{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:28Z","timestamp":1789642948267,"version":"4.0.0"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002715","name":"Alberta Livestock and Meat Agency","doi-asserted-by":"publisher","award":["2016A001R"],"award-info":[{"award-number":["2016A001R"]}],"id":[{"id":"10.13039\/501100002715","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alberta Prion Research Institute","award":["201600012, 201600029, and 201700005"],"award-info":[{"award-number":["201600012, 201600029, and 201700005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Pathogenic amyloids are the main feature of several neurodegenerative disorders, such as Creutzfeldt\u2013Jakob disease, Alzheimer\u2019s disease, and Parkinson\u2019s disease. High resolution structures of tau paired helical filaments (PHFs), amyloid-\u03b2(1-42) (A\u03b2(1-42)) fibrils, and \u03b1-synuclein fibrils were recently reported using cryo-electron microscopy. A high-resolution structure for the infectious prion protein, PrPSc, is not yet available due to its insolubility and its propensity to aggregate, but cryo-electron microscopy, X-ray fiber diffraction, and other approaches have defined the overall architecture of PrPSc as a 4-rung \u03b2-solenoid. Thus, the structure of PrPSc must have a high similarity to that of the fungal prion HET-s, which is part of the fungal heterokaryon incompatibility system and contains a 2-rung \u03b2-solenoid. This review compares the structures of tau PHFs, A\u03b2(1-42), and \u03b1-synuclein fibrils, where the \u03b2-strands of each molecule stack on top of each other in a parallel in-register arrangement, with the \u03b2-solenoid folds of HET-s and PrPSc.<\/jats:p>","DOI":"10.3390\/pathogens7020050","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T03:12:21Z","timestamp":1525662741000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparing the Folds of Prions and Other Pathogenic Amyloids"],"prefix":"10.3390","volume":"7","author":[{"given":"Jos\u00e9","family":"Flores-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, Edmonton, AB T6G 2M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, Edmonton, AB T6G 2M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-8706","authenticated-orcid":false,"given":"Holger","family":"Wille","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Centre for Prions and Protein Folding Diseases, University of Alberta, 204 Brain and Aging Research Building, Edmonton, AB T6G 2M8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.161.3839.388","article-title":"Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to Chimpanzee","volume":"161","author":"Gibbs","year":"1968","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s004060050027","article-title":"The case described by Alois Alzheimer in 1911","volume":"248","author":"Moller","year":"1998","journal-title":"Eur. 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