{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:53:58Z","timestamp":1776657238923,"version":"3.51.2"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-\/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin\u00b4s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the expanding spectrum of atypical clinical and radiological manifestations of HSE in patients treated with myelotoxic drugs. Moreover, we summarize the few central nervous system manifestations of SMZL reported in the literature and discuss distinct causes of neurological deterioration in patients with NHL.<\/jats:p>","DOI":"10.3390\/pathogens9030193","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T09:26:41Z","timestamp":1583486801000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin\u00b4s Lymphoma: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"9","author":[{"given":"Raffaele","family":"Nardone","sequence":"first","affiliation":[{"name":"Department of Neurology, Franz Tappeiner Hospital, 39012 Merano, Italy"},{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus University Salzburg, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Carnicelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Franz Tappeiner Hospital, 39012 Merano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Franz Tappeiner Hospital, 39012 Merano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slaven","family":"Pikija","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus University Salzburg, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Hauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Christian Doppler Medical Center, Paracelsus University Salzburg, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-5533","authenticated-orcid":false,"given":"Johann","family":"Sellner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus University Salzburg, 5020 Salzburg, Austria"},{"name":"Department of Neurology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, 81675 M\u00fcnchen, Germany"},{"name":"Department of Neurology, Krankenhaus Mistelbach-G\u00e4nserndorf, 2130 Mistelbach, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/17474086.2017.1318053","article-title":"Lymphoma classification update: B-cell non-Hodgkin lymphomas","volume":"10","author":"Jiang","year":"2017","journal-title":"Expert Rev. 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