{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:28Z","timestamp":1790819308080,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. There is no consensus regarding screening during pregnancy, prenatal\/postnatal treatment or short or medium term follow-up. Since 1992, France has offered systematic serological testing to non-immune pregnant women, monthly until delivery. Any maternal infection is thus detected; moreover, diagnosis of congenital infection can be made at birth and follow-up can be provided. \u201cGuidelines\u201d drawn up by a multidisciplinary group are presented here, concerning treatment, before and after birth. The recommendations are based on the regular analysis of the literature and the results of the working group. The evaluation of the recommendations takes into account the robustness of the recommendation and the quality of the evidence.<\/jats:p>","DOI":"10.3390\/pathogens8010024","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T04:08:20Z","timestamp":1550549300000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group"],"prefix":"10.3390","volume":"8","author":[{"given":"Fran\u00e7ois","family":"Peyron","sequence":"first","affiliation":[{"name":"Civil hospices of Lyon. Department of Parasitology and Mycology, Croix Rousse Hospital, 69317 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-3745","authenticated-orcid":false,"given":"Coralie","family":"L\u2019ollivier","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille, Department of Parasitology, Timone Hospital, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Department of Obstetrics and Gynecology, Louis Mourier Hospital, Colombes, Universit\u00e9 Paris-Diderot, Paris, Inserm UMR1137 IAME: Infection, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Wallon","sequence":"additional","affiliation":[{"name":"Civil hospices of Lyon. Department of Parasitology and Mycology, Croix Rousse Hospital, 69317 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Piarroux","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre-Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, 75651 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Department of Neonatology, Trousseau Hospital, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille, Ophtalmology Consultations, Sainte Marguerite Hospital, 13274 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-9603","authenticated-orcid":false,"given":"Luc","family":"Paris","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, Department of Parasitology-Mycology, Piti\u00e9-Salp\u00eatri\u00e8re\/Charles Foix University Hospital, 75651 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Garcia \u2013Meric","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Peyron, F., Mc Leod, R., Ajzenberg, D., Contopoulos-Ioannidis, D., Kieffer, F., Mandelbrot, L., Sibley, L.D., Pelloux, H., Villena, I., and Wallon, M. 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