{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:48:41Z","timestamp":1770648521882,"version":"3.49.0"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302660\/2015-1"],"award-info":[{"award-number":["302660\/2015-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406883\/2018-1"],"award-info":[{"award-number":["406883\/2018-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00837-15"],"award-info":[{"award-number":["APQ-00837-15"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01945-17"],"award-info":[{"award-number":["APQ-01945-17"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI116453"],"award-info":[{"award-number":["R01 AI116453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here, we studied the role of ST2 receptor in a murine model of oral infection with Brucella abortus, its influence on gut homeostasis and control of bacterial replication. Balb\/c (wild-type, WT) and ST2 deficient mice (ST2\u2212\/\u2212) were infected by oral gavage and the results were obtained at 3 and 14 days post infection (dpi). Our results suggest that ST2\u2212\/\u2212 are more resistant to B. abortus infection, as a lower bacterial colony-forming unit (CFU) was detected in the livers and spleens of knockout mice, when compared to WT. Additionally, we observed an increase in intestinal permeability in WT-infected mice, compared to ST2\u2212\/\u2212 animals. Breakage of the intestinal epithelial barrier and bacterial dissemination might be associated with the presence of the ST2 receptor; since, in the knockout mice no change in intestinal permeability was observed after infection. Together with enhanced resistance to infection, ST2\u2212\/\u2212 produced greater levels of IFN-\u03b3 and TNF-\u03b1 in the small intestine, compared to WT mice. Nevertheless, in the systemic model of infection ST2 plays no role in controlling Brucella replication in vivo. Our results suggest that the ST2 receptor is involved in the invasion process of B. abortus by the mucosa in the oral infection model.<\/jats:p>","DOI":"10.3390\/pathogens9050328","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T09:57:21Z","timestamp":1588067841000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection"],"prefix":"10.3390","volume":"9","author":[{"given":"Raiany","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Genetics, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila C.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Rungue","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-8038","authenticated-orcid":false,"given":"Viviani","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-3438","authenticated-orcid":false,"given":"Fabio V.","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviano","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra F.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego C.","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovanni","family":"D. Cassali","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Alves-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica T.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais\u2014Belo Horizonte, Minas Gerais 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.022622699","article-title":"Brucella melitensis: A nasty bug with hidden credentials for virulence","volume":"99","author":"Moreno","year":"2002","journal-title":"Proc. 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