{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:47:12Z","timestamp":1782946032539,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: Strongyloidiasis is a parasitic disease with global prevalence. In Spain, autochthonous cases are concentrated in the Mediterranean basin. We aimed to analyze clinical and epidemiological characteristics of Strongyloides stercoralis infection in Vega Baja del Segura (Spain), comparing autochthonous versus imported cases. Methods: Observational retrospective study of all strongyloidiasis cases from January 2009 to January 2019. Cases were diagnosed by stool larvae visualization, positive culture, PCR, Strongyloides serology, and\/or compatible histology. Results: We included 36 patients (21 men) with a mean age of 60.8 years \u00b117.6; 15 cases were autochthonous and 21 imported 80.9% from Latin America. Autochthonous cases were associated with older age (mean 71.3 vs. 53.3 years; p = 0.002), male sex (odds ratio (OR) 5.33; 95% confidence interval (CI) 1.15\u201324.68; p = 0.041), and agricultural activity (OR 13.5; 95% CI 2.4\u201373.7; p = 0.002). Fourteen were asymptomatic, three autochthonous cases presented with hyperinfection syndrome, and two patients died. There was no difference between autochthonous versus imported origin in eosinophilia at diagnosis (93.3% vs. 75%; p = 0.207), treatment received, or clinical response (85.7% vs. 88.9% cured; p = 1). Conclusion: In our region, imported strongyloidiasis coexists with autochthonous cases, which are mainly in older male farmers who are diagnosed at more advanced stages. Systematic screening programs are needed.<\/jats:p>","DOI":"10.3390\/pathogens9080601","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T10:14:06Z","timestamp":1595499246000},"page":"601","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Strongyloidiasis in Southern Alicante (Spain): Comparative Retrospective Study of Autochthonous and Imported Cases"],"prefix":"10.3390","volume":"9","author":[{"given":"Ana","family":"Lucas Dato","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Pacheco-Tenza","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Borrajo Brunete","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"},{"name":"Microbiology Department, Hospital Vega Baja, 03314 Orihuela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Mart\u00ednez L\u00f3pez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Garc\u00eda L\u00f3pez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Gonz\u00e1lez Cuello","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Gregori Colom\u00e9","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Navarro Cots","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"},{"name":"Microbiology Department, Hospital Vega Baja, 03314 Orihuela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Saugar","sequence":"additional","affiliation":[{"name":"Parasitology Department, Centro Nacional de Microbiolog\u00eda, Instituto Carlos III, 28903 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Garc\u00eda-Vazquez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Ruiz-Maci\u00e1","sequence":"additional","affiliation":[{"name":"Pathological Department, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-7706","authenticated-orcid":false,"given":"Jara","family":"Llenas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain"},{"name":"Clinical Medicine Department, Universidad Miguel Hern\u00e1ndez de Elche, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40475-014-0034-7","article-title":"Advances in the diagnosis of human strongyloidiasis","volume":"1","author":"Buonfrate","year":"2014","journal-title":"Curr. 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