{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:40:18Z","timestamp":1779248418503,"version":"3.51.4"},"reference-count":126,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007155","name":"MRC","doi-asserted-by":"publisher","award":["G0900466"],"award-info":[{"award-number":["G0900466"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The host cell represents a hostile environment that viruses must counter in order to establish infection. Human cytomegalovirus (HCMV) is no different and encodes a multitude of functions aimed at disabling, re-directing or hijacking cellular functions to promulgate infection. However, during the very early stages of infection the virus relies on the outcome of interactions between virion components, cell surface receptors and host signalling pathways to promote an environment that supports infection. In the context of latent infection\u2014where the virus establishes an infection in an absence of many gene products specific for lytic infection\u2014these initial interactions are crucial events. In this review, we will discuss key host responses triggered by viral infection and how, in turn, the virus ameliorates the impact on the establishment of non-lytic infections of cells. We will focus on strategies to evade intrinsic antiviral and innate immune responses and consider their impact on viral infection. Finally, we will consider the hypothesis that the very early events upon viral infection are important for dictating the outcome of infection and consider the possibility that events that occur during entry into non-permissive cells are unique and thus contribute to the establishment of latency.<\/jats:p>","DOI":"10.3390\/pathogens7010030","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T06:57:11Z","timestamp":1521529031000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-7161","authenticated-orcid":false,"given":"Matthew","family":"Murray","sequence":"first","affiliation":[{"name":"Institute of Immunity &amp; Transplantation, University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute of Immunity &amp; Transplantation, University College London, Royal Free Campus, London NW3 2PF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.1233028","article-title":"Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens","volume":"340","author":"Randow","year":"2013","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern Recognition Receptors and Inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/ni.2229","article-title":"Intrinsic antiviral immunity","volume":"13","author":"Yan","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.micro.53.1.155","article-title":"The induction of apoptosis by bacterial pathogens","volume":"53","author":"Weinrauch","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_5","first-page":"451","article-title":"Prevalence of rubella and cytomegalovirus antibodies among pregnant women in northern Turkey","volume":"31","author":"Uyar","year":"2008","journal-title":"New Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/rmv.655","article-title":"Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection","volume":"20","author":"Cannon","year":"2010","journal-title":"Rev. Med. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4437","article-title":"The pathogenesis of human cytomegalovirus","volume":"235","author":"Griffiths","year":"2015","journal-title":"J. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/00002030-200006160-00013","article-title":"Changes in the natural history of cytomegalovirus retinitis following the introduction of highly active antiretroviral therapy","volume":"14","author":"Deayton","year":"2000","journal-title":"AIDS"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3947\/ic.2013.45.3.260","article-title":"Cytomegalovirus Infections in Solid Organ Transplantation: A Review","volume":"45","author":"Ramanan","year":"2013","journal-title":"Infect. Chemother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.hoc.2010.11.011","article-title":"Cytomegalovirus in hematopoietic stem cell transplant recipients","volume":"25","author":"Ljungman","year":"2011","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S1473-3099(12)70197-4","article-title":"Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation","volume":"12","author":"Griffiths","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0042-1748054","article-title":"Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus","volume":"11","author":"Dahle","year":"2000","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1093\/cid\/cit609","article-title":"Congenital Cytomegalovirus Infection: Audiologic Outcome","volume":"57","author":"Fowler","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2009","journal-title":"Rev. Med. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.bbmt.2014.08.010","article-title":"Cytomegalovirus infection in patients who underwent allogeneic hematopoietic stem cell transplantation in portugal: A five-year retrospective review","volume":"20","author":"Sousa","year":"2014","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1086\/421999","article-title":"Vaccine development to prevent cytomegalovirus disease: Report from the National Vaccine Advisory Committee","volume":"39","author":"Arvin","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1073\/pnas.80.13.4139","article-title":"9-([2-Hydroxy-1-(Hydroxymethyl)Ethoxy]Methyl)Guanine: A Selective Inhibitor of Herpes Group Virus Replication","volume":"80","author":"Field","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S495","DOI":"10.1093\/clinids\/10.Supplement_3.S495","article-title":"Ganciclovir treatment of life-or sight-threatening cytomegalovirus infection: Experience in 314 immunocompromised patients","volume":"10","author":"Buhles","year":"1988","journal-title":"Rev. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1182\/blood.V90.6.2502","article-title":"Neutropenia in allogeneic marrow transplant recipients receiving ganciclovir for prevention of cytomegalovirus disease: Risk factors and outcome","volume":"90","author":"Salzberger","year":"1997","journal-title":"Blood"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40265-017-0860-8","article-title":"Letermovir: First Global Approval","volume":"78","author":"Kim","year":"2018","journal-title":"Drugs"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bies.201200170","article-title":"From reactivation of latent HIV-1 to elimination of the latent reservoir: The presence of multiple barriers to viral eradication","volume":"35","author":"Shan","year":"2013","journal-title":"BioEssays"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10958","DOI":"10.1073\/pnas.96.20.10958","article-title":"Latent reservoirs of HIV: Obstacles to the eradication of virus","volume":"96","author":"Chun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"313761","DOI":"10.1155\/2014\/313761","article-title":"Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection","volume":"2014","author":"Poole","year":"2014","journal-title":"New J. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"24674","DOI":"10.1038\/srep24674","article-title":"Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells","volume":"6","author":"Krishna","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1038\/ncomms14321","article-title":"Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein","volume":"8","author":"Krishna","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1126\/science.1235047","article-title":"Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection","volume":"340","author":"Weekes","year":"2013","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1099\/0022-1317-77-12-3099","article-title":"Detection of endogenous human cytomegalovirus in CD34+bone marrow progenitors","volume":"77","author":"Mendelson","year":"1996","journal-title":"J. Gen. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1182\/blood.V88.12.4526.bloodjournal88124526","article-title":"Human cytomegalovirus suppression of and latency in early hematopoietic progenitor cells","volume":"88","author":"Sindre","year":"1996","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1099\/0022-1317-72-9-2059","article-title":"Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells","volume":"72","author":"Sissons","year":"1991","journal-title":"J. Gen. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1073\/pnas.95.7.3937","article-title":"Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells","volume":"95","author":"Hahn","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0092-8674(01)80014-3","article-title":"Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors","volume":"91","author":"Fish","year":"1997","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2141.1991.tb04388.x","article-title":"Polymerase chain reaction for detection of human cytomegalovirus infection in a blood donor population","volume":"78","author":"Bevan","year":"1991","journal-title":"Br. J. Haematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1073\/pnas.0408994102","article-title":"Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers","volume":"102","author":"Reeves","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3390\/v5061395","article-title":"Regulation of human cytomegalovirus transcription in latency: Beyond the major immediate-early promoter","volume":"5","author":"Reeves","year":"2013","journal-title":"Viruses"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rmv.1862","article-title":"Cytomegalovirus latency and reactivation: Recent insights into an age old problem","volume":"26","author":"Dupont","year":"2016","journal-title":"Rev. Med. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"16255","DOI":"10.1073\/pnas.252630899","article-title":"Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: A model for latency","volume":"99","author":"Goodrum","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1128\/JVI.78.3.1440-1447.2004","article-title":"A Novel Viral Transcript with Homology to Human Interleukin-10 Is Expressed during Latent Human Cytomegalovirus Infection","volume":"78","author":"Jenkins","year":"2004","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11022","DOI":"10.1128\/JVI.79.17.11022-11034.2005","article-title":"Characterization of an Antisense Transcript Spanning the UL81-82 Locus of Human Cytomegalovirus","volume":"79","author":"Bego","year":"2005","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E10586","DOI":"10.1073\/pnas.1710522114","article-title":"Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency","volume":"114","author":"Cheng","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1128\/JVI.73.6.4806-4812.1999","article-title":"Quantitative Analysis of Latent Human Cytomegalovirus","volume":"73","author":"Slobedman","year":"1999","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1182\/blood.V93.1.394","article-title":"Peripheral blood CD14(+) cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome","volume":"93","author":"Mocarski","year":"1999","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2012.09.023","article-title":"Snapshots: Chromatin control of viral infection","volume":"435","author":"Knipe","year":"2013","journal-title":"Virology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.virusres.2010.09.019","article-title":"Chromatin-mediated regulation of cytomegalovirus gene expression","volume":"157","author":"Reeves","year":"2011","journal-title":"Virus Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nrmicro3135","article-title":"Keeping it quiet: Chromatin control of gammaherpesvirus latency","volume":"11","author":"Lieberman","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1099\/vir.0.015602-0","article-title":"Analysis of latent viral gene expression in natural and experimental latency models of human cytomegalovirus and its correlation with histone modifications at a latent promoter","volume":"91","author":"Reeves","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1128\/JVI.00348-10","article-title":"Cellular and viral control over the initial events of human cytomegalovirus experimental latency in CD34+ cells","volume":"84","author":"Saffert","year":"2010","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01754-17","DOI":"10.1128\/mBio.01754-17","article-title":"Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways to Maintain Latent Infection","volume":"8","author":"Krishna","year":"2017","journal-title":"mBio"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Keyes, L.R., Hargett, D., Soland, M., Bego, M.G., Rossetto, C.C., Almeida-Porada, G., and St. Jeor, S. (2012). HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14+ Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052827"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1128\/JVI.01547-16","article-title":"Long and short isoforms of the human cytomegalovirus UL138 protein silence IE1 transcription and promote latency","volume":"90","author":"Lee","year":"2016","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Buehler, J., Zeltzer, S., Reitsma, J., Petrucelli, A., Umashankar, M., Rak, M., Zagallo, P., Schroeder, J., Terhune, S., and Goodrum, F. (2016). Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005655"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1006\/viro.1993.1192","article-title":"Initiation of Human Cytomegalovirus Infection Requires Initial Interaction with Cell Surface Heparan Sulfate","volume":"193","author":"Compton","year":"1993","journal-title":"Virology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1128\/jvi.66.3.1761-1764.1992","article-title":"A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope","volume":"66","author":"Kari","year":"1992","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15470","DOI":"10.1073\/pnas.0406821101","article-title":"Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain","volume":"101","author":"Feire","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.coviro.2017.04.006","article-title":"The COMPLEXity in herpesvirus entry","volume":"24","author":"Sathiyamoorthy","year":"2007","journal-title":"Curr. Opin. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01818","article-title":"Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus","volume":"424","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1128\/JVI.00169-07","article-title":"Epidermal Growth Factor Receptor Is Not Required for Human Cytomegalovirus Entry or Signaling","volume":"81","author":"Isaacson","year":"2007","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wu, Y., Prager, A., Boos, S., Resch, M., Brizic, I., Mach, M., Wildner, S., Scrivano, L., and Adler, B. (2017). Human cytomegalovirus glycoprotein complex gH\/gL\/gO uses PDGFR-\u03b1 as a key for entry. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006281"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature07209","article-title":"Platelet-derived growth factor-\u03b1 receptor activation is required for human cytomegalovirus infection","volume":"455","author":"Soroceanu","year":"2008","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Stegmann, C., Hochdorfer, D., Lieber, D., Subramanian, N., St\u00f6hr, D., Laib Sampaio, K., and Sinzger, C. (2017). A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006273"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0042-6822(92)90200-9","article-title":"Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface","volume":"191","author":"Compton","year":"1992","journal-title":"Virology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1128\/JVI.01251-08","article-title":"Human Cytomegalovirus Glycoprotein B Is Required for Virus Entry and Cell-to-Cell Spread but Not for Virion Attachment, Assembly, or Egress","volume":"83","author":"Isaacson","year":"2009","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/JVI.01910-07","article-title":"Characterization of the human cytomegalovirus gH\/gL\/UL128-131 complex that mediates entry into epithelial and endothelial cells","volume":"82","author":"Ryckman","year":"2008","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1128\/JVI.02100-10","article-title":"Protein pUL128 of Human Cytomegalovirus Is Necessary for Monocyte Infection and Blocking of Migration","volume":"85","author":"Straschewski","year":"2011","journal-title":"J. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/JVI.80.2.710-722.2006","article-title":"Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion","volume":"80","author":"Ryckman","year":"2006","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/JVI.02090-10","article-title":"Human Cytomegalovirus-Regulated Paxillin in Monocytes Links Cellular Pathogenic Motility to the Process of Viral Entry","volume":"85","author":"Nogalski","year":"2011","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/tra.12355","article-title":"HCMV Induces Macropinocytosis for Host Cell Entry in Fibroblasts","volume":"17","author":"Hetzenecker","year":"2016","journal-title":"Traffic"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"20039","DOI":"10.1073\/pnas.1014509107","article-title":"Experimental human cytomegalovirus latency in CD14+ monocytes","volume":"107","author":"Hargett","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1128\/JVI.05878-11","article-title":"Inhibition of Inflammatory Interleukin-6 Activity via Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase Signaling Antagonizes Human Cytomegalovirus Reactivation from Dendritic Cells","volume":"85","author":"Reeves","year":"2011","journal-title":"J. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1128\/jvi.65.11.6371-6375.1991","article-title":"Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages","volume":"65","author":"Lathey","year":"1991","journal-title":"J. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2184.1972.tb00369.x","article-title":"Observations on Human Monocyte Kinetics after Pulse Labeling","volume":"5","author":"Whitelaw","year":"1972","journal-title":"Cell Prolif."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1128\/JVI.75.13.5949-5957.2001","article-title":"Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytes","volume":"75","author":"Beisser","year":"2001","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1099\/0022-1317-66-3-509","article-title":"Cytomegalovirus Infection of Human Teratocarcinoma Cells in Culture","volume":"66","author":"Gonczol","year":"1985","journal-title":"J. Gen. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1128\/JVI.01278-12","article-title":"A Myeloid Progenitor Cell Line Capable of Supporting Human Cytomegalovirus Latency and Reactivation, Resulting in Infectious Progeny","volume":"86","author":"Murphy","year":"2012","journal-title":"J. Virol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1128\/JVI.01436-13","article-title":"Myeloblastic Cell Lines Mimic Some but Not All Aspects of Human Cytomegalovirus Experimental Latency Defined in Primary CD34+ Cell Populations","volume":"87","author":"Albright","year":"2013","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22369","DOI":"10.1073\/pnas.0908787106","article-title":"Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility","volume":"106","author":"Chan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","first-page":"4726","article-title":"Expression of epidermal growth factor receptor in human cultured cells and tissues: Relationship to cell lineage and stage of differentiation","volume":"46","author":"Real","year":"1986","journal-title":"Cancer Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e01206-16","DOI":"10.1128\/JVI.01206-16","article-title":"Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling to Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells","volume":"91","author":"Kim","year":"2017","journal-title":"J. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1073\/pnas.1604317113","article-title":"Viral binding-induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41598-017-00999-8","article-title":"LPS promotes a monocyte phenotype permissive for human cytomegalovirus immediate-early gene expression upon infection but not reactivation from latency","volume":"7","author":"Kew","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.141108798","article-title":"A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation","volume":"98","author":"Skaletskaya","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12536","DOI":"10.1073\/pnas.96.22.12536","article-title":"A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2","volume":"96","author":"Goldmacher","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1128\/JVI.02124-06","article-title":"Human Cytomegalovirus UL38 Protein Blocks Apoptosis","volume":"81","author":"Terhune","year":"2007","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1128\/JVI.05746-11","article-title":"The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1","volume":"86","author":"Chaumorcel","year":"2012","journal-title":"J. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1142984","article-title":"Complex I Binding by a Virally Encoded RNA Regulates Mitochondria-Induced Cell Death","volume":"316","author":"Reeves","year":"2007","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chom.2008.03.002","article-title":"Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex","volume":"3","author":"Moorman","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.1114966108","article-title":"Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells","volume":"109","author":"Reeves","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.4049\/jimmunol.0903025","article-title":"PI3K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus Is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes","volume":"184","author":"Chan","year":"2010","journal-title":"J. Immunol."},{"key":"ref_88","first-page":"13","article-title":"HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors","volume":"6","author":"Kew","year":"2017","journal-title":"J. Mol. Biochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1073\/pnas.0405659101","article-title":"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase","volume":"101","author":"Roux","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by AKT and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.semcdb.2014.08.004","article-title":"MTORC1 signaling controls multiple steps in ribosome biogenesis","volume":"36","author":"Iadevaia","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2010.09.026","article-title":"Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress","volume":"40","author":"Sengupta","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.chom.2013.10.007","article-title":"Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion","volume":"14","author":"Li","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.4049\/jimmunol.177.10.7094","article-title":"Human Cytomegalovirus Envelope Glycoproteins B and H Are Necessary for TLR2 Activation in Permissive Cells","volume":"177","author":"Boehme","year":"2006","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/eji.201243109","article-title":"The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals","volume":"44","author":"Wikstrom","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.chom.2007.12.008","article-title":"Lymphotoxin-Mediated Crosstalk between B Cells and Splenic Stroma Promotes the Initial Type I Interferon Response to Cytomegalovirus","volume":"3","author":"Schneider","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1128\/JVI.00113-13","article-title":"Lymphoid-Tissue Stromal Cells Coordinate Innate Defense to Cytomegalovirus","volume":"87","author":"Verma","year":"2013","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-immunol-032713-120156","article-title":"Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids","volume":"32","author":"Wu","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e00047","DOI":"10.7554\/eLife.00047","article-title":"DNA-PK is a DNA sensor for IRF-3-dependent innate immunity","volume":"2012","author":"Ferguson","year":"2012","journal-title":"Elife"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Peters, N.E., Ferguson, B.J., Mazzon, M., Fahy, A.S., Krysztofinska, E., Arribas-Bosacoma, R., Pearl, L.H., Ren, H., and Smith, G.L. (2013). A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003649"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1128\/JVI.01040-16","article-title":"cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection","volume":"90","author":"Lio","year":"2016","journal-title":"J. Virol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41467-017-02624-8","article-title":"Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses","volume":"9","author":"Choi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.chom.2017.01.001","article-title":"Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity","volume":"21","author":"Fu","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1128\/MCB.23.6.1885-1895.2003","article-title":"Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor Suppressors Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Depende","volume":"23","author":"Kalejta","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.aab3291","article-title":"DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway","volume":"350","author":"Lau","year":"2015","journal-title":"Science"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/JVI.01748-09","article-title":"Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1","volume":"84","author":"DeFilippis","year":"2010","journal-title":"J. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1073\/pnas.0801295105","article-title":"Regulation of innate immune responses by DAI (DLM-1\/ZBP1) and other DNA-sensing molecules","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"De Regge, N., Van Opdenbosch, N., Nauwynck, H.J., Efstathiou, S., and Favoreel, H.W. (2010). Interferon alpha induces establishment of alphaherpesvirus latency in sensory neurons in vitro. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013076"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Da\u011f, F., D\u00f6lken, L., Holzki, J., Drabig, A., Weing\u00e4rtner, A., Schwerk, J., Lienenklaus, S., Conte, I., Geffers, R., and Davenport, C. (2014). Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003962"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"10286","DOI":"10.1128\/JVI.00373-11","article-title":"Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN-\u03b3) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State","volume":"85","author":"Kropp","year":"2011","journal-title":"J. Virol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.biochi.2007.01.004","article-title":"PML and PML nuclear bodies: Implications in antiviral defence","volume":"89","author":"Everett","year":"2007","journal-title":"Biochimie"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.3390\/v7062751","article-title":"Contribution of the major ND10 proteins PML, hDaxx and sp100 to the regulation of human cytomegalovirus latency and lytic replication in the monocytic cell line THP-1","volume":"7","author":"Wagenknecht","year":"2015","journal-title":"Viruses"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature24039","article-title":"CG dinucleotide suppression enables antiviral defence targeting non-self RNA","volume":"550","author":"Takata","year":"2017","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.immuni.2016.06.015","article-title":"The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA","volume":"45","author":"Gray","year":"2016","journal-title":"Immunity"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1128\/JVI.01215-08","article-title":"Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection","volume":"82","author":"Lukashchuk","year":"2008","journal-title":"J. Virol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.virol.2007.05.037","article-title":"Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells","volume":"367","author":"Hwang","year":"2007","journal-title":"Virology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.1128\/JVI.02639-08","article-title":"Human cytomegalovirus protein pp71 induces Daxx SUMOylation","volume":"83","author":"Hwang","year":"2009","journal-title":"J. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e02049-16","DOI":"10.1128\/JVI.02049-16","article-title":"The human cytomegalovirus IE1 protein antagonizes ND10-mediated intrinsic immunity via the inhibition of PML de novo SUMOylation","volume":"91","author":"Schilling","year":"2017","journal-title":"J. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"9853","DOI":"10.1128\/JVI.00500-10","article-title":"Nuclear localization of tegument-delivered pp71 in human cytomegalovirus-infected cells is facilitated by one or more factors present in terminally differentiated fibroblasts","volume":"84","author":"Penkert","year":"2010","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1099\/vir.0.83019-0","article-title":"Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression","volume":"88","author":"Groves","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Viswanathan, K., Smith, M.S., Malouli, D., Mansouri, M., Nelson, J.A., and Fr\u00fch, K. (2011). BST2\/tetherin enhances entry of human cytomegalovirus. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002332"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1128\/JVI.03416-14","article-title":"Human Cytomegalovirus Exploits Interferon-Induced Transmembrane Proteins To Facilitate Morphogenesis of the Virion Assembly Compartment","volume":"89","author":"Xie","year":"2015","journal-title":"J. Virol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1182\/bloodadvances.2016000638","article-title":"Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells","volume":"1","author":"Cheung","year":"2017","journal-title":"Blood Adv."},{"key":"ref_126","first-page":"423.e25","article-title":"Intrinsic Immunity Shapes Viral Resistance of Stem Cells","volume":"72","author":"Wu","year":"2018","journal-title":"Cell"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/7\/1\/30\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:57:22Z","timestamp":1760194642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/7\/1\/30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":126,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["pathogens7010030"],"URL":"https:\/\/doi.org\/10.3390\/pathogens7010030","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}