{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:31:35Z","timestamp":1776439895521,"version":"3.51.2"},"reference-count":67,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["ZIM; ZF4117904 AJ8"],"award-info":[{"award-number":["ZIM; ZF4117904 AJ8"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["Zoonoses research consortium PAC-Campylobacter, IP7\/ 01KI1725D"],"award-info":[{"award-number":["Zoonoses research consortium PAC-Campylobacter, IP7\/ 01KI1725D"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Zoonotic Campylobacter, including C. jejuni and C. coli, are among the most prevalent agents of food-borne enteritis worldwide. The immunopathological sequelae of campylobacteriosis are caused by Toll-like Receptor-4 (TLR4)-dependent host immune responses, induced by bacterial lipooligosaccharide (LOS). In order to investigate C. coli-host interactions, including the roles of the human gut microbiota and TLR4, upon infection, we applied a clinical acute campylobacteriosis model, and subjected secondary abiotic, TLR4-deficient IL10-\/- mice and IL10-\/- controls to fecal microbiota transplantation derived from human donors by gavage, before peroral C. coli challenge. Until day 21 post-infection, C. coli could stably colonize the gastrointestinal tract of human microbiota-associated (hma) mice of either genotype. TLR4-deficient IL10-\/- mice, however, displayed less severe clinical signs of infection, that were accompanied by less distinct apoptotic epithelial cell and innate as well as adaptive immune cell responses in the colon, as compared to IL10-\/- counterparts. Furthermore, C. coli infected IL10-\/-, as opposed to TLR4-deficient IL10-\/-, mice displayed increased pro-inflammatory cytokine concentrations in intestinal and, strikingly, systemic compartments. We conclude that pathogenic LOS might play an important role in inducing TLR4-dependent host immune responses upon C. coli infection, which needs to be further addressed in more detail.<\/jats:p>","DOI":"10.3390\/pathogens9050386","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T11:34:14Z","timestamp":1589801654000},"page":"386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota"],"prefix":"10.3390","volume":"9","author":[{"given":"Sigri","family":"Kl\u00f8ve","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Genger","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Weschka","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":false,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 - University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a018119","DOI":"10.1101\/cshperspect.a018119","article-title":"The evolution of Campylobacter jejuni and Campylobacter coli","volume":"7","author":"Sheppard","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_2","unstructured":"World Health Organization (2020, January 02). Campylobacter. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/campylobacter."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA), and European Centre for Disease Prevention and Control (ECDC) (2019). The European Union One Health 2018 Zoonoses Report. EFSA J., 17, e05926.","DOI":"10.2903\/j.efsa.2019.5926"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00103-011-1289-y","article-title":"Die Campylobacteriose des Menschen","volume":"54","author":"Alter","year":"2011","journal-title":"Bundesgesundheitsblatt Gesundh. Gesundh."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/mr.50.1.81-94.1986","article-title":"Pathophysiology of Campylobacter enteritis","volume":"50","author":"Walker","year":"1986","journal-title":"Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Klein, G. (2017). Chapter 1-Human campylobacteriosis. Campylobacter, Academic Press.","DOI":"10.1016\/B978-0-12-803623-5.00001-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000060405","article-title":"Campylobacter jejuni","volume":"8","author":"Kist","year":"2001","journal-title":"Contrib. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1086\/513783","article-title":"Association between Campylobacter infection and Guillain-Barre syndrome","volume":"176","author":"Allos","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_9","first-page":"E79","article-title":"Campylobacter: From microbiology to prevention","volume":"58","author":"Riso","year":"2017","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpeds.2004.01.057","article-title":"Innate immunity and toll-like receptors: Clinical implications of basic science research","volume":"144","author":"Abreu","year":"2004","journal-title":"J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1128\/IAI.71.7.3901-3908.2003","article-title":"Activation of toll-like receptor 2 (TLR2) and TLR4\/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains","volume":"71","author":"Pridmore","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/10408419609106458","article-title":"The lipooligosaccharides of pathogenic gram-negative bacteria","volume":"22","author":"Preston","year":"1996","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","article-title":"Bacterial endotoxin: Molecular relationships of structure to activity and function","volume":"8","author":"Rietschel","year":"1994","journal-title":"FASEB J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Haag, L.M., Fischer, A., Otto, B., Plickert, R., Kuhl, A.A., Gobel, U.B., Bereswill, S., and Heimesaat, M.M. (2012). Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-\/- mice via Toll-like-receptor-2 and -4 signaling. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040761"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Stahl, M., Ries, J., Vermeulen, J., Yang, H., Sham, H.P., Crowley, S.M., Badayeva, Y., Turvey, S.E., Gaynor, E.C., and Li, X. (2014). A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004264"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/IAI.01562-08","article-title":"Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes","volume":"77","author":"Rathinam","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1128\/IAI.00897-09","article-title":"Activation of human and chicken toll-like receptors by Campylobacter spp","volume":"78","author":"Keestra","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Fischer, A., Plickert, R., Haag, L.-M., Otto, B., K\u00fchl, A.A., Dashti, J.I., Zautner, A.E., Mu\u00f1oz, M., and Loddenkemper, C. (2011). Novel Murine Infection Models Provide Deep Insights into the \u201cM\u00e9nage \u00e0 Trois\u201d of Campylobacter jejuni, Microbiota and Host Innate Immunity. PLoS ONE, 6.","DOI":"10.1371\/annotation\/5247af81-4595-44b7-9c3f-2e45ad85abfa"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.micinf.2009.07.004","article-title":"Sialylation of Campylobacter jejuni lipo-oligosaccharides is associated with severe gastro-enteritis and reactive arthritis","volume":"11","author":"Mortensen","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut Microbiota in Health and Disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"d\u2019Hennezel, E., Abubucker, S., Murphy, L.O., and Cullen, T.W. (2017). Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling. mSystems, 2.","DOI":"10.1128\/mSystems.00046-17"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: Mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Paglino","year":"2004","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"526860","DOI":"10.1155\/2013\/526860","article-title":"Modification of intestinal microbiota and its consequences for innate immune response in the pathogenesis of campylobacteriosis","volume":"2013","author":"Masanta","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/649557","article-title":"Resilience to bacterial infection: Difference between species could be due to proteins in serum","volume":"201","author":"Warren","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1095\/biolreprod.106.056143","article-title":"Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice","volume":"76","author":"Robertson","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1056\/NEJM199305203282005","article-title":"Shock and Multiple-Organ Dysfunction after Self-Administration of Salmonella Endotoxin","volume":"328","author":"Kaulbach","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mousavi, S., Bereswill, S., and Heimesaat, M.M. (2020). Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040482"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fcimb.2014.00077","article-title":"The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice","volume":"4","author":"Heimesaat","year":"2014","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0163-4453(03)00042-2","article-title":"Campylobacter coli - an important foodborne pathogen","volume":"47","author":"Tam","year":"2003","journal-title":"J. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/CMR.00006-15","article-title":"Global Epidemiology of Campylobacter Infection","volume":"28","author":"Kaakoush","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1038\/s41598-018-21438-2","article-title":"Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli","volume":"8","author":"Culebro","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1128\/JB.00347-16","article-title":"Sequence Diversity within the Biosynthesis Locus and Common Biochemical Features of Campylobacter coli Lipooligosaccharides","volume":"198","author":"Culebro","year":"2016","journal-title":"J. Bacteriol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/21505594.2015.1042642","article-title":"Virulence genes and cytokine profile in systemic murine Campylobacter coli infection","volume":"6","author":"Raspor","year":"2015","journal-title":"Virulence"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Genger, C., Kl\u00f8ve, S., Mousavi, S., Bereswill, S., and Heimesaat, M.M. (2020). The conundrum of colonization resistance against Campylobacter reloaded: The gut microbota composition in conventional mice does not prevent from Campylobacter coli infection. Eur. J. Microbiol. Immun. (Bp).","DOI":"10.1556\/1886.2020.00004"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.4049\/jimmunol.170.8.3977","article-title":"Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut","volume":"170","author":"Ishihara","year":"2003","journal-title":"J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2249.2004.02464.x","article-title":"Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection","volume":"136","author":"Schmausser","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.4049\/jimmunol.171.8.4294","article-title":"A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages","volume":"171","author":"Haase","year":"2003","journal-title":"J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1348-0421.2007.tb03916.x","article-title":"Characterization of the inhabitancy of mouse intestinal bacteria (MIB) in rodents and humans by real-time PCR with group-specific primers","volume":"51","author":"Kibe","year":"2007","journal-title":"Microbiol. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Fischer, A., Siegmund, B., Kupz, A., Niebergall, J., Fuchs, D., Jahn, H.K., Freudenberg, M., Loddenkemper, C., and Batra, A. (2007). Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000662"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/gut.2006.104497","article-title":"Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli","volume":"56","author":"Heimesaat","year":"2007","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1084\/jem.20090900","article-title":"Interleukin (IL)-23 mediates Toxoplasma gondii\u2013induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17","volume":"206","author":"Heimesaat","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Erridge, C., Duncan, S.H., Bereswill, S., and Heimesaat, M.M. (2010). The Induction of Colitis and Ileitis in Mice Is Associated with Marked Increases in Intestinal Concentrations of Stimulants of TLRs 2, 4, and 5. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009125"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/gut.2009.197434","article-title":"MyD88\/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease","volume":"59","author":"Heimesaat","year":"2010","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Munoz, M., Fischer, A., Plickert, R., Haag, L.M., Otto, B., Kuhl, A.A., Loddenkemper, C., Gobel, U.B., and Heimesaat, M.M. (2010). Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015099"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Haag, L.M., Fischer, A., Otto, B., Plickert, R., Kuhl, A.A., Gobel, U.B., Bereswill, S., and Heimesaat, M.M. (2012). Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035988"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Boelke, S., Fischer, A., Haag, L.-M., Loddenkemper, C., K\u00fchl, A.A., G\u00f6bel, U.B., and Bereswill, S. (2012). Comprehensive Postmortem Analyses of Intestinal Microbiota Changes and Bacterial Translocation in Human Flora Associated Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040758"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1556\/EuJMI.2.2012.1.2","article-title":"Campylobacter jejuni infection of infant mice: Acute enterocolitis is followed by asymptomatic intestinal and extra-intestinal immune responses","volume":"2","author":"Haag","year":"2012","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_52","first-page":"98","article-title":"Murine infection models for the investigation of Campylobacter jejuni\u2014Host interactions and pathogenicity","volume":"128","author":"Heimesaat","year":"2015","journal-title":"Berl. Munch Tierarztl. Wochenschr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1556\/1886.2016.00036","article-title":"Dissecting the Interplay Between Intestinal Microbiota and Host Immunity in Health and Disease: Lessons Learned from Germfree and Gnotobiotic Animal Models","volume":"6","author":"Fiebiger","year":"2016","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.chom.2016.04.014","article-title":"Human Microbiota-Associated Mice: A Model with Challenges","volume":"19","author":"Arrieta","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"von Klitzing, E., Ekmekciu, I., Kuhl, A.A., Bereswill, S., and Heimesaat, M.M. (2017). Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176144"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13099-017-0154-4","article-title":"Acute ileitis facilitates infection with multidrug resistant Pseudomonas aeruginosa in human microbiota-associated mice","volume":"9","author":"Ekmekciu","year":"2017","journal-title":"Gut Pathog."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.3389\/fmicb.2017.02590","article-title":"Intestinal and Systemic Immune Responses upon Multi-drug Resistant Pseudomonas aeruginosa Colonization of Mice Harboring a Human Gut Microbiota","volume":"8","author":"Ekmekciu","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1556\/1886.2018.00006","article-title":"Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis","volume":"8","author":"Escher","year":"2018","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1556\/1886.2018.00005","article-title":"Peroral Low-Dose Toxoplasma gondii Infection of Human Microbiota-Associated Mice - A Subacute Ileitis Model to Unravel Pathogen-Host Interactions","volume":"8","author":"Heimesaat","year":"2018","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.3389\/fimmu.2019.02272","article-title":"Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota","volume":"10","author":"Heimesaat","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3389\/fimmu.2019.00554","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide-A Neuropeptide as Novel Treatment Option for Subacute Ileitis in Mice Harboring a Human Gut Microbiota","volume":"10","author":"Bereswill","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fimmu.2017.00397","article-title":"Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice","volume":"8","author":"Ekmekciu","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1556\/1886.2017.00022","article-title":"Multidrug-Resistant Pseudomonas Aeruginosa Induce Systemic Pro-Inflammatory Immune Responses in Colonized Mice","volume":"7","author":"Bereswill","year":"2017","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1556\/EuJMI.3.2013.3.4","article-title":"Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice","volume":"3","author":"Heimesaat","year":"2013","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1556\/1886.2015.00033","article-title":"The Role of Gelatinases in Campylobacter Jejuni Infection of Gnotobiotic Mice","volume":"5","author":"Alutis","year":"2015","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1556\/1886.2015.00020","article-title":"Matrix Metalloproteinase-2 Mediates Intestinal Immunopathogenesis in Campylobacter Jejuni-Infected Infant Mice","volume":"5","author":"Alutis","year":"2015","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Heimesaat, M.M., Lugert, R., Fischer, A., Alutis, M., Kuhl, A.A., Zautner, A.E., Tareen, A.M., Gobel, U.B., and Bereswill, S. (2014). Impact of Campylobacter jejuni cj0268c knockout mutation on intestinal colonization, translocation, and induction of immunopathology in gnotobiotic IL-10 deficient mice. 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