine, not the large intestine, play a major role in oral prion disease pathogenesis","volume":"15","author":"Donaldson","year":"2015","journal-title":"J. Virol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.imlet.2007.01.003","article-title":"Role of the draining lymph node in scrapie agent transmission from the skin","volume":"109","author":"Glaysher","year":"2007","journal-title":"Immunol. Lett."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/vr.158.10.325","article-title":"Postmortem diagnosis of preclinical and clinical scrapie in sheep by the detection of disease-associated PrP in their rectal mucosa","volume":"158","author":"Dagleish","year":"2006","journal-title":"Vet. Rec."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcpa.2005.08.001","article-title":"Detection of PrPSc in rectal biopsy and necroscopy samples from sheep with experimental scrapie","volume":"134","author":"Espenes","year":"2006","journal-title":"J. Comp. Pathol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/104063870601800605","article-title":"Detection of PrPCWD in postmortem rectal lymphoid tissues in Rocky Mountain elk (Cervus elaphus nelsoni) infected with chronic wasting disease","volume":"18","author":"Spraker","year":"2006","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1099\/vir.0.82342-0","article-title":"PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.)","volume":"88","author":"Wolfe","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2460\/ajvr.70.1.63","article-title":"Evaluation of immunohistochemical detection of prion protein in rectoanal mucosa-associated lymphoid tissue for diagnosis of scrapie in sheep","volume":"70","author":"Dennis","year":"2009","journal-title":"Am. J. Vet. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0140-6736(98)24035-9","article-title":"Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease","volume":"352","author":"Hilton","year":"1998","journal-title":"Lancet"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/path.1580","article-title":"Prevalence of lymphoreticular prion protein accumulation in UK tissue samples","volume":"203","author":"Hilton","year":"2004","journal-title":"J. Pathol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/bmj.325.7365.633","article-title":"Accumulation of prion protein in tonsil and appendix: Review of tissue samples","volume":"325","author":"Hilton","year":"2002","journal-title":"Br. Med. J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"f5675","DOI":"10.1136\/bmj.f5675","article-title":"Prevelent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: Large scale survey","volume":"347","author":"Gill","year":"2013","journal-title":"Br. Med. J."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mi.2013.30","article-title":"Microfold (M) cells: Important immunosurveillance posts in the intestinal epithelium","volume":"6","author":"Mabbott","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature08529","article-title":"Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune responses","volume":"462","author":"Hase","year":"2009","journal-title":"Nature"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/mi.2015.121","article-title":"Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria","volume":"9","author":"Rios","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.chom.2012.10.009","article-title":"Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion","volume":"12","author":"Tahoun","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2353\/ajpath.2008.070393","article-title":"Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: Evidence on defective M-cell formation in vivo","volume":"172","author":"Westphal","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1128\/JVI.02872-15","article-title":"Oral norovirus infection is blocked in mice lacking Peyer\u2019s patches and mature M cells","volume":"90","author":"Kolawole","year":"2015","journal-title":"J. Virol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1128\/JVI.00204-14","article-title":"Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells","volume":"88","author":"Liu","year":"2014","journal-title":"J. Virol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nm0901-976","article-title":"Transepithelial prion transport by M cells","volume":"7","author":"Heppner","year":"2001","journal-title":"Nat. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1128\/JVI.00969-10","article-title":"Transcytosis of murine-adapted bovine spongiform encephalopathy agents in an in vitro bovine M cell model","volume":"84","author":"Miyazawa","year":"2010","journal-title":"J. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.ajpath.2011.05.058","article-title":"Orally administered prion protein is incorporated by M cells and spreads to lymphoid tissues with macrophages in prion protein knockout mice","volume":"179","author":"Takakura","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/mi.2011.68","article-title":"M cell depletion blocks oral prion disease pathogenesis","volume":"5","author":"Donaldson","year":"2012","journal-title":"Mucosal Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Donaldson, D.S., Sehgal, A., Rios, D., Williams, I.R., and Mabbott, N.A. (2016). Increased abundance of M cells in the gut epithelium dramatically enhances oral prion disease susceptibility. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1006075"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3940(99)00934-9","article-title":"Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie","volume":"278","author":"Beekes","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_177","first-page":"166","article-title":"Induction of colonic M cells during intestinal inflammation","volume":"186","author":"Bennet","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.4049\/jimmunol.180.12.7840","article-title":"Comprehensive gene expression profiling of Peyer\u2019s patch M cells, villous M-like cells, and intestinal epithelial cells","volume":"180","author":"Terahara","year":"2008","journal-title":"J. Immunol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.4049\/jimmunol.0901563","article-title":"RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium","volume":"183","author":"Knoop","year":"2009","journal-title":"J. Immunol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ni.3732","article-title":"Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota","volume":"18","author":"Nagashima","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1086\/657415","article-title":"Murine cecal patch M cells transport infectious prions in vivo","volume":"202","author":"Foster","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/path.1962","article-title":"Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep","volume":"209","author":"Jeffrey","year":"2006","journal-title":"J. Pathol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"11280","DOI":"10.1523\/JNEUROSCI.2864-04.2004","article-title":"Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: Implications for species barrier in prion uptake from the intestine","volume":"24","author":"Mishra","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00441-015-2309-2","article-title":"RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)","volume":"364","author":"Mutoh","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.celrep.2016.06.080","article-title":"Microfold cells actively translocate Mycobacterium tuberculosis to initiate infection","volume":"16","author":"Nair","year":"2016","journal-title":"Cell Rep."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"12731","DOI":"10.1128\/JVI.01930-12","article-title":"Rapid transepithelial transport of prions following inhalation","volume":"86","author":"Kincaid","year":"2012","journal-title":"J. Virol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1128\/JVI.00760-15","article-title":"Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal and blood inoculations","volume":"89","author":"Elder","year":"2015","journal-title":"J. Virol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"32338","DOI":"10.1038\/srep32338","article-title":"Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular tissue distribution in vivo","volume":"6","author":"Urayama","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.4049\/jimmunol.179.11.7758","article-title":"In vivo depletion of CD11c+ cells impairs scrapie agent neuroinvasion from the intestine","volume":"179","author":"Raymond","year":"2007","journal-title":"J. Immunol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/dnares\/dsp013","article-title":"New approach for M-cell-specific molecules by screening comprehensive transcriptome analysis","volume":"16","author":"Nakato","year":"2009","journal-title":"DNA Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e1004975","DOI":"10.1080\/21688370.2015.1004975","article-title":"M cell-derived vesicles suggest a unique pathway for trans-epithelial antigen delivery","volume":"3","author":"Sakhon","year":"2015","journal-title":"Tissue Barriers"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1108003","article-title":"Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate","volume":"307","author":"Delamarre","year":"2005","journal-title":"Science"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2005.09.013","article-title":"Cell surface recycling of internalized antigen permits dendritic cell priming to B cells","volume":"23","author":"Bergtold","year":"2005","journal-title":"Immunity"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1084\/jem.177.5.1299","article-title":"Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo","volume":"177","author":"Liu","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/mi.2014.40","article-title":"Lymph-borne CD8a+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells","volume":"8","author":"Cerovic","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.166.3.1499","article-title":"Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production","volume":"166","author":"Ho","year":"2001","journal-title":"J. Immunol."},{"key":"ref_199","first-page":"1","article-title":"The interaction of immunodeficiency viruses with dendritic cells","volume":"276","author":"Steinman","year":"2003","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.4049\/jimmunol.1100987","article-title":"Lung CD103+ dendritic cells efficiently transport infuenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells","volume":"187","author":"Ho","year":"2011","journal-title":"J. Immunol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.4049\/jimmunol.161.3.1313","article-title":"Dendritic cells interact directly with Naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response","volume":"161","author":"Wykes","year":"1998","journal-title":"J. Immunol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1091334","article-title":"Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria","volume":"303","author":"Macpherson","year":"2004","journal-title":"Science"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1002\/1521-4141(200010)30:10<2808::AID-IMMU2808>3.0.CO;2-K","article-title":"A migratory population of skin-derived dendritic cells expresses CXCR5, responds to B lymphocyte chemoattractant in vitro, and co-localizes to B cell zones in lymph nodes in vivo","volume":"30","author":"Saeki","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.190.6.851","article-title":"A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein","volume":"190","author":"Berney","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ni.2309","article-title":"Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells","volume":"13","author":"Leon","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1099\/0022-1317-83-1-267","article-title":"Migrating intestinal dendritic cells transport PrPSc from the gut","volume":"83","author":"Huang","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1128\/JVI.02440-07","article-title":"Temporary depletion of CD11c+ dendritic cells delays lymphoinvasion after intraperitoneal scrapie infection","volume":"82","author":"Chabry","year":"2008","journal-title":"J. Virol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1128\/JVI.02345-06","article-title":"Role of the CD8+ dendritic cell subset in transmission of prions","volume":"81","author":"Sethi","year":"2007","journal-title":"J. Virol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1189\/jlb.1211633","article-title":"Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin","volume":"91","author":"Wathne","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.191.8.1381","article-title":"Localization of distinct Peyer\u2019s patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3, MIP-3\u00df, and secondary lymphoid organ chemokine","volume":"191","author":"Iwasaki","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Castro-Seoane, R., Hummerich, H., Sweeting, T., Tattum, M.H., Lineham, J.M., Fernandez de Marco, M., Brandner, S., Collinge, J., and Kl\u00f6hn, P.C. (2012). Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002538"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.4049\/jimmunol.177.9.6115","article-title":"Plasmacytoid dendritic cells do not migrate in intestinal or hepatic lymph","volume":"177","author":"Yrlid","year":"2006","journal-title":"J. Immunol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1182\/blood.V98.13.3733","article-title":"The normal cellular prion protein is strongly expressed by myeloid dendritic cells","volume":"98","author":"Burthem","year":"2001","journal-title":"Blood"},{"key":"ref_214","first-page":"1","article-title":"Expression profiles of prion and doppel proteins and of their receptors in mo`use splenocytes","volume":"38","author":"Cazareth","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00418-006-0250-x","article-title":"Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice","volume":"127","author":"Miyazawa","year":"2007","journal-title":"Histochem. Cell Biol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/15264","article-title":"Scrapie replication in lymphoid tissues depends on PrP-expressing follicular dendritic cells","volume":"5","author":"Brown","year":"1999","journal-title":"Nat. Med."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/4022","article-title":"PrP expression in B lymphocytes is not required for prion neuroinvasion","volume":"4","author":"Klein","year":"1998","journal-title":"Nat. Med."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jdermsci.2004.05.005","article-title":"Scrapie transmission following exposure through the skin is dependent on follicular dendritic cells in lymphoid tissues","volume":"35","author":"Mohan","year":"2004","journal-title":"J. Dermatol. Sci."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Loeuillet, C., Lemaire-Vielle, C., Naquet, P., Cesbron-Delauw, M.-F., Gagnon, J., and Cesbron, J.-Y. (2010). Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013166"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"McCulloch, L., Brown, K.L., Bradford, B.M., Hopkins, J., Bailey, M., Rajewsky, K., Manson, J.C., and Mabbott, N.A. (2011). Follicular dendritic cell-specific prion protein (PrPC) expression alone is sufficient to sustain prion infection in the spleen. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002402"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/srep00440","article-title":"Incunabular immunological events in prion trafficking","volume":"2","author":"Michel","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.4049\/jimmunol.182.3.1305","article-title":"Scrapie pathogenesis: The role of complement C1q in scrapie agent uptake by conventional dendritic cells","volume":"182","author":"Sebti","year":"2009","journal-title":"J. Immunol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.virol.2016.08.005","article-title":"Prion pathogenesis is unaltered following down-regulation of SIGN-R1","volume":"497","author":"Bradford","year":"2016","journal-title":"Virology"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncb1682","article-title":"Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission","volume":"10","author":"Sowinski","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/ni.1753","article-title":"HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic conduits and intestinal B cells via long-range intercellular conduits","volume":"10","author":"Xu","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/ncb1990","article-title":"M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex","volume":"11","author":"Hase","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/19336896.2015.1025189","article-title":"Prion aggregates transfer through tunneling nanotubes in endocytic vesicles","volume":"9","author":"Zhu","year":"2015","journal-title":"Prion"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ncb1841","article-title":"Prions hijack tunnelling nanotubes for intercellular spread","volume":"11","author":"Gousset","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/BJ20100698","article-title":"Characterization of the role of dendritic cells in prion transfer to primary neurons","volume":"431","author":"Langevin","year":"2010","journal-title":"Biochem. J."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cellimm.2012.11.007","article-title":"Characterisation of PrPSc transmission from immune cells to neuronal cells","volume":"279","author":"Tanaka","year":"2012","journal-title":"Cell. Immunol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.0308413101","article-title":"Cells release prions in association with exosomes","volume":"101","author":"Fevrier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00018-014-1735-8","article-title":"Prion strains are differentially released through the exosomal pathway","volume":"72","author":"Huor","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000149241","article-title":"In vitro interaction of scrapie agent and mouse peritoneal macrophages","volume":"16","author":"Carp","year":"1981","journal-title":"Intervirology"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000149289","article-title":"Effect of mouse peritoneal macrophages on scrapie infectivity during extended in vitro incubation","volume":"17","author":"Carp","year":"1982","journal-title":"Intervirology"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2005.02.042","article-title":"Role of gut macrophages in mice orally contaminated with scrapie or BSE","volume":"298","author":"Maignien","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/(SICI)1096-9896(200003)190:4<495::AID-PATH535>3.0.CO;2-T","article-title":"Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis","volume":"190","author":"Beringue","year":"2000","journal-title":"J. Pathol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/JVI.74.7.3338-3344.2000","article-title":"Tumor necrosis factor-alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie","volume":"74","author":"Mabbott","year":"2000","journal-title":"J. Virol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1128\/jvi.65.11.6292-6295.1991","article-title":"Abnormal Isoform of Prion Protein Accumulates in Follicular Dendritic Cells in Mice with Creutzfeldt-Jakob Disease","volume":"65","author":"Kitamoto","year":"1991","journal-title":"J. Virol."},{"key":"ref_239","first-page":"21","article-title":"Peripheral Pathogenesis of Scrapie in Normal and Immunocompromised Mice","volume":"45","author":"Fraser","year":"1994","journal-title":"Anim. Technol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/37789","article-title":"A crucial role for B cells in neuroinvasive scrapie","volume":"390","author":"Klein","year":"1997","journal-title":"Nature"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1099\/0022-1317-77-8-1935","article-title":"Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow","volume":"77","author":"Fraser","year":"1996","journal-title":"J. Gen. Virol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/233336a0","article-title":"Scrapie in immunologically deficient mice","volume":"233","author":"McFarlin","year":"1971","journal-title":"Nature"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1073\/pnas.96.7.3987","article-title":"Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication","volume":"96","author":"Raeber","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/path.1711680412","article-title":"PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice","volume":"168","author":"McBride","year":"1992","journal-title":"J. Pathol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1073\/pnas.051609398","article-title":"B-lymphocyte-restricted expression of the prion protein does not enable prion replication in PrP knockout mice","volume":"98","author":"Montrasio","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.4049\/jimmunol.150.7.2648","article-title":"Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice","volume":"150","author":"Kapasi","year":"1993","journal-title":"J. Immunol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0952-7915(98)80167-2","article-title":"Cytokine regulation of secondary lymphoid organ development","volume":"10","author":"Chaplin","year":"1998","journal-title":"Curr. Opin. Immunol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/25630","article-title":"Turning off follicular dendritic cells","volume":"395","author":"Mackay","year":"1998","journal-title":"Nature"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1074-7613(02)00397-7","article-title":"Distinct role of surface lymphotoxin epxressed by B cells in the organization of secondary lymphoid tissues","volume":"239","author":"Tumanov","year":"2002","journal-title":"Immunity"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cell.2012.05.032","article-title":"Follicular dendritic cells emerge from ubiquitous perivascular precursors","volume":"150","author":"Krautler","year":"2012","journal-title":"Cell"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2567.2011.03461.x","article-title":"Expression of mesenchyme-specific gene signatures by follicular dendritic cells: Insights from the meta-analysis of microarray data from multiple mouse cell populations","volume":"133","author":"Mabbott","year":"2011","journal-title":"Immunology"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(00)80588-9","article-title":"The lymphotoxin b receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues","volume":"9","author":"Mink","year":"1998","journal-title":"Immunity"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/382462a0","article-title":"Affinity maturation without germinal centres in lymphotoxin-a-deficient mice","volume":"382","author":"Matsumoto","year":"1996","journal-title":"Nature"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1074-7613(00)80292-7","article-title":"Distinct roles in lymphoid organogenesis for lymphotoxins a and b revealed in lymphotoxin b-deficient mice","volume":"6","author":"Koni","year":"1997","journal-title":"Immunity"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNFa-deficient mice: A critical requirement for TNFa in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centres, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1084\/jem.187.4.469","article-title":"Crucial role of tumour necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulp","volume":"187","author":"Tkachuk","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1073\/pnas.022626399","article-title":"Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells","volume":"99","author":"Prinz","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/77401","article-title":"Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie","volume":"6","author":"Mabbott","year":"2000","journal-title":"Nat. Med."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1126\/science.288.5469.1257","article-title":"Impaired prion replication in spleens of mice lacking functional follicular dendritic cells","volume":"288","author":"Montrasio","year":"2000","journal-title":"Science"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2567.2004.02074.x","article-title":"Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin","volume":"114","author":"Mohan","year":"2005","journal-title":"Immunology"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature02072","article-title":"Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion","volume":"425","author":"Prinz","year":"2003","journal-title":"Nature"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1128\/JVI.76.10.5131-5139.2002","article-title":"Temporary blockade of the tumour necrosis factor signaling pathway impedes the spread of scrapie to the brain","volume":"76","author":"Mabbott","year":"2002","journal-title":"J. Virol."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Heikenwalder, M., Federau, C., von Boehmer, L., Schwarz, P., Wagner, M., Zeller, N., Haybaeck, J., Prinz, M., Becher, B., and Aguzzi, A. (2007). Germinal centre B cells are dispensible for prion transport and neuroinvasion. J. Neuroimmunol., in press.","DOI":"10.1016\/j.jneuroim.2007.09.022"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1002\/eji.1830250836","article-title":"Follicular Dendritic Cells and the Maintenance of IgE Responses","volume":"25","author":"Helm","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1084\/jem.185.12.2111","article-title":"Lymphotoxin-a (LTa) supports development of splenic follicular structure that is required for IgG response","volume":"185","author":"Fu","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1084\/jem.187.7.1009","article-title":"B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin a-dependent fashion","volume":"187","author":"Fu","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.189.1.159","article-title":"Mature follicular dendritic cell networks depend on expression of lymphotoxin b receptor by radioresistant stromal cells and of lymphotoxin b and tumour necrosis factor by B cells","volume":"189","author":"Endres","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.4049\/jimmunol.164.5.2508","article-title":"Lymphotoxin-a-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation","volume":"164","author":"Fu","year":"2000","journal-title":"J. Immunol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.4049\/jimmunol.174.9.5358","article-title":"The influence of immune complex-bearing follicular dendritic cells on the IgM response, Ig class switching, and production of high affinity IgG","volume":"174","author":"Aydar","year":"2005","journal-title":"J. Immunol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nri3689","article-title":"Follicular dendritic cells: Dynamic antigen libraries","volume":"14","author":"Heesters","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1084\/jem.20071019","article-title":"Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8","volume":"205","author":"Kranich","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.immuni.2005.11.013","article-title":"FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses","volume":"24","author":"Victoratos","year":"2006","journal-title":"Immunity"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.4049\/jimmunol.179.9.6144","article-title":"Stromal complement receptor CD21\/35 facilitates lymphoid prion colonization and pathogenesis","volume":"179","author":"Zabel","year":"2007","journal-title":"J. Immunol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1128\/JVI.75.19.9320-9327.2001","article-title":"Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves","volume":"75","author":"McBride","year":"2001","journal-title":"J. Virol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(01)00331-2","article-title":"Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion","volume":"31","author":"Glatzel","year":"2001","journal-title":"Neuron"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/JVI.05581-11","article-title":"The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection","volume":"86","author":"Brown","year":"2012","journal-title":"J. Virol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.imbio.2007.04.001","article-title":"C1q binding and complement activation by prions and amyloid","volume":"212","author":"Sim","year":"2007","journal-title":"Immunobiology"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1016\/j.molimm.2006.12.027","article-title":"Prion protein activates and fixes complement directly via the classical pathway: Implications for the mechanism of scrapie agent propagation in lymphoid tissue","volume":"44","author":"Mitchell","year":"2007","journal-title":"Mol. Immunol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/86567","article-title":"Complement facilitates early prion pathogenesis","volume":"7","author":"Klein","year":"2001","journal-title":"Nat. Med."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/86562","article-title":"Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie","volume":"7","author":"Mabbott","year":"2001","journal-title":"Nat. Med."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.4049\/jimmunol.1201579","article-title":"Genetic depletion of complement receptors CD21\/35 prevents terminal prion disease in a mouse model of chronic wasting disease","volume":"189","author":"Michel","year":"2012","journal-title":"J. Immunol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/intimm\/dxt034","article-title":"Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease","volume":"25","author":"Michel","year":"2013","journal-title":"Int. Immunol."},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Kane, S.J., Farley, T.K., Gordon, E.O., Estep, J., Bender, H.R., Moreno, J.A., Bartz, J., Telling, G.C., Pickering, M.C., and Zabel, M.D. (2017). Complement regulatory protein factor H is a soluble prion receptor that potentiates peripheral prion pathogenesis. J. Immunol., in press.","DOI":"10.4049\/jimmunol.1701100"},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Kane, S.J., Swanson, E., Gordon, E.O., Rocha, S., Bender, H.R., Donius, L.R., Hannan, J.P., and Zabel, M.D. (2017). Relative impact of complement receptors CD21\/35 (Cr2\/1) on scrapie pathogenesis in mice. mSphere, in press.","DOI":"10.1128\/mSphereDirect.00493-17"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.imbio.2004.06.003","article-title":"Complement component C5 is not involved in scrapie pathogenesis","volume":"209","author":"Mabbott","year":"2004","journal-title":"Immunobiology"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.immuni.2013.02.023","article-title":"Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation","volume":"38","author":"Heesters","year":"2013","journal-title":"Immunity"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/1096-9896(200007)191:3<323::AID-PATH629>3.0.CO;2-Z","article-title":"Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy","volume":"191","author":"Jeffrey","year":"2000","journal-title":"J. Pathol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jcpa.2003.11.001","article-title":"Murine scrapie infection causes an abnormal germinal centre reaction in the spleen","volume":"130","author":"McGovern","year":"2004","journal-title":"J. Comp. Pathol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1099\/0022-1317-83-10-2617","article-title":"PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer","volume":"83","author":"Sigurdson","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/35876","article-title":"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt\u2019s lymphoma receptor-1","volume":"391","author":"Gunn","year":"1998","journal-title":"Nature"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/35018581","article-title":"A chemokine-driven feedback loop organizes lymphoid follicles","volume":"406","author":"Ansel","year":"2000","journal-title":"Nature"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.4049\/jimmunol.168.10.5117","article-title":"B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion","volume":"168","author":"Yu","year":"2002","journal-title":"J. Immunol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"e00124-17","DOI":"10.1128\/JVI.00124-17","article-title":"Oral prion disease pathogenesis is impeded in the specific absence of CXCR5-expressing dendritic cells","volume":"91","author":"Bradford","year":"2017","journal-title":"J. Virol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4049\/jimmunol.176.2.803","article-title":"CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes","volume":"176","author":"Jang","year":"2006","journal-title":"J. Immunol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1099\/vir.0.82816-0","article-title":"Experimental scrapie in \u2018plt\u2019 mice: An assessment of the role of dendritic-cell migration in the pathogenesis of prion diseases","volume":"88","author":"Levavasseur","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/ni1494","article-title":"Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells","volume":"8","author":"Phan","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2007.06.007","article-title":"B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node","volume":"27","author":"Carrasco","year":"2007","journal-title":"Immunity"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/ni.1745","article-title":"Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation","volume":"10","author":"Phan","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ni1542","article-title":"Follicular shuttling of marginal zone B cells facilitates antigen transport","volume":"9","author":"Cinamon","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1099\/0022-1317-83-2-479","article-title":"Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep","volume":"83","author":"Press","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1056\/NEJMoa030351","article-title":"Extraneural pathological prion protein in sporadic Creutzfeldt-Jakob disease","volume":"349","author":"Glatzel","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1073\/pnas.161055198","article-title":"Neuroinvasion by a Creutzfeldt-Jakob disease agent in the absence of B cells and follicular dendritic cells","volume":"98","author":"Schlomchik","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1099\/0022-1317-78-9-2389","article-title":"Immunodetection of PrPSc in spleens of some scrapie-infected sheep but not BSE-infected cows","volume":"78","author":"Somerville","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/vr.152.13.387","article-title":"Detection of disease-specific PrP in the distal ileum of cattle exposed orally to the agent of bovine spongiform encephalopathy","volume":"152","author":"Terry","year":"2003","journal-title":"Vet. Rec."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/vr.135.2.40","article-title":"Infectivity in the ileum of cattle challenged orally with bovine spongiform encephalopathy","volume":"135","author":"Wells","year":"1994","journal-title":"Vet. Rec."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1297-9716-42-21","article-title":"BSE infectivity in jejunum, ileum and ileocaecal junction of incubating cattle","volume":"42","author":"Hoffmann","year":"2011","journal-title":"Vet. Res."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1099\/0022-1317-82-10-2319","article-title":"Distribution of the prion protein in sheep terminally affected with BSE following experimental oral transmission","volume":"82","author":"Foster","year":"2001","journal-title":"J. Gen. Virol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1099\/vir.0.058958-0","article-title":"Evidence of subclinical prion disease in aged mice following exposure to bovine spongiform encephalopathy","volume":"95","author":"Brown","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"O\u2019Connor, T., Frei, N., Sponarova, J., Schwarz, P., Heikenwalder, M., and Agguzi, A. (2012). Lymphotxin, but not TNF, is required for prion invasion of lymph nodes. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002867"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2008.10.014","article-title":"Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas","volume":"29","author":"Heikenwalder","year":"2008","journal-title":"Immunity"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0034-5288(18)34518-1","article-title":"The antibody response of scrapie-affected mice to immunisation with sheep red blood cells","volume":"9","author":"Clarke","year":"1968","journal-title":"Res.Vet. Sci."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/infdis\/138.3.396","article-title":"Mitogen stimulation of splenocytes from mice infected with scrapie agent","volume":"138","author":"Garfin","year":"1978","journal-title":"J. Infect. Dis."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/iai.32.3.1176-1180.1981","article-title":"Evidence for Normal Cell-Mediated Immunity in Scrapie-Infected Mice","volume":"32","author":"Kingsbury","year":"1981","journal-title":"Infect. Immun."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0165-2427(85)90111-4","article-title":"ConA induced suppressor cells in scrapie-infected mice","volume":"8","author":"Elleman","year":"1985","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1051\/vetres\/2009048","article-title":"High prevalence of scrapie in a dairy goat herd: Tissue distribution of disease-associated PrP and effect of PRNP genotype and age","volume":"40","author":"Gonzalez","year":"2009","journal-title":"Vet. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/1040638712453582","article-title":"Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America: Effects of age, sex, polymorphism at PRNP codon 96, and disease progression","volume":"24","author":"Thomsen","year":"2012","journal-title":"J. Vet. Diagn. Intestig."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7589\/2011-12-362","article-title":"Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging cow elk (Cervus elaphus nelsoni)","volume":"49","author":"Monello","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"ref_319","first-page":"57","article-title":"Pathogenesis of natural scrapie in sheep","volume":"16","author":"Schreuder","year":"2000","journal-title":"Arch. Virol. Suppl."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-0463.2002.100104.x","article-title":"Ealry and late pathogenesis of natural scrapie infection in sheep","volume":"110","author":"Vromans","year":"2002","journal-title":"APMIS"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/vetres:2007061","article-title":"TSE pathogenesis in cattle and sheep","volume":"39","author":"Bossers","year":"2008","journal-title":"Vet. Res."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1099\/vir.0.021311-0","article-title":"Relevance of oral experimental challenge with classical scrapie in sheep","volume":"91","author":"Tabouret","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00705-007-0007-4","article-title":"Pathogenesis of bovine spongiform encephalopathy in sheep","volume":"153","author":"Vromans","year":"2008","journal-title":"Arch. Virol."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1128\/JCM.02209-08","article-title":"Validation of use of rectoanal mucosa-associated lymphoid tissue for immunohistochemical diagnosis of chronic wasting disease in white-tailed deer (Odocoileus virginianus)","volume":"47","author":"Keane","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/104063870902100103","article-title":"Antermortem detection of PrPCWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa","volume":"21","author":"Spraker","year":"2009","journal-title":"J. Vet. Diagn. Intestig."},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"Hoover, C.E., Davenport, K.A., Henderson, D.M., Denkers, N.D., Mathiason, C.K., Soto, C., Zabel, M.D., and Hoover, E.A. (2017). Pathways of prion spread during early chronic wasting disease in deer. J. Virol., in press.","DOI":"10.1128\/JVI.00077-17"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.191.3.435","article-title":"A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes","volume":"191","author":"Huang","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/mi.2015.77","article-title":"The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct","volume":"9","author":"Houston","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0168-1702(89)90040-3","article-title":"Pathogenesis of scrapie in mice after intragastric infection","volume":"12","author":"Kimberlin","year":"1989","journal-title":"Virus Res."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.20122574","article-title":"CXCR4 promotes B cell egress from Peyer\u2019s patches","volume":"210","author":"Schmidt","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1084\/jem.186.12.2013","article-title":"Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool","volume":"186","author":"Turner","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.20090209","article-title":"Visualizing B cell capture of cognate antigen from follicular dendritic cells","volume":"206","author":"Suzuki","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.4049\/jimmunol.1200349","article-title":"B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs","volume":"188","author":"Mok","year":"2012","journal-title":"J. Immunol."},{"key":"ref_334","doi-asserted-by":"crossref","unstructured":"Andreoletti, O., Litaise, C., Simmons, H., Corbiere, F., Lugan, S., Costes, P., Schelcher, F., Viette, D., Grassi, J., and Lacroux, C. (2012). Highly efficient prion transmission by blood transfusion. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002782"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1128\/JVI.02783-15","article-title":"Mononucleated blood cell populations display different abilities to transmit prion disease by the transfusion route","volume":"90","author":"Douet","year":"2016","journal-title":"J. Virol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.virol.2010.05.023","article-title":"PrP(Sc) is associated with B cells in the blood of scrapie-infected sheep","volume":"405","author":"Edwards","year":"2010","journal-title":"Virology"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1128\/JVI.02169-09","article-title":"B cells and platelets harbour prion infectivity in the blood of deer infected with chronic wasting disease","volume":"84","author":"Mathiason","year":"2010","journal-title":"J. Virol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/vr.159.10.327-b","article-title":"Prion protein in kidneys of scrapie-infected sheep","volume":"159","author":"Jeffrey","year":"2006","journal-title":"Vet. Rec."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/glia.22660","article-title":"Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease","volume":"62","author":"Schetters","year":"2014","journal-title":"Glia"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(03)00696-7","article-title":"Does the neuropathology of human patients with variant Creutzfeldt-Jakob disease reflect haematogenous spread of the disease","volume":"348","author":"Armstrong","year":"2003","journal-title":"Neurosci. Lett."},{"key":"ref_341","doi-asserted-by":"crossref","unstructured":"Felten, S.Y., and Felten, D.L. (1991). Innervation of Lymphoid Tissue. Psychoneuroimmunology, Academic Press Inc.. [2nd ed.].","DOI":"10.1016\/B978-0-12-043780-1.50006-3"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1099\/0022-1317-77-8-1925","article-title":"Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie","volume":"77","author":"Beekes","year":"1996","journal-title":"J. Gen. Virol."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1099\/0022-1317-78-5-1187","article-title":"Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord","volume":"78","author":"Baldauf","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1099\/0022-1317-79-3-601","article-title":"Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie","volume":"79","author":"Beekes","year":"1998","journal-title":"J. Gen. Virol."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(99)00223-2","article-title":"Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie","volume":"265","author":"McBride","year":"1999","journal-title":"Neurosci. Lett."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"19039","DOI":"10.1073\/pnas.0504253102","article-title":"Network of dendritic cells within the muscular layer of the mouse","volume":"102","author":"Macpherson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurones regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1172\/JCI200113155","article-title":"Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie","volume":"108","author":"Aucouturier","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/595791","article-title":"Bacterial colitis increases susceptibility to oral prion pathogenesis","volume":"199","author":"Sigurdson","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/272054a0","article-title":"Mitogenic Stimulation of the Host Enhances Susceptibility to Scrapie","volume":"272","author":"Dickinson","year":"1978","journal-title":"Nature"},{"key":"ref_351","doi-asserted-by":"crossref","unstructured":"Bremer, J., Heikenwalder, M., Haybaeck, J., Tiberi, C., Krautler, N.J., Kurrer, M.O., and Aguzzi, A. (2009). Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007160"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1106460","article-title":"Chronic lymphocytic inflammation specifies the organ tropism of prions","volume":"307","author":"Heikenwalder","year":"2005","journal-title":"Science"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nm1105-1137","article-title":"PrPSc in mammary glands of sheep affected by scrapie and mastitis","volume":"11","author":"Ligios","year":"2005","journal-title":"Nat. Med."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1126\/science.1066838","article-title":"Estimation of epidemic size and incubation time based on age characteristics of vCJD in the United Kingdom","volume":"294","author":"Valleron","year":"2001","journal-title":"Science"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4161\/pri.29237","article-title":"Variant CJD. 18 years of research and surveillance","volume":"2014","author":"Diack","year":"2014","journal-title":"Prion"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1474-4422(06)70413-6","article-title":"Predicting susceptibility and incubation time of human-to-human transmission of vCJD","volume":"5","author":"Bishop","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1099\/0022-1317-78-10-2707","article-title":"Severly combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy","volume":"78","author":"Brown","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"E6654","DOI":"10.1073\/pnas.1517993112","article-title":"Post-conversion sialylation of prions in lymphoid tissues","volume":"112","author":"Srivastava","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-4-26","article-title":"Epidemiological evidence of higher susceptibility to vCJD in the young","volume":"4","author":"Boelle","year":"2004","journal-title":"BMC Infect. Dis."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1474-9726.2008.00443.x","article-title":"B-cell diversity decreases in old age and is correlated with poor health status","volume":"8","author":"Gibson","year":"2009","journal-title":"Aging Cell"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4419-6451-9_15","article-title":"Memory T-cell homeostasis and senescence during aging","volume":"684","author":"Henson","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/imm.12294","article-title":"Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1\/CD169)","volume":"143","author":"Bradford","year":"2014","journal-title":"Immunology"},{"key":"ref_363","doi-asserted-by":"crossref","unstructured":"St. Rose, S., Hunter, N., Matthews, D., Foster, J., Chase-Topping, M.E., Kruuk, L.E.B., Shaw, D.J., Rhind, S.M., Will, R.G., and Woolhouse, M.E.J. (2006). Comparative evidence for a link between Peyer\u2019s patch development and susceptibility to transmissible spongiform encephalopathies. BMC Infect. Dis., 6.","DOI":"10.1186\/1471-2334-6-5"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.vetimm.2007.01.017","article-title":"Quantification of Peyer\u2019s patches in Cheviot sheep for future scrapie pathogenesis studies","volume":"116","author":"Hunter","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.4049\/jimmunol.0802695","article-title":"The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice","volume":"183","author":"Brown","year":"2009","journal-title":"J. Immunol."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/mi.2012.141","article-title":"The functional maturation of M cells is dramatically reduced in the Peyer\u2019s patches of aged mice","volume":"6","author":"Kobayashi","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/imm.12737","article-title":"Ageing adversely affects the migration and function of marginal zone B cells","volume":"151","author":"Turner","year":"2017","journal-title":"Immunology"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/104063870902100618","article-title":"Impact of age and sex of Rocky Mountain elk (Cervus elaphus nelsoni) on follicle counts from rectal mucosal biopsies for preclinical detection of chronic wasting disease","volume":"21","author":"Spraker","year":"2009","journal-title":"J. Vet. Diagn. Intestig."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7589\/2014-12-284","article-title":"Age and repeated biopsy influence antemortem PrPCWD testing in mule deer (Odocoileus hemionus) in Colorado, USA","volume":"51","author":"Geremia","year":"2015","journal-title":"J. Wildl. Dis."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/241536a0","article-title":"Developmental maturation of susceptibility to scrapie in mice","volume":"241","author":"Outram","year":"1973","journal-title":"Nature"},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/JVI.80.1.474-482.2006","article-title":"Resistance of neonatal mice to scrapie is associated with inefficient infection of the immature spleen","volume":"80","author":"Ierna","year":"2006","journal-title":"J. Virol."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1128\/JVI.01573-12","article-title":"Susceptibility of young sheep to oral infection with bovine spongiform encephalopathy decreases significantly after weaning","volume":"86","author":"Hunter","year":"2012","journal-title":"J. Virol."},{"key":"ref_374","first-page":"845","article-title":"Enhanced enteric invasion of scrapie agents into the villous columnar epithelium via maternal immunoglobulin","volume":"26","author":"Ano","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1073\/pnas.161274798","article-title":"Acridine and phenothiazine derivatives as pharmocotherapeutics for prion disease","volume":"98","author":"Korth","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ana.10336","article-title":"Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model","volume":"52","author":"Collins","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S1474-4422(09)70049-3","article-title":"Safety and efficacy of quinacrine in human prion disease (PRION-1 study): A patient-preference trial","volume":"8","author":"Collinge","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/WNL.0b013e3182a9f3b4","article-title":"Quinacrine treatment for sporadic Creutzfeldt-Jakob disease","volume":"81","author":"Geschwind","year":"2013","journal-title":"Neurology"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(98)05395-1","article-title":"Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies","volume":"353","author":"Farquhar","year":"1999","journal-title":"Lancet"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/JVI.78.10.4999-5006.2004","article-title":"Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models","volume":"78","author":"Ishiwaki","year":"2004","journal-title":"J. Virol."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1440-1789.2009.01058.x","article-title":"Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases","volume":"29","author":"Tsuboi","year":"2009","journal-title":"Neuropathology"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1006\/jmbi.2000.3840","article-title":"Tetracycline affects abnormal properties of synthetic PrP peptides and PrPSc in vitro","volume":"300","author":"Tagliavini","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1073\/pnas.162195499","article-title":"Tetracyclines affect prion infectivity","volume":"99","author":"Forloni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(13)70307-7","article-title":"Doxycycline in Creutzfeldt-Jakob disease: A phase 2, randomised, double-blind, placebo-controlled trial","volume":"13","author":"Haik","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/253556a0","article-title":"Extraneural competition between different scrapie agents leading to loss of infectivity","volume":"253","author":"Dickinson","year":"1975","journal-title":"Nature"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/newbio237244a0","article-title":"Competition between different scrapie agents in mice","volume":"237","author":"Dickinson","year":"1972","journal-title":"Nat. New Biol."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1073\/pnas.95.5.2520","article-title":"Vaccination with an attenuated Creutzfeldt-Jakob disease strain prevents expression of a virulent agent","volume":"95","author":"Manuelidis","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_388","doi-asserted-by":"crossref","unstructured":"Diaz-Espinoza, R., Morales, R., Concha-Marambio, L., Moreno-Gonzalez, I., Moda, F., and Soto, C. (2017). Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo. Mol. Psychiatry.","DOI":"10.1038\/mp.2017.84"},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature11058","article-title":"Sustained translational repression by eIF2aP mediates prion neurodegeneration","volume":"485","author":"Moreno","year":"2012","journal-title":"Nature"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"206ra138","DOI":"10.1126\/scitranslmed.3006767","article-title":"Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice","volume":"5","author":"Moreno","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1586\/14760584.2015.965691","article-title":"Prospects for safe and effective vaccines against prion diseases","volume":"14","author":"Mabbott","year":"2015","journal-title":"Exp. Rev. Vaccines"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrneurol.2012.258","article-title":"Immunotherapy in prion disease","volume":"9","author":"Roettger","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1126\/science.1063093","article-title":"Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies","volume":"294","author":"Heppner","year":"2001","journal-title":"Science"},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature01457","article-title":"Monoclonal antibodies inhibit prion replication and delay the development of prion disease","volume":"422","author":"White","year":"2003","journal-title":"Nature"},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuroscience.2005.02.031","article-title":"Mucosal vaccination delays or prevents prion infection via the oral route","volume":"133","author":"Knudsen","year":"2005","journal-title":"Neuroscience"},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.neuroscience.2008.02.051","article-title":"High titres of mucosal and systemic anti-PrP antibodies abrogates oral prion infection in mucosal vaccinated mice","volume":"153","author":"Chablagoity","year":"2008","journal-title":"Neuroscience"},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature12402","article-title":"The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein","volume":"501","author":"Sonati","year":"2013","journal-title":"Nature"},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature14510","article-title":"A naturally occuring variant of the human prion protein completely prevents prion disease","volume":"522","author":"Asante","year":"2015","journal-title":"Nature"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/6\/4\/60\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:51:09Z","timestamp":1760208669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/6\/4\/60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":398,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["pathogens6040060"],"URL":"https:\/\/doi.org\/10.3390\/pathogens6040060","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]}}}