{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:18:48Z","timestamp":1760239128491,"version":"build-2065373602"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006205","name":"Faculty of Science, Cairo University","doi-asserted-by":"publisher","award":["29"],"award-info":[{"award-number":["29"]}],"id":[{"id":"10.13039\/501100006205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>There is strong correlation between changes in abundance of specific bacterial species and several diseases including schistosomiasis. Several studies have described therapeutic effects of curcumin (CUR) which may arise from its regulative effects on intestinal microbiota. Thus, we examined the impact of CUR on the diversity of intestinal microbiota with\/without infection by Schistosoma mansoni cercariae for 56 days. Enterobacteriaceae was dominating in a naive and S. mansoni infected mice group without CUR treatment, the most predominant species was Escherichia coli with relative density (R.D%) = 80.66% and the least one was Pseudomonas sp. (0.52%). The influence of CUR on murine microbiota composition was examined one week after oral administration of high (40) and low (20 mg\/kg b.w.) CUR doses were administered three times, with two day intervals. CUR induced high variation in the Enterobacteriaceae family, characterized by a significant (p &lt; 0.001) reduction in E. coli and asignificant (p &lt; 0.001) increase in Pseudomonas sp. in both na\u00efve and S. mansoni-infected mice, compared to untreated mice, in a dose-dependent manner. Additionally, our study showed the effects of high CUR doses on S. mansoni infection immunological and parasitological parameters. These data support CUR\u2019s ability to promote Pseudomonas sp. known to produce schistosomicidal toxins and offset the sequelae of murine schistosomiasis.<\/jats:p>","DOI":"10.3390\/pathogens9090767","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T07:06:09Z","timestamp":1600499169000},"page":"767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Curcumin Have a Role in the Interaction between Gut Microbiota and Schistosoma mansoni in Mice?"],"prefix":"10.3390","volume":"9","author":[{"given":"Assmaa","family":"Anter","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-8510","authenticated-orcid":false,"given":"Mohamed Abd","family":"El-Ghany","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science, Cairo University, Giza 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Abou El Dahab","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Mahana","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fcimb.2012.00141","article-title":"Interactions between parasites and microbial communities in the human gut","volume":"2","author":"Berrilli","year":"2012","journal-title":"Front. 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